Author: Paul Schmid-Hempel
Publisher: Princeton University Press
ISBN: 9780691059242
Category : Science
Languages : en
Pages : 436
Book Description
In addition, the author develops new insights, especially in his examination of the intricate relationships between parasites and their social hosts through the rigorous use of evolutionary and ecological concepts.".
Parasites in Social Insects
Author: Paul Schmid-Hempel
Publisher: Princeton University Press
ISBN: 9780691059242
Category : Science
Languages : en
Pages : 436
Book Description
In addition, the author develops new insights, especially in his examination of the intricate relationships between parasites and their social hosts through the rigorous use of evolutionary and ecological concepts.".
Publisher: Princeton University Press
ISBN: 9780691059242
Category : Science
Languages : en
Pages : 436
Book Description
In addition, the author develops new insights, especially in his examination of the intricate relationships between parasites and their social hosts through the rigorous use of evolutionary and ecological concepts.".
Recombination and Meiosis
Author: Richard Egel
Publisher: Springer Science & Business Media
ISBN: 3540689842
Category : Science
Languages : en
Pages : 406
Book Description
Once per life cycle, mitotic nuclear divisions are replaced by meiosis I and II – reducing chromosome number from the diploid level to a haploid genome and recombining chromosome arms by crossing-over. In animals, all this happens during formation of eggs and sperm – in yeasts before spore formation. The mechanisms of reciprocal exchange at crossover/chiasma sites are central to mainstream meiosis. To initiate the meiotic exchange of DNA, surgical cuts are made as a form of calculated damage that subsequently is repaired by homologous recombination. These key events are accompanied by ancillary provisions at the level of chromatin organization, sister chromatid cohesion and differential centromere connectivity. Great progress has been made in recent years in our understanding of these mechanisms. Questions still open primarily concern the placement of and mutual coordination between neighboring crossover events. Of overlapping significance, this book features two comprehensive treatises of enzymes involved in meiotic recombination, as well as the historical conceptualization of meiotic phenomena from genetical experiments. More specifically, these mechanisms are addressed in yeasts as unicellular model eukaryotes. Furthermore, evolutionary subjects related to meiosis are treated.
Publisher: Springer Science & Business Media
ISBN: 3540689842
Category : Science
Languages : en
Pages : 406
Book Description
Once per life cycle, mitotic nuclear divisions are replaced by meiosis I and II – reducing chromosome number from the diploid level to a haploid genome and recombining chromosome arms by crossing-over. In animals, all this happens during formation of eggs and sperm – in yeasts before spore formation. The mechanisms of reciprocal exchange at crossover/chiasma sites are central to mainstream meiosis. To initiate the meiotic exchange of DNA, surgical cuts are made as a form of calculated damage that subsequently is repaired by homologous recombination. These key events are accompanied by ancillary provisions at the level of chromatin organization, sister chromatid cohesion and differential centromere connectivity. Great progress has been made in recent years in our understanding of these mechanisms. Questions still open primarily concern the placement of and mutual coordination between neighboring crossover events. Of overlapping significance, this book features two comprehensive treatises of enzymes involved in meiotic recombination, as well as the historical conceptualization of meiotic phenomena from genetical experiments. More specifically, these mechanisms are addressed in yeasts as unicellular model eukaryotes. Furthermore, evolutionary subjects related to meiosis are treated.
Evaluating Human Genetic Diversity
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309184746
Category : Science
Languages : en
Pages : 101
Book Description
This book assesses the scientific value and merit of research on human genetic differencesâ€"including a collection of DNA samples that represents the whole of human genetic diversityâ€"and the ethical, organizational, and policy issues surrounding such research. Evaluating Human Genetic Diversity discusses the potential uses of such collection, such as providing insight into human evolution and origins and serving as a springboard for important medical research. It also addresses issues of confidentiality and individual privacy for participants in genetic diversity research studies.
Publisher: National Academies Press
ISBN: 0309184746
Category : Science
Languages : en
Pages : 101
Book Description
This book assesses the scientific value and merit of research on human genetic differencesâ€"including a collection of DNA samples that represents the whole of human genetic diversityâ€"and the ethical, organizational, and policy issues surrounding such research. Evaluating Human Genetic Diversity discusses the potential uses of such collection, such as providing insight into human evolution and origins and serving as a springboard for important medical research. It also addresses issues of confidentiality and individual privacy for participants in genetic diversity research studies.
In the Light of Evolution
Author: National Academy of Sciences
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 388
Book Description
The Arthur M. Sackler Colloquia of the National Academy of Sciences address scientific topics of broad and current interest, cutting across the boundaries of traditional disciplines. Each year, four or five such colloquia are scheduled, typically two days in length and international in scope. Colloquia are organized by a member of the Academy, often with the assistance of an organizing committee, and feature presentations by leading scientists in the field and discussions with a hundred or more researchers with an interest in the topic. Colloquia presentations are recorded and posted on the National Academy of Sciences Sackler colloquia website and published on CD-ROM. These Colloquia are made possible by a generous gift from Mrs. Jill Sackler, in memory of her husband, Arthur M. Sackler.
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 388
Book Description
The Arthur M. Sackler Colloquia of the National Academy of Sciences address scientific topics of broad and current interest, cutting across the boundaries of traditional disciplines. Each year, four or five such colloquia are scheduled, typically two days in length and international in scope. Colloquia are organized by a member of the Academy, often with the assistance of an organizing committee, and feature presentations by leading scientists in the field and discussions with a hundred or more researchers with an interest in the topic. Colloquia presentations are recorded and posted on the National Academy of Sciences Sackler colloquia website and published on CD-ROM. These Colloquia are made possible by a generous gift from Mrs. Jill Sackler, in memory of her husband, Arthur M. Sackler.
Elements of Evolutionary Genetics
Author: Brian Charlesworth
Publisher: Roberts
ISBN:
Category : Science
Languages : en
Pages : 776
Book Description
This textbook shows readers how models of the genetic processes involved in evolution are made (including natural selection, migration, mutation, and genetic drift in finite populations), and how the models are used to interpret classical and molecular genetic data. The material is intended for advanced level undergraduate courses in genetics and evolutionary biology, graduate students in evolutionary biology and human genetics, and researchers in related fields who wish to learn evolutionary genetics. The topics covered include genetic variation, DNA sequence variability and its measurement, the different types of natural selection and their effects (e.g. the maintenance of variation, directional selection, and adaptation), the interactions between selection and mutation or migration, the description and analysis of variation at multiple sites in the genome, genetic drift, and the effects of spatial structure.
Publisher: Roberts
ISBN:
Category : Science
Languages : en
Pages : 776
Book Description
This textbook shows readers how models of the genetic processes involved in evolution are made (including natural selection, migration, mutation, and genetic drift in finite populations), and how the models are used to interpret classical and molecular genetic data. The material is intended for advanced level undergraduate courses in genetics and evolutionary biology, graduate students in evolutionary biology and human genetics, and researchers in related fields who wish to learn evolutionary genetics. The topics covered include genetic variation, DNA sequence variability and its measurement, the different types of natural selection and their effects (e.g. the maintenance of variation, directional selection, and adaptation), the interactions between selection and mutation or migration, the description and analysis of variation at multiple sites in the genome, genetic drift, and the effects of spatial structure.
Handbook of Statistical Genetics
Author: David J. Balding
Publisher: John Wiley & Sons
ISBN: 9780470997628
Category : Science
Languages : en
Pages : 1616
Book Description
The Handbook for Statistical Genetics is widely regarded as the reference work in the field. However, the field has developed considerably over the past three years. In particular the modeling of genetic networks has advanced considerably via the evolution of microarray analysis. As a consequence the 3rd edition of the handbook contains a much expanded section on Network Modeling, including 5 new chapters covering metabolic networks, graphical modeling and inference and simulation of pedigrees and genealogies. Other chapters new to the 3rd edition include Human Population Genetics, Genome-wide Association Studies, Family-based Association Studies, Pharmacogenetics, Epigenetics, Ethic and Insurance. As with the second Edition, the Handbook includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between the chapters, tying the different areas together. With heavy use of up-to-date examples, real-life case studies and references to web-based resources, this continues to be must-have reference in a vital area of research. Edited by the leading international authorities in the field. David Balding - Department of Epidemiology & Public Health, Imperial College An advisor for our Probability & Statistics series, Professor Balding is also a previous Wiley author, having written Weight-of-Evidence for Forensic DNA Profiles, as well as having edited the two previous editions of HSG. With over 20 years teaching experience, he’s also had dozens of articles published in numerous international journals. Martin Bishop – Head of the Bioinformatics Division at the HGMP Resource Centre As well as the first two editions of HSG, Dr Bishop has edited a number of introductory books on the application of informatics to molecular biology and genetics. He is the Associate Editor of the journal Bioinformatics and Managing Editor of Briefings in Bioinformatics. Chris Cannings – Division of Genomic Medicine, University of Sheffield With over 40 years teaching in the area, Professor Cannings has published over 100 papers and is on the editorial board of many related journals. Co-editor of the two previous editions of HSG, he also authored a book on this topic.
Publisher: John Wiley & Sons
ISBN: 9780470997628
Category : Science
Languages : en
Pages : 1616
Book Description
The Handbook for Statistical Genetics is widely regarded as the reference work in the field. However, the field has developed considerably over the past three years. In particular the modeling of genetic networks has advanced considerably via the evolution of microarray analysis. As a consequence the 3rd edition of the handbook contains a much expanded section on Network Modeling, including 5 new chapters covering metabolic networks, graphical modeling and inference and simulation of pedigrees and genealogies. Other chapters new to the 3rd edition include Human Population Genetics, Genome-wide Association Studies, Family-based Association Studies, Pharmacogenetics, Epigenetics, Ethic and Insurance. As with the second Edition, the Handbook includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between the chapters, tying the different areas together. With heavy use of up-to-date examples, real-life case studies and references to web-based resources, this continues to be must-have reference in a vital area of research. Edited by the leading international authorities in the field. David Balding - Department of Epidemiology & Public Health, Imperial College An advisor for our Probability & Statistics series, Professor Balding is also a previous Wiley author, having written Weight-of-Evidence for Forensic DNA Profiles, as well as having edited the two previous editions of HSG. With over 20 years teaching experience, he’s also had dozens of articles published in numerous international journals. Martin Bishop – Head of the Bioinformatics Division at the HGMP Resource Centre As well as the first two editions of HSG, Dr Bishop has edited a number of introductory books on the application of informatics to molecular biology and genetics. He is the Associate Editor of the journal Bioinformatics and Managing Editor of Briefings in Bioinformatics. Chris Cannings – Division of Genomic Medicine, University of Sheffield With over 40 years teaching in the area, Professor Cannings has published over 100 papers and is on the editorial board of many related journals. Co-editor of the two previous editions of HSG, he also authored a book on this topic.
Recombination Variability and Evolution
Author: A.B. Korol
Publisher: Springer Science & Business Media
ISBN: 9780412494109
Category : Science
Languages : en
Pages : 384
Book Description
Using an interdisciplinary approach, the authors provide an adaptionist interpretation of the basic features of recombination, its evolutionary significance as a key process in reproduction and its importance in genetic mapping. The book synthesizes much recent information in the fields of evloutionary genetics of recombination, the analysis of genetic markers and breeding applications. The authors analyse recombination through a consideration of computer models, large Drosophila populations and an empirical approach to current theories. Practically-orientated readers will be interested in the discussion of a wide spectrum of mapping methods and the new algorithms proposed for genetic mapping of quantitative loci.
Publisher: Springer Science & Business Media
ISBN: 9780412494109
Category : Science
Languages : en
Pages : 384
Book Description
Using an interdisciplinary approach, the authors provide an adaptionist interpretation of the basic features of recombination, its evolutionary significance as a key process in reproduction and its importance in genetic mapping. The book synthesizes much recent information in the fields of evloutionary genetics of recombination, the analysis of genetic markers and breeding applications. The authors analyse recombination through a consideration of computer models, large Drosophila populations and an empirical approach to current theories. Practically-orientated readers will be interested in the discussion of a wide spectrum of mapping methods and the new algorithms proposed for genetic mapping of quantitative loci.
Gene Genealogies, Variation and Evolution: A primer in coalescent theory
Author: Jotun Hein
Publisher: Oxford University Press, USA
ISBN: 9780191546150
Category : Population genetics
Languages : en
Pages : 298
Book Description
Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. Rich in examples and illustrations it is ideal for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine, and for students studying the evolution of human population and disease. It is also an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia - ;Coalescent theory is a central concept in the study of genetic sequence variation that probabilistically describes the genealogy relating the sampled sequences. In this text, besides fulfilling the glaring need for such a book, the authors present this theory in a straightforward and elementary manner and describe the statistical and computational methods used in modelling and analyzing genetic sequence variation. Rich in examples and illustrations the book covers basic concepts, complications arising from geographical structure and recombination before considering aspects of statistical inference based on these models. The book ends with chapters on Gene Mapping, which combines sequence variation data with phenotypic data (such as disease) to define areas of the genome where genes are responsible for the trait, and Human Evolution, a research area that is experiencing a renaissance due to the enormous amounts of data produced in molecular studies. Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. It is highly suitable for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine and students studying the evolution of human population and disease, and will be an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia - ;an excellent and timely book that should appeal to a variety of people in genetics and applied mathematics. - Professor Montgomery Slatkin (Berkeley);the authors are outstanding experts in the field, and the book is topical and timely. - Professor David Balding (Imperial College);Hein, Schierup and Wiuf have written the first general book on the coalescent. It is an engaging combination of clear mathematical derivation and real data examples. - Professor Joe Felsenstein (University of Washington)
Publisher: Oxford University Press, USA
ISBN: 9780191546150
Category : Population genetics
Languages : en
Pages : 298
Book Description
Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. Rich in examples and illustrations it is ideal for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine, and for students studying the evolution of human population and disease. It is also an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia - ;Coalescent theory is a central concept in the study of genetic sequence variation that probabilistically describes the genealogy relating the sampled sequences. In this text, besides fulfilling the glaring need for such a book, the authors present this theory in a straightforward and elementary manner and describe the statistical and computational methods used in modelling and analyzing genetic sequence variation. Rich in examples and illustrations the book covers basic concepts, complications arising from geographical structure and recombination before considering aspects of statistical inference based on these models. The book ends with chapters on Gene Mapping, which combines sequence variation data with phenotypic data (such as disease) to define areas of the genome where genes are responsible for the trait, and Human Evolution, a research area that is experiencing a renaissance due to the enormous amounts of data produced in molecular studies. Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. It is highly suitable for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine and students studying the evolution of human population and disease, and will be an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia - ;an excellent and timely book that should appeal to a variety of people in genetics and applied mathematics. - Professor Montgomery Slatkin (Berkeley);the authors are outstanding experts in the field, and the book is topical and timely. - Professor David Balding (Imperial College);Hein, Schierup and Wiuf have written the first general book on the coalescent. It is an engaging combination of clear mathematical derivation and real data examples. - Professor Joe Felsenstein (University of Washington)
Fitness Landscapes and the Origin of Species (MPB-41)
Author: Sergey Gavrilets
Publisher: Princeton University Press
ISBN: 0691187053
Category : Science
Languages : en
Pages : 497
Book Description
The origin of species has fascinated both biologists and the general public since the publication of Darwin's Origin of Species in 1859. Significant progress in understanding the process was achieved in the "modern synthesis," when Theodosius Dobzhansky, Ernst Mayr, and others reconciled Mendelian genetics with Darwin's natural selection. Although evolutionary biologists have developed significant new theory and data about speciation in the years since the modern synthesis, this book represents the first systematic attempt to summarize and generalize what mathematical models tell us about the dynamics of speciation. Fitness Landscapes and the Origin of Species presents both an overview of the forty years of previous theoretical research and the author's new results. Sergey Gavrilets uses a unified framework based on the notion of fitness landscapes introduced by Sewall Wright in 1932, generalizing this notion to explore the consequences of the huge dimensionality of fitness landscapes that correspond to biological systems. In contrast to previous theoretical work, which was based largely on numerical simulations, Gavrilets develops simple mathematical models that allow for analytical investigation and clear interpretation in biological terms. Covering controversial topics, including sympatric speciation and the effects of sexual conflict on speciation, this book builds for the first time a general, quantitative theory for the origin of species.
Publisher: Princeton University Press
ISBN: 0691187053
Category : Science
Languages : en
Pages : 497
Book Description
The origin of species has fascinated both biologists and the general public since the publication of Darwin's Origin of Species in 1859. Significant progress in understanding the process was achieved in the "modern synthesis," when Theodosius Dobzhansky, Ernst Mayr, and others reconciled Mendelian genetics with Darwin's natural selection. Although evolutionary biologists have developed significant new theory and data about speciation in the years since the modern synthesis, this book represents the first systematic attempt to summarize and generalize what mathematical models tell us about the dynamics of speciation. Fitness Landscapes and the Origin of Species presents both an overview of the forty years of previous theoretical research and the author's new results. Sergey Gavrilets uses a unified framework based on the notion of fitness landscapes introduced by Sewall Wright in 1932, generalizing this notion to explore the consequences of the huge dimensionality of fitness landscapes that correspond to biological systems. In contrast to previous theoretical work, which was based largely on numerical simulations, Gavrilets develops simple mathematical models that allow for analytical investigation and clear interpretation in biological terms. Covering controversial topics, including sympatric speciation and the effects of sexual conflict on speciation, this book builds for the first time a general, quantitative theory for the origin of species.
Genetics and the Origin of Species
Author: Theodosius Dobzhansky
Publisher:
ISBN:
Category :
Languages : en
Pages : 364
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 364
Book Description