The Biophysics of Cell Membranes PDF Download
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Author: Richard M. Epand
Publisher: Springer
ISBN: 9811062447
Category : Science
Languages : en
Pages : 224
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Book Description
This volume focuses on the modulation of biological membranes by specific biophysical properties. The readers are introduced to emerging biophysical approaches that mimick specific states (like membrane lipid asymmetry, membrane curvature, lipid flip-flop, lipid phase separation) that are relevant to the functioning of biological membranes. The first chapter describes innovative methods to mimic the prevailing asymmetry in biological membranes by forming asymmetrical membranes made of monolayers with different compositions. One of the chapters illustrates how physical parameters, like curvature and elasticity, can affect and modulate the interactions between lipids and proteins. This volume also describes the sensitivity of certain ion channels to mechanical forces and it presents an analysis of how cell shape is determined by both the cytoskeleton and the lipid domains in the membrane. The last chapter provides evidence that liposomes can be used as a minimal cellular model to reconstitute processes related to the origin of life. Each topic covered in this volume is presented by leading experts in the field who are able to present clear, authoritative and up-to-date reviews. The novelty of the methods proposed and their potential for a deeper molecular description of membrane functioning are particularly relevant experts in the areas of biochemistry, biophysics and cell biology, while also presenting clear and thorough introductions, making the material suitable for students in these fields as well.
Author: Richard M. Epand
Publisher: Springer
ISBN: 9811062447
Category : Science
Languages : en
Pages : 224
Get Book Here
Book Description
This volume focuses on the modulation of biological membranes by specific biophysical properties. The readers are introduced to emerging biophysical approaches that mimick specific states (like membrane lipid asymmetry, membrane curvature, lipid flip-flop, lipid phase separation) that are relevant to the functioning of biological membranes. The first chapter describes innovative methods to mimic the prevailing asymmetry in biological membranes by forming asymmetrical membranes made of monolayers with different compositions. One of the chapters illustrates how physical parameters, like curvature and elasticity, can affect and modulate the interactions between lipids and proteins. This volume also describes the sensitivity of certain ion channels to mechanical forces and it presents an analysis of how cell shape is determined by both the cytoskeleton and the lipid domains in the membrane. The last chapter provides evidence that liposomes can be used as a minimal cellular model to reconstitute processes related to the origin of life. Each topic covered in this volume is presented by leading experts in the field who are able to present clear, authoritative and up-to-date reviews. The novelty of the methods proposed and their potential for a deeper molecular description of membrane functioning are particularly relevant experts in the areas of biochemistry, biophysics and cell biology, while also presenting clear and thorough introductions, making the material suitable for students in these fields as well.
Author: et al Litha Beekman
Publisher:
ISBN: 9781485130055
Category : Academic writing
Languages : en
Pages : 178
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Book Description
"Academic Literacy is an essential tool for people moving into the tertiary phase of education, to support the achievement of their goals. It covers all the necessary academic skills and competencies for constructive and successful study - not only reading, writing, listening and verbal communication, but also critical thinking, possibly the core skill needed at this level of study. Other skills it aims to develop are: understanding and engaging in academic study; vocabulary; reading for study purposes; argument; paraphrasing and summarising; writing paragraphs; assignment writing; and preparing for examinations. New to the edition : An updated and expanded chapter on developing vocabulary and using dictionaries -- Renewed focus on critical thinking and reflective writing -- A refreshed chapter on writing paragraphs, including reflection on constructing effective paragraphs -- Supplemental text on assignment writing and referencing." --Publisher's description.
Author: Vidosav D. Majstorovic
Publisher: Springer
ISBN: 3030181774
Category : Technology & Engineering
Languages : en
Pages : 330
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Book Description
This book gathers the proceedings of the 12th International Conference on Measurement and Quality Control – Cyber Physical Issues (IMEKO TC 14 2019), held in Belgrade, Serbia, on 4–7 June 2019. The event marks the latest in a series of high-level conferences that bring together experts from academia and industry to exchange knowledge, ideas, experiences, research findings, and information in the field of measurement of geometrical quantities. The book addresses a wide range of topics, including: 3D measurement of GPS characteristics, measurement of gears and threads, measurement of roughness, micro- and nano-metrology, laser metrology for precision measurements, cyber physical metrology, optical measurement techniques, industrial computed tomography, multisensor techniques, intelligent measurement systems, evaluating measurement uncertainty, dimensional management in industry, product quality assurance methods, and big data analytics. By providing updates on key issues and highlighting recent advances in measurement and quality control, the book supports the transfer of vital knowledge to the next generation of academics and practitioners.
Author: Rita Sattler
Publisher: Springer
ISBN: 331989689X
Category : Medical
Languages : en
Pages : 321
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Book Description
It has become evident over the last years that abnormalities in RNA processing play a fundamental part in the pathogenesis of neurodegenerative diseases. Cellular viability depends on proper regulation of RNA metabolism and subsequent protein synthesis, which requires the interplay of many processes including transcription, pre--‐mRNA splicing, mRNA editing as well as mRNA stability, transport and translation. Dysfunction in any of these processes, often caused by mutations in the coding and non--‐ coding RNAs, can be very destructive to the cellular environment and consequently impair neural viability. The result of this RNA toxicity can lead to a toxic gain of function or a loss of function, depending on the nature of the mutation. For example, in repeat expansion disorders, such as the newly discovered hexanucleotide repeat expansion in theC9orf72 gene found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), a toxic gain of function leads to the formation of RNA foci and the sequestration of RNA binding proteins (RBPs). This in return leads to a loss of function of those RBPs, which is hypothesized to play a significant part in the disease progression of ALS and FTD. Other toxicities arising from repeat expansions are the formation of RNA foci, bi--‐directional transcription and production of repeat associated non--‐ATG (RAN) translation products. This book will touch upon most of these disease mechanisms triggered by aberrant RNA metabolism and will therefore provide a broad perspective of the role of RNA processing and its dysfunction in a variety of neurodegenerative disorders, including ALS, FTD, Alzheimer’s disease, Huntington’s disease, spinal muscular atrophy, myotonic dystrophy and ataxias. The proposed authors are leading scientists in the field and are expected to not only discuss their own work, but to be inclusive of historic as well as late breaking discoveries. The compiled chapters will therefore provide a unique collection of novel studies and hypotheses aimed to describe the consequences of altered RNA processing events and its newest molecular players and pathways.
Author: Pier Luigi Luisi
Publisher: Springer Science & Business Media
ISBN: 9048199441
Category : Medical
Languages : en
Pages : 296
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Book Description
In the last ten years there has been a considerable increase of interest on the notion of the minimal cell. With this term we usually mean a cell-like structure containing the minimal and sufficient number of components to be defined as alive, or at least capable of displaying some of the fundamental functions of a living cell. In fact, when we look at extant living cells we realize that thousands of molecules are organized spatially and functionally in order to realize what we call cellular life. This fact elicits the question whether such huge complexity is a necessary condition for life, or a simpler molecular system can also be defined as alive. Obviously, the concept of minimal cell encompasses entire families of cells, from totally synthetic cells, to semi-synthetic ones, to primitive cell models, to simple biomimetic cellular systems. Typically, in the experimental approach to the construction of minimal the main ingredient is the compartment. Lipid vesicles (liposomes) are used to host simple and complex molecular transformations, from single or multiple enzymic reactions, to polymerase chain reactions, to gene expression. Today this research is seen as part of the broader scenario of synthetic biology but it is rooted in origins of life studies, because the construction of a minimal cell might provide biophysical insights into the origins of primitive cells, and the emergence of life on earth. The volume provides an overview of physical, biochemical and functional studies on minimal cells, with emphasis to experimental approaches. 15 International experts report on their innovative contributions to the construction of minimal cells.
Author: S. Guidet
Publisher: Springer Science & Business Media
ISBN: 1461518091
Category : Medical
Languages : en
Pages : 365
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Book Description
Progress in Cell Cycle Research is a new annual series designed to be the source for up-to-date research on this rapidly expanding field. Review articles by international experts examine various aspects of cell division regulation from fundamental perspectives to potential medical applications. Researchers as well as advanced undergraduate and graduate students in cell biology, biochemistry, and molecular biology will benefit from this series.
Author: Henry F. Diaz
Publisher: Springer Science & Business Media
ISBN: 1402029438
Category : Science
Languages : en
Pages : 515
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Book Description
The book examines potentially important factors that may have affected the Hadley and Walker Circulations and evaluates changes in the Hadley Circulation and the monsoons as simulated by coupled models of past climate conditions, and predicted future conditions under an enhanced greenhouse effect. This book is meant to serve as a fundamental reference work for current and future researchers, graduate students in the atmospheric sciences and geosciences, and climate specialists involved in interdisciplinary research.
Author: A. S. Chanderbali
Publisher:
ISBN:
Category :
Languages : en
Pages : 102
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Book Description
Author: Michael E. Auer
Publisher: Springer Nature
ISBN: 3030682013
Category : Technology & Engineering
Languages : en
Pages : 885
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Book Description
This book contains papers in the fields of engineering pedagogy education, public–private partnership and entrepreneurship education, research in engineering pedagogy, evaluation and outcomes assessment, Internet of Things & online laboratories, IT & knowledge management in education and real-world experiences. We are currently witnessing a significant transformation in the development of education and especially post-secondary education. To face these challenges, higher education has to find innovative ways to quickly respond to these new needs. There is also pressure by the new situation in regard to the Covid pandemic. These were the aims connected with the 23rd International Conference on Interactive Collaborative Learning (ICL2020), which was held online by University of Technology Tallinn, Estonia from 23 to 25 September 2020. Since its beginning in 1998, this conference is devoted to new approaches in learning with a focus on collaborative learning. Nowadays the ICL conferences are a forum of the exchange of relevant trends and research results as well as the presentation of practical experiences in Learning and Engineering Pedagogy. In this way, we try to bridge the gap between ‘pure’ scientific research and the everyday work of educators. Interested readership includes policymakers, academics, educators, researchers in pedagogy and learning theory, school teachers, learning industry, further and continuing education lecturers, etc.
Author: Ganeshan Wignaraja
Publisher: Springer
ISBN: 1349262676
Category : Business & Economics
Languages : en
Pages : 296
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Book Description
The East Asian experience suggests that technological development is fundamental to export success in outward-oriented economies. This study analyses export performance in Sri Lanka at a national and firm level, focusing on the acquisition of industrial technological capabilities during a period of trade liberalization. It compares Sri Lanka's record with Korea, Taiwan and Thailand. Analysis of the export and technological record of enterprises of varying performance highlights the policies which enhance competitiveness in developing and transition economies.
