Principles of Molecular Recognition PDF Download
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Author: A.D. Buckingham
Publisher: Springer Science & Business Media
ISBN: 9780751401257
Category : Science
Languages : en
Pages : 232
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Book Description
The importance of molecular recognition in chemistry and biology is reflected in a recent upsurge in relevant research, promoted in particular by high-profile initiatives in this area in Europe, the USA and Japan. Although molecular recognition is necessarily microscopic in origin, its consequences are de facto macroscopic. Accordingly, a text that starts with intermolecular interactions between simple molecules and builds to a discussion of molecular recognition involving larger scale systems is timely. This book was planned with such a development in mind. The book begins with an elementary but rigorous account of the various types of forces between molecules. Chapter 2 is concerned with the hydrogen bond between pairs of simple molecules in the gas phase, with particular reference to the preferred relative orientation of the pair and the ease with which this can be distorted. This microscopic view continues in chapter 3 wherein the nature of interactions between solute molecules and solvents or between two or more solutes is examined from the experimental standpoint, with various types of spectroscopy providing the probe of the nature of the interactions. Molecular recognition is central to the catalysis of chemical reactions, especially when bonds are to be broken and formed under the severe con straint that a specific configuration is to result, as in the production of enan tiotopically pure compounds. This important topic is considered in chapter 4.
Author: A.D. Buckingham
Publisher: Springer Science & Business Media
ISBN: 9780751401257
Category : Science
Languages : en
Pages : 232
Get Book Here
Book Description
The importance of molecular recognition in chemistry and biology is reflected in a recent upsurge in relevant research, promoted in particular by high-profile initiatives in this area in Europe, the USA and Japan. Although molecular recognition is necessarily microscopic in origin, its consequences are de facto macroscopic. Accordingly, a text that starts with intermolecular interactions between simple molecules and builds to a discussion of molecular recognition involving larger scale systems is timely. This book was planned with such a development in mind. The book begins with an elementary but rigorous account of the various types of forces between molecules. Chapter 2 is concerned with the hydrogen bond between pairs of simple molecules in the gas phase, with particular reference to the preferred relative orientation of the pair and the ease with which this can be distorted. This microscopic view continues in chapter 3 wherein the nature of interactions between solute molecules and solvents or between two or more solutes is examined from the experimental standpoint, with various types of spectroscopy providing the probe of the nature of the interactions. Molecular recognition is central to the catalysis of chemical reactions, especially when bonds are to be broken and formed under the severe con straint that a specific configuration is to result, as in the production of enan tiotopically pure compounds. This important topic is considered in chapter 4.
Author: Dipankar Chatterji
Publisher: CRC Press
ISBN: 1482219697
Category : Medical
Languages : en
Pages : 139
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Book Description
Basics of Molecular Recognition explores fundamental recognition principles between monomers or macromolecules that lead to diverse biological functions. Based on the author's longtime courses, the book helps readers understand the structural aspects of macromolecular recognition and stimulates further research on whether molecules similar to DNA o
Author: Hans-Joachim Böhm
Publisher: Wiley-VCH
ISBN: 9783527305216
Category : Science
Languages : en
Pages : 0
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Book Description
The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding. Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. Nowadays, computer-aided prediction and intelligent molecular design make a large contribution to the constant search for, e. g., improved enzyme inhibitors, and new concepts such as that of pharmacophores are being developed. An up-to-date presentation of an eternally young topic, this book is an indispensable information source for chemists, biochemists and pharmacologists dealing with the binding of ligands to proteins.
Author: Mohammed Zourob
Publisher: Springer Science & Business Media
ISBN: 1441909192
Category : Technology & Engineering
Languages : en
Pages : 864
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Book Description
Recognition receptors play a key role in the successful implementation of chemical and biosensors. Molecular recognition refers to non-covalent speci?c binding between molecules, one of which is typically a macromolecule or a molecular assembly, and the other is the target molecule (ligand or analyte). Biomolecular recognition is typically driven by many weak interactions such as hydrogen bo- ing, metal coordination, hydrophobic forces, van der Waals forces, pi-pi interactions and electrostatic interaction (due to permanent charges, dipoles, and quadrupoles) the polarization of charge distributions by the interaction partner leading to ind- tion and dispersion forces, and Pauli-exclusion-principle-derived inter-atomic repulsion, and a strong, “attractive” force arising largely from the entropy of the solvent and termed the hydrophobic effect. In recent years, there has been much progress in understanding the forces that drive the formation of such complexes, and how these forces are relate to the physical properties of the interacting molecules and their environment allows rational design of molecules and materials that interact in speci?c and desired ways. This book presents a signi?cant and up-to-date review of the various recognition elements, their immobilization, characterization techniques by a panel of dist- guished scientists. This work is a comprehensive approach to the recognition receptors area presenting a thorough knowledge of the subject and an effective integration of these receptors on sensor surfaces in order to appropriately convey the state-of the-art fundamentals and applications of the most innovative approaches.
Author: Peter B Crowley
Publisher: Royal Society of Chemistry
ISBN: 1788019792
Category : Science
Languages : en
Pages : 329
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Book Description
Building on decades of “host-guest” research, recent years have seen a surge of activity in water-soluble supramolecular receptors for protein recognition and assembly. Progress has been particularly rich in the area of calixarenes, cucurbiturils and molecular tweezers. Emerging applications include controlled protein assembly in solution, crystal engineering, supramolecular control of catalysis (both in vitro and in vivo), as well as novel mechanisms of protein-interaction inhibition with relevance to amyloids and disease. One challenge at the interface of supramolecular chemistry and protein science is to increase interaction and collaboration between chemists and biochemists/structural biologists.This book addresses the exciting interface of supramolecular chemistry and protein science. Chapters cover supramolecular approaches to protein recognition, assembly and regulation. Principles outlined will highlight the opportunities that are readily accessible to collaborating chemists and biochemists, enriching the breadth and scope of this multidisciplinary field. Supramolecular Protein Chemistry will be of particular interest to graduate students and researchers working in supramolecular chemistry, protein science, self-assembly, biomaterials, biomedicine and biotechnology.
Author: Reed M. Izatt
Publisher: John Wiley & Sons
ISBN: 111900912X
Category : Science
Languages : en
Pages : 552
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Book Description
The sustainable use of natural resources is an important global challenge, and improved metal sustainability is a crucial goal for the 21st century in order to conserve the supply of critical metals and mitigate the environmental and health issues resulting from unrecovered metals. Metal Sustainability: Global Challenges, Consequences and Prospects discusses important topics and challenges associated with sustainability in metal life cycles, from mining ore to beneficiation processes, to product manufacture, to recovery from end-of-life materials, to environmental and health concerns resulting from generated waste. The broad perspective presented highlights the global interdependence of the many stages of metal life cycles. Economic issues are emphasized and relevant environmental, health, political, industrial and societal issues are discussed. The importance of applying green chemistry principles to metal sustainability is emphasized. Topics covered include: • Recycling and sustainable utilization of precious and specialty metals • Formal and informal recycling from electronic and other high-tech wastes • Global management of electronic wastes • Metal reuse and recycling in developing countries • Effects of toxic and other metal releases on the environment and human health • Effect on bacteria of toxic metal release • Selective recovery of platinum group metals and rare earth metals • Metal sustainability from a manufacturing perspective • Economic perspectives on sustainability, mineral development, and metal life cycles • Closing the Loop – Minerals Industry Issues The aim of this book is to improve awareness of the increasingly important role metals play in our high-tech society, the need to conserve our metal supply throughout the metal life cycle, the importance of improved metal recycling, and the effects that unhindered metal loss can have on the environment and on human health.
Author: Lei Ye
Publisher: CRC Press
ISBN: 9814364878
Category : Science
Languages : en
Pages : 283
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Book Description
Molecular imprinting is one of the most efficient methods to fabricate functional polymer structures with pre-defined molecular recognition selectivity. Molecularly imprinted polymers (MIPs) have been used as antibody and enzyme mimics in a large number of applications. The outstanding stability and straightforward preparation make MIPs ideal subst
Author: George W. Gokel
Publisher: Elsevier
ISBN: 0128031999
Category : Science
Languages : en
Pages : 4627
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Book Description
Comprehensive Supramolecular Chemistry II, Second Edition, Nine Volume Set is a ‘one-stop shop’ that covers supramolecular chemistry, a field that originated from the work of researchers in organic, inorganic and physical chemistry, with some biological influence. The original edition was structured to reflect, in part, the origin of the field. However, in the past two decades, the field has changed a great deal as reflected in this new work that covers the general principles of supramolecular chemistry and molecular recognition, experimental and computational methods in supramolecular chemistry, supramolecular receptors, dynamic supramolecular chemistry, supramolecular engineering, crystallographic (engineered) assemblies, sensors, imaging agents, devices and the latest in nanotechnology. Each section begins with an introduction by an expert in the field, who offers an initial perspective on the development of the field. Each article begins with outlining basic concepts before moving on to more advanced material. Contains content that begins with the basics before moving on to more complex concepts, making it suitable for advanced undergraduates as well as academic researchers Focuses on application of the theory in practice, with particular focus on areas that have gained increasing importance in the 21st century, including nanomedicine, nanotechnology and medicinal chemistry Fully rewritten to make a completely up-to-date reference work that covers all the major advances that have taken place since the First Edition published in 1996
Author: Songjun Li
Publisher: Elsevier
ISBN: 012801444X
Category : Technology & Engineering
Languages : en
Pages : 312
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Book Description
Molecularly Imprinted Catalysts: Principle, Synthesis, and Applications is the first book of its kind to provide an in-depth overview of molecularly imprinted catalysts and selective catalysis, including technical details, principles of selective catalysis, preparation processes, the catalytically active polymers themselves, and important progress made in this field. It serves as an important reference for scientists, students, and researchers who are working in the areas of molecular imprinting, catalysis, molecular recognition, materials science, biotechnology, and nanotechnology.Comprising a diverse group of experts from prestigious universities and industries across the world, the contributors to this book provide access to the latest knowledge and eye-catching achievements in the field, and an understanding of what progress has been made and to what extent it is being advanced in industry. - The first book in the field on molecularly imprinted catalysts (MIPs) - Provides a systematic background to selective catalysis, especially the basic concepts and key principles of the different MIP-based catalysts - Features state-of-the art presentation of preparation methods and applications of MIPs - Written by scientists from prestigious universities and industries across the world, and edited by veteran researchers in molecular imprinting and selective catalysis
Author: Joseph O. Hirschfelder
Publisher: John Wiley & Sons
ISBN: 0471400653
Category : Science
Languages : en
Pages : 1283
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Book Description
An essential cross-disciplinary reference for molecular interactions Molecular Theory of Gases and Liquids offers a rigorous, comprehensive treatment of molecular characteristics and behaviors in the gaseous and fluid states. A unique cross-disciplinary approach provides useful insight for students of chemistry, chemical engineering, fluid dynamics, and a variety of related fields, with thorough derivations and in-depth explanations throughout. Appropriate for graduate students and working scientists alike, this book details advanced concepts without sacrificing depth of coverage or technical detail.
