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Author: Professor Satyajit D. Sarker
Publisher: John Wiley & Sons
ISBN: 1119972841
Category : Science
Languages : en
Pages : 414
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Book Description
Steroid dimers are an important group of compounds produced by various marine organisms, and also synthesized in the laboratories. This group of compounds possesses various pharmacological and biological properties, and can also be used to create “molecular umbrellas” for drug delivery. Steroid Dimers: Chemistry and Applications in Drug Design and Delivery provides an up-to-date overview on the chemistry and applications of steroid dimers of natural and synthetic origins. The book includes easy-to-follow synthetic protocols for various classes of important dimeric steroids, source details, valuable spectroscopic data and depiction of unique structural features of natural steroidal dimers, and the Structure-Activity-Relationships (SARs) of some pharmacologically active dimeric steroids. Topics covered include: introduction to steroid dimers synthesis and chemistry of noncyclic and cyclic steroid dimers naturally occurring steroid dimers – cephalostatins, ritterazines and crellastatins biological and pharmacological functions of steroid dimers and their application in drug design and discovery steroid dimers as “molecular umbrellas” for drug delivery Steroid Dimers: Chemistry and Applications in Drug Design and Delivery is an essential guide to this important class of natural and synthetic compounds for researchers and students of natural products chemistry and biochemistry, synthetic organic and medicinal chemistry, and drug design, discovery and delivery.
Author: Professor Satyajit D. Sarker
Publisher: John Wiley & Sons
ISBN: 1119972841
Category : Science
Languages : en
Pages : 414
Get Book Here
Book Description
Steroid dimers are an important group of compounds produced by various marine organisms, and also synthesized in the laboratories. This group of compounds possesses various pharmacological and biological properties, and can also be used to create “molecular umbrellas” for drug delivery. Steroid Dimers: Chemistry and Applications in Drug Design and Delivery provides an up-to-date overview on the chemistry and applications of steroid dimers of natural and synthetic origins. The book includes easy-to-follow synthetic protocols for various classes of important dimeric steroids, source details, valuable spectroscopic data and depiction of unique structural features of natural steroidal dimers, and the Structure-Activity-Relationships (SARs) of some pharmacologically active dimeric steroids. Topics covered include: introduction to steroid dimers synthesis and chemistry of noncyclic and cyclic steroid dimers naturally occurring steroid dimers – cephalostatins, ritterazines and crellastatins biological and pharmacological functions of steroid dimers and their application in drug design and discovery steroid dimers as “molecular umbrellas” for drug delivery Steroid Dimers: Chemistry and Applications in Drug Design and Delivery is an essential guide to this important class of natural and synthetic compounds for researchers and students of natural products chemistry and biochemistry, synthetic organic and medicinal chemistry, and drug design, discovery and delivery.
Author: Bimal Banik
Publisher: Elsevier
ISBN: 0128175931
Category : Science
Languages : en
Pages : 1046
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Book Description
Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6. - Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability - Reflects on techniques for a broad range of compounds and materials - Highlights sustainable and green chemistry pathways for molecular synthesis
Author: Atta-ur Rahman
Publisher: Elsevier
ISBN: 0080541771
Category : Science
Languages : en
Pages : 1109
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Book Description
In Volume 18 of this well-established series, Professor Atta-ur-Rahman again brings together the work of several of the world's leading authorities in organic chemistry. Their contributions demonstrate the rapid, ongoing development of this field by illustrating many of the latest advances in synthetic methods, total synthesis, structure determination, biosynthetic pathways, and biological activity.The opening chapter presents an overview of strategies for the synthesis of several classes of natural products with an emphasis on complex polycyclic systems. Subsequent chapters discuss the synthesis of specific classes of compounds, including morphine, polyketides, acetogenins, nonactic acid derivatives, complex spirocyclic ethers, ä-lactam and pyridone derivatives, inositol phosphates, sphingolipids, brassinosteroids, Hernandia lignans, and dimeric steroidal pyrazine alkaloids. Finally, the ever stronger links between chemistry and biology are reinforced by chapters on the origin and function of secondary metabolites, bioactive conformations of gastrin hormones, and immunochemistry.
Author: George Plopper
Publisher: Jones & Bartlett Learning
ISBN: 1284066169
Category : Science
Languages : en
Pages : 1857
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Book Description
The ideal text for students in advanced cell biology courses, Lewin’s CELLS, Third Edition continues to offer a comprehensive, rigorous overview of the structure, organization, growth, regulation, movements, and interactions of cells, with an emphasis on eukaryotic cells. The text provides students with a solid grounding in the concepts and mechanisms underlying cell structure and function, and will leave them with a firm foundation in cell biology as well as a “big picture” view of the world of the cell. Revised and updated to reflect the most recent research in cell biology, Lewin’s CELLS, Third Edition includes expanded chapters on Nuclear Structure and Transport, Chromatin and Chromosomes, Apoptosis, Principles of Cell Signaling, The Extracellular Matrix and Cell Adhesion, Plant Cell Biology, and more. All-new design features and a chapter-by-chapter emphasis on key concepts enhance pedagogy and emphasize retention and application of new skills.
Author: Atta-ur-Rahman
Publisher: Bentham Science Publishers
ISBN: 1681089173
Category : Medical
Languages : en
Pages : 350
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Book Description
Frontiers in Natural Product Chemistry is a book series devoted to publishing monographs that highlight important advances in natural product chemistry. The series covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds, including research on natural substances derived from plants, microbes and animals. Reviews of structure elucidation, biological activity, organic and experimental synthesis of natural products as well as developments of new methods are also included in the series. Volume seven of the series brings seven reviews covering these topics: - Plant-Derived Anticancer Compounds Used in Cancer Therapies - Pradimicin and Benanomicin Antibiotics - The Chemical Compositions of Bixa orellana and their Pharmacological Activities - Overview of Phytochemistry and Pharmacology of Nilakanthi (Ajuga bracteosa Wall. ex Benth.) - Tetracyclic benzocarbazoles and derivatives - Chalcones as Antiinflammatory, Antidiabetic, and Antidepressant Agents - Bioactive Steroids from Marine Organisms
Author: Raymond Spier
Publisher: Academic Press
ISBN: 0126575568
Category : Medical
Languages : en
Pages : 409
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Book Description
There has been a dramatic increase in the perception of the value of animal cell biotechnology to the research and manufacturing communities in recent years. This volume seeks to keep the reader up-to-date with this progress. This sixth and final volume in the series concentrates on the biology of animal cells in culture, giving special attention to the relationship between biology and the ability to use such cells productively. As the search continues for greater productivity, there is a need to understand the switches within cells that control expression. Additional abilities to manipulate those switches in a controllable manner are also required. In the last five years, considerable progress has been made in the elucidation of the mechanisms for cell signaling and control of gene expression. The 13 chapters of this volume are devoted to these subjects and to techniques in areas of particular concern in manufacturing circles. The achievements in the field to date are described in this book, which, together with its five companion volumes in the series, will provide a building block for the future development of animal cell biotechnology.
Author:
Publisher: Elsevier
ISBN: 044463469X
Category : Science
Languages : en
Pages : 568
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Book Description
Natural products present in the plant and animal kingdom offer a huge diversity of chemical structures, which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up to the pharmaceutical industry exciting opportunities in the field of new drug development. The series covers all of the above as well as the synthesis, testing and recording of the medicinal properties of natural products. With articles written by leading authorities in their respective fields of research, Studies in Natural Products Chemistry, Volume 46 presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products. It is a valuable resource for all those working in natural product and medicinal chemistry. - Focuses on the chemistry of bioactive natural products - Contains contributions by leading authorities in the field - Presents sources of new pharmacophores
Author: Alison Fiander
Publisher: Cambridge University Press
ISBN: 131638151X
Category : Medical
Languages : en
Pages : 557
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Book Description
Fully updated to reflect changes to the curriculum and question format since publication of the original edition, this book is essential reading for all Part 1 MRCOG candidates. A chapter has been added to mirror the new curriculum domain of data interpretation. Edited by experienced RCOG examiners and written by contributors to the RCOG's revision course, this comprehensive textbook provides extensive coverage of all curriculum areas covered by the Part 1 examination (the basic sciences which are vital to the clinical practice of obstetrics and gynaecology). Fully illustrated in colour throughout to aid understanding, this is the one textbook that every Part 1 candidate should own. The content is complementary to RCOG's eLearning programme StratOG (https://stratog.rcog.org.uk) which offers a range of products to support training and professional development in obstetrics and gynaecology, including banks of Single Best Answer (SBA) questions that offer candidates invaluable practice at tackling this demanding examination.
Author:
Publisher: ScholarlyEditions
ISBN: 1464935319
Category : Medical
Languages : en
Pages : 70
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Book Description
Ophthalmic Steroids: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Ophthalmic Steroids in a concise format. The editors have built Ophthalmic Steroids: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Ophthalmic Steroids in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Ophthalmic Steroids: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Ulrich Westphal
Publisher: Springer Science & Business Media
ISBN: 3642824862
Category : Medical
Languages : en
Pages : 620
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Book Description
