Cell-Penetrating Peptides

Cell-Penetrating Peptides PDF Author: Makoto Oba
Publisher: John Wiley & Sons
ISBN: 352735011X
Category : Science
Languages : en
Pages : 421

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Book Description
The definitive reference on the rational design of cell-penetrating peptides enables readers to develop tailor-made peptides for their specific needs. In recent years, cell-penetrating peptides (CPPs) have become valuable tools for the cellular delivery of proteins, nucleic acids, and drugs. These small peptide sequences can be artificially designed and synthesized with custom-made characteristics to mediate the efficient and non-toxic transport of biomolecules, drugs, or nanoparticles into the cell. Cell-Penetrating Peptides: Design, Development, and Applications provides an up-to-date account of the development and use of CPPs for delivering membrane-impermeable bioactive molecules into cells. Bringing together contributions from leading researchers from around the world, this comprehensive volume describes the characteristics and mechanisms of CPPs as well as their application in both medicine, biotechnology and agriculture. Covers rational design and development of cell-penetrating peptides for use in cellular delivery of small molecule drugs, proteins, nucleic acids, and nanoparticles Presents the chemical and biological characteristics of CPP action in vitro and in vivo Describes the structure and design principles of both synthetic and naturally occurring CPPs Discusses key medical applications of CPPs such as oral delivery, intranasal delivery, and clinical trials Cell-Penetrating Peptides: Design, Development, and Applications is an essential resource for biochemists, medicinal chemists, molecular biologists, biotechnologists, and researchers studying CPPs in both academia and industry.

Cell-Penetrating Peptides

Cell-Penetrating Peptides PDF Author: Makoto Oba
Publisher: John Wiley & Sons
ISBN: 352735011X
Category : Science
Languages : en
Pages : 421

Get Book Here

Book Description
The definitive reference on the rational design of cell-penetrating peptides enables readers to develop tailor-made peptides for their specific needs. In recent years, cell-penetrating peptides (CPPs) have become valuable tools for the cellular delivery of proteins, nucleic acids, and drugs. These small peptide sequences can be artificially designed and synthesized with custom-made characteristics to mediate the efficient and non-toxic transport of biomolecules, drugs, or nanoparticles into the cell. Cell-Penetrating Peptides: Design, Development, and Applications provides an up-to-date account of the development and use of CPPs for delivering membrane-impermeable bioactive molecules into cells. Bringing together contributions from leading researchers from around the world, this comprehensive volume describes the characteristics and mechanisms of CPPs as well as their application in both medicine, biotechnology and agriculture. Covers rational design and development of cell-penetrating peptides for use in cellular delivery of small molecule drugs, proteins, nucleic acids, and nanoparticles Presents the chemical and biological characteristics of CPP action in vitro and in vivo Describes the structure and design principles of both synthetic and naturally occurring CPPs Discusses key medical applications of CPPs such as oral delivery, intranasal delivery, and clinical trials Cell-Penetrating Peptides: Design, Development, and Applications is an essential resource for biochemists, medicinal chemists, molecular biologists, biotechnologists, and researchers studying CPPs in both academia and industry.

Polymeric Micelles for Drug Delivery

Polymeric Micelles for Drug Delivery PDF Author: Prashant Kesharwani
Publisher: Woodhead Publishing
ISBN: 0323886299
Category : Technology & Engineering
Languages : en
Pages : 716

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Book Description
Polymeric Micelles for Drug Delivery provides a comprehensive overview on the synthesis, characterization and application of polymeric micelles in drug delivery applications. The use of nanomedicines and carriers, such as polymeric micelles, has made it possible to deliver drugs, genes and therapeutic agents to localized disease sites to maximize clinical benefit while limiting unwanted side effects. This book thoroughly reviews the development and application of polymeric micelles for drug delivery, covering various polymer types and the synthesis, characterization and pharmacokinetics of different micelles. Subsequent chapters go on to look at the range of drug delivery applications of polymeric micelles – such as mucosal and transdermal – and the assorted stimuli-responsive micelles available. The book concludes with an important analysis of the environmental and regulatory aspects associated with micelle development and clinical translation. - Explores how polymeric micelles can be utilized in a range of different drug delivery approaches, from traditional oral delivery to ocular and dermal delivery - Describes the various polymer types used in the synthesis and characterization of polymeric micelles - Covers recent advances in polymeric micelles, such as drug co-delivery, triblock polymeric micelles, delivery of genetic materials, and more

The Center of the World

The Center of the World PDF Author: Allen James Fromherz
Publisher: Univ of California Press
ISBN: 0520398564
Category : History
Languages : en
Pages : 335

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Book Description
This sweeping history reorients our understanding of the Middle East, placing the Gulf at the heart of globalized trade and cross-cultural encounters. World history began in the Persian Gulf. The ancient port cities that dotted its coastlines created the first global seaboard, a place from where faiths and cultures from around the world set sail and made contact. More than a history, The Center of the World shows us that contradictions that define our modern age have always been present. For over four thousand years, the Gulf—sometimes called the Persian Gulf, sometimes the Arabian Gulf—has been a global crossroads while managing to avoid control by the world’s greatest empires. In its history, we see a world of rapid change, fluctuating centers of trade, a dependency on uncertain global markets, and intense cross-cultural encounters that hold a mirror to the contemporary world. Focusing each chapter on a different port around the Gulf, The Center of the World shows how the people of the Gulf adapted to larger changes in world history, creating a system of free trade, merchant rule, and commerce that continues to define the region today.

Siraf

Siraf PDF Author: David Whitehouse
Publisher: British Institute of Persian S
ISBN: 9781842173947
Category : History
Languages : en
Pages : 0

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Book Description
Accompanying CD-ROM contains ... "folders (in Gis format and in Graphics format).--CD-ROM label.

The Commerce and Navigation of the Ancients in the Indian Ocean

The Commerce and Navigation of the Ancients in the Indian Ocean PDF Author: William Vincent
Publisher:
ISBN:
Category : Classical geography
Languages : en
Pages : 852

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Book Description


Sasanian Archaeology: Settlements, Environment and Material Culture

Sasanian Archaeology: Settlements, Environment and Material Culture PDF Author: St John Simpson
Publisher: Archaeopress Publishing Ltd
ISBN: 1803274190
Category : History
Languages : en
Pages : 538

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Book Description
This collection of essays offers an examination of the Sasanian empire based almost entirely on archaeological and scientific research, much presented here for the first time. The book is divided into three parts examining Sasanian sites, settlements and landscapes; their complex agricultural resources; and their crafts and industries.

Islamic Architecture

Islamic Architecture PDF Author: Robert Hillenbrand
Publisher: Columbia University Press
ISBN: 9780231101325
Category : Architecture
Languages : en
Pages : 716

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Book Description
This is the definitive survey of Islamic architecture. Working from a social, rather than a technical perspective, Hillenbrand shows how the buildings fulfilled their intended functions within the community. Lavishly illustrated.

History of Padang Lawas 1

History of Padang Lawas 1 PDF Author: Cahier d’Archipel 42
Publisher: Kepustakaan Populer Gramedia
ISBN: 2910513696
Category : History
Languages : en
Pages : 522

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Book Description
For the last century and a half, the name of Padang Lawas, in the present province of North Sumatra, Indonesia, has been associated with a number of isolated Hindu- Buddhist remains located in the middle of the island. These remains are all the more remarkable because they form the largest Indianized archaeological complex yet to be seen in the northern half of Sumatra. This book is the latest contribution to the accumulation of knowledge on the ancient history of Padang Lawas. The ?fteen studies brought together here present the main results of the archaeological research programme conducted from 2006 until 2010 by the Ecole francaise d’Extréme-Orient in cooperation with the Indonesian National Centre for Archaeological Research. This programme was focused on one of the sites known in this region, namely Si Pamutung, presently located near the con?uence of the Bammun and Batang Pane Rivers. These contributions are devoted ?rstly to the directly visible features of Si Pamutung, namely its environmental setting and its Hindu-Buddhist remains made of brick and stone.

The Persian Gulf in History

The Persian Gulf in History PDF Author: L. Potter
Publisher: Springer
ISBN: 0230618456
Category : History
Languages : en
Pages : 323

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Book Description
Exploring the history of the Persian Gulf from ancient times until the present day, leading authorities treat the internal history of the region and describe the role outsiders have played there. The book focuses on the unity and identity of Gulf society and how the Gulf historically has been part of a cosmopolitan Indian Ocean world.

Introduction to Islamic Archaeology

Introduction to Islamic Archaeology PDF Author: Marcus Milwright
Publisher: Edinburgh University Press
ISBN: 0748629955
Category : History
Languages : en
Pages : 273

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Book Description
Traces archaeology's contribution to Islamic culture from its earliest manifestations to the present This introduction to the archaeology of the Islamic world traces the history of the discipline from its earliest manifestations through to the present and evaluates the contribution made by archaeology to the understanding of key aspects of Islamic culture. The author argues that it is essential for the results of archaeological research to be more fully integrated into the wider historical study of the Islamic world. His organisation of the book into broad themes allows a focus on issues that are relevant across different regions and periods, and the broad geographical scope reflects the main focus of archaeological work in the Islamic world to the present day. Key Features Includes short case studies to allow the reader to examine the ways in which archaeologists collect and interpret material in specific contexts Considers archaeological work conducted in the area stretching from Afghanistan and the Central Asian republics in the east to Spain in the west Draws comparisons with Islamic regions of sub-Saharan Africa and the Indian subcontinent Includes a Glossary of archaeological terminology and Arabic, Persian and Turkish terms