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Author: Nathan Back
Publisher: Springer
ISBN: 1461446120
Category : Medical
Languages : en
Pages : 671
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Book Description
It can be concluded (under the specific experimental procedures em ployed) that:- 1) HCG labelled with 1 - 2 atoms of radioactive iodine did not differ sig nificantly from the unlabelled hormone; 2) The ovary alone exhibited a capacity to affix specifically HCG; 3) The amount of radioactive material in the ovary was directly proport ional to the quantity of labelled HCG injected; 4) When the HCG present in the circulation is bound to an antiserum to HCG, the antigen-antibody complex is not concentrated by the ovary; 5) Circulating labelled HCG decreased to 50% within 30 minutes following a single intravenous injection; 6) There are four different phases of ovarian uptake of HCG, namely: the first phase, when there is only an inflow from the circulation and stor age mainly in the follicular envelopes; the second phase, when there is a greater inflow than outflow; the third phase, when the inflow is equal to the outflow; and the fourth period, when the outflow is bigger than the in flow. REFERENCES 1. Lunenfeld, B. and Eshkol, A. Vitamins and Hormones (1967) 25:165 2. Eshkol, A. In: Recent Research on Gonadotropbio Hormones, eds. E. T. Bell andJ. A. Loraine, Edinburgh, Livingstone (1967), p. 202. 3. Eshkol, A. and Lunenfeld, B. Proc. Tel-Hashomer Hosp. (1967) 6:4. ACKNOWLEOOMEN'IS This work was supported in part by a grant from the Population Council, N. Y. , U. S. A. andbyGrantNo.
Author: Nathan Back
Publisher: Springer
ISBN: 1461446120
Category : Medical
Languages : en
Pages : 671
Get Book
Book Description
It can be concluded (under the specific experimental procedures em ployed) that:- 1) HCG labelled with 1 - 2 atoms of radioactive iodine did not differ sig nificantly from the unlabelled hormone; 2) The ovary alone exhibited a capacity to affix specifically HCG; 3) The amount of radioactive material in the ovary was directly proport ional to the quantity of labelled HCG injected; 4) When the HCG present in the circulation is bound to an antiserum to HCG, the antigen-antibody complex is not concentrated by the ovary; 5) Circulating labelled HCG decreased to 50% within 30 minutes following a single intravenous injection; 6) There are four different phases of ovarian uptake of HCG, namely: the first phase, when there is only an inflow from the circulation and stor age mainly in the follicular envelopes; the second phase, when there is a greater inflow than outflow; the third phase, when the inflow is equal to the outflow; and the fourth period, when the outflow is bigger than the in flow. REFERENCES 1. Lunenfeld, B. and Eshkol, A. Vitamins and Hormones (1967) 25:165 2. Eshkol, A. In: Recent Research on Gonadotropbio Hormones, eds. E. T. Bell andJ. A. Loraine, Edinburgh, Livingstone (1967), p. 202. 3. Eshkol, A. and Lunenfeld, B. Proc. Tel-Hashomer Hosp. (1967) 6:4. ACKNOWLEOOMEN'IS This work was supported in part by a grant from the Population Council, N. Y. , U. S. A. andbyGrantNo.
Author: Nathan Back
Publisher:
ISBN: 9781461446132
Category :
Languages : en
Pages : 676
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Book Description
Author: Nathan Back
Publisher:
ISBN:
Category :
Languages : en
Pages : 660
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Book Description
Author: Dr. Wolfgang König
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 304
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Book Description
Incorporates the developments in the field during the 25 years since the last major overview of peptide and protein hormones. Reviews the most important features of the hormones, including structure/activity relationships. Also describes their medical use, noting that western society encourages an overabundance of aggressive stress hormones, and that the role of doctors is to return them into balance with cooperative sex hormones. Of particular use to researchers, students, and practitioners is a special listing of the hormones according to a network of structural similarity and regulating cascades. Annotation copyright by Book News, Inc., Portland, OR
Author: Nathan Back
Publisher:
ISBN:
Category :
Languages : en
Pages : 660
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Book Description
Author: Jean Martinez
Publisher: Ellis Horwood
ISBN:
Category : Medical
Languages : en
Pages : 384
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Book Description
Author: Choh Hao Li
Publisher: Elsevier
ISBN: 1483257967
Category : Nature
Languages : en
Pages : 285
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Book Description
Hormonal Proteins and Peptides, Volume I reviews extensively the knowledge on the biology and chemistry of the protein and peptide hormones. This book presents the structures of the various protein and peptide hormones. Organized into five chapters, this volume begins with an overview of the chemistry of several hormonal glycoproteins. This text then presents the research on the purification and chemistry of thyroid-stimulating hormone (TSH). Other chapters consider the study of ovine interstitial cell-stimulating hormone, and concentrate to some extent on the very closely related bovine species. This book discusses as well some aspects of the biology of the pituitary interstitial cell-stimulating hormone or luteinizing hormone in mammalian species. The final chapter deals with the correlation of the primary structure with function for a better understanding of the mechanism of action of the hormone at a molecular level. This book is a valuable resource for biologists, biochemists, and research workers.
Author: Sidney Udenfriend
Publisher: Academic Press
ISBN: 1483218015
Category : Science
Languages : en
Pages : 383
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Book Description
Chemistry, Biology, and Medicine of Neurohypophyseal Hormones and Their Analogs, Volume 8 covers the advances in methods to study peptide hormone action at the molecular level. The book discusses the anatomy, physiology, and clinical disorders of the neurohypophysis; the biosynthesis of neurohypophyseal peptides; and the structure-activity relationships of neurohypophyseal peptides, with an emphasis on the role of conformational features. The text also describes conformational studies of neurohypophyseal hormones by physical chemical techniques; the central nervous system effects of neurohypophyseal peptides; and the effects of neurohypophyseal hormones on the kidney. The effects of neurohypophyseal hormones on the cardiovascular systems are also considered. Chemists, neurobiologists, and people involved in the study of neurohypophyseal hormones will find the book invaluable.
Author: M. Margoulies
Publisher:
ISBN:
Category : Drugs
Languages : en
Pages : 600
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Book Description
Author: Ajay K. Banga
Publisher: CRC Press
ISBN: 9781566763295
Category : Medical
Languages : en
Pages : 336
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Book Description
From the Preface At the time of this writing, the American biotechnology and pharmaceutical industry has more than two dozen biotechnology-derived therapeutic proteins on the market, while several hundred are in various stages of human clinical trials or at the FDA for review. Today, more than a thousand companies are involved in biotechnology research, with a total revenue of $7.7 billion for 1993. Therapeutic peptides and proteins are expected to mitigate suffering in coming years as anticancer agents, hormones, growth factors, analgesics, anti-hypertensives, and thrombolytics, among others. However, the clinical application of these therapeutic peptides and proteins is limited by several problems, such as lack of physical and chemical stability or the lack of desirable attributes for adequate absorption or distribution. Thus, as these therapeutic peptides and proteins are made available, it will be essential to formulate these drugs into safe, stable and efficacious delivery systems. The pharmaceutical scientist involved in this effort needs to call upon the knowledge of several disciplines, such as pharmaceutics, medicinal chemistry, biochemistry, and microbiology, and needs to keep abreast with the latest research in the published literature. This book presents these principles in a simple, interesting and practically useful manner for the benefit of scientists working in this area and to further research in this area. This book will also provide useful information for students and academic researchers and add to their interest in this area. The book should also be useful in a hospital setting to understand potential physicochemical stability problems that may result during reconstitution or administration of the new recombinant proteins. Since this field is relatively new and rapidly evolving, efforts were made to include very recent literature in the book. As a result, over 40% of the literature citations in the book are for the work published in the last two years.
