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Author: John Mitrofanis
Publisher: Morgan & Claypool Publishers
ISBN: 1643277200
Category : Science
Languages : en
Pages : 172
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Book Description
Parkinson's disease is a neurological disorder with cardinal motor signs of resting tremor, bradykinesia and lead-pipe rigidity. In addition, many patients display non-motor symptoms, including a diminished sensation of smell, gastrointestinal problems, various disorders of sleep and some cognitive impairment. These clinical features - particularly the motor signs - manifest after a progressive death of many dopaminergic neurones in the brain. Although currently available, conventional therapies can reduce the signs of the disease, the progression of this neuronal death has proved difficult to slow or stop, and the condition is relentlessly progressive. Hence, there is a real need to develop a treatment that is neuroprotective, one that slows the pathology of the disease effectively. At present, there are several neuroprotective therapies in the experimental pipeline, but these are for the patients of tomorrow. This book focuses on two therapies that are readily available for the patients of today. They involve the use of exercise and light (i.e. photobiomodulation, the use of red to infrared light therapy (λ=600-1070nm) on body tissues). The two therapies are tied together in several ways. First, in animal models of Parkinson's disease, they each have been shown to offer the key feature of neuroprotection, stimulating a series of built-in protective mechanisms within the neurones, that helps their survival, to self-protect and/or self-repair. There are also some promising indications of neuroprotection and many beneficial outcomes in parkinsonian patients. Further, both exercise and light therapies are similar in that they are non-invasive and safe to use, with no known adverse side-effects, making their combination with the conventional therapies, such as dopamine replacement drug therapy and deep brain stimulation, all the more feasible. Given the heterogeneity of Parkinson's disease in humans, tackling the condition from a range of different angles - with a number of different therapies - would only serve to enhance the positive outcomes. This book considers the use of exercise and light therapies, proposing that they have the potential to make a powerful "dynamic duo", offering a most effective neuroprotective treatment option to patients.
Author: John Mitrofanis
Publisher: Morgan & Claypool Publishers
ISBN: 1643277200
Category : Science
Languages : en
Pages : 172
Get Book Here
Book Description
Parkinson's disease is a neurological disorder with cardinal motor signs of resting tremor, bradykinesia and lead-pipe rigidity. In addition, many patients display non-motor symptoms, including a diminished sensation of smell, gastrointestinal problems, various disorders of sleep and some cognitive impairment. These clinical features - particularly the motor signs - manifest after a progressive death of many dopaminergic neurones in the brain. Although currently available, conventional therapies can reduce the signs of the disease, the progression of this neuronal death has proved difficult to slow or stop, and the condition is relentlessly progressive. Hence, there is a real need to develop a treatment that is neuroprotective, one that slows the pathology of the disease effectively. At present, there are several neuroprotective therapies in the experimental pipeline, but these are for the patients of tomorrow. This book focuses on two therapies that are readily available for the patients of today. They involve the use of exercise and light (i.e. photobiomodulation, the use of red to infrared light therapy (λ=600-1070nm) on body tissues). The two therapies are tied together in several ways. First, in animal models of Parkinson's disease, they each have been shown to offer the key feature of neuroprotection, stimulating a series of built-in protective mechanisms within the neurones, that helps their survival, to self-protect and/or self-repair. There are also some promising indications of neuroprotection and many beneficial outcomes in parkinsonian patients. Further, both exercise and light therapies are similar in that they are non-invasive and safe to use, with no known adverse side-effects, making their combination with the conventional therapies, such as dopamine replacement drug therapy and deep brain stimulation, all the more feasible. Given the heterogeneity of Parkinson's disease in humans, tackling the condition from a range of different angles - with a number of different therapies - would only serve to enhance the positive outcomes. This book considers the use of exercise and light therapies, proposing that they have the potential to make a powerful "dynamic duo", offering a most effective neuroprotective treatment option to patients.
Author: Laura King Edwards
Publisher:
ISBN: 9781945805837
Category : Neuronal ceroid-lipofuscinoses
Languages : en
Pages : 0
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Book Description
Laura has it all: a great job, a loving family, a new husband, and a house in her hometown, where she can watch her sister, Taylor, grow up. But one month after her wedding, Laura and her family receive shocking news: Taylor has Batten disease. A rare, fatal disease that will cause Taylor to go blind, suffer seizures, and lose the ability to walk and talk. There is no cure. Laura thought she'd get to watch her baby sister grow up, but instead she'll have to watch her die. Unwilling to take no cure for an answer, Laura founds a charity with family and friends, Taylor's Tale, to save children with the disease. Meanwhile, Taylor starts running, completing her first race blind. Inspired, Laura, a lifelong runner, begins running in half marathons to raise money and awareness. And also to run away from the pain. Taylor's Tale becomes a world leader in the fight against Batten disease, but not quickly enough to save Taylor. Stripped of her faith, Laura falls into a dark despair. But Taylor's unwavering courage in the face of certain death gives Laura a renewed sense of purpose to turn her family's tragedy into an opportunity--to ensure others won't have to suffer as her sister has suffered. Run to the Light is Laura's inspiring account of how she found the courage to face indescribable loss, and of what it means to really believe.
Author: Michael Sandler
Publisher: Crown
ISBN: 0307985946
Category : Sports & Recreation
Languages : en
Pages : 322
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Book Description
How could something we have for free—our bare feet—be better for running than $150 shoes? The truth is that running in shoes is high-impact, unstable, and inflexible. Shoes promote a heel-centric ground strike, which weakens your feet, knees, and hips, and leads to common running injuries. In contrast, barefoot running is low-impact, forefoot-centric, stable, and beneficial to your body. It encourages proper form and strengthens your feet in miraculous ways. When you run in shoes, you not only risk developing poor form, but you also hinder the natural relationship with the ground that running facilitates. Barefoot running restores the delightful sensory and spiritual connections to the earth that you were meant to experience. Barefoot Running offers the only step-by-step direction runners need at any age to overcome injuries, run faster than ever, and rediscover the pure joy of running. Once you tear off your shoes and learn to dance with nature, you’ll tread lightly and freely, hearing only the earth’s symphony and feeling only the dirt beneath your feet. Hit the ground running with revolutionary techniques for starting out slowly, choosing minimalist footwear, navigating rough weather and rugged terrain, and building your feet into living shoes.
Author: Baird Harper
Publisher: Simon and Schuster
ISBN: 1501147374
Category : Fiction
Languages : en
Pages : 197
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Book Description
A brilliant feat of storytelling, Red Light Run is the radiant and stunning debut from Best New American Voices writer Baird Harper. When two cars collide at an intersection in a leafy Chicago suburb, Hartley Nolan is not the person police expect to find behind the wheel. After all, he barely drinks; everyone knows it’s his wife who’s the alcoholic. But the bigger question on people’s minds is what brought Sonia Senn, dead at the scene, back to her hometown in such a hurry that night? In eleven tightly linked stories, Red Light Run pulls us into the inner lives of Hartley, Sonia, and a host of other characters to untangle the mounting forces that carry them to their fates. Among the ensemble in this prismatic collection are a real estate agent who seeks gossip on the market rather than houses, a trailer park developer whose entire livelihood is laid to waste by a single cigarette, a divorced mother battling her daughter-in-law for hegemony over her kitchen, a widower hell-bent on destroying the invasive species of beetle that’s wiping out his oak trees, and a down-and-out handyman with a desperate plan for revenge. And then there’s Sonia Senn, with a dark secret of her own, and Hartley Nolan, who has risen above his roots to become a commodities trader in Chicago only to end up sentenced to eight years at Grassland State Prison. With infectiously grim humor and wry insight, these characters contemplate their realities in relation to one tragic moment, propelling us toward a startling revelation about the long and sometimes crooked arc of justice.
Author: Mark Cucuzzella, MD
Publisher: Vintage
ISBN: 1101912383
Category : Health & Fitness
Languages : en
Pages : 386
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Book Description
A straightforward, easy-to-follow look at the anatomy, biomechanics, and nutrition of running. Dr. Cucuzzella "aims to improve the fitness and well-being of all, from the uninitiated to beginners to veterans who still have new tricks to learn" (Amby Burfoot, Boston Marathon winner, writer at large for Runner’s World magazine, and author of The Runner’s Guide to the Meaning of Life). Despite our natural ability and our human need to run, each year more than half of all runners suffer injuries. Pain and discouragement inevitably follow. Cucuzzella's book outlines the proven, practical techniques to avoid injury and reach the goal of personal fitness and overall health. With clear drawings and black-and-white photographs, the book provides illustrated exercises designed to teach healthy running, along with simple progressions and a running schedule that shows the reader how to tailor their training regimen to their individual needs and abilities.
Author: Wesley Cartier
Publisher: Houghton Mifflin Harcourt
ISBN: 9780152048280
Category : Juvenile Fiction
Languages : en
Pages : 28
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Book Description
"A boy runs so fast that he imagines himself to be a rabbit, a bobcat, a horse, and a cheetah."--[Source inconnue].
Author: Simran Jeet Singh
Publisher: Penguin
ISBN: 0525555099
Category : Juvenile Nonfiction
Languages : en
Pages : 49
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Book Description
The true story of Fauja Singh, who broke world records to become the first one hundred-year-old to run a marathon, shares valuable lessons on the source of his grit, determination to overcome obstacles, and commitment to positive representation of the Sikh community. Every step forward is a victory. Fauja Singh was born determined. He was also born with legs that wouldn't allow him to play cricket with his friends or carry him to school miles from his village in Punjab. But that didn't stop him. Working on his family's farm, Fauja grew stronger to meet his own full potential. He never stopped striving. At the age of 81, after a lifetime of making his body, mind, and heart stronger, Fauja decided to run his first marathon. He went on to break records all around the world and became the first person over 100 to complete the grueling long-distance race. With exuberant text by Simran Jeet Singh and exhilarating illustrations by Baljinder Kaur, the true story of Fauja Singh reminds us that it's both where we start and how we finish that make our journeys unforgettable.
Author: Christopher McDougall
Publisher: Profile Books
ISBN: 184765228X
Category : Sports & Recreation
Languages : en
Pages : 296
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Book Description
A New York Times bestseller 'A sensation ... a rollicking tale well told' - The Times At the heart of Born to Run lies a mysterious tribe of Mexican Indians, the Tarahumara, who live quietly in canyons and are reputed to be the best distance runners in the world; in 1993, one of them, aged 57, came first in a prestigious 100-mile race wearing a toga and sandals. A small group of the world's top ultra-runners (and the awe-inspiring author) make the treacherous journey into the canyons to try to learn the tribe's secrets and then take them on over a course 50 miles long. With incredible energy and smart observation, McDougall tells this story while asking what the secrets are to being an incredible runner. Travelling to labs at Harvard, Nike, and elsewhere, he comes across an incredible cast of characters, including the woman who recently broke the world record for 100 miles and for her encore ran a 2:50 marathon in a bikini, pausing to down a beer at the 20 mile mark.
Author: John Lewis
Publisher: Abrams
ISBN: 168335382X
Category : Comics & Graphic Novels
Languages : en
Pages : 170
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Book Description
RUN, the Eisner Award-Winner for Best Graphic Memoir, is one of the most heralded books of the year including being named a: New York Times Top 5 YA Books of the Year · Top 10 Great Graphic Novels for Teens (Young Adult Library Services Association) · Washington Post Best Books of the Year · Variety Best Books of the Year · School Library Journal Best Books of the Year · Kirkus Reviews Best Books of the Year · Amazon Best History Book of 2021 • Top Ten Title of the Year (In the Margins Book Award) · In the Margins Book Award for Nonfiction winner · Top Ten Graphic Novels for Adults (American Library Association) · Best Books for Young Readers (U of Penn Graduate School of Education) · Books All Young Georgians Should Read (Georgia Center for the Book) First you march, then you run. From the #1 bestselling, award–winning team behind March comes the first book in their new, groundbreaking graphic novel series, Run: Book One. “Run recounts the lost history of what too often follows dramatic change—the pushback of those who refuse it and the resistance of those who believe change has not gone far enough. John Lewis’s story has always been a complicated narrative of bravery, loss, and redemption, and Run gives vivid, energetic voice to a chapter of transformation in his young, already extraordinary life.” –Stacey Abrams “In sharing my story, it is my hope that a new generation will be inspired by Run to actively participate in the democratic process and help build a more perfect Union here in America.” –Congressman John Lewis The sequel to the #1 New York Times bestselling graphic novel series March—the continuation of the life story of John Lewis and the struggles seen across the United States after the Selma voting rights campaign. To John Lewis, the civil rights movement came to an end with the signing of the Voting Rights Act in 1965. But that was after more than five years as one of the preeminent figures of the movement, leading sit–in protests and fighting segregation on interstate busways as an original Freedom Rider. It was after becoming chairman of SNCC (the Student Nonviolent Coordinating Committee) and being the youngest speaker at the March on Washington. It was after helping organize the Mississippi Freedom Summer and the ensuing delegate challenge at the 1964 Democratic National Convention. And after coleading the march from Selma to Montgomery on what became known as “Bloody Sunday.” All too often, the depiction of history ends with a great victory. But John Lewis knew that victories are just the beginning. In Run: Book One, John Lewis and longtime collaborator Andrew Aydin reteam with Nate Powell—the award–winning illustrator of the March trilogy—and are joined by L. Fury—making an astonishing graphic novel debut—to tell this often overlooked chapter of civil rights history.
Author: Haruki Murakami
Publisher: Vintage Canada
ISBN: 0307373088
Category : Biography & Autobiography
Languages : en
Pages : 194
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Book Description
From the best-selling author of The Wind-Up Bird Chronicle and After Dark, a rich and revelatory memoir about writing and running, and the integral impact both have made on his life. In 1982, having sold his jazz bar to devote himself to writing, Haruki Murakami began running to keep fit. A year later, he’d completed a solo course from Athens to Marathon, and now, after dozens of such races, not to mention triathlons and a slew of critically acclaimed books, he reflects upon the influence the sport has had on his life and—even more important—on his writing. Equal parts training log, travelogue, and reminiscence, this revealing memoir covers his four-month preparation for the 2005 New York City Marathon and includes settings ranging from Tokyo’s Jingu Gaien gardens, where he once shared the course with an Olympian, to the Charles River in Boston among young women who outpace him. Through this marvellous lens of sport emerges a cornucopia of memories and insights: the eureka moment when he decided to become a writer, his greatest triumphs and disappointments, his passion for vintage LPs and the experience, after the age of fifty, of seeing his race times improve and then fall back. By turns funny and sobering, playful and philosophical, What I Talk About When I Talk About Running is both for fans of this masterful yet guardedly private writer and for the exploding population of athletes who find similar satisfaction in distance running.
