Sense and Senility: The Neuropathology of the Aged Human Brain PDF Download
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Author: David M.A. Mann
Publisher: Springer Science & Business Media
ISBN: 1461560012
Category : Medical
Languages : en
Pages : 202
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Book Description
nly two things are certain in life, one is that all of us will inevita Obly grow older, the other is that at some point during or at the end of this process we shall die. Inherent to the passage of time is a deterio ration in the structural and functional integrity of our bodies, this pro gressing to such an extent that one or more organ systems will eventu ally begin to fail with the continued health and well-being of the individual coming under threat. Age-associated deficiencies in the musculo-skeletal, cardiovascular, or endocrine systems producing arthri tis, hypertension, stroke or diabetes are all too apparent in our elderly population yet internally caused failures in the function of the nervous system provide the common, and mostly intractable, problems of memory and intellect or locomotion that face and frustrate clinicians. Perhaps the most important factor which can decide the outcome of research studies professing to examine the effects of the passage of time (i. e. the 'process of aging') on the function of the nervous system, or indeed any other organ system, is the selection of appropriate or repre sentative subjects for investigation. The heart of this problem lies in defining what might be considered as 'normal' aging as distinct from age-associated disease; setting the 'goal posts of normality' continues to 1 be a matter of considerable debate.
Author: David M.A. Mann
Publisher: Springer Science & Business Media
ISBN: 1461560012
Category : Medical
Languages : en
Pages : 202
Get Book Here
Book Description
nly two things are certain in life, one is that all of us will inevita Obly grow older, the other is that at some point during or at the end of this process we shall die. Inherent to the passage of time is a deterio ration in the structural and functional integrity of our bodies, this pro gressing to such an extent that one or more organ systems will eventu ally begin to fail with the continued health and well-being of the individual coming under threat. Age-associated deficiencies in the musculo-skeletal, cardiovascular, or endocrine systems producing arthri tis, hypertension, stroke or diabetes are all too apparent in our elderly population yet internally caused failures in the function of the nervous system provide the common, and mostly intractable, problems of memory and intellect or locomotion that face and frustrate clinicians. Perhaps the most important factor which can decide the outcome of research studies professing to examine the effects of the passage of time (i. e. the 'process of aging') on the function of the nervous system, or indeed any other organ system, is the selection of appropriate or repre sentative subjects for investigation. The heart of this problem lies in defining what might be considered as 'normal' aging as distinct from age-associated disease; setting the 'goal posts of normality' continues to 1 be a matter of considerable debate.
Author: David Mann
Publisher: Springer
ISBN: 9781461560029
Category : Medical
Languages : en
Pages : 198
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Book Description
nly two things are certain in life, one is that all of us will inevita Obly grow older, the other is that at some point during or at the end of this process we shall die. Inherent to the passage of time is a deterio ration in the structural and functional integrity of our bodies, this pro gressing to such an extent that one or more organ systems will eventu ally begin to fail with the continued health and well-being of the individual coming under threat. Age-associated deficiencies in the musculo-skeletal, cardiovascular, or endocrine systems producing arthri tis, hypertension, stroke or diabetes are all too apparent in our elderly population yet internally caused failures in the function of the nervous system provide the common, and mostly intractable, problems of memory and intellect or locomotion that face and frustrate clinicians. Perhaps the most important factor which can decide the outcome of research studies professing to examine the effects of the passage of time (i. e. the 'process of aging') on the function of the nervous system, or indeed any other organ system, is the selection of appropriate or repre sentative subjects for investigation. The heart of this problem lies in defining what might be considered as 'normal' aging as distinct from age-associated disease; setting the 'goal posts of normality' continues to 1 be a matter of considerable debate.
Author: James F. Willott, PhD
Publisher: Springer Publishing Company
ISBN: 0826117171
Category : Medical
Languages : en
Pages : 389
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Book Description
Neurogerontology tells the story of how the aging brain affects all aspects of cognition and physical performance. It comprehensively links the principles and substance of neuroscience with gerontology and psychology. Written largely from a behavioral neuroscience perspective, Neurogerontology explores the functional relationships between the central nervous system and psychological phenomena of aging, including perception, arousal, learning, cognition, and motor behavior. Willot emphasizes healthy aging, but dementia and other pathological conditions are discussed when relevant. This evidence-based approach to the neuroscience of aging makes this a valuable reference for professionals, as well as an informative textbook for students in gerontology courses.
Author: Gary B. Kaplan
Publisher: American Psychiatric Pub
ISBN: 1585627712
Category : Medical
Languages : en
Pages : 281
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Book Description
The 1990s, appropriately termed "the decade of the brain," witnessed unprecedented advances in our knowledge of psychiatric neuroscience. Yet with every advance, we realized afresh that we were still in the beginning stages of a much longer journey. This text chronicles the next step of that journey. Structured around a proven teaching methodology that uniquely integrates the clinical aspects of psychiatric disorders with their neurobiology, this volume begins with two introductory chapters on functional neural circuitry and neural signaling pathways. The remaining six chapters present current knowledge on the neuroanatomic and neurochemical mechanisms underlying schizophrenia, addiction, anxiety, depression, bipolar disorder, and dementia/Alzheimer's disease. For clarity and consistency, each chapter features the same four divisions -- clinical presentation, neural circuitry, signaling pathways, and psychopharmacology -- as they relate to Schizophrenia, which reviews studies of the neural basis of schizophrenia and describes how the cortex, the thalamus, the basal ganglia, and the medial temporal lobe work together during normal brain function and then how each is perturbed in psychosis. Addiction, which focuses on the consequences of psychoactive substance use, including compulsive practices (e.g., eating, sex, Internet browsing) that might also involve the same brain circuits and signaling pathways. Of exceptional value are two unique illustrations that capture -- for the first time -- much of what we know about the anatomy and neurochemistry underlying the behavioral symptoms of addiction. Anxiety, which presents current hypotheses regarding neurocircuitry and signaling pathways for the three best-studied (from a neurobiologic perspective) anxiety disorders: panic disorder, posttraumatic stress disorder, and obsessive-compulsive disorder. Depression, which offers evidence for the involvement of highly interconnected cortical and limbic structures such as the prefrontal cortex, medial thalamus, amygdala, ventral striatum, hippocampus, and the hypothalamic-pituitary-adrenal axis in unipolar major depression, and suggests target areas (such as the cAMP pathway) for study in the development of new antidepressants. Bipolar disorder, which shows that specific abnormalities in signal transduction pathways, including protein kinase activity, G protein levels, and gene expression, are unique to bipolar patients, concluding that the actions of lithium and anticonvulsants on intracellular signaling pathways provide a new paradigm for novel pharmacological interventions. Dementia and Alzheimer's disease, which details current findings on neurofibrillary degeneration, relevant genes and proteins, pathogenesis (metabolic decline, defective cell repair, and Aß toxicity), and treatment strategies (neurotransmitter replacement, and neuroprotective and regenerative approaches). Discusses frontotemporal dementia, dementia with Lewy bodies, Parkinson's disease, and vascular dementia. Meticulously researched and clearly written by 15 contributors -- all recognized experts from leading research and teaching institutions in the United States -- this compact and extensively illustrated volume stands out in the literature because it combines readability and practicality with the breadth and depth typically found only in far lengthier works. Psychiatric practitioners, residents, and students alike will welcome this informative, easy-to-read text, which will also be of special interest to mental health and pharmaceutical industry professionals, and of general interest to anyone who wants to know more about the biology of psychiatric illness.
Author: Beller Health
Publisher: Independently Published
ISBN: 9781097268511
Category :
Languages : en
Pages : 114
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Book Description
Book 9 focuses on a new dementia type, LATE, mistaken as Alzheimer's disease until now.LATE stands for Limbic-predominant age-related TDP-43 encephalopathy, the protein buildup responsible for this dementia. This book is organic, like the series, meaning we never consider our books as finished. Science evolves, which is why our books go through continuous updates. Since LATE is a new dementia classification, we expect continuous further information to emerge. Watch Amazon alerts for potential digital updates. We provide free digital copies on all paperback purchases, so everybody receives free updates.
Author: Timothy L. Kauffman
Publisher: Elsevier Health Sciences
ISBN: 0443102333
Category : Medical
Languages : en
Pages : 583
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Book Description
This manual gives step-by-step guidance on the evaluation and treatment of geriatric diseases and disorders. It covers incidence of disorders, diagnostic tests, associated diagnoses, clinical implications for mobility, and rehabilitation techniques. It offers a broad overview of the effects of aging on all body systems. Special geriatric considerations for laboratory assessment, thermoregulations, and pharmacology are also discussed. This manual is a resource for all training clinicians in geriatric care and is a quick-reference guide for students and practitioners in this field.
Author: Roger A. Barker
Publisher: Psychology Press
ISBN: 9780863776281
Category : Medical
Languages : en
Pages : 356
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Book Description
This book begins with a synopsis of experimental work underlying degeneration and recovery in the nervous system, which is then discussed in the context of strategies to repair the central nervous system (CNS) and peripheral nervous system (PNS). The major part of the book is given over to the approach involving the use of transplanted tissues to replace and restore disrupted neural networks. This experimental work has formed the basis for the emerging clinical trials employing neural grafts for diseases such as Parkinson's and Huntington's, which are discussed in detail. The book then goes on to discuss newer cellular strategies involving the manipulation of neural cells both in culture and genetically, an approach that may ultimately be employed in the clinical situation. Neural Repair, Transplantation and Rehabilitation is unique in bridging the gap from experimental studies to clinical trials, whilst also providing the non-specialist with a background in rehabilitation strategies as well as basic neuroscience. It is recommended for all those involved in the management of patients with degenerative and traumatic injuries to the nervous system.
Author: J. Marwah
Publisher:
ISBN:
Category : Alzheimer's disease
Languages : en
Pages : 264
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Book Description
Author:
Publisher:
ISBN:
Category : American literature
Languages : en
Pages : 3126
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Book Description
Author: Christine Anne Langlois
Publisher: McGraw-Hill Ryerson
ISBN: 9780070864771
Category : Couples
Languages : en
Pages : 292
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Book Description
