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Author: Bernhard Strauss
Publisher: MIT Press
ISBN: 0262045214
Category : Science
Languages : en
Pages : 433
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Book Description
Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence. Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell--and yet never before has it been so unclear what to do with this knowledge. In this volume, leading researchers argue for a new theory framework for understanding and treating cancer. The contributors propose a complex systems view of cancer, presenting conceptual building blocks for a new research paradigm supported by empirical evidence. The contributors first discuss the new research framework in terms of theoretical foundations and then take up the relevance of a systems approach, reviewing such topics as nonlinearity, recurrence after treatment, the cellular attractor concept, network theory, and non-coding DNA--the "dark matter" of our genome. They address the temporality of cancer progression, drawing on evolutionary theory and clinical experience. Finally, they cover the dominant role of the tissue microenvironment in cancer, analyzing topics including altered metabolic pathways, the disease-defining influence on metastasis, and the interconnectedness of different environmental niches across levels of organization.
Author: Bernhard Strauss
Publisher: MIT Press
ISBN: 0262045214
Category : Science
Languages : en
Pages : 433
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Book Description
Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence. Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell--and yet never before has it been so unclear what to do with this knowledge. In this volume, leading researchers argue for a new theory framework for understanding and treating cancer. The contributors propose a complex systems view of cancer, presenting conceptual building blocks for a new research paradigm supported by empirical evidence. The contributors first discuss the new research framework in terms of theoretical foundations and then take up the relevance of a systems approach, reviewing such topics as nonlinearity, recurrence after treatment, the cellular attractor concept, network theory, and non-coding DNA--the "dark matter" of our genome. They address the temporality of cancer progression, drawing on evolutionary theory and clinical experience. Finally, they cover the dominant role of the tissue microenvironment in cancer, analyzing topics including altered metabolic pathways, the disease-defining influence on metastasis, and the interconnectedness of different environmental niches across levels of organization.
Author: Athena Aktipis
Publisher: Princeton University Press
ISBN: 0691163847
Category : Medical
Languages : en
Pages : 256
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Book Description
A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer’s ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn’t mean we should give up on treating cancer—in fact, evolutionary approaches offer new and promising options for the disease’s prevention and treatments that aim at long-term management rather than simple eradication. Looking across species—from sponges and cacti to dogs and elephants—we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future—and that we cannot win a war against evolution—treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer’s fundamental nature and our relationship to it.
Author: Ruth Sackman
Publisher: Square One Publishers, Inc.
ISBN: 9780757000935
Category : Health & Fitness
Languages : en
Pages : 244
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Book Description
The Foundation for Advancement in Cancer Therapy (FACT) has long worked to educate cancer patients about alternative therapies, enabling them to make informed decisions on treatment options. Unfortunately, there still remains a major gap in the distribution of information. To meet this challenge, Ruth Sackman has written Rethinking Cancer. Here, you'll find pertinent information on a wide range of topics, including the role of nutrition in health and strategies for achieving detoxification. The author provides both valid research and specific advice.
Author: Foundation for Advancement in Cancer Therapy (F.A.C.T.)
Publisher:
ISBN: 9780970206145
Category :
Languages : en
Pages : 382
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Book Description
Ruth Sackman (1915-2008) was a trailblazer, indeed, a warrior, for a different concept and treatment of cancer. For nearly 40 years, as president/co-founder of the Foundation for Advancement in Cancer Therapy (F.A.C.T.), a nonprofit 501(c)(3) educational organization (est. 1971), she counseled doctors and patients worldwide about nontoxic, biologically-sound therapies, helping countless numbers of people achieve long-term recovery. When Ruth started out in the 70s, the ¿alternative¿ scene was very different from today. In those pre-Internet times, reliable information on unconventional treatments was very hard to come by. Most people assumed the legal protocols ¿ surgery, chemo, radiation ¿ were their only options and the medical establishment was very quick to condemn anything else as ¿quackery.¿ But Ruth was unshakeable in making the logical case that therapy should focus on improving the condition of the whole body, rather than the conventional emphasis on killing cancer cells as the answer to cancer. Ruth¿s voice is unique ¿ fearless, authoritative, yet plain-spoken and practical. Healing Cancer contains a wide range of her writings on subjects of great value to anyone seeking to take charge of their health. She is powerful in her understanding of the body¿s incredible self-healing capacity, when given proper support, and in making sense of the information and misinformation overload we confront in our hyper-paced world. In the Introduction, Consuelo Reyes, her protégé of 20 years, relates the gripping tale of how Ruth became a beloved expert on ¿alternative cancer therapy,¿ a term she initiated. Consuelo also provides chapter notes/updates, but Ruth¿s writings are the heart and soul of this book ¿ best read carefully and often for maximum wisdom. For more information, visit F.A.C.T.¿s website: RethinkingCancer.org
Author: T. Colin Campbell
Publisher: BenBella Books, Inc.
ISBN: 1937856259
Category : Health & Fitness
Languages : en
Pages : 310
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Book Description
New York Times Bestseller What happens when you eat an apple? The answer is vastly more complex than you imagine. Every apple contains thousands of antioxidants whose names, beyond a few like vitamin C, are unfamiliar to us, and each of these powerful chemicals has the potential to play an important role in supporting our health. They impact thousands upon thousands of metabolic reactions inside the human body. But calculating the specific influence of each of these chemicals isn't nearly sufficient to explain the effect of the apple as a whole. Because almost every chemical can affect every other chemical, there is an almost infinite number of possible biological consequences. And that's just from an apple. Nutritional science, long stuck in a reductionist mindset, is at the cusp of a revolution. The traditional “gold standard" of nutrition research has been to study one chemical at a time in an attempt to determine its particular impact on the human body. These sorts of studies are helpful to food companies trying to prove there is a chemical in milk or pre-packaged dinners that is “good" for us, but they provide little insight into the complexity of what actually happens in our bodies or how those chemicals contribute to our health. In The China Study, T. Colin Campbell (alongside his son, Thomas M. Campbell) revolutionized the way we think about our food with the evidence that a whole food, plant-based diet is the healthiest way to eat. Now, in Whole, he explains the science behind that evidence, the ways our current scientific paradigm ignores the fascinating complexity of the human body, and why, if we have such overwhelming evidence that everything we think we know about nutrition is wrong, our eating habits haven't changed. Whole is an eye-opening, paradigm-changing journey through cutting-edge thinking on nutrition, a scientific tour de force with powerful implications for our health and for our world.
Author: Henry H. Heng
Publisher: Academic Press
ISBN: 0128136367
Category : Medical
Languages : en
Pages : 564
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Book Description
Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. - Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicine - Gathers the most pressing questions in genomic and cytogenomic research - Offers alternative explanations to timely puzzles in the field - Contains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more
Author: Nortin M. Hadler, M.D.
Publisher: Univ of North Carolina Press
ISBN: 0807869236
Category : Health & Fitness
Languages : en
Pages : 273
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Book Description
For those fortunate enough to reside in the developed world, death before reaching a ripe old age is a tragedy, not a fact of life. Although aging and dying are not diseases, older Americans are subject to the most egregious marketing in the name of "successful aging" and "long life," as if both are commodities. In Rethinking Aging, Nortin M. Hadler examines health-care choices offered to aging Americans and argues that too often the choices serve to profit the provider rather than benefit the recipient, leading to the medicalization of everyday ailments and blatant overtreatment. Rethinking Aging forewarns and arms readers with evidence-based insights that facilitate health-promoting decision making. Over the past decades, Hadler has established himself as a leading voice among those who approach the menu of health-care choices with informed skepticism. Only the rigorous demonstration of efficacy is adequate reassurance of a treatment's value, he argues; if it cannot be shown that a particular treatment will benefit the patient, one should proceed with caution. In Rethinking Aging, Hadler offers a doctor's perspective on the medical literature as well as his long clinical experience to help readers assess their health-care options and make informed medical choices in the last decades of life. The challenges of aging and dying, he eloquently assures us, can be faced with sophistication, confidence, and grace.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309134161
Category : Medical
Languages : en
Pages : 455
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Book Description
Cancer care today often provides state-of-the-science biomedical treatment, but fails to address the psychological and social (psychosocial) problems associated with the illness. This failure can compromise the effectiveness of health care and thereby adversely affect the health of cancer patients. Psychological and social problems created or exacerbated by cancer-including depression and other emotional problems; lack of information or skills needed to manage the illness; lack of transportation or other resources; and disruptions in work, school, and family life-cause additional suffering, weaken adherence to prescribed treatments, and threaten patients' return to health. Today, it is not possible to deliver high-quality cancer care without using existing approaches, tools, and resources to address patients' psychosocial health needs. All patients with cancer and their families should expect and receive cancer care that ensures the provision of appropriate psychosocial health services. Cancer Care for the Whole Patient recommends actions that oncology providers, health policy makers, educators, health insurers, health planners, researchers and research sponsors, and consumer advocates should undertake to ensure that this standard is met.
Author: Neil C. Manson
Publisher: Cambridge University Press
ISBN: 1139463209
Category : Philosophy
Languages : en
Pages : 15
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Book Description
Informed consent is a central topic in contemporary biomedical ethics. Yet attempts to set defensible and feasible standards for consenting have led to persistent difficulties. In Rethinking Informed Consent in Bioethics, first published in 2007, Neil Manson and Onora O'Neill set debates about informed consent in medicine and research in a fresh light. They show why informed consent cannot be fully specific or fully explicit, and why more specific consent is not always ethically better. They argue that consent needs distinctive communicative transactions, by which other obligations, prohibitions, and rights can be waived or set aside in controlled and specific ways. Their book offers a coherent, wide-ranging and practical account of the role of consent in biomedicine which will be valuable to readers working in a range of areas in bioethics, medicine and law.
Author: Karen Glanz
Publisher:
ISBN:
Category : Health behavior
Languages : en
Pages : 52
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Book Description
