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Author: Scott Dessain
Publisher: Academic Press
ISBN: 0128092092
Category : Medical
Languages : en
Pages : 277
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Book Description
Preserving the Promise: Improving the Culture of Biotech Investment critically examines why most biotech startups fail, as they emerge from universities into an ecosystem that inhibits rather than encourages innovation. This "Valley of Death" squanders our public investments in medical research and with them, the promise of longer and healthier lives. The authors explicate the Translation Gap faced by early stage biotech companies, the result of problematic technology transfer and investment practices, and provide specific prescriptions for improving translation of important discoveries into safe and effective therapies. In Preserving the Promise, Dessain and Fishman build on their collective experience as company founders, healthcare investor (Fishman) and physician/scientist (Dessain). The book offers a forward-looking, critical analysis of "conventional wisdom" that encumbers commercialization practices. It exposes the self-defeating habits of drug development in the Valley of Death, that waste money and extinguish innovative technologies through distorted financial incentives. Explains why translation of biotech discovery into medicine succeeds so infrequently that it’s been dubbed the Valley of Death Uncovers specific decision-making strategies that more effectively align incentives, improving clinical and financial outcomes for investors, inventor/entrepreneurs, and patients Examines the critical, early stages of commercialization, where technology transfer offices and Angels act as gatekeepers to development, and where tension between short-term financial and long-term clinical aspirations sinks important technologies Deconstructs the forces driving biotech, recasts them in a proven conceptual framework, and offers practical guidance for making the system better
Author: Scott Dessain
Publisher: Academic Press
ISBN: 0128092092
Category : Medical
Languages : en
Pages : 277
Get Book Here
Book Description
Preserving the Promise: Improving the Culture of Biotech Investment critically examines why most biotech startups fail, as they emerge from universities into an ecosystem that inhibits rather than encourages innovation. This "Valley of Death" squanders our public investments in medical research and with them, the promise of longer and healthier lives. The authors explicate the Translation Gap faced by early stage biotech companies, the result of problematic technology transfer and investment practices, and provide specific prescriptions for improving translation of important discoveries into safe and effective therapies. In Preserving the Promise, Dessain and Fishman build on their collective experience as company founders, healthcare investor (Fishman) and physician/scientist (Dessain). The book offers a forward-looking, critical analysis of "conventional wisdom" that encumbers commercialization practices. It exposes the self-defeating habits of drug development in the Valley of Death, that waste money and extinguish innovative technologies through distorted financial incentives. Explains why translation of biotech discovery into medicine succeeds so infrequently that it’s been dubbed the Valley of Death Uncovers specific decision-making strategies that more effectively align incentives, improving clinical and financial outcomes for investors, inventor/entrepreneurs, and patients Examines the critical, early stages of commercialization, where technology transfer offices and Angels act as gatekeepers to development, and where tension between short-term financial and long-term clinical aspirations sinks important technologies Deconstructs the forces driving biotech, recasts them in a proven conceptual framework, and offers practical guidance for making the system better
Author: United States. Congress. Senate. Special Committee on Aging
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 64
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Book Description
Author: Gail Lee Dubrow
Publisher: JHU Press
ISBN: 9780801870521
Category : Architecture
Languages : en
Pages : 476
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Book Description
This essay collection draws upon work presented at three national conferences on women and historic preservation held at Bryn Mawr College in 1994, Arizona State University in 1997, and at Mount Vernon College in 2000.
Author: Vannetta Chapman
Publisher: Harvest House Publishers
ISBN: 0736946136
Category : Fiction
Languages : en
Pages : 308
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Book Description
A Promise for Miriam, the first book in a brand-new romantic series from popular author Vannetta Chapman, introduces the Amish community of Pebble Creek and some of the kind, caring people there. As they face challenges to their community from the English world, they come together to reach out to their non-Amish neighbors while still preserving their cherished Plain ways. Amish schoolteacher Miriam King loves her students. At 26, most women her age are married with children of their own, but she hasn’t yet met anyone who can convince her to give up the Plain school that sits along the banks of Pebble Creek. Then newcomer Gabriel Miller steps into her life, bringing his daughter, an air of mystery, and challenges Miriam has never faced before. Will Gabe be able to let go of the past that haunts him? He thinks he just wants to be left alone, but the loving and warm community he and his daughter have moved to has other plans for him. After a near tragedy is averted, he hesitantly returns offers of help and friendship, and he discovers he can make a difference to the people of Pebble Creek—and maybe find love again.
Author: Howard Sutherland
Publisher:
ISBN: 9781330533871
Category : Self-Help
Languages : en
Pages : 36
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Book Description
Excerpt from The Promise of Life These are days of stress and of endeavor, when in the pursuit of the material, one is apt to forget that another life shall follow this as surely as night the day, gentler Spring the stern and uncompromising Winter. Let there be no question in our minds as to this. Let us not permit the metaphysician to cloud the issue, nor the scientist to clothe it with doubt. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.
Author: Edward L. Springer
Publisher:
ISBN:
Category : Wood chips
Languages : en
Pages : 8
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Book Description
Author: Lucy Tapper
Publisher:
ISBN: 9781907860171
Category :
Languages : en
Pages : 32
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Book Description
Promises For You is a delightful gift book filled with love and promises, for a very special person, to help and guide a child as they grow..The story follows a charming little penguin on a colourful journey with you by their side discovering all the wonders the world has to offer. The giver(s) promise to be there for them helping them have a sense of wellbeing, happiness and security. Beautifully illustrated in full colour over 32 pages, this book makes a perfect baby shower, new-born or young person's birthday or Christening present. With space for a personalized message in the front, this hardback book makes a wonderful keepsake gift.
Author: Douglas W. Portmore
Publisher: Oxford University Press
ISBN: 0190905336
Category : Philosophy
Languages : en
Pages : 656
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Book Description
Consequentialism is a major moral theory in contemporary philosophy: it is the view that the only thing that matters when making moral decisions is the outcome of those decisions. Consequentialists hold that to morally assess an act, we must first evaluate and rank the various ways that things could turn out depending on whether it or some alternative act is performed. Whether we should perform that act thus depends on how its outcome ranks relative to those of its alternatives. Consequentialism rivals deontology, contractualism, and virtue ethics, but, more importantly, it has influenced contemporary moral philosophy such that the consequentialist/non-consequentialist distinction is one of the most central in normative ethics. After all, every plausible moral theory must concede that the goodness of an act's consequences is something that matters, even if it's not the only thing that matters. Thus, all plausible moral theories will accept that both 1) an act's producing good consequences constitutes a moral reason to perform it, and 2) the better its consequences, the more of a moral reason there is to perform it. In this way, much of consequentialist ethical theory is important for normative ethics in general. This Oxford Handbook contains thirty-two previously unpublished contributions by top moral philosophers examining the current state of play in consequentialism and pointing to new directions for future research. The volume is organized into four major sections: foundational issues; objections to consequentialism; its forms and limits; and consequentialism's implications for policy, practice, and social reform.
Author: Briton Hadden
Publisher:
ISBN:
Category : Current events
Languages : en
Pages : 792
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Book Description
Author: Dale D. Goble
Publisher: Island Press
ISBN: 9781597260084
Category : Nature
Languages : en
Pages : 0
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Book Description
The Endangered Species Act at Thirty is a comprehensive, multidisciplinary review of issues surrounding the Endangered Species Act, with a specific focus on the act's actual implementation record over the past thirty years. The result of a unique, multi-year collaboration among stakeholder groups from across the political spectrum, the two volumes offer a dispassionate consideration of a highly polarized topic. Renewing the ConservationPromise, Volume 1, puts the reader in a better position to make informed decisions about future directions in biodiversity conservation by elevating the policy debate from its current state of divisive polemics to a more-constructive analysis. It helps the reader understand how the Endangered Species Act has been implemented, the consequences of that implementation, and how the act could be changed to better serve the needs of both the species it is designed to protect and the people who must live within its mandates. As debate over reforming the Endangered Species Act heats up in the coming months, these two books will be essential references for policy analysts and lawmakers; professionals involved with environmental law, science, or management; and academic researchers and students concerned with environmental law, policy, management, or science.
