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Author: Urs Nydegger
Publisher: Springer Nature
ISBN: 3031322762
Category : Family & Relationships
Languages : en
Pages : 148
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Book Description
This book is about lifelong ageing of humans. The basic biochemical and genetic mechanisms remain ill known, and differ among individuals. The book starts out to explore the plant and animal kingdoms to answer questions human ageing needs for understanding. First, we come to scrutinize time running out and what ‘normal’ means with impacts on the genome and on protein half- lives and function. Ageing goes beyond biochemical skid treated by geroprotector drugs, including biosimilars; albeit early diagnosis with standard medical laboratory assays, here addressed, sheds light with focus on basic research. Modern tools, including machine learning, and DNA technology, e.g. genomics, have already provided for unanticipated insights. The chapters then turn around senescence of the entire organism based on variable ageing of single organs embedded in neuronal networks . Psychological stress factors, dementia opposed to vigilance, and distinction of ageing from overt disease are contrasting in humans and are opposed in the book. Senescence, seen as a one way track may be reverted into rejuvenation, made possible by insights into immunosenescence and genomic approaches. Risk management in health insurance finds important clues in this book. The topics addressed between the book covers help to understand the trend to the ever- prolonging life expectancy beyond the centenarian age group; nursing care takers and pharmaceutical industry are invited to understand what’ is going on in senior people to make their geriatric population remain fit or become frail.
Author: Urs Nydegger
Publisher: Springer Nature
ISBN: 3031322762
Category : Family & Relationships
Languages : en
Pages : 148
Get Book Here
Book Description
This book is about lifelong ageing of humans. The basic biochemical and genetic mechanisms remain ill known, and differ among individuals. The book starts out to explore the plant and animal kingdoms to answer questions human ageing needs for understanding. First, we come to scrutinize time running out and what ‘normal’ means with impacts on the genome and on protein half- lives and function. Ageing goes beyond biochemical skid treated by geroprotector drugs, including biosimilars; albeit early diagnosis with standard medical laboratory assays, here addressed, sheds light with focus on basic research. Modern tools, including machine learning, and DNA technology, e.g. genomics, have already provided for unanticipated insights. The chapters then turn around senescence of the entire organism based on variable ageing of single organs embedded in neuronal networks . Psychological stress factors, dementia opposed to vigilance, and distinction of ageing from overt disease are contrasting in humans and are opposed in the book. Senescence, seen as a one way track may be reverted into rejuvenation, made possible by insights into immunosenescence and genomic approaches. Risk management in health insurance finds important clues in this book. The topics addressed between the book covers help to understand the trend to the ever- prolonging life expectancy beyond the centenarian age group; nursing care takers and pharmaceutical industry are invited to understand what’ is going on in senior people to make their geriatric population remain fit or become frail.
Author: Bernard Swynghedauw
Publisher:
ISBN: 9783030151126
Category : Family medicine
Languages : en
Pages : 121
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Book Description
This book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and pathological features of senescence, and delineates possibilities for "treating" it. Following an introduction to the emerging medical landscape, the increasing incidence of a new epidemiological group (age-related "chronic non-transmissible diseases"), and the multiple origins of aging, the book explores and characterizes the senescent cell, which is linked to benign and pathological age-related manifestations. In turn, the closing chapters discuss how to "treat" or "prevent" the aging process, underscoring the central role of physical exercise and caloric reduction as compared to new senolytic approaches. Appendices are also provided, and address circadian rhythms, telomere shortening, diabetic cardiomyopathy, and senescence in plants and bacteria. Given its scope, the book will primarily be of interest to geriatricians, but will also appeal to a wider range of clinicians.
Author: Granville Stanley Hall
Publisher: Wellhausen Press
ISBN: 1445532174
Category :
Languages : en
Pages : 546
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Book Description
Many of the earliest books, particularly those dating back to the 1900s and before, are now extremely scarce and increasingly expensive. We are republishing these classic works in affordable, high quality, modern editions, using the original text and artwork.
Author: G. Stanley Hall
Publisher: Forgotten Books
ISBN: 9780265221341
Category : Self-Help
Languages : en
Pages : 548
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Book Description
Excerpt from Senescence: The Last Half of Life Loughlin, who has not only typed and read the proof of all the book but has been of great assistance in finding references and made many helpful suggestions. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.
Author: Virgil Francis
Publisher: Virgil Francis
ISBN:
Category : Fiction
Languages : en
Pages : 230
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Book Description
In the 30th century, science has reached unimaginable heights, and at the forefront is Frances Smith- the genius who pioneered nanotechnology. But what happens when the creator becomes the hunted? The Senescence Sentence is a suspenseful sci-fi thriller that explores the darkest corners of technological innovation and human nature. Frances Smith, once hailed as a hero, is now a fugitive. Accused of a crime he didn’t commit; he must resolve the mystery behind this mistake while being relentlessly pursued. This is not just a battle for his reputation. It’s a race against time to recover his stolen creation, now twisted into a weapon of mass destruction. The government has also abolished the traditional jail system, and Frances discovers a terrifying new form of punishment that threatens to break him in every possible way. His sanity, physical strength, and the safety of his family are pushed to the brink. ◆Features of The Senescence Sentence: Compelling Sci-Fi Thriller: This is a fast-paced story filled with suspense, action, and mind-bending twists. Complex Characters: Protagonist - Frances Smith must balance the weight of his intelligence with the moral implications of his invention. Cutting Edge Themes: This novel will make you explore the future of nanotechnology and its potential for both groundbreaking advancements and terrifying misuse. Emotional Depth: The story will make you experience the toll on Frances as he battles not only external enemies but also the inner turmoil that threatens to destroy him, and his family. Fans of sci-fi thrillers will be captivated by the intricate plot. Those who enjoy stories of survival, conspiracy, and plot twists will also find themselves immersed in Frances’s journey. Readers looking for intelligent and thought-provoking fiction will appreciate the exploration of the ethical implications of advanced nanotechnology. ✓Grab your copy to find the answers: Can Frances expose the truth and stop the catastrophic consequences of his invention from falling into the wrong hands? Or, Will he succumb to the horrifying reality of his new world?
Author: Granville Stanley Hall
Publisher: Nabu Press
ISBN: 9781294297093
Category :
Languages : en
Pages : 556
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Book Description
This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book.
Author:
Publisher: Elsevier
ISBN: 0443188874
Category : Science
Languages : en
Pages : 480
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Book Description
Senescence, Senotherapeutics and Mitochondria, Volume 136 offers updates on this unique topics, with chapters covering Cellular Senescence in Aging: Molecular Basis, Implications and Therapeutic Interventions, Mitochondria-associated Cellular Senescence Mechanisms: Biochemical and Pharmacological Perspectives, Mitochondria in cell senescence: Friend or Foe?, The role of mitochondria and mitophagy in cell senescence, Small molecules targeting mitochondrial dysfunction for potential senotheraputics, Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction, Mitochondrial targeting peptides and probes, Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases, and much more. Other sections cover Targeting of mitostasis-proteostasis axis by antioxidant polysaccharides in neurodegeneration, Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders, Melatonin as mitochondria-targeted drugs, Coenzyme Q-related compounds to maintain healthy mitochondria during aging, Changing ROS, NAD and AMP: a path to longevity via mitochondrial therapeutics, and more. Updates on how mitochondria are closely related to the survival of senescent cells using either mitochondria-targeted senolytic or redox modulator senomorphic strategies Differentiates itself from other books with its multidisciplinary perspectives and multidimensional clinical approaches Offers a novel perspective on both the basic and clinical sciences for a wide group of well-established academicians, students and researchers in medicinal chemistry, gerontology, geriatrics, oncology, pharmacology, pathology, bioinformatics, sports science and nutritional sciences
Author: Wang Zhiwei
Publisher: BoD – Books on Demand
ISBN: 9535109979
Category : Medical
Languages : en
Pages : 162
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Book Description
Senescence is a biological process that causes a progressive deterioration of structure and function of all organs chronologically. Recent studies have revealed the detailed molecular mechanisms of senescence using cell culture system and experimental organisms. It is thought that senescence is a potential cause for the development of various age-related disorders such as cancer, cardiovascular and neurodegenerative disorders. This book discusses in detail senescence and its related diseases by distinguished researchers and practicing clinicians. The cumulative knowledge from the studies could lead to developing new approaches for anti-senescence interventions.
Author: Aise Seda Artis
Publisher: BoD – Books on Demand
ISBN: 9535105590
Category : Medical
Languages : en
Pages : 167
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Book Description
Hemodynamics is study of the mechanical and physiologic properties controlling blood pressure and flow through the body. The factors influencing hemodynamics are complex and extensive. In addition to systemic hemodynamic alterations, microvascular alterations are frequently observed in critically ill patients. The book "Hemodynamics: New Diagnostic and Therapeuric Approaches" is formed to present the up-to-date research under the scope of hemodynamics by scientists from different backgrounds.
Author: Stephen S. Hall
Publisher: HMH
ISBN: 0547561571
Category : Science
Languages : en
Pages : 452
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Book Description
A Discover Best Science Book of the Year: “A fascinating, accurate and accessible account of some of [the] contemporary efforts to combat aging” (The New York Times). Los Angeles Times Book Prize Finalist Named a Best Book of the Year by the New York Times, San Jose Mercury News, and Library Journal An award-winning writer explores science’s boldest frontier—extension of the human life span—interviewing dozens of people involved in the quest to allow us to live longer, better lives. Delving into topics from cancer to stem cells to cloning, Merchants of Immortality looks at humankind’s quest for longevity and tackles profound questions about our hopes for defeating health problems like heart attacks, Parkinson’s disease, and diabetes. The story follows a close-knit but fractious band of scientists as well as entrepreneurs who work in the shadowy area between profit and the public good. The author tracks the science of aging back to the iconoclastic Leonard Hayflick—who was the first to show that cells age, and whose epic legal battles with the federal government cleared the path for today’s biotech visionaries. Among those is the charismatic Michael West, a former creationist who founded the first biotech company devoted to aging research. West has won both ardent admirers and committed foes in his relentless quest to promote stem cells, therapeutic cloning, and other technologies of “practical immortality.” Merchants of Immortality breathes scintillating life into the most momentous science of our day, assesses the political and bioethical controversies it has spawned, and explores its potentially dramatic effect on the length and quality of our lives. “Timely and engrossing . . . This is top-drawer journalism.” —Publishers Weekly, starred review “A carefully documented examination of how society deals with life-and-death matters.” —Kirkus Reviews, starred review “An important survey of the entire landscape of the science aimed at extending human life.” —Newsday “[This] highly readable and important book . . . provide[s] new insights into the intersection of science and politics.” —The Washington Post
