Stochastic Models for Carcinogenesis PDF Download
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Author: Wai-Yuan Tan
Publisher: CRC Press
ISBN: 1000715647
Category : Mathematics
Languages : en
Pages : 268
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Book Description
An up-to-date survey of mathematical models of carcinogenesis, providing the most recent findings of cancer biology as evidence of the models, as well as extensive bibliographies of cancer biology and in-depth mathematical analyses for each of the models. May be used as a reference for biostaticians, biometricians, mathematical and molecular biologists, applied mathematicians, oncologists, cancer and toxicology researchers, environmental scientists, and graduate students in these fields.
Author: Wai-Yuan Tan
Publisher: CRC Press
ISBN: 1000715647
Category : Mathematics
Languages : en
Pages : 268
Get Book Here
Book Description
An up-to-date survey of mathematical models of carcinogenesis, providing the most recent findings of cancer biology as evidence of the models, as well as extensive bibliographies of cancer biology and in-depth mathematical analyses for each of the models. May be used as a reference for biostaticians, biometricians, mathematical and molecular biologists, applied mathematicians, oncologists, cancer and toxicology researchers, environmental scientists, and graduate students in these fields.
Author: Andrej Yu Yakovlev
Publisher: World Scientific
ISBN: 9810218311
Category : Medical
Languages : en
Pages : 287
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Book Description
This research monograph discusses newly developed mathematical models and methods that provide biologically meaningful inferences from data on cancer latency produced by follow-up and discrete surveillance studies. Methods for designing optimal strategies of cancer surveillance are systematically presented for the first time in this book. It offers new approaches to the stochastic description of tumor latency, employs biologically-based models for making statistical inference from data on tumor recurrence and also discusses methods of statistical analysis of data resulting from discrete surveillance strategies. It also offers insight into the role of prognostic factors based on the interpretation of their effects in terms of parameters endowed with biological meaning, as well as methods for designing optimal schedules of cancer screening and surveillance. Last but not least, it discusses survival models allowing for cure rates and the choice of optimal treatment based on covariate information, and presents numerous examples of real data analysis.
Author: W. Y. Tan
Publisher: World Scientific
ISBN: 9812779485
Category : Political Science
Languages : en
Pages : 592
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Book Description
Composed of contributions from an international team of leading researchers, this book pulls together the most recent research results in the field of cancer modeling to provide readers with the most advanced mathematical models of cancer and their applications.Topics included in the book cover oncogenetic trees, stochastic multistage models of carcinogenesis, effects of ionizing radiation on cell cycle and genomic instability, induction of DNA damage by ionizing radiation and its repair, epigenetic cancer models, bystander effects of radiation, multiple pathway models of human colon cancer, and stochastic models of metastasis. The book also provides some important applications of cancer models to the assessment of cancer risk associated with various hazardous environmental agents, to cancer screening by MRI, and to drug resistance in cancer chemotherapy. An updated statistical design and analysis of xenograft experiments as well as a statistical analysis of cancer occult clinical data are also provided.The book will serve as a useful source of reference for researchers in biomathematics, biostatistics and bioinformatics; for clinical investigators and medical doctors employing quantitative methods to develop procedures for cancer diagnosis, prevention, control and treatment; and for graduate students.
Author: Wai-Yuan Tan
Publisher: CRC Press
ISBN: 1000723461
Category : Mathematics
Languages : en
Pages : 280
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Book Description
An up-to-date survey of mathematical models of carcinogenesis, providing the most recent findings of cancer biology as evidence of the models, as well as extensive bibliographies of cancer biology and in-depth mathematical analyses for each of the models. May be used as a reference for biostaticians, biometricians, mathematical and molecular biologists, applied mathematicians, oncologists, cancer and toxicology researchers, environmental scientists, and graduate students in these fields.
Author: W. Y. Tan
Publisher: World Scientific
ISBN: 9789810248697
Category : Science
Languages : en
Pages : 464
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Book Description
This book presents a systematic treatment of Markov chains, diffusion processes and state space models, as well as alternative approaches to Markov chains through stochastic difference equations and stochastic differential equations. It illustrates how these processes and approaches are applied to many problems in genetics, carcinogenesis, AIDS epidemiology and other biomedical systems.One feature of the book is that it describes the basic MCMC (Markov chain and Monte Carlo) procedures and illustrates how to use the Gibbs sampling method and the multilevel Gibbs sampling method to solve many problems in genetics, carcinogenesis, AIDS and other biomedical systems.As another feature, the book develops many state space models for many genetic problems, carcinogenesis, AIDS epidemiology and HIV pathogenesis. It shows in detail how to use the multilevel Gibbs sampling method to estimate (or predict) simultaneously the state variables and the unknown parameters in cancer chemotherapy, carcinogenesis, AIDS epidemiology and HIV pathogenesis. As a matter of fact, this book is the first to develop many state space models for many genetic problems, carcinogenesis and other biomedical problems.
Author: Arino
Publisher: CRC Press
ISBN: 9780824784249
Category : Mathematics
Languages : en
Pages : 812
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Book Description
This book is an outcome of the Second International Conference on Mathematical Population Dynamics. It is intended for mathematicians, statisticians, biologists, and medical researchers who are interested in recent advances in analyzing changes in populations of genes, cells, and tumors.
Author: Thomas S. Deisboeck
Publisher: CRC Press
ISBN: 1439814422
Category : Mathematics
Languages : en
Pages : 492
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Book Description
Cancer is a complex disease process that spans multiple scales in space and time. Driven by cutting-edge mathematical and computational techniques, in silico biology provides powerful tools to investigate the mechanistic relationships of genes, cells, and tissues. It enables the creation of experimentally testable hypotheses, the integration of dat
Author: Miriam Christine Poirier
Publisher: World Scientific
ISBN: 981323721X
Category : Medical
Languages : en
Pages : 391
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Book Description
As chemical exposures and cancer rates increase worldwide, there is a need for students, researchers, public health professionals, and physicians to understand the mechanisms connecting exposure with human cancer risk. This new book is an essential reference, as well as introduction to the field of chemical carcinogenesis, with particular focus on DNA damage as a critical link between exposure and disease, and emphasis on biomarkers associated with cancer risk in humans. In addition to DNA damage, related topics covered include metabolism of selected chemical carcinogens, exposure-induced epigenetic changes, cancer-associated mutations and reduction of DNA damage and cancer risk by chemoprevention. The book is designed to be a comprehensive guide to basic principles, a teaching tool for academics, and a map for the development of protective mechanisms to reduce human cancer risk.
Author: Trevor M. Penning
Publisher: Springer Science & Business Media
ISBN: 1617379956
Category : Medical
Languages : en
Pages : 447
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Book Description
This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.
Author: Dominik Wodarz
Publisher: World Scientific
ISBN: 9814481874
Category : Science
Languages : en
Pages : 266
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Book Description
The book shows how mathematical and computational models can be used to study cancer biology. It introduces the concept of mathematical modeling and then applies it to a variety of topics in cancer biology. These include aspects of cancer initiation and progression, such as the somatic evolution of cells, genetic instability, and angiogenesis. The book also discusses the use of mathematical models for the analysis of therapeutic approaches such as chemotherapy, immunotherapy, and the use of oncolytic viruses.
