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Author: Sheng Wu
Publisher: Frontiers Media SA
ISBN: 2832549993
Category : Science
Languages : en
Pages : 138
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Book Description
Scientific evidence from both preclinical, and clinical studies indicates that male and female patients with cardiovascular disease (CVD) exhibit different clinical, epidemiological, and pathological characteristics, with sexually dimorphic biological factors exhibiting a significant influence in the development of CVD and therapeutic responses. Sexually dimorphic physiology that contributes to sex differences in cardiovascular therapeutic responses may include; immune responses, cardio-renal health, the blood-brain barrier, coronary atherosclerosis pathology, complications of COVID-19 infections, and the interplay between psychological factors and sedentarism. Furthermore, current knowledge indicates the role of hormonal regulation has a significant impact in sex-specific differences across the clinical cardiology field. The National Institute of Health (NIH) previously adopted a policy to encourage researchers to consider sex as a biological variable (SABV) as well as Sex and Gender Equity in Research (SAGER). In order to promote sexual dimorphic cardiovascular therapeutic development, we have organized this special topic “Sex Differences and Cardiovascular Therapeutics” to provide a scientific forum for cardiovascular scientists and clinicians to present their newest findings in characterizing sex differences in cardiovascular therapeutics. Potential areas of research within this collection may include, but are not limited to: 1) Different outcomes and responses to drug treatment in cardiovascular disease between male and female. 2) Mechanisms of sexual dimorphic response and outcomes related to drug treatment of cardiovascular disease. 3) Sex hormones and their receptors in cardiovascular function in animal studies and clinical therapeutic applications. 4) Gender affirming hormone therapy and cardiovascular function. 5) Regulatory guidance for cardiovascular therapeutics in relation to sex-specific differences.
Author: Sheng Wu
Publisher: Frontiers Media SA
ISBN: 2832549993
Category : Science
Languages : en
Pages : 138
Get Book Here
Book Description
Scientific evidence from both preclinical, and clinical studies indicates that male and female patients with cardiovascular disease (CVD) exhibit different clinical, epidemiological, and pathological characteristics, with sexually dimorphic biological factors exhibiting a significant influence in the development of CVD and therapeutic responses. Sexually dimorphic physiology that contributes to sex differences in cardiovascular therapeutic responses may include; immune responses, cardio-renal health, the blood-brain barrier, coronary atherosclerosis pathology, complications of COVID-19 infections, and the interplay between psychological factors and sedentarism. Furthermore, current knowledge indicates the role of hormonal regulation has a significant impact in sex-specific differences across the clinical cardiology field. The National Institute of Health (NIH) previously adopted a policy to encourage researchers to consider sex as a biological variable (SABV) as well as Sex and Gender Equity in Research (SAGER). In order to promote sexual dimorphic cardiovascular therapeutic development, we have organized this special topic “Sex Differences and Cardiovascular Therapeutics” to provide a scientific forum for cardiovascular scientists and clinicians to present their newest findings in characterizing sex differences in cardiovascular therapeutics. Potential areas of research within this collection may include, but are not limited to: 1) Different outcomes and responses to drug treatment in cardiovascular disease between male and female. 2) Mechanisms of sexual dimorphic response and outcomes related to drug treatment of cardiovascular disease. 3) Sex hormones and their receptors in cardiovascular function in animal studies and clinical therapeutic applications. 4) Gender affirming hormone therapy and cardiovascular function. 5) Regulatory guidance for cardiovascular therapeutics in relation to sex-specific differences.
Author: Bohuslav Ostadal
Publisher: Springer Nature
ISBN: 3030586774
Category : Science
Languages : en
Pages : 284
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Book Description
Cardiovascular diseases are the leading cause of mortality in men and women. Unfortunately, women have traditionally been excluded from clinical trials, and female animals have been used less or sex was not reported in basic research studies. Until recently, consideration of both sexes was not required in clinical and preclinical studies focusing on cardiovascular diseases. However, the number of clinical and experimental papers dealing with sex differences and heart disease significantly increases during the last years. This trend is obviously the result of at least two facts: the number of examples of different behavior of the male and female heart under physiological and pathological conditions is steadily increasing and there were controversial reports on the beneficial and adverse effect of hormonal replacement therapy. Detailed molecular and cellular mechanisms of these differences are still unknown but one is clear already today: sex differences are so important that they should be considered by the selection of optimum diagnostic and therapeutic procedures in clinical practice. The book presents 16 manuscripts on sex differences of heart disease, as developed by several investigators; the volume is organized in four parts. Part I, dealing with sex differences in cardiac ischemic injury, includes 5 chapters on experimental aspects of cardiac ischemia/reperfusion injury, the role of testosterone, and clinical aspects of ischemic heart disease. Part II is devoted to sex differences in heart failure and includes four chapters. Discussion in this part of the book is centered around the sex differences in heart failure due to volume overload. Part III of this volume includes four papers on risk factors of cardiovascular diseases, namely hypertension and obesity, and, finally, three chapters in part IV deal with sex differences of cardiac mitochondria under different pathological conditions. We believe this book will be very useful for cardiovascular scientists, graduate students, postdoctoral fellows and other health professionals.
Author: Niti R. Aggarwal
Publisher: Elsevier
ISBN: 0128193700
Category : Science
Languages : en
Pages : 722
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Book Description
Significant biological differences exist between men and women that contribute to sex-specific differences in cardiovascular disease (CVD) risk factors, pathophysiology, presentation, response to therapy, and prognosis. It is essential for clinicians to be cognizant of these sex-specific differences in order to reduce the disparity in diagnosis and management of cardiovascular diseases in both genders.Sex Differences in Cardiac Disease provides a timely review of the contemporary data on these sex-specific differences in pathophysiology, clinical presentation, diagnostic evaluation, and management of cardiovascular diseases that fills a void for clinicians in practice and training. With contributions from renowned experts in the field and guideline writers, the text provides a state-of-the-art review of each topic encompassing the full spectrum of CVD in men and women. Sex-specific guideline-based recommendations are highlighted when available. Tailored to meet the needs of the busy clinicians and researchers, this text provides concise practical data to care for men and women at risk for or with CVD. The book serves as an essential resource for researchers, cardiologists, obstetricians, gynecologists, internists, family practitioners, nurse practitioners and physician assistants, and respective trainees who treat men and women with CVD. - Provides a comprehensive state-of-the-art text written by internationally renowned experts in the field of CVD disease, serving as an indispensable resource for clinicians and researchers - Enables the reader to understand the sexual dimorphism in the pathophysiology, diagnosis, management, and outcomes of the full spectrum of cardiovascular issues including ischemic heart disease, valvular disorders, arrhythmias, and heart failure - Provides a concise evidence-based practical review of medical topics, with key points and eye-catching visual infographics to meet the needs of the busy clinicians, policy makers and researchers
Author: Babbette LaMarca, Ph.D.
Publisher: Academic Press
ISBN: 0128131977
Category : Medical
Languages : en
Pages : 392
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Book Description
Sex Differences in Cardiovascular Physiology and Pathophysiology is a comprehensive look into the often overlooked and underappreciated fundamental sex differences between men and women and how those differences affect the cardiovascular system. It covers cardiovascular function, anatomy, cell signaling and the development of pathology. With contributions from world-renowned research investigators, this up-to-date reference compiles critical knowledge on cardiovascular sex differences, providing researchers and clinicians with a better understanding of the diagnosis, prevention and treatment of cardiovascular diseases in both men and women. Identifies the fundamental sex differences in the physiology and pathophysiology of the cardiovascular system Describes cell signaling pathways involved in sex-associated cardiovascular function and diseases Puts the sex differences in cardiovascular diseases in the forefront to improve cardiovascular prognoses
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309132975
Category : Medical
Languages : en
Pages : 287
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Book Description
It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.
Author: Jawahar L. Mehta
Publisher: Springer
ISBN: 3319711350
Category : Medical
Languages : en
Pages : 360
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Book Description
This book reviews all aspects of the diagnosis and management of heart disease in women, covering areas such as gender differences in metabolic syndrome, hypertension and atherogenesis. Gender differences in cardiovascular diseases are widespread, but while gender medicine takes into account the effects of sex and gender on the health of women and men, traditionally, women have been underrepresented in cardiovascular clinical trials, in management of different cardiac diseases and drug use. Gender Differences in the Pathogenesis and Management of Heart Disease deals with the gender-specific differences in cardiac physiology and diseases and brings into perspective the critical significance of gender in management of cardiovascular disease presentations and management. As such it is of enormous use to all clinical staff who manage women with cardiovascular disease.
Author: Manuel Martínez-Sellés
Publisher: Frontiers Media SA
ISBN: 2889710785
Category : Medical
Languages : en
Pages : 101
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Book Description
Author: Vera Regitz-Zagrosek
Publisher: Springer Science & Business Media
ISBN: 3642307264
Category : Medical
Languages : en
Pages : 599
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Book Description
This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.
Author: Kanu Chatterjee
Publisher: JP Medical Ltd
ISBN: 935025879X
Category : Medical
Languages : en
Pages : 530
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Book Description
Cardiac Drugs describes the latest advances in the rapidly evolving area of cardiovascular pharmacology. Written by renowned, USbased experts in cardiology, this book discusses the drug groups for different diseases, such as acute coronary syndromes, hypertension, angina and heart failure. Separate chapters examine cardiac drugs in pregnancy and lactation, and future directions. Enhanced by full colour images and illustrations, this easy to follow text offers practical advice on how to manage cardiac diseases, with a focus on hands-on therapeutic guidance for clinicians.
Author: Marek Malik
Publisher: Academic Press
ISBN: 0128177292
Category : Science
Languages : en
Pages : 986
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Book Description
Sex and Cardiac Electrophysiology: Differences in Cardiac Electrical Disorders Between Men and Women is a comprehensive investigation into all aspects of sex differences in cardiac electrophysiology. As there are substantial differences between female and male patients in physiology, pathology triggering factors, disease progression, clinical approaches and treatment outcome, this book provides a comprehensive examination. In cardiology, the differences between women and men are more recognized, hence this title summarizes these important differences, providing the essential information needed for clinical specialists and researchers involved in the design and implementation of clinical studies. - Explores topics ranging from the physiologic differences between women and men to the differences in clinical handling of arrhythmic disorders between female and male patients - Provides sex differences in cardiac electrophysiology in separate chapters - Covers the sex differences of cardiac electrical disorders, providing insights beyond cardiac metabolic syndrome, hypertension, atherogenesis and heart failure
