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Author: Andrzej Lange
Publisher: Nova Publishers
ISBN: 9781594544231
Category : Allocation of organs, tissues, etc
Languages : en
Pages : 196
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Book Description
The progress in HLA research achieved in the last decade has been extremely beneficial for understanding of the human genome structure, evolution of human beings and the association between HLA and complex related factors like immune responsiveness and patomechanism of some diseases. It was also found that some HLA specificities may bear a witness not only to a susceptibility to some diseases but also may reflect the ability of the host to mount immune responsiveness. All these achievements enabled successful clinical application of haematopoietic stem cells transplantation. Nowadays, it is apparent that the perfect matching at allele level of HLA specificities constitute the most important factor affecting surviving of patients transplanted from unrelated donors. This is also shown in this volume. To secure reliability of HLA typing , DNA techniques should be implemented and laboratories should comply with requirements expressed by European Federation for Immunogenetics (EFI) and American Society for Histocompatibility and Immunogenetics (ASHI). HLA typing is a complex procedure which should involve internal and external quality controls. Haematopoietic stem cell transplantation may be the best example of introducing modern technologies and very active translation of basic research in the fields of genetics and cell biology into the clinic. Even more impressive is international collaboration in searching for the best possible donor wherever in the world it might be. More than 8 million donors are registered world-wide. There is an ongoing interest in improving the international co-operation in order to secure the best donors for recipients. These chapters are of special interest as the co-operation for donors selection for HSCT is an activity across the oceans.
Author: Andrzej Lange
Publisher: Nova Publishers
ISBN: 9781594544231
Category : Allocation of organs, tissues, etc
Languages : en
Pages : 196
Get Book Here
Book Description
The progress in HLA research achieved in the last decade has been extremely beneficial for understanding of the human genome structure, evolution of human beings and the association between HLA and complex related factors like immune responsiveness and patomechanism of some diseases. It was also found that some HLA specificities may bear a witness not only to a susceptibility to some diseases but also may reflect the ability of the host to mount immune responsiveness. All these achievements enabled successful clinical application of haematopoietic stem cells transplantation. Nowadays, it is apparent that the perfect matching at allele level of HLA specificities constitute the most important factor affecting surviving of patients transplanted from unrelated donors. This is also shown in this volume. To secure reliability of HLA typing , DNA techniques should be implemented and laboratories should comply with requirements expressed by European Federation for Immunogenetics (EFI) and American Society for Histocompatibility and Immunogenetics (ASHI). HLA typing is a complex procedure which should involve internal and external quality controls. Haematopoietic stem cell transplantation may be the best example of introducing modern technologies and very active translation of basic research in the fields of genetics and cell biology into the clinic. Even more impressive is international collaboration in searching for the best possible donor wherever in the world it might be. More than 8 million donors are registered world-wide. There is an ongoing interest in improving the international co-operation in order to secure the best donors for recipients. These chapters are of special interest as the co-operation for donors selection for HSCT is an activity across the oceans.
Author: Morgan M. Mastrocinque
Publisher:
ISBN:
Category : Kidneys
Languages : en
Pages : 68
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Book Description
When considering the matching of donor and recipient pairs for kidney transplantation, there are many aspects that must be compared and evaluated in order to ensure the best outcomes for recipients. Historically, a focus has been placed on evaluating the number of mismatches in various loci of Human Leukocyte Antigens (HLAs) in addition to other clinical factors including blood type, history of disease, etc. While HLA is still a standard technique for determining the histocompatibility of donor-recipient pairs, recent research has shown that other methods such as immunogenicity scores and eplet load may provide a more nuanced approach to donor-recipient matching, resulting in the ability to increase both quantity and quality of kidney transplants that occur. Based on evidence that eplet-based matching may provide improved outcomes for kidney transplant recipients, this thesis develops computational tools, namely a small Python-based library, to aid in the evaluation of this matching methodology and explores data in order to demonstrate computationally the potential impacts of eplet load-based matching when considering race. A secondary evaluation is also made to see how introducing an additional HLA (HLA-DQ) potentially affects re-matching success. Results demonstrate that matching on eplet load yielded an average 8x increase in matches than when using HLA mismatches.
Author: Nicolaus Kröger
Publisher:
ISBN: 9781013273667
Category : Medical
Languages : en
Pages : 688
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Book Description
This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Author: Anil Chandraker
Publisher: Springer Science & Business Media
ISBN: 1461400082
Category : Medical
Languages : en
Pages : 250
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Book Description
Though kidney transplantation is considered a routine procedure, there are still significant challenges in post-transplant management. Core Concepts in Renal Transplantation is a clinically focused authoritative guide to the management of kidney transplantation. This comprehensive, state-of-the-art reference summarizes the recent changes in the field of transplantation, offering the complete range of up-to-date information on all the various aspects of basic immunobiology and the medical care of the transplant recipient. Written by a team of renowned authorities in renal transplantation, this concise resource is intended for both the nephrologist and the non-specialist with an interest in kidney transplantation.
Author: X. Rogiers
Publisher: Springer Science & Business Media
ISBN: 9783798512566
Category : Medical
Languages : en
Pages : 182
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Book Description
Aimed at the trainee surgeon and experienced transplant surgeon, this compendium on split-liver grafting contains articles written by faculty members of the first International Course on Split-Liver Transplantation. It covers the main aspects of the field and is geared towards helping surgeons select the best surgical techniques as well as identifying the pitfalls. The text features detailed instructions on the various procedures as well as an overview of the area.
Author: Ernesto A. Pretto
Publisher: Oxford Textbook in Anaesthesia
ISBN: 0199651426
Category : Medical
Languages : en
Pages : 497
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Book Description
Saving lives through organ transplantation has become increasingly possible thanks to advances in research and care. Today, the complex field of transplantation continues to develop rapidly, fuelled by demographic change and further evolutions in scientific understanding. The Oxford Textbook of Transplant Anaesthesia and Critical Care has been written and edited by pioneers in the field of organ transplantation with an international team of authors, in order to equip anaesthetists and intensivists with the knowledge and training necessary to provide high quality and evidence-based care. The text addresses fundamentals aspects of scientific knowledge, care of the donor patient, transplant ethics and special considerations. Dedicated sections address each of the major organs; kidney, pancreas, liver, heart and lung, intestinal and multivisceral. Within each organ-based section, expert authors explore underlying disease, planning for transplantation, specialized procedures, perioperative and critical care management as well as post-transplant considerations. Focus points for future developments in transplant immunology are also set out, inspiring current practitioners to engage with current clinical research and help participate in the further advancement of the science of transplantation. The print edition of the Oxford Textbook of Transplant Anaesthesia and Critical Care comes with a year's access to the online version on Oxford Medicine Online. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables.
Author: Ramadas Pisharody
Publisher: Elsevier Health Sciences
ISBN: 8131232050
Category : Medical
Languages : en
Pages : 166
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Book Description
The basic functional unit of kidney is the glomerulus. Any renal derangement at that level can lead to a multitude of diseases. The renal as well as glomerular disorders secondary to other causes such as hypertension, diabetes, other vasculites, drugs, malignancies, etc. have been adequately addressed. However, the primary glomerular disorders, due to an ambiguity regarding their genesis, have yet to be explored properly. Though these diseases are clubbed under the common head of "primary", they consist of various distinct subtypes with markedly different mechanisms of pathogenesis, course of the disease, response to treatment and prognoses. This clinical update explores the various types of pimary glomerular diseases with an aim to enhance the reader’s knowledge and aid in timely recognition and precise diagnosis of glomerular diseases to help chart the appropriate treatment of each individual condition. The first chapter elucidates the clinicopathological correlation of primary glomerular diseases to help differentiate them from each other and from other similar differential diagnoses without resorting to renal biopsy in all the cases. The second, third and fourth, chapters explore the various aspects of Proliferative Glomerulonephritis, Idiopathic Nephrotic Syndrome and Heredofamilial Glomerular Diseases. The last chapter summarizes the clinically relevant current perspectives regarding the pathogenesis and treatment modalities of all the primary glomerular diseases. This book will help the readers understand the intricacies of the aspects mentioned above and guide the practitioner to diagnose and manage Primary Glomerular Diseases with special reference to practical experience in India. The authors have put together the most relevant facts about the disease for an easy comprehension and understanding of primary glomerular diseases by practitioners and students across the specialty.
Author: Hillard M. Lazarus
Publisher: Springer Science & Business Media
ISBN: 1597454788
Category : Medical
Languages : en
Pages : 885
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Book Description
Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.
Author: Lesley A. Sharp
Publisher: Univ of California Press
ISBN: 0520277988
Category : Medical
Languages : en
Pages : 236
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Book Description
In The Transplant Imaginary, author Lesley Sharp explores the extraordinarily surgically successful realm of organ transplantation, which is plagued worldwide by the scarcity of donated human parts, a quandary that generates ongoing debates over the marketing of organs as patients die waiting for replacements. These widespread anxieties within and beyond medicine over organ scarcity inspire seemingly futuristic trajectories in other fields. Especially prominent, longstanding, and promising domains include xenotransplantation, or efforts to cull fleshy organs from animals for human use, and bioengineering, a field peopled with “tinkerers” intent on designing implantable mechanical devices, where the heart is of special interest. Scarcity, suffering, and sacrifice are pervasive and, seemingly, inescapable themes that frame the transplant imaginary. Xenotransplant experts and bioengineers at work in labs in five Anglophone countries share a marked determination to eliminate scarcity and human suffering, certain that their efforts might one day altogether eliminate any need for parts of human origin. A premise that drives Sharp’s compelling ethnographic project is that high-stakes experimentation inspires moral thinking, informing scientists’ determination to redirect the surgical trajectory of transplantation and, ultimately, alter the integrity of the human form.
Author: Georgios Tsoulfas
Publisher: BoD – Books on Demand
ISBN: 1789233402
Category : Medical
Languages : en
Pages : 454
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Book Description
One of the most interesting and at the same time most challenging fields of medicine and surgery has been that of organ donation and transplantation. It is a field that has made tremendous strides during the last few decades through the combined input and efforts of scientists from various specialties. What started as a dream of pioneers has become a reality for the thousands of our patients whose lives can now be saved and improved. However, at the same time, the challenges remain significant and so do the expectations. This book will be a collection of chapters describing these same challenges involved including the ethical, legal, and medical issues in organ donation and the technical and immunological problems the experts are facing involved in the care of these patients.The authors of this book represent a team of true global experts on the topic. In addition to the knowledge shared, the authors provide their personal clinical experience on a variety of different aspects of organ donation and transplantation.
