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Author: Jules J. Berman
Publisher: Academic Press
ISBN: 0128143940
Category : Medical
Languages : en
Pages : 400
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Book Description
Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution. - Clarifies the foundational concepts of Precision Medicine, distinguishing this field from its predecessors such as genomics, pharmacogenetics, and personalized medicine - Gathers the chief conceptual advances in the fields of genetics, pathology, and bioinformatics, and synthesizes a coherent narrative for the field of Precision Medicine - Delivers its message in plain language, and in a relaxed, conversational writing style, making it easy to understand the complex subject matter - Guides the reader through a coherent and logical narrative, gradually providing expertise and skills along the way - Covers the importance of data sharing in Precision Medicine, and the many data-related challenges that confront this fragile new field
Author: Jules J. Berman
Publisher: Academic Press
ISBN: 0128143940
Category : Medical
Languages : en
Pages : 400
Get Book Here
Book Description
Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution. - Clarifies the foundational concepts of Precision Medicine, distinguishing this field from its predecessors such as genomics, pharmacogenetics, and personalized medicine - Gathers the chief conceptual advances in the fields of genetics, pathology, and bioinformatics, and synthesizes a coherent narrative for the field of Precision Medicine - Delivers its message in plain language, and in a relaxed, conversational writing style, making it easy to understand the complex subject matter - Guides the reader through a coherent and logical narrative, gradually providing expertise and skills along the way - Covers the importance of data sharing in Precision Medicine, and the many data-related challenges that confront this fragile new field
Author: Jules J. Berman
Publisher: Academic Press
ISBN: 0128171278
Category : Science
Languages : en
Pages : 360
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Book Description
Evolution's Clinical Guidebook: Translating Ancient Genes into Precision Medicine demonstrates, through well-documented examples, how an understanding of the phylogenetic ancestry of humans allows us to make sense out of the flood of genetic data streaming from modern laboratories and how it can lead us to new ways to prevent, diagnose and treat diseases. Topics cover evolution and human genome, meiosis and other recombinants events, embryology, speciation, phylogeny, rare and common diseases, and the evolution of aging. This book is a valuable source for bioinformaticians and those in the biomedical field who need knowledge, down to gene level, to fully comprehend currently available data. - Offers an innovative approach, focusing on how disease-associated pathways evolved - Explains how the fields of phylogeny and embryology have become closely tied to the fields of genetics and bioinformatics - Demonstrates how students and biomedical professionals can apply the knowledge obtained in this book to the theory and practice of precision medicine
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309222222
Category : Medical
Languages : en
Pages : 142
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Book Description
Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.
Author: Yechiel Michael Barilan
Publisher: Oxford University Press
ISBN: 0198863462
Category : Medical ethics
Languages : en
Pages : 353
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Book Description
The book provides a multidisciplinary and interdisciplinary discussion of the ethos and ethics of precision / personal medicine, involving scientists who have shaped the field, in dialogue with ethicists, social scientists and philosophers of science.
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309447356
Category : Medical
Languages : en
Pages : 125
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Book Description
On January 20, 2015, President Obama announced the Precision Medicine Initiative (PMI) in his State of the Union address. The PMI, by developing new approaches for detecting, measuring, and analyzing a wide range of biomedical information including molecular, genomic, cellular, clinical, behavioral, physiological, and environmental parameters, is intended to enable a new era of medicine in which researchers, providers, and patients work together to develop individualized care. Part of this effort included the creation of a national, large-scale research participant group, or cohort. The PMI Cohort Program is aimed at extending precision medicine to many diseases, including both rare and common diseases such as diabetes, heart disease, Alzheimer's disease, obesity, and mental illnesses such as depression, bipolar disorder, and schizophrenia, by building a national research cohort of 1 million or more U.S. participants. An important challenge to assembling the PMI Cohort will be to reach individuals who are socioeconomically disadvantaged. Individuals who are socioeconomically disadvantaged have lower health literacy; often belong to racial, ethnic, and minority communities; and are often less likely to participate in research studies and biorepositories. To explore possible strategies and messaging designs, the Roundtable on Health Literacy formed an ad hoc committee charged with planning and conducting a 1-day public workshop on the intersection of health literacy and precision medicine. The workshop participants discussed a variety of topics including an overview of precision medicine and its potential, the relevance of health literacy to the success of precision medicine efforts, and perspectives and understanding of different groups, such as health care providers, consumers, and insurers. This publication summarizes the presentations and discussions from the workshop.
Author: Mukesh Verma
Publisher: Academic Press
ISBN: 0128095024
Category : Science
Languages : en
Pages : 346
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Book Description
Progress and Challenges in Precision Medicine presents an insightful overview to the myriad factors of personalized and precision medicine. The availability of the human genome, large amounts of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the age of personalized and precision medicine. Bringing together a global range of experts on precision medicine, this book collects previously scattered information into one concise volume which covers the most important developments so far in precision medicine and also suggests the most likely avenues for future development. The book includes clinical information, informatics, public policy implications, and information on case studies. It is a useful reference and background work for students, researchers, and clinicians working in the biomedical and medical fields, as well as policymakers in the health sciences. - Provides an overview of the growing field of precision medicine - Contains chapters from geographically diverse experts in their field - Explores important aspects of precision medicine, including applications, ethics, and development
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309462630
Category : Medical
Languages : en
Pages : 145
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Book Description
Those involved in the drug development process face challenges of efficiency and overall sustainability due in part to high research costs, lengthy development timelines, and late-stage drug failures. Novel clinical trial designs that enroll participants based on their genetics represent a potentially disruptive change that could improve patient outcomes, reduce costs associated with drug development, and further realize the goals of precision medicine. On March 8, 2017, the Forum on Drug Discovery, Development, and Translation and the Roundtable on Genomics and Precision Health of the National Academies of Sciences, Engineering, and Medicine hosted the workshop Enabling Precision Medicine: The Role of Genetics in Clinical Drug Development. Participants examined successes, challenges, and possible best practices for effectively using genetic information in the design and implementation of clinical trials to support the development of precision medicines, including exploring the potential advantages and disadvantages of such trials across a variety of disease areas. This publication summarizes the presentations and discussions from the workshop.
Author: Sherif El-Khamisy
Publisher: Springer
ISBN: 3319607332
Category : Medical
Languages : en
Pages : 262
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Book Description
The mammalian genome is constantly challenged by exogenous and endogenous threats. Although much is known about the mechanisms that maintain genome integrity, little is known about the applications of this knowledge to combat human disease. The past 20 years has witnessed extensive research and progress in this area and scientists started to design new therapies harnessing individual genetic differences among patients to combat degenerative disorders and cancer. We summarize these advancements and discuss perspectives for the future of personalized medicine.
Author: Hans-Peter Deigner
Publisher: Academic Press
ISBN: 0128054336
Category : Medical
Languages : en
Pages : 376
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Book Description
Precision Medicine: Tools and Quantitative Approaches discusses precision and personalized medicine, two relevant topics that are revolutionizing diagnostics and treatment, while also providing a shift toward prevention. The book covers the most relevant features and explanations underlying developments in the field. A timely review on prerequisites, causes and consequences is given. Unique to this book is a combined view on technical and data analysis aspects that is mandatory for obtaining and interpreting results. This book is a valuable source for researchers in medical and life sciences, physicians and students with an interest in this emerging field of precision medicine. - Provides technological aspects in precision medicine with aspects of modern statistical and bioinformatics models and methods - Brings timely reviews on status and chances in precision medicine and associated aspects of data analysis, statistics and data interpretation - Encompasses easy access to relevant approaches, interactions and original literature
Author: Lee Gutkind
Publisher: Underland Press
ISBN: 1937163075
Category : Medical
Languages : en
Pages : 242
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Book Description
Is personalized medicine—what some scientists call genetic medicine—a pipe dream or a panacea? Francis Collins, current director of the National Institutes of Health and director of the Human Genome Project, considers this new era “the greatest revolution since Leonardo,” while Nobel Laureate Leland Hartwell compares personalized medicine to a train that has not yet left the station—“a very slow train with a very long way to go . . . before we arrive at our destination.” There is no denying that new technology, which has triggered an explosion of scientific information, is ushering in a revolution in medicine—for specialists, general practitioners and the public. Anyone can spit in a cup and, for a small fee, learn about his or her individual genetic make-up. But how useful is this information, really, to us or to our doctors? What’s more, how much do we truly want to know—and have others know—about our possible destiny? There is more than we can imagine at stake. In An Immense New Power to Heal, authors Lee Gutkind and Pagan Kennedy delve into the personal side of personalized medicine and offer the physician’s perspective and the patient’s experience through intimate narratives and case studies. They also offer an intriguing background of the personalized medicine movement including the fascinating personalities of the key scientists involved as well as a glimpse into the in-fighting that accompanies any race for a scientific breakthrough. The result is a highly engaging, lively, and provocative discussion about this revolution in health care, and most importantly, what it really means for patients now and in the future.
