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Author: Michael S. Goligorsky
Publisher: Academic Press
ISBN: 0123809290
Category : Science
Languages : en
Pages : 473
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Book Description
Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts. - Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers - Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney
Author: Michael S. Goligorsky
Publisher: Academic Press
ISBN: 0128233192
Category : Science
Languages : en
Pages : 530
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Book Description
Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current revisit of the field of Regenerative Nephrology. This second edition features subjects as diverse as age and gender influencing regenerative processes; mechanisms and pathways of premature cell senescence affecting kidney regeneration; the ways intrinsic regenerative processes can become subverted by noxious stressors eventuating in disease progression; novel mechanistic and engineering efforts to recreate functional kidney or its component parts; cell reprogramming and reconditioning as emerging tools of future regenerative efforts; and effects of various biologicals on kidney regeneration. These newer additions to the armamentarium of Regenerative Medicine and Nephrology have become an integral part of the second edition of the book. Cutting-edge investigations are summarized by the constellation of the most experienced contributing authors coming together from around the world under the umbrella of the second edition. - A significant expansion of section on induced pluripotent cells and trajectories of their differentiation. This will be followed by mechanisms and modalities of cell reprogramming for therapeutic purposes - A new section on tissue engineering of the kidney of interest to nephrologists and urologists - An entire section dedicated to causes of regenerative failure with the emphasis on recent discoveries of senescent cells in kidney disease, pathologic effects of senescent cells, advents in senotherapies and rejuvenation therapies - A vastly expanded section on pharmacotherapies promoting kidney regeneration, trials of engineered organs, manufacturing in regenerative medicine and smooth transition to the clinical trials, with an update on some ethical issues
Author: Michael S. Goligorsky
Publisher: Academic Press
ISBN: 0123809290
Category : Science
Languages : en
Pages : 473
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Book Description
Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts. - Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers - Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney
Author: Melissa Helen Little
Publisher: Academic Press
ISBN: 012800438X
Category : Science
Languages : en
Pages : 615
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Book Description
Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. - Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities - Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally - Explains the underlying developmental mechanisms which influence the kidney's inherent repair capacity - Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine
Author: Geraldo Bezerra da Silva Junior
Publisher: Springer Nature
ISBN: 3031115708
Category : Medical
Languages : en
Pages : 538
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Book Description
Our world is facing unprecedented technological development, which affects all the sectors of society. The 4th industrial revolution has brought numerous advances that are currently integrated in our daily life, including artificial intelligence (A.I.), internet of things (IoT), genetic engineering, 3D-printing and robotics. The health care sector is one of the most impacted by these technologies of the so-called digital era. From the simple advent of medical records to robotic surgery, health care has significantly changed from the XX to XXI century and is constantly changing, incorporating novel technologies. Nephrology is itself an innovative branch of medicine, created as a discipline in the 1960s, with breakthrough inventions, such as the dialysis machine, which made it possible to prolong life of those who suffer from chronic kidney disease; kidney transplant, with point-of-care immunosuppression that favours maintenance of kidney allografts for long years; kidney biopsy, which made it possible to discover the mysteries of glomerulonephritis and nephropathology. Novel technologies, such as A.I., IoT, robotics, stem cells, 3D-printing, mHealth, eHealth and several others are starting to be applied in nephrology, with promising results. It is possible that a great part of these technologies will become routinely available in clinical practice, and the burden of kidney diseases will significantly decrease once prevention, prediction, detection, monitoring and treatment of kidney diseases are more precise, with patients taking part in the process and becoming more and more connected. This book gathers essential information on the technologies that have been applied in nephrology and that can be applied in the future, with real possibilities of improving the care of kidney diseases. At first glance, this work is directed to the entire nephrology community and all the healthcare professionals that deal with kidney diseases. Researchers from different fields, not directly linked to nephrology, may also be interested in the book since many of the topics presented are related to other areas and serve as examples of their uses in medicine, such as artificial intelligence, robotics, and big data. Finally, the content provides an important resource to medical students, discussing technologies that will certainly be integrated in their professional practice.
Author: Tanzir Islam Britto
Publisher: BookRix
ISBN: 3755446014
Category : Medical
Languages : en
Pages : 57
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Book Description
Dive into the captivating world of nephrology with "Renal Chronicles: Exploring Kidney Health." From renal physiology to transplantation and beyond, this comprehensive book unravels the complexities of kidney diseases and their management. Discover the anatomy, diagnostic tools, and therapeutic strategies in chronic kidney disease and dialysis. Explore the intricacies of transplantation and delve into the complications encountered in nephrology practice. Written by experts, this invaluable resource empowers medical students, practitioners, and researchers to navigate the fascinating field of nephrology with confidence. Enhance your understanding and shape the future of kidney health.
Author: Neil Turner
Publisher: Oxford University Press
ISBN: 0199592543
Category : Medical
Languages : en
Pages : 3045
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Book Description
Illustrated in full colour throughout, this comprehensive edition provides the reader with complete information on clinical and practical problems in nephrology.
Author: Neil N. Turner
Publisher: Oxford University Press
ISBN: 0191017655
Category : Medical
Languages : en
Pages : 3045
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Book Description
This fourth edition of the Oxford Textbook of Clinical Nephrology builds on the success and international reputation of the publication as an important resource for the practising clinician in the field. It provides practical, scholarly, and evidence-based coverage of the full spectrum of clinical nephrology, written by a global faculty of experts. The most relevant and important reference to clinical nephrology, this is an authoritative and comprehensive textbook combining the clinical aspects of renal disease essential to daily clinical practice with extensive information about the underlying basic science and current evidence available. Each section of the textbook has been critically and comprehensively edited under the auspices of a leading expert in the field. This new edition has been significantly expanded and reapportioned to reflect developments and new approaches to topics, and includes treatment algorithms to aid and enhance patient care where possible. The fourth edition offers increased focus on the medical aspects of transplantation, HIV-associated renal disease, and infection and renal disease, alongside entirely new sections on genetic topics and clinical and physiological aspects of fluid/electrolyte and tubular disorders. The emphasis throughout is on marrying advances in scientific research with clinical management. Richly illustrated throughout in full colour, this is a truly modern and attractive edition which reinforces the Oxford Textbook of Clinical Nephrology's position as an indispensable reference work of consistent quality and reliability. Enriched and refined by careful revision, this new edition continues the tradition of excellence. This print edition of The Oxford Textbook of Clinical Nephrology comes with a year's access to the online version on Oxford Medicine Online. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables. Oxford Medicine Online is mobile optimized for access when and where you need it.
Author: Giovanni B. Fogazzi
Publisher: Oxford University Press, USA
ISBN: 9780192630742
Category : Medical
Languages : en
Pages : 188
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Book Description
From review from the Lancet of the first edition in comparison with a competing title: 'Every nephrologist knows and teaches that urine microscopy is an important diagnostic aid. What has been urgently needed is a colour guide to the subject.....I preferred the pictures in the European book. They were of high quality, not repetitive and with clear legends...if I wanted to teach myself.. then the European book was well ahead. The latter is also accompanied by an elegant introductory essay by JS Cameron on the history of urine analysis. Every renal unit needs at least one of these books.' The Lancet' These few comments should not obscure the significant contribution of The Urinary Sediment to the diagnostic armamentarium of the nephrologist. Each renal unit should have a copy for daily clinical discussions...Finally this book should be included in the required reading list of courses in renal medicine.' Nephrology Dialysis TransplantationThis is the second edition of a full colour reference atlas published first to excellent reviews in 1994. Every renal unit needs to have a reference text of this kind and urine microscopy is an important diagnostic aid in nephrology. After the 'Historical Introduction' by J Stewart Cameron, chapter 1 descibes the methods used to prepare and analyse the urine samples. Chapter 2, which is the most important section of the book, describes with the help of 249 illustrations (over 200 in full colour) the elements of the urinary sediment. Chapter 3 deals with the urinary sediment of the normal subject, while chapter 4 deals with the urinary changes which are observed in the main diseases of the kidney and urinary tract. Chapter 5 describes the changes of the urinary sediment caused by drugs. Chapter 6 is about the interpretation of the urinary findings shown in the previous chapters. Chapter 7 covers the new systems to analyse the urinary sediments. An appendix shows how to adjust the microscope to analyse the urine specimens. The primary audience is practising nephrologists and nephrologists in training, and also those in internal medicine rotating through the renal unit who perform routinely the analysis of the urinary sediment. Clinical pathologists would also find this an attractive and useful book. The illustrations are outstanding and additional clinical information has been added in this new edition. From review from the Lancet of the first edition in comparison with a competing title: 'Every nephrologist knows and teaches that urine microscopy is an important diagnostic aid. What has been urgently needed is a colour guide to the subject.....I preferred the pictures in the European book. They were of high quality, not repetitive and with clear legends...if I wanted to teach myself.. then the European book was well ahead. The latter is also accompanied by an elegant introductory essay by JS Cameron on the history of urine analysis. Every renal unit needs at least one of these books.' The Lancet
Author: Xin J. Zhou
Publisher: Cambridge University Press
ISBN: 1316613984
Category : Medical
Languages : en
Pages : 691
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Book Description
An algorithmic approach to interpreting renal pathology, updated in light of recent advances in understanding and new classification schemes.
Author: John Daugirdas
Publisher: Lippincott Williams & Wilkins
ISBN: 1496363248
Category : Medical
Languages : en
Pages : 453
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Book Description
Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Offering authoritative coverage of all aspects of diagnosing, treating, and preventing the progression of chronic kidney disease (CKD), this highly regarded handbook is an invaluable resource for nephrologists, internists, nurse practitioners, physician assistants, and other healthcare professionals who care for early-stage CKD patients. Incorporating the considerable advances in the field since the previous edition, Handbook of Chronic Kidney Disease Management, 2nd Edition, provides a truly global perspective on managing patients with mild to moderate CKD.
