Quantitative analysis of neuroanatomy

Quantitative analysis of neuroanatomy PDF Author: Julian M L Budd
Publisher: Frontiers Media SA
ISBN: 2889197964
Category : Computational neuroscience
Languages : en
Pages : 246

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Book Description
The true revolution in the age of digital neuroanatomy is the ability to extensively quantify anatomical structures and thus investigate structure-function relationships in great detail. Large-scale projects were recently launched with the aim of providing infrastructure for brain simulations. These projects will increase the need for a precise understanding of brain structure, e.g., through statistical analysis and models. From articles in this Research Topic, we identify three main themes that clearly illustrate how new quantitative approaches are helping advance our understanding of neural structure and function. First, new approaches to reconstruct neurons and circuits from empirical data are aiding neuroanatomical mapping. Second, methods are introduced to improve understanding of the underlying principles of organization. Third, by combining existing knowledge from lower levels of organization, models can be used to make testable predictions about a higher-level organization where knowledge is absent or poor. This latter approach is useful for examining statistical properties of specific network connectivity when current experimental methods have not yet been able to fully reconstruct whole circuits of more than a few hundred neurons.

An Introductory Course in Computational Neuroscience

An Introductory Course in Computational Neuroscience PDF Author: Paul Miller
Publisher: MIT Press
ISBN: 0262347563
Category : Science
Languages : en
Pages : 405

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Book Description
A textbook for students with limited background in mathematics and computer coding, emphasizing computer tutorials that guide readers in producing models of neural behavior. This introductory text teaches students to understand, simulate, and analyze the complex behaviors of individual neurons and brain circuits. It is built around computer tutorials that guide students in producing models of neural behavior, with the associated Matlab code freely available online. From these models students learn how individual neurons function and how, when connected, neurons cooperate in a circuit. The book demonstrates through simulated models how oscillations, multistability, post-stimulus rebounds, and chaos can arise within either single neurons or circuits, and it explores their roles in the brain. The book first presents essential background in neuroscience, physics, mathematics, and Matlab, with explanations illustrated by many example problems. Subsequent chapters cover the neuron and spike production; single spike trains and the underlying cognitive processes; conductance-based models; the simulation of synaptic connections; firing-rate models of large-scale circuit operation; dynamical systems and their components; synaptic plasticity; and techniques for analysis of neuron population datasets, including principal components analysis, hidden Markov modeling, and Bayesian decoding. Accessible to undergraduates in life sciences with limited background in mathematics and computer coding, the book can be used in a “flipped” or “inverted” teaching approach, with class time devoted to hands-on work on the computer tutorials. It can also be a resource for graduate students in the life sciences who wish to gain computing skills and a deeper knowledge of neural function and neural circuits.

Computational Neuroscience for Advancing Artificial Intelligence: Models, Methods and Applications

Computational Neuroscience for Advancing Artificial Intelligence: Models, Methods and Applications PDF Author: Alonso, Eduardo
Publisher: IGI Global
ISBN: 1609600231
Category : Computers
Languages : en
Pages : 394

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Book Description
"This book argues that computational models in behavioral neuroscience must be taken with caution, and advocates for the study of mathematical models of existing theories as complementary to neuro-psychological models and computational models"--

Computational Neuroscience and Cognitive Modelling

Computational Neuroscience and Cognitive Modelling PDF Author: Britt Anderson
Publisher: SAGE
ISBN: 1446297373
Category : Psychology
Languages : en
Pages : 241

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Book Description
"For the neuroscientist or psychologist who cringes at the sight of mathematical formulae and whose eyes glaze over at terms like differential equations, linear algebra, vectors, matrices, Bayes’ rule, and Boolean logic, this book just might be the therapy needed." - Anjan Chatterjee, Professor of Neurology, University of Pennsylvania "Anderson provides a gentle introduction to computational aspects of psychological science, managing to respect the reader’s intelligence while also being completely unintimidating. Using carefully-selected computational demonstrations, he guides students through a wide array of important approaches and tools, with little in the way of prerequisites...I recommend it with enthusiasm." - Asohan Amarasingham, The City University of New York This unique, self-contained and accessible textbook provides an introduction to computational modelling neuroscience accessible to readers with little or no background in computing or mathematics. Organized into thematic sections, the book spans from modelling integrate and firing neurons to playing the game Rock, Paper, Scissors in ACT-R. This non-technical guide shows how basic knowledge and modern computers can be combined for interesting simulations, progressing from early exercises utilizing spreadsheets, to simple programs in Python. Key Features include: Interleaved chapters that show how traditional computing constructs are simply disguised versions of the spread sheet methods. Mathematical facts and notation needed to understand the modelling methods are presented at their most basic and are interleaved with biographical and historical notes for contex. Numerous worked examples to demonstrate the themes and procedures of cognitive modelling. An excellent text for postgraduate students taking courses in research methods, computational neuroscience, computational modelling, cognitive science and neuroscience. It will be especially valuable to psychology students.

Dynamical Systems in Neuroscience

Dynamical Systems in Neuroscience PDF Author: Eugene M. Izhikevich
Publisher: MIT Press
ISBN: 0262514206
Category : Medical
Languages : en
Pages : 459

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Book Description
Explains the relationship of electrophysiology, nonlinear dynamics, and the computational properties of neurons, with each concept presented in terms of both neuroscience and mathematics and illustrated using geometrical intuition. In order to model neuronal behavior or to interpret the results of modeling studies, neuroscientists must call upon methods of nonlinear dynamics. This book offers an introduction to nonlinear dynamical systems theory for researchers and graduate students in neuroscience. It also provides an overview of neuroscience for mathematicians who want to learn the basic facts of electrophysiology. Dynamical Systems in Neuroscience presents a systematic study of the relationship of electrophysiology, nonlinear dynamics, and computational properties of neurons. It emphasizes that information processing in the brain depends not only on the electrophysiological properties of neurons but also on their dynamical properties. The book introduces dynamical systems, starting with one- and two-dimensional Hodgkin-Huxley-type models and continuing to a description of bursting systems. Each chapter proceeds from the simple to the complex, and provides sample problems at the end. The book explains all necessary mathematical concepts using geometrical intuition; it includes many figures and few equations, making it especially suitable for non-mathematicians. Each concept is presented in terms of both neuroscience and mathematics, providing a link between the two disciplines. Nonlinear dynamical systems theory is at the core of computational neuroscience research, but it is not a standard part of the graduate neuroscience curriculum—or taught by math or physics department in a way that is suitable for students of biology. This book offers neuroscience students and researchers a comprehensive account of concepts and methods increasingly used in computational neuroscience. An additional chapter on synchronization, with more advanced material, can be found at the author's website, www.izhikevich.com.

Data-Driven Computational Neuroscience

Data-Driven Computational Neuroscience PDF Author: Concha Bielza
Publisher: Cambridge University Press
ISBN: 110849370X
Category : Computers
Languages : en
Pages : 709

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Book Description
Trains researchers and graduate students in state-of-the-art statistical and machine learning methods to build models with real-world data.

Neural Engineering

Neural Engineering PDF Author: Chris Eliasmith
Publisher: MIT Press
ISBN: 9780262550604
Category : Computers
Languages : en
Pages : 384

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Book Description
A synthesis of current approaches to adapting engineering tools to the study of neurobiological systems.

Theoretical Neuroscience

Theoretical Neuroscience PDF Author: Peter Dayan
Publisher: MIT Press
ISBN: 0262541858
Category : Medical
Languages : en
Pages : 477

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Book Description
Theoretical neuroscience provides a quantitative basis for describing what nervous systems do, determining how they function, and uncovering the general principles by which they operate. This text introduces the basic mathematical and computational methods of theoretical neuroscience and presents applications in a variety of areas including vision, sensory-motor integration, development, learning, and memory. The book is divided into three parts. Part I discusses the relationship between sensory stimuli and neural responses, focusing on the representation of information by the spiking activity of neurons. Part II discusses the modeling of neurons and neural circuits on the basis of cellular and synaptic biophysics. Part III analyzes the role of plasticity in development and learning. An appendix covers the mathematical methods used, and exercises are available on the book's Web site.

Computational Vision

Computational Vision PDF Author: Hanspeter A. Mallot
Publisher: MIT Press
ISBN: 9780262133814
Category : Medical
Languages : en
Pages : 318

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Book Description
This text provides an introduction to computational aspects of early vision, in particular, color, stereo, and visual navigation. It integrates approaches from psychophysics and quantitative neurobiology, as well as theories and algorithms from machine vision and photogrammetry. When presenting mathematical material, it uses detailed verbal descriptions and illustrations to clarify complex points. The text is suitable for upper-level students in neuroscience, biology, and psychology who have basic mathematical skills and are interested in studying the mathematical modeling of perception.

Encyclopedia of Computational Neuroscience

Encyclopedia of Computational Neuroscience PDF Author: Dieter Jaeger
Publisher:
ISBN: 9781461473206
Category : Computational neuroscience
Languages : en
Pages :

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Book Description


Quantitative analysis of neuroanatomy

Quantitative analysis of neuroanatomy PDF Author: Julian M L Budd
Publisher: Frontiers Media SA
ISBN: 2889197964
Category : Computational neuroscience
Languages : en
Pages : 246

Get Book Here

Book Description
The true revolution in the age of digital neuroanatomy is the ability to extensively quantify anatomical structures and thus investigate structure-function relationships in great detail. Large-scale projects were recently launched with the aim of providing infrastructure for brain simulations. These projects will increase the need for a precise understanding of brain structure, e.g., through statistical analysis and models. From articles in this Research Topic, we identify three main themes that clearly illustrate how new quantitative approaches are helping advance our understanding of neural structure and function. First, new approaches to reconstruct neurons and circuits from empirical data are aiding neuroanatomical mapping. Second, methods are introduced to improve understanding of the underlying principles of organization. Third, by combining existing knowledge from lower levels of organization, models can be used to make testable predictions about a higher-level organization where knowledge is absent or poor. This latter approach is useful for examining statistical properties of specific network connectivity when current experimental methods have not yet been able to fully reconstruct whole circuits of more than a few hundred neurons.