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Author: Konstanze Margarete Hebeda
Publisher:
ISBN:
Category :
Languages : en
Pages : 148
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Book Description
Author: Konstanze Margarete Hebeda
Publisher:
ISBN:
Category :
Languages : en
Pages : 148
Get Book Here
Book Description
Author: Thierry Patrice
Publisher: Royal Society of Chemistry
ISBN: 1847551653
Category : Medical
Languages : en
Pages : 292
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Book Description
For centuries, light has been used to cure various diseases. However, it is only recently that a new medical field has arisen. Photodynamic therapy (PDT), also known as photochemotherapy, is a fast growing technique which was initially devoted to cancer care but which is now recognised as a promising treatment technique in a variety of clinical fields. Written by recognised experts, Photodynamic Therapy provides a comprehensive explanation of what PDT is and how it has developed as a technique in areas such as the detection of lung cancer and applications in dermatology, gynaecology and neurosurgery. This book is ideal both as an introduction to PDT and as an informative text for those wishing to expand their knowledge. Practitioners in biological sciences, biotechnology and medicinal and pharmaceutical chemistry will find it an invaluable source of information.
Author: Flora Fitzgerald
Publisher: Nova Biomedical Books
ISBN: 9781536119121
Category : Photochemotherapy
Languages : en
Pages : 0
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Book Description
As a new concept of cancer treatment, photodynamic therapy (PDT) has gained great attention in the last few decades. Compared to classical treatments such as surgery, chemotherapy and radiotherapy, PDT is a noninvasive, localized treatment of lesions that shows fewer side effects and has low systemic toxicity. In Chapter One, the basic mechanisms, applications and functional nanomaterials-based drug delivery systems for photodynamic therapy of cancer are reviewed. Chapter Two summarizes the application of different carbon based nanomaterials as agents for PDT and discusses current state-of-the-art use of fullerenes and their derivatives, carbon nanotubes and graphene quantum dots in PDT. Chapter Three covers the benefits and pitfalls of using chemi- and bioluminescent systems as intracellular excitation sources in PDT. Bioluminescence is a widespread natural phenomenon, which consists on emission of light resulting from the oxidation of a substrate in a reaction catalyzed by an enzyme in a biological system. Chapter Four addresses in the synthesis, characterization, and photodynamic activity of a novel hydrophobic photosensitizer 5,10,15,20-tetrakis(benzo[b]thiophene) Porphyrin (BTP) and water soluble photosensitizer 5,10,15,20-Tetrakis(7- sulfonatobenzo[b]thiophene) Porphyrin (SBTP). The authors lab is engaged in the synthesis of PDT molecules incorporating benzothiophene moiety to the meso-position of porphyrin molecules. Chapter Five discusses the Guidelines for Gastroenterological Endoscopy in Patients on Oral Antithrombotic Treatment established by the Japan Gastroenterological Endoscopy Society (JGES).These guidelines classify endoscopic interventions according to the risk of hemorrhage and specify the management of various antithrombotic drugs. Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are classified as high-risk procedures for hemorrhage, but PDT is not included in the guidelines. Because PDT causes ischemic necrosis of tumor tissue, the authors say this could possibly be performed safely in patients on oral antithrombotic therapy. The authors of Chapter Six developed a method of the initial concentration of protoporphyrin-IX in the operated removing glioblastoma tissue using the calibration curve of the fluorescent intensity and the known Pp-IX concentration in order to estimate of the more correlated with the cure rate.
Author: Thierry Patrice
Publisher: Royal Society of Chemistry
ISBN: 9780854043064
Category : Medical
Languages : en
Pages : 306
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Book Description
Written by recognised experts, Photodynamic Therapy provides a comprehensive explanation of what PDT is and how it has developed as a technique.
Author: Michael R. Hamblin
Publisher: CRC Press
ISBN: 1315278162
Category : Science
Languages : en
Pages : 502
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Book Description
This book covers the broad field of cellular, molecular, preclinical, and clinical imaging either associated with or combined with photodynamic therapy (PDT). It showcases how this approach is used clinically for cancer, infections, and diseases characterized by unwanted tissue such as atherosclerosis or blindness. Because the photosensitizers are also fluorescent, the book also addresses various imaging systems such as confocal microscopy and small animal imaging systems, and highlights how they have been used to follow and optimize treatment, and to answer important mechanistic questions. Chapters also discuss how imaging has made important contributions to clinical outcomes in skin, bladder, and brain cancers, as well as in the development of theranostic agents for detection and treatment of disease. This book provides a resource for physicians and research scientists in cell biology, microscopy, optics, molecular imaging, oncology, and drug discovery.
Author: Abdul-Amir Yassine
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Photodynamic Therapy (PDT) is a minimally invasive oncology treatment that uses light-activated photosensitizers to destroy tumors locally. It has been approved for a variety of superficial tumor indications such as the skin. For deep-seated tumors like brain glioma, the treatment (via interstitial light illumination with fiber optic probes) is yet to be approved due to several challenges that hinder its efficacy. Much of the research to improve interstitial PDT's (iPDT) therapeutic index has been directed towards developing targeted photosensitizers. However, another factor that highly affects iPDT efficacy is the light penetration inside the tissues, especially when the tumor is surrounded by extremelysensitive healthy tissues such as white matter in the brain. This thesis introduces PDT-SPACE, an open-source software for automatic iPDT planning. We present novel computer-aided design (CAD) algorithms to allocate powers to a set of light diffusers and determine the location and lengths of those diffusers in order to minimize the damage to surrounding organs-at-risk (OAR), while maximizing the damage to the tumor. We also generalize the power allocation algorithm to generate tailored power profiles for cylindrical diffusers to better conform the light distribution to the tumor shape and further decrease the damage. We simulate our methods onnine virtual brain tumors constructed from glioblastoma multiforme (GBM) MRI images taken from the cancer imaging archive. Through the various optimizations presented, we show that the treatment plans generated by PDT-SPACE can reduce damage to OAR by more than 70% on average compared to state-of-the-art techniques, while destroying at least 98% of the tumor. Additionally, we present several techniques utilizing machine learning to generate robust treatment plans that take into account inter-patient variations of tissue optical properties. These robust treatment plans are more adaptable to the biological uncertainties of individual patients. Finally, we show how PDT-SPACE serves as a prospective methodology to analyze the effect of different combinations of optimization parameters on iPDT efficacy for various oncological indications while avoiding the technical difficulties that come with in-vivo direct measurements. We present different treatment plans (each with its own trade-off) to treat bone metastasis resulting from colorectal cancer recurrence.
Author: Valentina Rapozzi
Publisher: Springer
ISBN: 3319127306
Category : Medical
Languages : en
Pages : 253
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Book Description
This volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches to overcome resistance in tumor cells.
Author: David Kessel
Publisher: CRC Press
ISBN: 9780849358166
Category : Medical
Languages : en
Pages : 358
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Book Description
This two-volume text provides a summary of current studies relating to the use of photosensitizing agents in the diagnosis and therapy of cancer. This interesting work describes synthesis of new sensitizers, photochemical and photobiological properties of dyes currently used for photodynamic therapy, plus those being examined with a view toward providing therapeutic advantages. It contains results and methodology from leading experts on the use of porphyrins and other photosensitizers for detection of neoplastic disease and for photodynamic therapy of neoplastic disease. The volumes focus on the major clinical and pre-clinical research groups. They also include an appended bibliography which lists all pertinent publications in this field. This easy-to-understand book is written for all workers in the field of photodynamic therapy and provides an introduction to those beginning research on some aspect of tumor photosensitization.
Author: Haini Zhang
Publisher:
ISBN:
Category : Electronic dissertations
Languages : en
Pages : 36
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Book Description
Incomplete brain tumor removal always causes neurologic deficit, disease recurrence and high mortality. Protoporphyrin IX (PpIX) accumulated in glioma cells with exogenous 5-aminolevulinic acid (5-ALA) serves as contrast agent for fluorescence-guided surgery and as well as acts as a photosensitizer for photodynamic therapy (PDT). However, the accurate tumor delineation using PpIX is limited by autofluorescence and superficial penetration depth. LS301 is a tumor-targeted near-infrared (NIR) contrast agent developed in our lab which allows deeper tumor imaging and avoids autofluorescence. My project aims to investigate whether LS301 can improve PpIX mediated PDT and tumor removal surgery. We have demonstrated co-localization of LS301 and PpIX in DBT and U87-MG glioma cell lines and are currently testing the effect of LS301 on PpIX mediated PDT in vitro. We will also compare LS301-PpIX with PpIX only PDT and tumor removal in mouse models of brain cancer. This study can potentially increase efficacy of PDT and fluorescence-guided brain tumor resection.
Author: Barbara W. Henderson
Publisher: CRC Press
ISBN: 1000148017
Category : Technology & Engineering
Languages : en
Pages : 484
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Book Description
Covering all aspects of photodynamic therapy, 70 expert contributors from the fields of photochemistry, photobiology, photophysics, pharmacology, oncology and surgery, provide multidisciplinary discussions on photodynamic therapy - a rapidly-developing approach to the treatment of solid tumours.;Photodynamic Therapy: Basic Principles and Clinical Applications describes the molecular and cellular effects of photodynamic treatment; elucidates the complex events leading to photodynamics tissue destruction, particularly vascular and inflammatory responses; discusses the principles of light penetration through tissues and optical dosimetry; examines photosensitizer pharmacology and delivery systems; reviews in detail photosensitizer structure-activity relationships; illustrates novel devices that aid light dosimetry and fluorescence detection; and extensively delineates clinical applications, including early diagnosis and treatment.;A comprehensive and up-to-date reference, this book should be useful for oncologists, pharmacologists, surgeons, photobiologists, optical engineers, laser technicians, biologists, physicists, chemists and biochemists involved in cancer research, as well as graduate-level students in these disciplines.
