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Author: Lambert Brandsma
Publisher: Springer Science & Business Media
ISBN: 3642879217
Category : Science
Languages : en
Pages : 250
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Book Description
Polar organometallic compounds are indispensable for the synthetic chemist. As this book shows, these almost ideal reagents are easy to prepare with high specificity under mild conditions and yet react quite readily with a great variety of substrates. Many compounds can be metallated directly at positions which would otherwise be difficult to substitute. Functional groups and heteroatoms already present in a molecule direct metallation to sites in their vicinity. The rules which govern polar organometallic chemistry often are not dominated by the usual n-delocalization and inductive effects; dipolar interactions, chelation, polarization, etc. often can be much more important. This affords novel synthetic opportunities. A good example is the development of a basically new type of aromatic substitution chemistry not based on positively charged intermediates. Seebach's injunction, "Thinking of polar organometallic compounds as carbanions is an impoverishment rather than a simplification" (International Symposium, Chemistry of Carbanions, Durham 1984), stresses the need to consider the metal not only as an integral, but perhaps also as the key component of these reagents. Rather than wandering off as solvated cations and acting as uninvolved spectators, the metals, rather than the anion moieties, can initiate and govern the subsequent reactions. To the founders of this field, e. g. Grignard, Ziegler, Gilman, Wittig, and their followers, the metal was critical. The title of Schlosser's book, "Polare Organometalle", certainly was apt.
Author: Lambert Brandsma
Publisher: Springer Science & Business Media
ISBN: 3642879217
Category : Science
Languages : en
Pages : 250
Get Book Here
Book Description
Polar organometallic compounds are indispensable for the synthetic chemist. As this book shows, these almost ideal reagents are easy to prepare with high specificity under mild conditions and yet react quite readily with a great variety of substrates. Many compounds can be metallated directly at positions which would otherwise be difficult to substitute. Functional groups and heteroatoms already present in a molecule direct metallation to sites in their vicinity. The rules which govern polar organometallic chemistry often are not dominated by the usual n-delocalization and inductive effects; dipolar interactions, chelation, polarization, etc. often can be much more important. This affords novel synthetic opportunities. A good example is the development of a basically new type of aromatic substitution chemistry not based on positively charged intermediates. Seebach's injunction, "Thinking of polar organometallic compounds as carbanions is an impoverishment rather than a simplification" (International Symposium, Chemistry of Carbanions, Durham 1984), stresses the need to consider the metal not only as an integral, but perhaps also as the key component of these reagents. Rather than wandering off as solvated cations and acting as uninvolved spectators, the metals, rather than the anion moieties, can initiate and govern the subsequent reactions. To the founders of this field, e. g. Grignard, Ziegler, Gilman, Wittig, and their followers, the metal was critical. The title of Schlosser's book, "Polare Organometalle", certainly was apt.
Author: Lambert Brandsma
Publisher: Springer Science & Business Media
ISBN: 3642615171
Category : Science
Languages : en
Pages : 234
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Book Description
Preparative Polar Organometallic Chemistry is a collection of laboratory procedures for the synthesis and functionalization of organoalkali and Grignard compounds. The second volume with methods for generation and transformation of compounds bearing the metal at an sp3 carbon complements the first in which the metal was bound to an sp2 carbon atom in the reagent. Synthetically important intermediates such as metallated S,S-acetales, imines, nitriles, isonitriles and ketones are illustrated. All procedures have been worked out in full detail and tested in the author's own laboratory. Both books are intended to be practical bench-top laboratory manuals for working organic chemists, from the student to the advanced scientist.
Author: L. Brandsma
Publisher: Springer
ISBN:
Category : Science
Languages : en
Pages : 260
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Book Description
Author: John A. Joule
Publisher: John Wiley & Sons
ISBN: 1405193654
Category : Science
Languages : en
Pages : 719
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Book Description
This book has so closely matched the requirements of its readership over the years that it has become the first choice for chemists worldwide. Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, the vast majority of organic work done in the pharmaceutical and agrochemical industries is heterocyclic chemistry. The fifth edition of Heterocyclic Chemistry maintains the principal objective of earlier editions – to teach the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second- and third-year undergraduate chemistry students. The inclusion of more advanced and current material also makes the book a valuable reference text for postgraduate taught courses, postgraduate researchers, and chemists at all levels working with heterocyclic compounds in industry. Fully updated and expanded to reflect important 21st century advances, the fifth edition of this classic text includes the following innovations: Extensive use of colour to highlight changes in structure and bonding during reactions Entirely new chapters on organometallic heterocyclic chemistry, heterocyclic natural products, especially in biochemical processes, and heterocycles in medicine New sections focusing on heterocyclic fluorine compounds, isotopically labeled heterocycles, and solid-phase chemistry, microwave heating and flow reactors in the heterocyclic context Essential teaching material in the early chapters is followed by short chapters throughout the text which capture the essence of heterocyclic reactivity in concise resumés suitable as introductions or summaries, for example for examination preparation. Detailed, systematic discussions cover the reactivity and synthesis of all the important heterocyclic systems. Original references and references to reviews are given throughout the text, vital for postgraduate teaching and for research scientists. Problems, divided into straightforward revision exercises, and more challenging questions (with solutions available online), help the reader to understand and apply the principles of heterocyclic reactivity and synthesis.
Author: Ionel Haiduc
Publisher: John Wiley & Sons
ISBN: 3527613552
Category : Science
Languages : en
Pages : 484
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Book Description
Supramolecular chemistry has become not only a major field of chemistry, but is also a vivid interface between chemistry, biology, physics, and materials science. Although still a relatively young field, termini such as molecular recognition, host-guest chemistry, or self-assembly are now common knowledge even for chemistry students, and research has already been honored with a Nobel Prize. This first book on supramolecular organometallic chemistry combines two areas in chemistry that are experiencing the fastest developments. It provides a comprehensive review of various organometallic assemblies, arranged according to the types of intermolecular bonding. Details on the synthesis, structures, and properties of these compounds will be a valuable asset to the scientific community. The broad spectrum of assemblies containing main group element, transition metal, or f-element metal and a diverse range of ligands, held together by different bonding interactions make this a fascinating compilation. Illustrated extensively, this book is a very easily accessible, yet wide-ranging source of information.
Author: Basil J. Wakefield
Publisher: Academic Press
ISBN: 0080538177
Category : Science
Languages : en
Pages : 269
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Book Description
The book opens with a general overview of the constitution and reactivity of organomagnesium compounds, followed by information on handling them and on their detection and estimation. Throughout, practical aspects aswell as principles are emphasized. The chapters on the synthesis of organomagnesium compounds cover the preparation of special forms of metallic magnesium and the reaction of magnesium with substrates such as dienes, as well as the traditional preparation of Grignard reagents. Preparations by metallation and metal-halogen exchanges are also included, as are newer methods such as hydromagnesiation of alkenes and alkynes. Systematic coverage is provided on synthetically useful reactions of organomagnesium compounds. Of fundamental importance in organic synthesis are carbon-carbon bond forming reactions; additions to carbon-carbon, carbon-nitrogen, carbon-oxygen, and carbon-sulfur multiple bonds; and nucleophilic substitution at carbon. The formation of carbon-heteroatom bonds in organic compounds is described, where the heteroatom is hydrogen, nitrogen, oxygen, sulfur, or halogen. Finally, the use of organomagnesium compounds in preparing other organometalloid and organometallic compounds is outlined. Representative experimental procedures are included throughout the book, and tables with references to well-described examples are provided. - Presents a general overview of the constitution and reactivity of organomagnesium compounds - Provides coverage on the detection and estimation of organomagnesium compounds - Emphasizes practical aspects as well as principles - Covers the preparation of special forms of metallic magnesium and the reaction of magnesium with substrates such as dienes - Includes preparations by metallation and metal-halogen exchanges - Reviews new preparation methods such as hydromagnesiation of alkenes and alkynes - Outlines information on synthetically useful reactions of organomagnesium compounds - Describes the formation of carbon-heteroatom bonds in organic compounds - Addresses the use of organomagnesium compounds in preparing other organometalloid and organometallic compounds - Includes representative procedures and tables with references to well-described examples
Author: L. Brandsma
Publisher: Elsevier
ISBN: 1483290034
Category : Science
Languages : en
Pages : 334
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Book Description
The first edition of Preparative Acetylenic Chemistry was published in 1971 as one of a series of laboratory manuals containing experimental procedures. The book was used extensively by students during practical courses and laboratory research work and enabled procedures to be carried out by persons with relatively limited bench experience. Discussions about their results have in many cases led to modified procedures or descriptions which have now been incorporated in this considerably revised and up-dated edition.The new book contains a collection of some 250 experimental procedures on a scale of at least 0.1 molar for the preparation of a wide variety of compounds with a triple bond. A number of procedures in the old edition have been omitted and replaced by others; the subdivision and titling of the chapters and experiments have been changed; and the indexes have been replaced by a type-compound-method index. Some new and attractive methods have been included, e.g. eliminations under phase-transfer conditions and couplings under the influence of zero-valent palladium compounds. In a number of cases, additional experiments have been described in order to give a more complete picture of the scope of the concerned methods.This collection is based on almost 30 years active bench experience by the author and all the procedures have been checked at least once in the author's laboratory. It will undoubtedly provide as much useful and practical assistance as did its predecessor.
Author: Jane E. Macintyre
Publisher: CRC Press
ISBN: 9780412430602
Category : Science
Languages : en
Pages : 1362
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Book Description
Containing chemical, physical and structural data on 45,000 organometallics, this new edition of Dictionary of Organometallic Compounds is completely reviews and expanded. All compounds from the first edition have been reviewed, new references from the recent chemical literature have been added. Interesting new compounds, which have appeared in the literature from 1985 to 1993, have also been incorporated. A unique new feature is the Index of Synthetic Reagents, which groups compounds according to their use in synthetic organic chemistry. Compounds included: - organometallics representing all important structural types - compounds with an established use, such as orignard reagents, catalysts, starting materials, laboratory chemicals Type of information included: - accurate systematic chemical names, tradenames, trivial names - CAS Registry numbers - molecular formulae and weights - details on synthesis/preparation - uses in synthetic organic chemistry - physical data including melting/boiling points, solubility, magnetic susceptibility - concise bibliography
Author: George S. Zweifel
Publisher: John Wiley & Sons
ISBN: 1119086728
Category : Science
Languages : en
Pages : 416
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Book Description
This book bridges the gap between sophomore and advanced / graduate level organic chemistry courses, providing students with a necessary background to begin research in either an industry or academic environment. • Covers key concepts that include retrosynthesis, conformational analysis, and functional group transformations as well as presents the latest developments in organometallic chemistry and C–C bond formation • Uses a concise and easy-to-read style, with many illustrated examples • Updates material, examples, and references from the first edition • Adds coverage of organocatalysts and organometallic reagents
Author: A. McKillop
Publisher: Elsevier
ISBN: 9780080423180
Category : Science
Languages : en
Pages : 698
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Book Description
The individual chapters in this volume cover the scope and impact of main group organometallic compounds and reagents on organic synthesis during the last ten to fifteen years. In a number of chapters, topics are dealt with in detail that either were not covered at all in COMC (eg selenium, tellurium) or were given scant attention (eg oxymercuration, organoantimony compounds). Certain topics, like directed metallation and LiKOR bases have only achieved prominence in synthesis in the last ten years, and are now reviewed by leading experts.
