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Author: Carl-Fredrik Mandenius
Publisher: John Wiley & Sons
ISBN: 3527683372
Category : Science
Languages : en
Pages : 520
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Book Description
In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production, process development, and multi-product reactors, using case studies from academia as well as from industry. A final section addresses the latest trends, including culture media design and systems biotechnology, which are expected to have an increasing impact on bioreactor design. With its focus on cutting-edge technologies and discussions of future developments, this handbook will remain an invaluable reference for many years to come.
Author: Carl-Fredrik Mandenius
Publisher: John Wiley & Sons
ISBN: 3527683372
Category : Science
Languages : en
Pages : 520
Get Book Here
Book Description
In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production, process development, and multi-product reactors, using case studies from academia as well as from industry. A final section addresses the latest trends, including culture media design and systems biotechnology, which are expected to have an increasing impact on bioreactor design. With its focus on cutting-edge technologies and discussions of future developments, this handbook will remain an invaluable reference for many years to come.
Author: John A. List
Publisher: Crown Currency
ISBN: 0593239482
Category : Business & Economics
Languages : en
Pages : 289
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Book Description
NATIONAL BESTSELLER • A leading economist answers one of today’s trickiest questions: Why do some great ideas make it big while others fail to take off? “Brilliant, practical, and grounded in the very latest research, this is by far the best book I’ve ever read on the how and why of scaling.”—Angela Duckworth, CEO of Character Lab and New York Times bestselling author of Grit LONGLISTED FOR THE PORCHLIGHT BUSINESS BOOK AWARD “Scale” has become a favored buzzword in the startup world. But scale isn't just about accumulating more users or capturing more market share. It's about whether an idea that takes hold in a small group can do the same in a much larger one—whether you’re growing a small business, rolling out a diversity and inclusion program, or delivering billions of doses of a vaccine. Translating an idea into widespread impact, says University of Chicago economist John A. List, depends on one thing only: whether it can achieve “high voltage”—the ability to be replicated at scale. In The Voltage Effect, List explains that scalable ideas share a common set of attributes, while any number of attributes can doom an unscalable idea. Drawing on his original research, as well as fascinating examples from the realms of business, policymaking, education, and public health, he identifies five measurable vital signs that a scalable idea must possess, and offers proven strategies for avoiding voltage drops and engineering voltage gains. You’ll learn: • How celebrity chef Jamie Oliver expanded his restaurant empire by focusing on scalable “ingredients” (until it collapsed because talent doesn’t scale) • Why the failure to detect false positives early on caused the Reagan-era drug-prevention program to backfire at scale • How governments could deliver more services to more citizens if they focused on the last dollar spent • How one education center leveraged positive spillovers to narrow the achievement gap across the entire community • Why the right set of incentives, applied at scale, can boost voter turnout, increase clean energy use, encourage patients to consistently take their prescribed medication, and more. By understanding the science of scaling, we can drive change in our schools, workplaces, communities, and society at large. Because a better world can only be built at scale.
Author: Schäfer Morgensen, Kasper
Publisher: Nordic Council of Ministers
ISBN: 9289370319
Category : Technology & Engineering
Languages : en
Pages : 49
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Book Description
Available online: https://pub.norden.org/temanord2021-523/ In this project, a tool was developed to calculate savings from ecodesign and energy labelling policy in the Nordic countries, and a "snapshot" calculation was done. Two different calculation methods were used, and both are implemented on the online platform Nordcrawl where assumption and input data can be changed to produce alternative calculations. In the top-down method, estimated EU savings are scaled-down, using suitable product specific scales, for the Nordics. In the bottom-up method, actual savings are estimated using sales data. The study shows large savings from ecodesign and energy labelling in the Nordic countries. The top-down calculations estimate yearly primary energy savings 2030 (final electricity savings in parenthesis) of about 52 TWh (12) for Denmark, 63 TWh (28) for Sweden, 43 TWh (19) for Norway, 84 TWh (21) for Finland, and 4 TWh (2) for Iceland.
Author: Anurag Singh Rathore
Publisher: CRC Press
ISBN: 1003805477
Category : Medical
Languages : en
Pages : 509
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Book Description
The fourth edition of Process Validation in Manufacturing of Biopharmaceuticals is a practical and comprehensive resource illustrating the different approaches for successful validation of biopharmaceutical processes. A pivotal text in its field, this new edition provides guidelines and current practices, contains industrial case studies, and is expanded to include in-depth analysis of the new Process Validation (PV) guidance from the US FDA. Key Features: Offers readers a thorough understanding of the key concepts that form the basis of a good process validation program for biopharmaceuticals. Includes case studies from the various industry leaders that demonstrate application of these concepts. Discusses the use of modern tools such as multivariate analysis for facilitating a process validation exercise. Covers process characterization techniques for scaling down unit operations in biopharmaceutical manufacturing, including chromatography, chemical modification reactions, ultrafiltration, and microfiltration, and practical methods to test raw materials and in-process samples. Providing a thorough understanding of the key concepts that form the basis of a good process validation program, this book will help readers ensure that PV is carried out and exceeds expectations. Fully illustrated, this is a much-needed practical guide for biopharmaceutical manufacturers.
Author: Farzad Sharifian
Publisher: John Benjamins Publishing
ISBN: 9027204047
Category : Language Arts & Disciplines
Languages : en
Pages : 257
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Book Description
Presents a multidisciplinary theoretical model of cultural conceptualisations and language which draws on analytical tools and theoretical advancements in several disciplines, including cognitive linguistics, cognitive anthropology, anthropological linguistics, distributed cognition, complexity science, and cognitive psychology.
Author: Swapnil Dubey
Publisher: BPB Publications
ISBN: 9355512848
Category : Computers
Languages : en
Pages : 368
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Book Description
Managing Real-world Production-grade Challenges at Scale KEY FEATURES ● Built for GCP professionals and Cloud enthusiasts with cloud-agnostic tactics. ● Exhaustive coverage of automatic, manual, and predictive scaling and specialized strategies. ● Every concept is pragmatized with real-time production scenarios derived from prominent technologists. DESCRIPTION ‘Scaling Google Cloud Platform’ equips developers with the know-how to get the most out of its services in storage, serverless computing, networking, infrastructure monitoring, and other IT tasks. This book explains the fundamentals of cloud scaling, including Cloud Elasticity, creating cloud workloads, and selecting the appropriate cloud scaling key performance indicators (KPIs). The book explains the sections of GCP resources that can be scaled, as well as their architecture and internals, and best practices for using these components in an operational setting in detail. The book also discusses scaling techniques such as predictive scaling, auto-scaling, and manual scaling. This book includes real-world examples illustrating how to scale many Google Cloud services, including the compute engine, GKE, VMWare Engine, Cloud Function, Cloud Run, App Engine, BigTable, Spanner, Composer, Dataproc, and Dataflow. At the end of the book, the author delves into the two most common architectures—Microservices and Bigdata to examine how you can perform reliability engineering for them on GCP. WHAT YOU WILL LEARN ● Learn workload migration strategy and execution, both within and between clouds. ● Explore methods of increasing Google Cloud capacity for running VMware Engine and containerized applications. ● Scaling up and down methods include manual, predictive, and automatic approaches. ● Increase the capacity of your Dataproc cluster to handle your big data computing needs. ● Learn Google Dataflow's scalability considerations for large-scale installations. ● Explore Google Composer 2 and scale up your Cloud Spanner instances. ● Learn to set up Cloud functions and Cloud run. ● Discuss general SRE procedures on microservices and big data. WHO THIS BOOK IS FOR This book is designed for Cloud professionals, software developers, architects, DevOps team, and engineering managers to explain scaling strategies for GCP services and assumes readers know GCP basics. TABLE OF CONTENTS 1. Basics of Scaling Cloud Resources 2. KPI for Cloud Scalability 3. Cloud Elasticity 4. Challenges of Infrastructure Complexity and the Way Forward 5. Scaling Compute Engine 6. Scaling Kubernetes Engine 7. Scaling VMware Engine 8. Scaling App Engine 9. Scaling Google Cloud Function and Cloud Run 10. Configuring Bigtable for Scale 11. Configuring Cloud Spanner for Scale 12. Scaling Google Composer 2 13. Scaling Google Dataproc 14. Scaling Google Dataflow 15. Site Reliability Engineering 16. SRE Use Cases
Author: Thomas Noll
Publisher: Springer Science & Business Media
ISBN: 9048134196
Category : Medical
Languages : en
Pages : 850
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Book Description
Regeneration of tissue to replace damaged or injured tissue is the goal of t- sue engineering. Biomaterials like polyglycolic acid, collagen and small-intestinal submuscosa provide a temporary scaffold to guide new tissue growth and or- nization. Typically, they need to be biodegradable, showing good cell atta- ment and proliferation and they should possess appropriate mechanical properties (Kim et al. , 2000). Synthetic polymers ful ll most of these requirements but lack cell-adhesion peptides on their surface to enhance cell attachment. Ce- adhesion peptides are present in ECM proteins like collagen and elastin. Thus a synthetic polymer coated with ECM proteins would result in a scaffold that mimics the natural cellular environment with enhanced cell attachment and p- liferation. The new bioactive scaffold will be made by combining a synthetic polymer coated with a layer of recombinant ECM proteins produced by CHO cells. The rst step consists of identifying polymers that give best results in terms of CHO cell attachment and growth. Classical techniques to determine biomass are inappropriate to evaluate 3-D structures. Thus a screening system based on stable GFP expressing CHO cells was used to compare the different scaffolds. Simple uorescent measurement after cell lysis allows determining cell attachment and p- liferation on synthetic polymers. Finally CHO cells producing human recombinant collagen I and elastin were generated. We showed that both proteins are expressed and secreted by CHO DG44 cells. 2 Materials and Methods 2.
Author:
Publisher:
ISBN:
Category : Administrative law
Languages : en
Pages : 742
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Book Description
The Code of Federal Regulations is the codification of the general and permanent rules published in the Federal Register by the executive departments and agencies of the Federal Government.
Author: Mark S Lundstrom
Publisher: World Scientific Publishing Company
ISBN: 981457175X
Category : Technology & Engineering
Languages : en
Pages : 389
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Book Description
The transistor is the key enabler of modern electronics. Progress in transistor scaling has pushed channel lengths to the nanometer regime where traditional approaches to device physics are less and less suitable. These lectures describe a way of understanding MOSFETs and other transistors that is much more suitable than traditional approaches when the critical dimensions are measured in nanometers. It uses a novel, “bottom-up approach” that agrees with traditional methods when devices are large, but that also works for nano-devices. Surprisingly, the final result looks much like the traditional, textbook, transistor models, but the parameters in the equations have simple, clear interpretations at the nanoscale. The objective is to provide readers with an understanding of the essential physics of nanoscale transistors as well as some of the practical technological considerations and fundamental limits. This book is written in a way that is broadly accessible to students with only a very basic knowledge of semiconductor physics and electronic circuits.
Author: Byong H. Lee
Publisher: John Wiley & Sons
ISBN: 1119042771
Category : Technology & Engineering
Languages : en
Pages : 951
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Book Description
ADVANCED FERMENTATION AND CELL TECHNOLOGY A comprehensive and up-to-date reference covering both conventional and novel industrial fermentation technologies and their applications Fermentation and cell culture technologies encompass more than the conventional microbial and enzyme systems used in the agri-food, biochemical, bioenergy and pharmaceutical industries. New technologies such as genetic engineering, systems biology, protein engineering, and mammalian cell and plant cell systems are expanding rapidly, as is the demand for sustainable production of bioingredients, drugs, bioenergy and biomaterials. As the growing biobased economy drives innovation, industrial practitioners, instructors, researchers, and students must keep pace with the development and application of novel fermentation processes and a variety of cell technologies. Advanced Fermentation and Cell Technology provides a balanced and comprehensive overview of the microbial, mammalian, and plant cell technologies used by the modern biochemical process industry to develop new and improved processes and products. This authoritative volume covers the essential features of advanced fermentation and cell technology, and highlights the interaction of food fermentation and cell culture biopharmaceutical actives. Detailed chapters, organized into five sections, cover microbial cell technology, animal and plant cell technology, safety issues of new biotechnologies, and applications of microbial fermentation to food products, chemicals, and pharmaceuticals. Written by an internationally-recognized expert in food biotechnology, this comprehensive volume: Covers both conventional and novel industrial fermentation technologies and their applications in a range of industries Discusses current progress in novel fermentation, cell culture, commercial recombinant bioproducts technologies Includes overviews of the global market size of bioproducts and the fundamentals of cell technology Highlights the importance of sustainability, Good Manufacturing Practices (GMP), quality assurance, and regulatory practices Explores microbial cell technology and culture tools and techniques such as genome shuffling and recombinant DNA technology, RNA interference and CRISPR technology, molecular thermodynamics, protein engineering, proteomics and bioinformatics, and synthetic biology Advanced Fermentation and Cell Technology is an ideal resource for students of food science, biotechnology, microbiology, agricultural sciences, biochemical engineering, and biochemistry, and is a valuable reference for food scientists, researchers, and technologists throughout the food industry, particularly the dairy, bakery, and fermented beverage sectors.
