Regulation and Function of the Virus Induced Gene Vago in Drosophila PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Regulation and Function of the Virus Induced Gene Vago in Drosophila PDF full book. Access full book title Regulation and Function of the Virus Induced Gene Vago in Drosophila by Safia Deddouche. Download full books in PDF and EPUB format.
Author: Safia Deddouche
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Viral infections continue to be a major cause of morbidity and mortality world-wide. In particular, the past three decades have witnessed the onset of some 25 new viral diseases. Moreover recent outbreaks such as Chikungunya fever in La Réunion demonstrate the enormous public health problem associated with arthropod-borne virus infections. At this stage, our understanding of how the vector responds to virus infection is very limited. The goal of my PhD studies was to use Drosophila melanogaster as a model to study the host response of insects to virus infection. In flies like in mammals, viral infection triggers the expression of a large number of genes. I have provided genetic evidence that the inducible gene Vago limits viral replication. This was the first demonstration that an inducible molecule controls viral replication in drosophila. Interestingly, I have shown that Vago induction is dependant of the Dicer-2 molecule. I also note that Dicer-2 belongs to the same DEXD/H-box helicase family as RIG-I like receptors, which sense viral infection and mediate interferon induction in mammals. I posit that this family represents an evolutionary conserved set of sensors, which detect viral nucleic acids and direct antiviral responses. My work points out that the well known RNaseIII enzyme Dicer-2 plays a dual role during infection: (i) a direct role counteracting viral replication by cutting viral RNA and (ii) a sensing role that triggers antiviral gene expression in Drosophila.
Author: Safia Deddouche
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Viral infections continue to be a major cause of morbidity and mortality world-wide. In particular, the past three decades have witnessed the onset of some 25 new viral diseases. Moreover recent outbreaks such as Chikungunya fever in La Réunion demonstrate the enormous public health problem associated with arthropod-borne virus infections. At this stage, our understanding of how the vector responds to virus infection is very limited. The goal of my PhD studies was to use Drosophila melanogaster as a model to study the host response of insects to virus infection. In flies like in mammals, viral infection triggers the expression of a large number of genes. I have provided genetic evidence that the inducible gene Vago limits viral replication. This was the first demonstration that an inducible molecule controls viral replication in drosophila. Interestingly, I have shown that Vago induction is dependant of the Dicer-2 molecule. I also note that Dicer-2 belongs to the same DEXD/H-box helicase family as RIG-I like receptors, which sense viral infection and mediate interferon induction in mammals. I posit that this family represents an evolutionary conserved set of sensors, which detect viral nucleic acids and direct antiviral responses. My work points out that the well known RNaseIII enzyme Dicer-2 plays a dual role during infection: (i) a direct role counteracting viral replication by cutting viral RNA and (ii) a sensing role that triggers antiviral gene expression in Drosophila.
Author: Wilfredo Lopez
Publisher:
ISBN:
Category : Drosophila melanogaster
Languages : en
Pages : 176
Get Book Here
Book Description
Author:
Publisher: Academic Press
ISBN: 0128159820
Category : Science
Languages : en
Pages : 376
Get Book Here
Book Description
Nucleic Acid Sensing and Immunity - PART B, Volume 345 gives a comprehensive overview of the nucleic acid machinery, from plants to mammalians, along with their regulation. Chapters in this updated volume include Nucleic acids sensing in allergic disorders, Nucleic acids sensing in autoimmune disorders, Nucleic acid sensing in inflammatory disorders, Viral nucleic acid sensing inflammasomes in intestinal host defense, Genome damage sensing leads to tissue homeostasis in Drosophila, Nucleic acids sensing in plants, Nucleic Acid sensing in invertebrates, amongst other topics. - Provides an accurate, state-of-the-art resource on RNA sensing - Includes the work of a well-known tumor immunologist - Links intestinal host defense and viral nucleic acid sensing - Presents a chapter on the negative regulation of DNA sensing, a timely topic
Author: Chenhe Su
Publisher: Frontiers Media SA
ISBN: 2832541402
Category : Medical
Languages : en
Pages : 203
Get Book Here
Book Description
This Research Topic is the second volume of the “Community Series in Antiviral Innate Immune Sensing, Regulation, and Viral Immune Evasion”. Please see the first volume here. The innate immune system is crucial to defend against viruses or other pathogenic microbes in the early phases of infection. The response starts with detecting evolutionarily conserved structures, termed pathogen-associated molecular patterns (PAMPs), by a set of germline-encoded pattern-recognition receptors (PRRs). Following the detection of specific viral PAMPs, PRRs trigger the activation of intracellular signaling cascades, ultimately leading to the induction of type I interferons (IFNs), pro-inflammatory cytokines, and antiviral genes through the activation of interferon regulatory factor 3 (IRF3) and IRF7. Antiviral pathways need to be tightly regulated to ensure successful antiviral defenses and avoid aberrant or dysregulation of host immune signaling. We believe that the Research Topic will give updated insights into the dynamic fields of PAMPs sensing in antiviral innate immunity and viral immune evasion. We hope it will serve the purpose of encouraging new research. This Research Topic will provide an overall picture of antiviral innate immune sensing signal pathways, regulation, and viral immune evasion. We welcome the submission of Original Research, Review, Mini-Review, Hypothesis and Theory, and Perspective articles that cover, but are not limited to, the following subtopics:
Author: Jens Rolff
Publisher: OUP Oxford
ISBN: 0191579149
Category : Science
Languages : en
Pages : 272
Get Book Here
Book Description
Under continual attack from both microbial pathogens and multicellular parasites, insects must cope with immune challenges every day of their lives. However, this has not prevented them from becoming the most successful group of animals on the planet. Insects possess highly-developed innate immune systems which have been fine-tuned by an arms race with pathogens spanning hundreds of millions of years of evolutionary history. Recent discoveries are revealing both an unexpected degree of specificity and an indication of immunological memory - the functional hallmark of vertebrate immunity. The study of insect immune systems has accelerated rapidly in recent years and is now becoming an important interdisciplinary field. Furthermore, insects are a phenomenally rich and diverse source of antimicrobial chemicals. Some of these are already being seriously considered as potential therapeutic agents to control microbes such as MRSA. Despite a burgeoning interest in the field, this is the first book to provide a coherent synthesis and is clearly structured around two broadly themed sections: mechanisms of immunity and evolutionary ecology. This novel text adopts an interdisciplinary and concept-driven approach, integrating insights from immunology, molecular biology, ecology, evolutionary biology, parasitology, and epidemiology. It features contributions from an international team of leading experts. Insect Infection and Immunity is suitable for both graduate students and researchers interested in insect immunity from either an evolutionary, genetical, physiological or molecular perspective. Due to its interdisciplinary and concept-driven approach, it will also appeal to a broader audience of immunologists, parasitologists and evolutionary biologists requiring a concise overview.
Author: Farzana Khan Perveen
Publisher: BoD – Books on Demand
ISBN: 9535138537
Category : Technology & Engineering
Languages : en
Pages : 270
Get Book Here
Book Description
This book contains 12 chapters divided into two sections. Section 1 is "Drosophila - Model for Genetics." It covers introduction, chromosomal polymorphism, polytene chromosomes, chromosomal inversion, chromosomal evolution, cell cycle regulators in meiosis and nongenetic transgenerational inheritance in Drosophila. It also includes ecological genetics, wild-type strains, morphometric analysis, cytostatics, frequencies of early and late embryonic lethals (EEL and LEL) and mosaic imaginal discs of Drosophila for genetic analysis in biomedical research. Section 2 is "Drosophila - Model for Therapeutics." It explains Drosophila as model for human diseases, neurodegeneration, heart-kidney metabolic disorders, cancer, pathophysiology of Parkinson's disease, dopamine, neuroprotective therapeutics, mitochondrial dysfunction and translational research. It also covers Drosophila role in ubiquitin-carboxyl-terminal hydrolase-L1 (UCH-L1) protein, eye development, anti-dUCH antibody, neuropathy target esterase (NTE), organophosphorous compound-induced delayed neuropathy (OPIDN) and hereditary spastic paraplegia (HSP). It also includes substrate specificities, kinetic parameters of recombinant glutathione S-transferases E6 and E7 (DmGSTE6 and DmGSTE7), detoxification and insecticidal resistance and antiviral immunity in Drosophila.
Author: Elizabeth Jockusch
Publisher: Academic Press
ISBN: 012387680X
Category : Science
Languages : en
Pages : 224
Get Book Here
Book Description
Advances in Insect Physiology is committed to publishing volumes containing comprehensive and in-depth reviews on all aspects of insect physiology. First published in 1963, these volumes are an essential reference source for invertebrate physiologists, insect neurobiologists, entomologists, zoologists and insect biochemists. This volume is themed on small RNAs and RNAi in insects. Contains comprehensive and in-depth reviews Essential reference source for invertebrate physiologists, insect neurobiologists, entomologists, zoologists and insect biochemists This volume is themed on small RNAs and RNAi in insects
Author:
Publisher: Academic Press
ISBN: 0128155353
Category : Medical
Languages : en
Pages : 404
Get Book Here
Book Description
Advances in Virus Research, Volume 100 presents the latest release in this ongoing series that provides the broadest topical coverage. New sections to this release include the species problem in virology, a short intro/history of AVR, the role of immune responses in HIV and mother-to-child transmission, autophagy/polio/dengue, ASFV biology and vaccine approaches, morbillivirus pathogenesis, viruses of plant-interacting fungi, parvovirus evolution, protein localization and interaction studies in plants, respiratory coronaviruses and their reservoirs, H5N8, an orchestra of reovirus receptors, antiviral immune response and the route of infection in Drosophila melanogaster, and more. - Presents a valuable resource for information on all topics of virus research, from bacteriophages to human viruses - Provides a longstanding record for authoritative coverage by first-class experts - Includes work from a dedicated team of editors who assure that articles are timely and informative
Author: Gheyath Khaled Nasrallah
Publisher: Frontiers Media SA
ISBN: 2889718905
Category : Science
Languages : en
Pages : 121
Get Book Here
Book Description
Author: Fengliang Jin
Publisher: Frontiers Media SA
ISBN: 2832540902
Category : Medical
Languages : en
Pages : 424
Get Book Here
Book Description
Insects are a group of abundant and diverse organisms that have successfully adapted to the most challenging conditions on earth. The success of insects in adverse environments indicates the advanced defense mechanisms employed by these organisms, but they are often targeted by specialized microorganisms (viruses, bacteria, nematodes, & fungi) and parasitoids. Insects exhibit both humoral and cellular immune responses against pathogens. The lack of an adaptive immune system has compelled insects to choose immediate non-specific but sophisticated responses that include the production of antimicrobial peptides, phenoloxidase, apoptosis, phagocytosis, encapsulation, and nodulation. In recent decades, technological advances have been made in decrypting the molecular and mechanistic basis of insect immunity. However, there is a need to understand the insect immune responses to single or mixed encounters. Future challenges include a better understanding of functional cooperation of various endosymbiotic microbes and their role in insect defenses. Post-transcriptional modulation of immune responses regulated by non-coding RNAs (microRNA & long non-coding RNAs) has become critically important to study by using modern bioinformatics and experimental tools. Therefore, investigating the dynamics of insect immune responses will substantially increase the capacity for confronting harmful agricultural and medical pests. Furthermore, most insect cellular immune activities have been conducted in a laboratory setting, therefore confirming the existing knowledge in a natural environment would provide crucial information.
