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Author:
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ISBN: 9780444800138
Category :
Languages : en
Pages : 335
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Book Description
Author:
Publisher:
ISBN: 9780444800138
Category :
Languages : en
Pages : 335
Get Book Here
Book Description
Author: BA BRIDGES (Ed)
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Author: B. A. Bridges
Publisher:
ISBN:
Category :
Languages : en
Pages : 335
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Author:
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ISBN:
Category :
Languages : en
Pages :
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Author: Shiv Shankar Shukla
Publisher: CRC Press
ISBN: 100019731X
Category : Science
Languages : en
Pages : 164
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Book Description
Genetic toxicology is considered to be an important assessment tool as there is genetic impact of artificial chemicals. Insight on Genotoxicity discusses testing, mechanism, prediction, and bioindicator of genotoxicity taking into consideration recent advances in nano-engineered particles. Corollary of DNA dent is also discussed in detail taking into consideration the impact of ICH guidelines on genotoxicity testing, which is important for drug discovery innovation and development. Perspective review of genotoxicity evaluation in phytopharmaceuticals has been mentioned along with the prevention of genotoxicity in brief viewpoint. Salient Features Presents methods, standard protocols, and guidelines for genotoxicity testing Examines the impact of ICH Guidelines on genetic toxicity testing which is a regulatory requirement for drug discovery and development Defines appropriate strategies about advances in in vivo genotoxicity testing which have been listed along with progress and prospects Discusses advancement in the high-throughput approaches for genotoxicity testing Details computational prediction of genotoxicity with consideration of mutagenicity, chromosomal damage caused and strategies for computational prediction in drug development
Author: Friedrich E. Würgler
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: National Research Council
Publisher: National Academies Press
ISBN: 0309171806
Category : Nature
Languages : en
Pages : 347
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Book Description
Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309112982
Category : Science
Languages : en
Pages : 300
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Book Description
The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.
Author: Ib Knudsen
Publisher:
ISBN:
Category : Carcinogens
Languages : en
Pages : 376
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Book Description
Genotoxic compounds in the diet represent a truly international problem. This problem was recognized in Japan and the United States of America only a few years ago by the application of in vitro mutagenicity tests to prepared and unprepared components of our diet. Now new discoveries are appearing every day concerning genotoxic compounds in our food supply from all over the world. It seems likely that naturally occurring genotoxic compounds in the diet as well as genotoxic compounds formed during storage, preparation, and digestion of the food are important for the induction of cancer in humans and of hereditary changes in human germ cells. Other scientific data indicate that dietary constituents have the potential to modify the genotoxic effect of these compounds in humans. These findings indicate new possibilities for the prevention of human diseases of genotoxic origin through relevant changes in the composition of the diet. With this background, and due to the rapid accumulation of new data in the field, it was approved by the Board of the International Association of Environmental Mutagen Societies that one of the satellite meetings of the Fourth International Conference on Environmental Mutagens in Scandinavia 1985 should cover the aspects of mutagens and carcinogens in the diet. The satellite symposium on "Genetic Toxicology of the Diet" took place in Copenhagen, June 19-22, 1985. The present volume contains the proceedings of this symposium.
