Reproducibility and Replicability in Parkinson's Disease and Age-Related Movement Disorders PDF Download
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Author: Vinita Ganesh Chittoor
Publisher: Frontiers Media SA
ISBN: 2832538754
Category : Medical
Languages : en
Pages : 130
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Book Description
Author: Vinita Ganesh Chittoor
Publisher: Frontiers Media SA
ISBN: 2832538754
Category : Medical
Languages : en
Pages : 130
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Book Description
Author: Alessandro Zampogna
Publisher: Frontiers Media SA
ISBN: 2832551599
Category : Medical
Languages : en
Pages : 125
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Book Description
The management of movement disorders is undergoing rapid transformation through the use of innovative health technologies, such as wearable sensors, mobile apps, robotics, and telemedicine systems. These technologies continue to evolve, providing new solutions for early diagnosis, remote monitoring, tailored treatments, and enhanced rehabilitative strategies that cater to individual needs through personalized approaches. With the aid of new health technologies, motor abnormalities can be sensitively recognized and objectively assessed, providing quantifiable measures to detect subtle changes associated with treatment response and disease progression. Moreover, long-term instrumental monitoring offers the opportunity for improving therapeutic strategies by gathering ecological data directly at patients’ homes in free-living situations.
Author: Kenneth M. Heilman
Publisher: Cambridge University Press
ISBN: 1108453600
Category : Medical
Languages : en
Pages : 331
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Book Description
Examines the alterations of cognition, perception, and behavior that occur with healthy brain aging, their mechanisms, and their management.
Author: Anton Bespalov
Publisher: Springer Nature
ISBN: 3030336565
Category : Cardiology
Languages : en
Pages : 424
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Book Description
This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.
Author: Donald W. Pfaff
Publisher: Springer
ISBN: 9781493934737
Category : Medical
Languages : en
Pages : 0
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Book Description
Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.
Author: Masamitsu Yamaguchi
Publisher: Springer
ISBN: 9811305293
Category : Medical
Languages : en
Pages : 314
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Book Description
Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila’s value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases. The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.
Author: Gabor Stefanics
Publisher: Frontiers Media SA
ISBN: 2889195600
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
Languages : en
Pages : 204
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Book Description
Current theories of visual change detection emphasize the importance of conscious attention to detect unexpected changes in the visual environment. However, an increasing body of studies shows that the human brain is capable of detecting even small visual changes, especially if such changes violate non-conscious probabilistic expectations based on repeating experiences. In other words, our brain automatically represents statistical regularities of our visual environmental. Since the discovery of the auditory mismatch negativity (MMN) event-related potential (ERP) component, the majority of research in the field has focused on auditory deviance detection. Such automatic change detection mechanisms operate in the visual modality too, as indicated by the visual mismatch negativity (vMMN) brain potential to rare changes. VMMN is typically elicited by stimuli with infrequent (deviant) features embedded in a stream of frequent (standard) stimuli, outside the focus of attention. In this research topic we aim to present vMMN as a prediction error signal. Predictive coding theories account for phenomena such as mismatch negativity and repetition suppression, and place them in a broader context of a general theory of cortical responses. A wide range of vMMN studies has been presented in this Research Topic. Twelve articles address roughly four general sub-themes including attention, language, face processing, and psychiatric disorders. Additionally, four articles focused on particular subjects such as the oblique effect, object formation, and development and time-frequency analysis of vMMN. Furthermore, a review paper presented vMMN in a hierarchical predictive coding framework. Each paper in this Research Topic is a valuable contribution to the field of automatic visual change detection and deepens our understanding of the short term plasticity underlying predictive processes of visual perceptual learning.
Author: Paul Levay
Publisher: Facet Publishing
ISBN: 1783303735
Category : Language Arts & Disciplines
Languages : en
Pages : 352
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Book Description
In resource poor, cost saving times, this book provides practical advice on new methods and technologies involved in systematic searching and explores the role of information professionals in delivering these changes The editors bring together expert international practitioners and researchers to highlight the latest thinking on systematic searching. Beginning by looking at the methods and techniques underlying systematic searching, the book then examines the current challenges and the potential solutions to more effective searching in detail, before considering the role of the information specialist as an expert searcher. Systematic Searching blends theory and practice and takes into account different approaches to information retrieval with a special focus being given to searching for complex topics in a health-related environment. The book does not presume an in-depth prior knowledge or experience of systematic searching and includes case studies, practical examples and ideas for further research and reading. The book is divided into three parts: Methods covers theoretical approaches to evidence synthesis and the implications that these have for the search process, including searching for complex topics and choosing the right sources. Technology examines new technologies for retrieving evidence and how these are leading to new directions in information retrieval and evidence synthesis. People considers the future of the information specialist as an expert searcher and explores how information professionals can develop their skills in searching, communication and collaboration to ensure that information retrieval practice is, and remains, evidence-based. Systematic Searching will be essential reading for library and information service providers and information specialists, particularly those in a health-related environment. It will also be of interest to students of library and information science, systematic reviewers, researchers and practitioners conducting complex searches in settings including social care, education and criminal justice.
Author: Selma Supek
Publisher: Springer
ISBN: 3642330452
Category : Technology & Engineering
Languages : en
Pages : 999
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Book Description
Magnetoencephalography (MEG) is an invaluable functional brain imaging technique that provides direct, real-time monitoring of neuronal activity necessary for gaining insight into dynamic cortical networks. Our intentions with this book are to cover the richness and transdisciplinary nature of the MEG field, make it more accessible to newcomers and experienced researchers and to stimulate growth in the MEG area. The book presents a comprehensive overview of MEG basics and the latest developments in methodological, empirical and clinical research, directed toward master and doctoral students, as well as researchers. There are three levels of contributions: 1) tutorials on instrumentation, measurements, modeling, and experimental design; 2) topical reviews providing extensive coverage of relevant research topics; and 3) short contributions on open, challenging issues, future developments and novel applications. The topics range from neuromagnetic measurements, signal processing and source localization techniques to dynamic functional networks underlying perception and cognition in both health and disease. Topical reviews cover, among others: development on SQUID-based and novel sensors, multi-modal integration (low field MRI and MEG; EEG and fMRI), Bayesian approaches to multi-modal integration, direct neuronal imaging, novel noise reduction methods, source-space functional analysis, decoding of brain states, dynamic brain connectivity, sensory-motor integration, MEG studies on perception and cognition, thalamocortical oscillations, fetal and neonatal MEG, pediatric MEG studies, cognitive development, clinical applications of MEG in epilepsy, pre-surgical mapping, stroke, schizophrenia, stuttering, traumatic brain injury, post-traumatic stress disorder, depression, autism, aging and neurodegeneration, MEG applications in cognitive neuropharmacology and an overview of the major open-source analysis tools.
Author: Hardy J. Rideout
Publisher: Springer
ISBN: 3319499696
Category : Medical
Languages : en
Pages : 280
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Book Description
This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.
