Selective Estrogen Receptor Modulators PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Selective Estrogen Receptor Modulators PDF full book. Access full book title Selective Estrogen Receptor Modulators by Andrea Manni. Download full books in PDF and EPUB format.
Author: Andrea Manni
Publisher: Springer Science & Business Media
ISBN: 1592591574
Category : Medical
Languages : en
Pages : 417
Get Book Here
Book Description
Experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs. The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of co-activators and co-repressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. The clinical presentation reviews the data accumulated on currently available SERMs, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. A tentative approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer.
Author: Marietta Anthony
Publisher:
ISBN: 9781573313582
Category : Selective estrogen receptor modulators
Languages : en
Pages : 0
Get Book Here
Book Description
This volume examines basic and clinical findings on the role played by the oestrogen receptor (ER) and its modulation in multiple physiologic systems. The authors examine the potential of selective modification of ER actions for preventing chronic diseases and promoting healthy ageing. Research gaps and potential agendas for NIH research of ER action are identified, and related intervention strategies to extend the beneficial clinical outcomes are explored.
Author: Andrea Manni
Publisher: Springer Science & Business Media
ISBN: 1592591574
Category : Medical
Languages : en
Pages : 417
Get Book Here
Book Description
Experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs. The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of co-activators and co-repressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. The clinical presentation reviews the data accumulated on currently available SERMs, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. A tentative approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer.
Author: Antonio Cano
Publisher: Springer Science & Business Media
ISBN: 3540347429
Category : Medical
Languages : en
Pages : 364
Get Book Here
Book Description
The increasing awareness on the varied consequences of hypogonadism in distinct organs and systems has supported the notion of estrogens as systemic agents. This observation is congruent with the variety of tissues affected by - trogens when used in hormone therapy formulations on hypogonadic women. Apart from the genital tract and the breast, recognized as traditional targets for estrogens, the skeleton, the vascular tree, or the central nervous system, are good examples of territories that have demonstrated sensitivity to estrogens. This evidence has created great interest, as shown by the great amount of lit- ature that has been produced on the bene?ts and risks associated with the use of estrogens. In parallel to the clinical interest, basic research has improved our kno- edge on the complexities involved in estrogen action at the molecular level. Together with effects mediated through speci?c receptors, a concept that has been the mainstay of the interpretation of estrogen action for years, there is enough evidence to hold the notion of receptor-independent effects. The substantial advances in modern technology applied to research have helped in enlightening the particulars of this versatile action of estrogens. This more detailed knowledge on the sophisticated mechanism of action of estrogens has nourished the emergence of multiple hypotheses speculating with the p- sibility of manipulating estrogen action. The notion that a widely extended regulatory system of cell function, as it is the estrogen receptor machinery, might be modulated at wish has arisen as an attractive, although still elusive postulate.
Author: V. Craig Jordan
Publisher: World Scientific
ISBN: 1848169582
Category : Medical
Languages : en
Pages : 544
Get Book Here
Book Description
This volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs OCo tamoxifen and raloxifene OCo are known to have saved the lives of millions of women around the world and improved the health of millions more. Estrogen is the central hormone of women's health and reproduction. The book is a journey through 40 years of discovery and success in advancing women's health, with the prospect of improved innovation through medicinal chemistry for the future.
Author:
Publisher: ScholarlyEditions
ISBN: 1464947309
Category : Medical
Languages : en
Pages : 45
Get Book Here
Book Description
Selective Estrogen Receptor Modulators: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Selective Estrogen Receptor Modulators in a compact format. The editors have built Selective Estrogen Receptor Modulators: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Selective Estrogen Receptor Modulators in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Selective Estrogen Receptor Modulators: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Goutam Brahmachari
Publisher: John Wiley & Sons
ISBN: 3527337946
Category : Science
Languages : en
Pages : 544
Get Book Here
Book Description
Ein multidisziplinärer Überblick über die aktuellen Themen und Zukunftstrends in der Erforschung von Naturstoffen mit Schwerpunkt auf pharmazeutischen und medizinischen Anwendungen.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 17
Get Book Here
Book Description
Estrogens promote growth of certain breast endometrial cancers. Selective estrogen receptor modulators (SERMs), ligands that block the activity of estrogen in only selective tissues, allow to control the growth of these cancers while avoiding the many unwanted side effects associated with the use of antiestrogens. The goal of our work is to identify the mechanisms that control the activity of SERMs and to develop efficient high-throughput strategies for the identification of novel SERMs. SERMs exert their activities by binding to the two estrogen receptors, Era and ERb. Ligand binding changes the position of a-helix 12 (H12) in the ER ligand-binding domain and regulates the interaction of ERs with cellular coactivators and corepressors. Previously, we identified that the F-domain, a receptor-specific domain that follows H12, contributes to coactivator binding and specificity of Era but not ERb. We have continued these studies by analyzing the role of the F-domain in SERM-and corepressor binding and in modulating the transcriptional response to hormone. Moreover, we have identified and optimized a strategy to introduce fluorescence labels into H12 or the F-domain. These fluorescent receptors will allow us to monitor the dynamics and structural reorganization of ER upon SERM binding.
Author: Donato Agnusdei
Publisher: CRC Press
ISBN: 9781853178207
Category : Medical
Languages : en
Pages : 176
Get Book Here
Book Description
Selective oestrogen receptor modulators (SERMs) are now recognised as a valuable method of maintaining the health of postmenopausal women. Aimed at the non-specialist, the book initially discusses the epidemiology of the menopause and the mechanism of action of oestrogen before concentrating specifically on the effect of SERMs, their safety profile and their role in clinical practice.
Author: Vincent Falanga
Publisher: CRC Press
ISBN: 9781853172045
Category : Medical
Languages : en
Pages : 520
Get Book Here
Book Description
Gene therapy, bioengineered skin, and other methods in advanced biology are revolutionizing the treatment of wounds. Written by experts in research and clinical practice, Cutaneous Wound Healing examines the current knowledge and emerging treatment methods. This volume explains the normal molecular and cellular functions that occur when a wound heals, as well as dysfunctional events, such as a chronic wound or an ulcer. Such dysfunctions signal an imbalance in the body, explained here along with possible treatments. The book's mini-atlas is an indispensable reference tool. Dermatologists, plastic surgeons, and general practitioners can benefit from this text.
Author: Faustino R. Pérez-López
Publisher: Springer
ISBN: 9783030139353
Category : Medical
Languages : en
Pages : 488
Get Book Here
Book Description
Supported by the latest scientific data, this book serves as a guide to the clinical assessment of women’s health during the second half of life (post-reproductive years), including approaches to the management of the most frequent age-related diseases and disorders and the most recent advances in treatment. In addition, it discusses preventive aspects of healthcare in post-reproductive women, identifying lifestyle measures to enhance healthy aging. By highlighting research gaps, it promotes the development of quick and easy-to-use assessment tools and predictive markers of age-related co-morbidities. As such, the book is a valuable resource for researchers and clinicians alike.
