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Author: Sachin Kumar Singh
Publisher: Springer Nature
ISBN: 9819903610
Category : Medical
Languages : en
Pages : 302
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Book Description
This book thoroughly reviews the advancements in design and applications of Polymeric Micelles (PMs) in drug delivery. It provides information on the synthesis of amphiphilic block copolymers and their types, functional chemistry for targeting and sensing, and biomedical applications. The book further provides the possibilities for designing PMs in a range of drug delivery approaches. The book addresses the molecular parameters of amphiphilic block copolymers that are required for functionalizing PMs for drug delivery applications. Additionally, the book presents recent advances in applications of PMs such as co-delivery, sensing, theranostics, delivery of nucleic acids, and proteins. Towards the end, it discusses different physico-chemical strategies to enhance the stability and drug retention of polymeric micelles and reviews the preclinical and clinical toxicity and immunogenicity-related aspects of polymeric micelles. This book is an invaluable source for academics, research, and industry professionals working in the field of polymeric micelles and drug delivery.
Author: Sachin Kumar Singh
Publisher: Springer Nature
ISBN: 9819903610
Category : Medical
Languages : en
Pages : 302
Get Book Here
Book Description
This book thoroughly reviews the advancements in design and applications of Polymeric Micelles (PMs) in drug delivery. It provides information on the synthesis of amphiphilic block copolymers and their types, functional chemistry for targeting and sensing, and biomedical applications. The book further provides the possibilities for designing PMs in a range of drug delivery approaches. The book addresses the molecular parameters of amphiphilic block copolymers that are required for functionalizing PMs for drug delivery applications. Additionally, the book presents recent advances in applications of PMs such as co-delivery, sensing, theranostics, delivery of nucleic acids, and proteins. Towards the end, it discusses different physico-chemical strategies to enhance the stability and drug retention of polymeric micelles and reviews the preclinical and clinical toxicity and immunogenicity-related aspects of polymeric micelles. This book is an invaluable source for academics, research, and industry professionals working in the field of polymeric micelles and drug delivery.
Author: Prashant Kesharwani
Publisher: Woodhead Publishing
ISBN: 0323886299
Category : Technology & Engineering
Languages : en
Pages : 716
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Book Description
Polymeric Micelles for Drug Delivery provides a comprehensive overview on the synthesis, characterization and application of polymeric micelles in drug delivery applications. The use of nanomedicines and carriers, such as polymeric micelles, has made it possible to deliver drugs, genes and therapeutic agents to localized disease sites to maximize clinical benefit while limiting unwanted side effects. This book thoroughly reviews the development and application of polymeric micelles for drug delivery, covering various polymer types and the synthesis, characterization and pharmacokinetics of different micelles. Subsequent chapters go on to look at the range of drug delivery applications of polymeric micelles – such as mucosal and transdermal – and the assorted stimuli-responsive micelles available. The book concludes with an important analysis of the environmental and regulatory aspects associated with micelle development and clinical translation. Explores how polymeric micelles can be utilized in a range of different drug delivery approaches, from traditional oral delivery to ocular and dermal delivery Describes the various polymer types used in the synthesis and characterization of polymeric micelles Covers recent advances in polymeric micelles, such as drug co-delivery, triblock polymeric micelles, delivery of genetic materials, and more
Author: Neeraj Mishra
Publisher: Springer Nature
ISBN: 9819969174
Category : Medical
Languages : en
Pages : 440
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Book Description
This book focuses on current advancements in the field of block copolymers and covers design, concept, and various therapeutic applications in the drug delivery. It also reviews the use of block copolymers in drug delivery applications from the development of sustained release products to smart polymeric delivery systems such as stimuli-responsive polymeric systems, for example, thermosensitive, redox-sensitive, photo-sensitive, and enzyme-sensitive. The book further discusses the nano assemblies from amphiphilic block copolymers as nanomedicine platforms for diagnosis and therapy due to their relatively small size, high drug loading capacity, controlled drug release, in vivo stability, and prolonged blood circulation. The chapters also review the various patents and ongoing clinical trials on the applications, covering several important new concepts and findings in the field of block copolymers. The book is aimed at researchers, academicians, and industrial scientists involved in the development of drug-delivery systems based on polymers.
Author: Prashant L. Pingale
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3111320960
Category : Science
Languages : en
Pages : 831
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Book Description
Nanotechnology can treat diseases by site-specific and target-oriented delivery of precise medicines. Nanomaterials improve the efficacy of drugs and selective diagnosis. The book covers detection and treatment. It explains the use of nanocarriers for a variety of diseases such as cardiovascular and respiratory diseases, cancer, and ulcerative colitis. It includes topical, transdermal, and ocular drug delivery and combined medication delivery.
Author: Maulin P. Shah
Publisher: Springer Nature
ISBN: 3031459563
Category : Science
Languages : en
Pages : 501
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Book Description
Environmental pollution is a worldwide concern now. A major section of the world population is struggling for drinking water. Polluted soil is resulting into low agricultural productivity and thus creating challenges in the way of sustainable livelihood of a large section of human population. Biological treatment can offer both green solutions for wastewater treatment and resource recovery as well. Like algal-based systems can be utilized for wastewater treatment and production of biofuels from the biomass grown on the wastewater. Bio-based nanomaterials have been extensively studied for their employability in the health care, process optimization, water resource management, dealing with environmental pollutants, biosensors, and many others. Bioprospecting of novel biological agents, bio-based products, and bioresource recovery are paving the way for sustainable development as they are providing local solutions for a number of problems. In this proposed book, we start with the introduction to bio-nanotechnological principles and later on discuss bio-based nanomaterials employability for a diverse range of applications from environment to energy to health care. This book provides with current trends in bio-nanotechnology for anthropogonic purposes, prospects, challenges, and way forward.
Author: Anand Gupta
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Polymeric micelles are nano-particulate core-shell structures that form spontaneously in aqueous solutions of block copolymers composed of hydrophilic and hydrophobic portions when their concentration surpasses the critical micelle concentration (CMC) at a given temperature. They are used as drug delivery systems for highly potent and extremely hydrophobic drugs such as anticancer or anti-inflammatory agents to enhance safety, efficacy, and solubility. Critical quality attributes of polymeric micelles, that tend to govern their destiny in the human body are their size and polydispersity. Ensuring manufacturing consistency for complex drug products such as polymeric nanoparticles is challenging. This can be attributed, in part, to the complex nature of the manufacturing processes and a lack of understanding of critical material attributes such as drug-polymer interactions and critical process parameters such as organic to aqueous phase ratios. Currently, the manufacturing of polymeric micelles in the pharmaceutical industry is via batch processing which has various disadvantages such as scalability, irreproducibility, down-time between batches and other issues leading to product waste, and increased expenses. To overcome potential batch-to-batch variation typically observed using traditional batch manufacturing processes, the current work focused on continuous processing of polymeric micelles and the establishment and assessment of key material attributes and process parameters. A modified continuous processing platform (based on the University of Connecticut prototype liposomal manufacturing platform) was successfully developed and built to produce polymeric micelles. Moreover, this study outlines the relationship between critical independent variables (such as polymer concentration, organic to aqueous flow rate ratios and temperature) and critical quality attributes (such as the size and polydispersity) of polymeric micelles produced by continuous processing. The controlled nanoprecipitation process achieved via co-axial co-flow and radial mixing of jets improved the control and reproducibility of polymeric micelle particle size and polydispersity compared to batch processing. Multiple design of experiments studies were implemented to produce polymeric micelles with controlled size in the range between 15 and 70 nm. Four different molecular weight block copolymers (i.e. PEG-PLA-4kD, and PEG-PCL 7kD, 14kD and 28kD) were investigated to produce polymeric micelles using the turbulent jet co-flow technology. Moreover, curcumin-loaded polymeric micelles, as an example of an API containing polymeric micelles, were produced to establish and validate the continuous processing system. Paclitaxel-loaded polymeric micelles were produced to demonstrate the system's capacity to produce Q1/Q2 equivalent drug product similar to the reference listed drug product: Genexol®PM.
Author: Kamalesh K. Sirkar
Publisher: Cambridge University Press
ISBN: 1107469732
Category : Technology & Engineering
Languages : en
Pages : 923
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Book Description
Providing chemical engineering undergraduate and graduate students with a basic understanding of how separation of a mixture of molecules, macromolecules or particles is achieved, this textbook is a comprehensive introduction to the engineering science of separation. • Students learn how to apply their knowledge to determine the separation achieved in a given device or process • Real-world examples are taken from biotechnology, chemical, food, petrochemical, pharmaceutical and pollution control industries • Worked examples, elementary separator designs and chapter-end problems are provided, giving students a practical understanding of separation. The textbook systematically develops different separation processes by considering the forces causing the separation and how this separation is influenced by the patterns of bulk flow in the separation device. Readers will be able to take this knowledge and apply it to their own future studies and research in separation and purification. Online resources include solutions to the exercises and guidance for computer simulations.
Author: Dibyendu Ganguli
Publisher: Springer Science & Business Media
ISBN: 1461500478
Category : Science
Languages : en
Pages : 214
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Book Description
"Nanotechnology" is now very well known as one of the most important key technologies in science and industry. In the field of material science and engineering, nanoparticles should be unit materials, as well as atoms and molecules, to build ceramics, devices, catalysts, and machines, and the "nanoparticle technology" is thus attracting. This novel technology includes various methodologies for nanoparticles: preparation, surface-modification via chemical and/or physical treatments, immobilization and arrangement on supports or substrates, to achieve high performance for luminescence properties in light emitting devices, and high efficiency for catalytic and photocatalytic reactions in chemical synthesis, chemical decomposition, and artificial photosynthesis, etc. It should be needless to say that the preparation of nanoparticles, having precisely controlled particle size, size distribution, chemical composition, and surface properties, is essentially important to realize "true nanoparticle technology". This book, written by Dr. Dibyendu Ganguli and Dr. Munia Ganguli, deals with the preparation methodologies for inorganic nanoparticles using macro- and microemulsions as "microreactor". There are several differences between these two emulsions, in addition to water droplet size: thermodynamic stability, and fusion-redispersion dynamics of the droplets. The properties of the nanoparticles prepared in these emulsion systems are seriously influenced and controlled by the selection of dynamic and static conditions.
Author: Kangde Yao
Publisher: CRC Press
ISBN: 1439821151
Category : Medical
Languages : en
Pages : 492
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Book Description
Due to their unique properties, chitosan-based materials have emerged as useful resources in a variety of medicines, drug controlled-release carriers, tissue engineering scaffolds, and immobilized enzymes. But many of these materials have yet to reach the commercial market. Therefore, more work must be completed to fill the gap between research and
Author: Richard G Jones
Publisher: Royal Society of Chemistry
ISBN: 1847559425
Category : Science
Languages : en
Pages : 465
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Book Description
The IUPAC system of polymer nomenclature has aided the generation of unambiguous names that re ect the historical development of chemistry. However, the explosion in the circulation of information and the globalization of human activities mean that it is now necessary to have a common language for use in legal situations, patents, export-import regulations, and environmental health and safety information. Rather than recommending a ‘unique name’ for each structure, rules have been developed for assigning ‘preferred IUPAC names’, while continuing to allow alternatives in order to preserve the diversity and adaptability of nomenclature. Compendium of Polymer Terminology and Nomenclature is the only publication to collect the most important work on this subject into a single volume. It serves as a handy compendium for scientists and removes the need for time consuming literature searches. One of a series issued by the International Union of Pure and Applied Chemistry (IUPAC), it covers the terminology used in many and varied aspects of polymer science as well as the nomenclature of several di erent types of polymer including regular and irregular single-strand organic polymers, copolymers and regular double-strand (ladder and spiro) organic polymers.
