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Publisher: Academic Press
ISBN: 0128244860
Category : Science
Languages : en
Pages : 358
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Book Description
Advances in Cancer Research, volume 153 provides a timely review of the biology, biochemistry, and current approaches to therapeutically target the RAS oncoprotein, the most frequently mutated oncogene family in human cancers. 2021 saw the approval of the first direct RAS inhibitor (sotorasib) for use in treating non-small cell lung cancers harboring KRAS(G12C) mutations. The successful approval and use of this drug highlights that the once "undruggable RAS is indeed pharmacologically tractable. This volume provides an overview of efforts to develop additional approaches to therapeutically target oncogenic RAS. In addition, the reader will find excellent reviews on the history and research efforts to understand the biochemistry and oncogenic activity of RAS in human cancers. - Overview of the history and development of efforts to pharmacologically inhibit RAS. - Discussion of the biochemistry and biology of different RAS mutant proteins and how this might be effectively leveraged in the development of anti-RAS therapies. - Up-to-date reviews of the cutting-edge approaches to develop new anti-RAS pharmacologics.
Author:
Publisher: Academic Press
ISBN: 0128244860
Category : Science
Languages : en
Pages : 358
Get Book Here
Book Description
Advances in Cancer Research, volume 153 provides a timely review of the biology, biochemistry, and current approaches to therapeutically target the RAS oncoprotein, the most frequently mutated oncogene family in human cancers. 2021 saw the approval of the first direct RAS inhibitor (sotorasib) for use in treating non-small cell lung cancers harboring KRAS(G12C) mutations. The successful approval and use of this drug highlights that the once "undruggable RAS is indeed pharmacologically tractable. This volume provides an overview of efforts to develop additional approaches to therapeutically target oncogenic RAS. In addition, the reader will find excellent reviews on the history and research efforts to understand the biochemistry and oncogenic activity of RAS in human cancers. - Overview of the history and development of efforts to pharmacologically inhibit RAS. - Discussion of the biochemistry and biology of different RAS mutant proteins and how this might be effectively leveraged in the development of anti-RAS therapies. - Up-to-date reviews of the cutting-edge approaches to develop new anti-RAS pharmacologics.
Author: Reginald Massey
Publisher: Abhinav Publications
ISBN: 8170173744
Category : Dance
Languages : en
Pages : 184
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Book Description
All The Major Dance Styles Of The Indian Subcontinent Share A Common Root System Of Ethical And Aesthetic Values. Hence No Single Style Can Claim To Be Purer Or Older Than Any Other. Kathak- The Style That Grew, Took Shape And Flourished In The Northern Regions Of The Subcontinent-Has Been Misunderstood And Misinterpreted On Account Of Ignorance And Prejudice From Various Quarters. This Book Sets Out, Therefore, To Rectify Incorrect Perceptions By Presenting Historical Facts And Placing Kathak Dance In Its Proper Cultural Context. The Background Of The Dance Is Explained In Detail; The Religious, Social And Political Influences Over The Centuries Are Recounted; Myth, Theory And Reality Are Expounded Upon; Current Trends Are Described And Future Possibilities Examine; And, Not Least, The Sheer Beauty Of Kathak Is Exposed To Both The Eye And The Intellect. This Book Provides Not Only Information On Technique And Training But Also Tells The Dance Lover What To Look For In A Typical Kathak Performance. It Will, Indeed, Assist The Reader Better To Appreciate And Understand A Great Dance Style. The Names And Addresses Of Recognised Dance Schools And Teachers, Both In India And Abroad, Will Prove Useful, As Will The Glossary And Bibliography. India S Kathak Dance: Past, Present, Future Is Essential Reading For All Those Who Wish To Be Acquainted With India S Immense Cultural And Artistic Achievements.
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Publisher:
ISBN:
Category : Celtic philology
Languages : en
Pages : 276
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Book Description
Author: Ulrich Bathmann
Publisher: Frontiers Media SA
ISBN: 288963468X
Category :
Languages : en
Pages : 462
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Book Description
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Publisher:
ISBN:
Category : Middle East
Languages : en
Pages : 612
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Book Description
Most years contain the Proceedings and Annual report of the society.
Author: Alfred Wittinghofer
Publisher: Springer
ISBN: 3709118069
Category : Science
Languages : en
Pages : 447
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Book Description
This first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins. Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field.
Author: Royal Asiatic Society of Great Britain and Ireland
Publisher:
ISBN:
Category : Electronic journals
Languages : en
Pages : 534
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Book Description
List of members.
Author: Werner Forman
Publisher: Vintage
ISBN: 9781860461552
Category : History
Languages : en
Pages : 256
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Book Description
Few nations on earth have experienced more complete and far-reaching change over the past few decades than the United Arab Emirates. Today a land of six-lane highways and glittering streams of motorcars, where space-age cities of ivory-white and crystal glass emerge like a mirage from the haze of desert and sea, this federation of seven ancient Emirates - Abu Dhabi, Dubai, Sharjah, Ras al-Khaimah, Umm al Qawain, Ajman and Fujairah - is not only the world's fourth largest oil-producer, but also its richest state per head of population, and the new commercial hub of the Middle East. Yet only fifty years ago, when oil-exploration started, there was no electricity, no plumbing or telephone system, not a single public hospital nor modern school, no bridges, no deep-water harbour, no metalled roads, no more than a handful of cars and scarcely a building more impressive than the crumbling mud-brick forts and watchtowers of Abu Dhabi and Dubai. Where now high-rise stacks, gilded domes and minarets tower over wide boulevards, where cascades of water are flaunted with conspicuous opulence, and where acres of shrubs burgeon on the desert shore, stood sleepy settlements of reed, coral and mudbrick houses, sweltering on sand spits and islands in the most ferocious summer heat. 1996 is the twenty-fifth anniversary of the founding of the United Arab Emirates. In Phoenix Rising, the photographer Werner Forman explores in a series of superbly evocative images, themes of continuity and change in a country with a long and ancient history, taking as much delight in its abundant treasures and old ways as in its dynamic new architecture and drive towards the future. Michael Asher's text provides an admirably clear account of the history of the region, the resilience of its people and of its phoenix-like ability to reinvent itself in adversity.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 516
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Book Description
Author:
Publisher:
ISBN:
Category : Oncogenic viruses
Languages : en
Pages : 1254
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Book Description
