Role of Trans-10, Cis-12 Conjugated Linoleic Acid (CLA) and Other CLA Isomers in the Regulation of Milk Fat Synthesis and Lipid Metabolism PDF Download
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Author: James W. Perfield
Publisher:
ISBN:
Category :
Languages : en
Pages : 346
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Book Description
Author: James W. Perfield
Publisher:
ISBN:
Category :
Languages : en
Pages : 346
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Book Description
Author: James W. Perfield (II.)
Publisher:
ISBN: 9780542532726
Category :
Languages : en
Pages : 169
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Book Description
Milk fat depression (MFD) is a challenging problem that involves the interrelationship between digestive processes in the rumen and the synthesis of milk fat by the mammary gland. Recent investigations have resulted in the biohydrogenation theory to explain MFD, and the concept that under certain dietary conditions pathways of rumen biohydrogenation are altered to produce unique fatty acid intermediates, some of which are potent inhibitors of milk fat synthesis. Trans-10, cis-12 conjugated linoleic acid (CLA) is one such intermediate, and the relationship between this isomer and a reduced milk fat output is well recognized. However, it was not known if these effects were direct or due to an intermediate produced in the metabolism of this CLA isomer. Therefore, an initial experiment provided the Delta6 desaturation product of trans-10, cis -12 CLA (cis-6, trans-10, cis-12 18:3) by abomasal infusion and it was demonstrated to not affect milk fat synthesis. These data substantiated a mechanism of action directly involving trans-10, cis-12 CLA, rather than one requiring metabolism of the isomer or the involvement of a downstream metabolite. Continuing research in the area of MFD has led investigators to suggest a role for other biohydrogenation intermediates in the regulation of milk fat synthesis. Candidate fatty acids whose increases were correlated with MFD were identified through a systematic and detailed sample analysis. Compounds that were tested for effects on milk fat in the dairy cow included: trans-8, cis-10 CLA, cis-9, trans-11 CLA, trans-10, trans-12 CLA and cis-11, trans-13 CLA. Despite the uptake and incorporation into milk fat of these CLA isomers by the mammary gland, none affected milk fat synthesis or any other variables related to milk production. The application of CLA as a management tool to induce a controlled reduction in milk fat production has been suggested and would require it to be in a form to avoid metabolism in the rumen. Amide-protected and lipid-encapsulated protection methods were tested for their ability to deliver trans -10, cis-12 CLA post-ruminally for absorption and subsequent regulation of milk fat. Incorporation of this CLA isomer into milk fat was determined to be similar for both supplements.
Author: Daniel Gunnar Peterson
Publisher:
ISBN:
Category :
Languages : en
Pages : 286
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Book Description
Author: Young W. Park
Publisher: John Wiley & Sons
ISBN: 1118534204
Category : Technology & Engineering
Languages : en
Pages : 1063
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Book Description
Milk is nature’s most complete food, and dairy products are considered to be the most nutritious foods of all. The traditional view of the role of milk has been greatly expanded in recent years beyond the horizon of nutritional subsistence of infants: it is now recognized to be more than a source of nutrients for the healthy growth of children and nourishment of adult humans. Alongside its major proteins (casein and whey), milk contains biologically active compounds, which have important physiological and biochemical functions and significant impacts upon human metabolism, nutrition and health. Many of these compounds have been proven to have beneficial effects on human nutrition and health. This comprehensive reference is the first to address such a wide range of topics related to milk production and human health, including: mammary secretion, production, sanitation, quality standards and chemistry, as well as nutrition, milk allergies, lactose intolerance, and the bioactive and therapeutic compounds found in milk. In addition to cow’s milk, the book also covers the milk of non-bovine dairy species which is of economic importance around the world. The Editors have assembled a team of internationally renowned experts to contribute to this exhaustive volume which will be essential reading for dairy scientists, nutritionists, food scientists, allergy specialists and health professionals.
Author: Bruce Linder Larson
Publisher:
ISBN:
Category : Lactation
Languages : en
Pages :
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Author: Lance Hall Baumgard
Publisher:
ISBN:
Category :
Languages : en
Pages : 364
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Author: Srikant Viswanadha
Publisher:
ISBN:
Category : Linoleic acid
Languages : en
Pages : 118
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Book Description
Author: Graham C. Burdge
Publisher: Elsevier
ISBN: 012811231X
Category : Science
Languages : en
Pages : 256
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Book Description
Polyunsaturated Fatty Acid Metabolism explores a number of major roles of PUFA in the body, including its role as a component of cell membranes and how it provides substrates for the synthesis of lipid second messengers. Recent studies are unraveling the effect of interactions between diet and endocrine factors and genetic and epigenetic variation on the regulation of PUFA biosynthesis in animals. Together, these recent findings provide novel insights into the impact of differences in PUFA supply on health. This book captures these findings in a manner that marks the state-of-the-art, placing them in the wider context of PUFA metabolism and nutritional science. Users will find a comprehensive discussion on the topic that presents the contributions of leading researchers who combine their knowledge to create a cohesive academic resource for researchers, those involved in production, and health policymakers. - Provides a comprehensive view of polyunsaturated fatty acid metabolism - Describes underlying metabolism on lipids that include polyunsaturated fatty acids - Includes discussions on recent findings on the genetic and epigenetic regulation of polyunsaturated fatty acid metabolism
Author: Benjamin Alan Corl
Publisher:
ISBN:
Category :
Languages : en
Pages : 404
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Book Description
Author: Sudha Venkatramanan
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
"Conjugated linoleic acid (CLA) reduces body weight and fat mass in animals. Human trials investigating effects of CLA on blood lipids, body weight and composition have shown inconsistent effects. The purpose of the present study therefore was to investigate effects of milk enriched with CLA on blood lipids -triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), high- density lipoprotein (HDL) cholesterol, body weight and body composition in moderately overweight, hyperlipidemic humans. Fifteen adult participants completed three 8-week dietary treatments in a crossover design. Treatments were: (i) control milk low in cis-9, trans-11 CLA (ii) milk naturally enriched with cis-9, trans-11 CLA, (iii) milk synthetically enriched with trans-10, cis-12 CLA and cis-9, trans-11 CLA. CLA did not affect blood lipid profile. No significant changes were observed in body weights and fat compartments with the CLA isomers. Thus CLA does not affect lipid profile, body weight and composition in moderately hyperlipidemic individuals." --
