Short-term Tests for Carcinogens, Mutagens, and Other Genotoxic Agents PDF Download
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Author: Anne Trontell
Publisher:
ISBN:
Category : Carcinogenicity testing
Languages : en
Pages : 36
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Book Description
Author: Anne Trontell
Publisher:
ISBN:
Category : Carcinogenicity testing
Languages : en
Pages : 36
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Book Description
Author: H.F. Stich
Publisher: Springer Science & Business Media
ISBN: 1461258472
Category : Medical
Languages : en
Pages : 535
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Book Description
The recent surge of interest in designing, validating, and implementing short-term tests for carcinogens has been spurred by the fairly convincing correlation be tween the carcinogenicity and mutagenicity of chemicals and physical agents and by the assumption that DNA alteration, mutations, and chromosome aberrations are somehow involved in neoplastic transformation. Moreover, it has been tacitly assumed that the mutagenic capacity alone of compounds would induce regulatory agencies to pass rules for their removal from the environment and would lead the public to avoid them. The actual response, however, is quite different. Governmental departments shy away from making any decisions on the basis of in vitro test systems. The public at large is becoming irritated by daily an nouncements that many of their cherished habits could adversely affect their health. Industry appears to feel threatened and may reduce its search for new beneficial chemicals. The reluctance to accept wholeheartedly the mutagenicity tests for the detection of carcinogens is partly due to uncertainty about the in volvement of mutations in neoplastic transformation, partly due to the present difficulty of extrapolating results from various endpoints obtained on numerous organisms to man, and partly due to a multitude of complex events that lead in vivo to the evolvement of benign or malignant tumors.
Author: Douglas L. Kladder
Publisher:
ISBN:
Category : Housing and health
Languages : en
Pages : 202
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Book Description
Author:
Publisher:
ISBN:
Category : Housing and health
Languages : en
Pages : 16
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Book Description
Author: K.H. Norpoth
Publisher: Springer Science & Business Media
ISBN: 3642672027
Category : Medical
Languages : en
Pages : 424
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Book Description
The varying cancer incidence from country to country and region to region suggests that en vironmental factors play a considerable role in the aetiology of cancer. Whether these factors in the environment moderate the effect of car cinogenic chemicals or whether they might them selves be carcinogenic is not known at the present time. What is known is that there are various chemicals, both naturally occurring and man-made, which can induce cancer in man. In the Western world estimates vary as to how much cancer is occupational in origin; the figures range from 1% to 40%. It is our feeling that probably about 10% of cancer has a direct oc cupational origin. Nevertheless this number is considerable and it behoves us therefore to identify those chemicals which are carcinogenic and to reduce human exposure. Recent work on the mode of action of carcinogenic chemicals suggests that the majority exert their effect through an activation step to give elec trophilic metabolites. Such metabolites have as a common feature the ability to react with cel lular nucleophiles to give covalently bound products. Such reaction will occur after carcino gen treatment of animals with nucleic acids par ticularly in target organs. It is reaction with nucleic acids that provides the basis of a num ber of short-term tests for carcinogens, since the basic composition of DNA is similar in micro-organisms and in human cells.
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9241547677
Category : Medical
Languages : en
Pages : 111
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Book Description
This handbook focuses on residential radon exposure from a public health point of view and provides detailed recommendations on reducing health risks from radon and sound policy options for preventing and mitigating radon exposure. The material in the handbook reflects the epidemiological evidence that indoor radon exposure is responsible for a substantial number of lung cancers in the general population. Information is provided on the selection of devices to measure radon levels and on procedures for the reliable measurement of these levels. Discussed also are control options for radon in new dwellings, radon reduction in existing dwellings as well as assessment of the costs and benefits of different radon prevention and remedial actions. Also covered are radon risk communication strategies and organization of national radon programs.--Publisher's description.
Author:
Publisher:
ISBN:
Category : Environmental health
Languages : en
Pages : 264
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Book Description
Author: National Cancer Institute (U.S.)
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 548
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Book Description
Author: V.T. Covello
Publisher: Springer Science & Business Media
ISBN: 1489912169
Category : Technology & Engineering
Languages : en
Pages : 326
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Book Description
Much has already been written about risk assessment. Epidemiologists write books on how risk assessment is used to explore the factors that influence the distribution of disease in populations of people. Toxicologists write books on how risk assess ment involves exposing animals to risk agents and concluding from the results what risks people might experience if similarly exposed. Engineers write books on how risk assessment is utilized to estimate the risks of constructing a new facility such as a nuclear power plant. Statisticians write books on how risk assessment may be used to analyze mortality or accident data to determine risks. There are already many books on risk assessment-the trouble is that they all seem to be about different sUbjects! This book takes another approach. It brings together all the methods for assessing risk into a common framework, thus demonstrating how the various methods relate to one another. This produces four important benefits: • First, it provides a comprehensive reference for risk assessment. This one source offers readers concise explanations of the many methods currently available for describing and quantifying diverse types of risks. • Second, it consistently evaluates and compares available risk assessment methods and identifies their specific strengths and limitations. Understand ing the limitations of risk assessment methods is important. The field is still in its infancy, and the problems with available methods are disappoint ingly numerous. At the same time, risk assessment is being used.
Author: Wei Luo
Publisher: CRC Press
ISBN: 1000389502
Category : Computers
Languages : en
Pages : 1044
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Book Description
Selected papers from the International Conference on New Computational Social Science, focusing on the following five aspects: Big data acquisition and analysis, Integration of qualitative research and quantitative research, Sociological Internet experiment research, Application of ABM simulation method in Sociology Research, Research and development of new social computing tools. With the rapid development of information technology, especially sweeping progress in the Internet of things, cloud computing, social networks, social media and big data, social computing, as a data-intensive science, is an emerging field that leverages the capacity to collect and analyze data with an unprecedented breadth, depth and scale. It represents a new computing paradigm and an interdisciplinary field of research and application. A broad comprehension of major topics involved in social computing is important for both scholars and practitioners. This proceedings presents and discusses key concepts and analyzes the state-of-the-art of the field. The conference not only gave insights on social computing, but also affords conduit for future research in the field. Social computing has two distinct trends: One is on the social science issues, such as computational social science, computational sociology, social network analysis, etc; The other is on the use of computational techniques. Finally some new challenges ahead are summarized, including interdisciplinary cooperation and training, big data sharing for scientific data mashups, and privacy protect.
