Making Meaning

Making Meaning PDF Author: Developmental Studies Center (Oakland, Calif.)
Publisher:
ISBN: 9781576214190
Category : Language arts (Elementary)
Languages : en
Pages :

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Book Description
Is designed to help the teacher make informed instructional decisions and track students' reading comprehension and social development as they teach the Making Meaning lesson. Consumable.

Making Meaning

Making Meaning PDF Author: Developmental Studies Center (Oakland, Calif.)
Publisher:
ISBN: 9781576214190
Category : Language arts (Elementary)
Languages : en
Pages :

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Book Description
Is designed to help the teacher make informed instructional decisions and track students' reading comprehension and social development as they teach the Making Meaning lesson. Consumable.

Scenarios and Responses to Future Deep Oil Spills

Scenarios and Responses to Future Deep Oil Spills PDF Author: Steven A. Murawski
Publisher: Springer
ISBN: 3030129632
Category : Science
Languages : en
Pages : 549

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Book Description
It has often been said that generals prepare for the next war by re-fighting the last. The Deepwater Horizon (DWH) oil spill was unlike any previous – an underwater well blowout 1,500 meters deep. Much has been learned in the wake of DWH and these lessons should in turn be applied to both similar oil spill scenarios and those arising from “frontier” explorations by the marine oil industry. The next deep oil well blowout may be at 3,000 meters or even deeper. This volume summarizes regional (Gulf of Mexico) and global megatrends in marine oil exploration and production. Research in a number of key areas including the behavior of oil and gas under extreme pressure, impacts on biological resources of the deep sea, and the fate of oil and gas released in spills is synthesized. A number of deep oil spills are simulated with detailed computer models, and the likely effects of the spills and potential mitigation measures used to combat them are compared. Recommended changes in policies governing marine oil exploration and development are proposed, as well as additional research to close critical and emerging knowledge gaps. This volume synthesizes state-of-the-art research in deep oil spill behavior and response. It is thus relevant for government and industry oil spill responders, policy formulators and implementers, and academics and students desiring an in-depth and balanced overview of key issues and uncertainties surrounding the quest for deep oil and potential impacts on the environment.

Approaches to Blocking the Immune Response to Gene Transfer with Viral Vectors

Approaches to Blocking the Immune Response to Gene Transfer with Viral Vectors PDF Author: Katherine High
Publisher: Frontiers E-books
ISBN: 2889190552
Category :
Languages : en
Pages : 96

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Book Description
Viral vectors are superior tools for gene therapy and as a genetic vaccine platform because viruses have evolved to efficiently infect and transfer their genomes to cells. Several impressive successes in viral vector-based gene therapies have been reported in humans, including restoration of vision in patients with Leber’s congenital amaurosis by retinal gene transfer and cures for severe immune deficiencies by gene transfer to hematopoietic stem cells. However, the mammalian immune system has evolved in parallel to fend off invading pathogens such as viruses. Innate and antigen-specific adaptive immune responses against viral vectors and therapeutic transgene products pose serious hurdles for successful gene therapy. Pre-existing immunity in humans, resulting from prior exposure to the parent virus that forms the basis for the gene transfer vehicle may be derived from, often prevents efficient gene transfer. This problem also reduces our ability to use certain vectors for genetic vaccination or in anti-cancer therapy. For these reasons, the gene transfer community has been extensively studying the mechanisms of immune responses against viral vectors and has started to develop strategies and protocols to block or circumvent such responses. Choice, design and engineering of a vector as well as the route of administration/target tissue can be optimized/ altered to minimize immune responses or evade pre-existing immunity. Immune suppression and modulation strategies are being developed in order to minimize inflammation, prevent antibody or T cell responses against vectors, and to promote tolerance to therapeutic gene products. Combinations of these approaches will likely facilitate clinical applications of gene therapy for many target diseases and also aid in vaccine development.

Emergency Response Guidebook

Emergency Response Guidebook PDF Author: U.S. Department of Transportation
Publisher: Simon and Schuster
ISBN: 1626363765
Category : House & Home
Languages : en
Pages : 352

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Book Description
Does the identification number 60 indicate a toxic substance or a flammable solid, in the molten state at an elevated temperature? Does the identification number 1035 indicate ethane or butane? What is the difference between natural gas transmission pipelines and natural gas distribution pipelines? If you came upon an overturned truck on the highway that was leaking, would you be able to identify if it was hazardous and know what steps to take? Questions like these and more are answered in the Emergency Response Guidebook. Learn how to identify symbols for and vehicles carrying toxic, flammable, explosive, radioactive, or otherwise harmful substances and how to respond once an incident involving those substances has been identified. Always be prepared in situations that are unfamiliar and dangerous and know how to rectify them. Keeping this guide around at all times will ensure that, if you were to come upon a transportation situation involving hazardous substances or dangerous goods, you will be able to help keep others and yourself out of danger. With color-coded pages for quick and easy reference, this is the official manual used by first responders in the United States and Canada for transportation incidents involving dangerous goods or hazardous materials.

Redirection of Th1 and Th2 Responses

Redirection of Th1 and Th2 Responses PDF Author: Robert L. Coffman
Publisher: Springer Science & Business Media
ISBN: 3662097095
Category : Medical
Languages : en
Pages : 158

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Book Description
The two major subsets of CD4+ helper T cells, designated Th1 and Th2, have quite different patterns of cytokine production and, as a consequence, have very different roles in immune responses. The articles in this volume review both basic and clinical studies of T cell heterogeneity, including: the mechanisms by which Th1 and Th2 cells develop and maintain their differences in cytokine production; the different roles of Th1 and Th2 cells in allergy, autoimmunity and infectious diseases; the prospects and strategies for therapeutic manipulation of Th1 and Th2 cells; and the control of Th1 and Th2 responses by regulatory T cell subsets. The volume should give the reader a view of the development and function of Th1 and Th2 cells and the attempts to treat immunological diseases with therapies directed towards altering the Th1/Th2 balance.

The Book of Call and Response

The Book of Call and Response PDF Author: John Feierabend
Publisher: First Steps in Music
ISBN: 9781622775118
Category : Music
Languages : en
Pages : 88

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Book Description
Whether sung around a campfire, in a classroom, or on a family road trip, call and response songs, in which a leader sings a phrase and a group sings back a reply, are a wonderful interactive experience for kids! Because they are easy to learn and fun to sing, call and response songs are a wonderful way to engage children, while at the same time plant the seeds of musical sensitivity and imagination. This special book, for the first time, collects the most cherished of these songs (some in danger of being lost or forgotten), enabling your family to carry on the tradition of laughter and learning that call and response songs have inspired for generations!

The Th2 Type Immune Response in Health and Disease

The Th2 Type Immune Response in Health and Disease PDF Author: William C. Gause
Publisher: Springer
ISBN: 1493929119
Category : Medical
Languages : en
Pages : 183

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Book Description
The type 2 immune response that develops during infectious disease has undergone major paradigm shifts in the last several years as new cell types and pathways have been identified. It is now clear that the type 2 immune response, characterized by elevations in specific cytokines, including IL-4, IL-5 and IL-13, is associated with helminth infections in both humans and mice. This response is complex and includes effector functions that mediate resistance, contributing to expulsion and in some cases destruction, of the parasite. But just as importantly, the type 2 immune response can also mediate tolerance mechanisms, which can mitigate tissue injury as these large multicellular parasites transit through vital organs. The tolerance mechanisms include both tissue repair and immune regulatory effects. These latter aspects of the helminth-induced type 2 immune response are increasingly recognized as a potential resource that can be mined for the development of novel immunotherapies that may enhance wound healing, control of autoimmune and inflammatory diseases and regulation of metabolic homeostasis. In this book, leading researchers in this exciting and dynamic field discuss the latest findings and emerging concepts, providing an intellectual framework that can be used as a basis for new discoveries and potentially new treatments for diseases associated with inflammation.

Differential Radiosensitivity of First- and Second-set Responses to Allogenic and Xenogenic Skin Grafts in Sublethally Irradiated Mice

Differential Radiosensitivity of First- and Second-set Responses to Allogenic and Xenogenic Skin Grafts in Sublethally Irradiated Mice PDF Author: M. L. Tyan
Publisher:
ISBN:
Category : Mice as laboratory animals
Languages : en
Pages : 22

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Book Description


Responses of Midbrain Cells in Macaca Mulatta Related to Transmission of Impulses Associated with Noxious Stimulation

Responses of Midbrain Cells in Macaca Mulatta Related to Transmission of Impulses Associated with Noxious Stimulation PDF Author: James Alexander McMillan
Publisher:
ISBN:
Category :
Languages : en
Pages : 200

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Book Description


Psychopharmacology Abstracts

Psychopharmacology Abstracts PDF Author:
Publisher:
ISBN:
Category : Psychopharmacology
Languages : en
Pages : 276

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Book Description