Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement PDF Download
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Author: Nina Dragicevic
Publisher: Springer
ISBN: 3662478625
Category : Medical
Languages : en
Pages : 387
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Book Description
Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure and function, mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners and also students.
Author: Nina Dragicevic
Publisher: Springer
ISBN: 3662478625
Category : Medical
Languages : en
Pages : 387
Get Book Here
Book Description
Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure and function, mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners and also students.
Author: Nina Dragicevic
Publisher: Springer
ISBN: 3662532700
Category : Medical
Languages : en
Pages : 411
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Book Description
Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered, and the latest findings are provided on skin structure and function, mathematics in skin permeation, and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners, students and dermatological scientists or dermatologists.
Author: Nina Dragicevic
Publisher: Springer
ISBN: 3662532735
Category : Medical
Languages : en
Pages : 496
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Book Description
Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered, and the latest findings are provided on skin structure and function, mathematics in skin permeation, and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners, and also students.
Author: Eric Wane Smith
Publisher: CRC Press
ISBN: 1420039202
Category : Medical
Languages : en
Pages : 448
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Book Description
Thoroughly updated, this second edition is the most comprehensive reference on the methods available for the enhancement of percutaneous penetration. The book examines a broad scope of chemical enhancers and various physical methods of enhancement. The range of chemicals discussed is, arguably, unsurpassed anywhere in the literature. This edition contains comprehensive descriptions of the latest techniques and several chapters cover the modern analytical techniques adapted to assess and measure penetration enhancement. New to this volume are chapters addressing penetration retardation, important for substances such as sunscreen agents, for which skin penetration is not desirable.
Author: Vinod P. Shah
Publisher: Springer
ISBN: 1493912895
Category : Medical
Languages : en
Pages : 393
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Book Description
This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.
Author: Kenji Sugibayashi
Publisher: Springer
ISBN: 4431565264
Category : Medical
Languages : en
Pages : 410
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Book Description
This book reviews skin permeation and disposition of chemical compounds. Skin is utilized as an administration site for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Their usefulness is closely related to the permeation and disposition of entrapped active ingredients through and into the skin. Skin permeation, disposition, and metabolism of chemicals are first summarized in the general introduction. Then primary topical formulations are explained in the second part, “Basic Formulations Applied to Skin”. The explanation for the active compounds and formulations are of the most important parts required to fabricate these formulations. Skin absorption of chemicals is generally much lower than oral and the other mucosal absorptions, so that skin-penetration enhancement is a key issue to have good formulations topically applied. Part 3 presents “Skin Penetration Enhancement”. In addition, Part 4, “Selection of Topically Applied Chemical Candidates”, deals with selection methods of topically applied ingredients for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Parts 5 and 6, “Safety Assessment of Topically Applied Compounds“ and “Experimental Methods of Skin Permeation“, respectively, show safety issues and experimental methods for topical formulations. The final part consists of comments on therapeutic and cosmetic formulations by medical doctors and pharmacists. Their comments are especially helpful for pharmaceutical and cosmetic researchers who study dermatopharmacokinetics and topical formulations. This volume is particularly useful for those working in R&D, graduate students, and educators in the area of pharmaceutics, cosmetic sciences, dermatological sciences, pharmacology, toxicology, biopharmacy, pharmacokinetics, physical pharmacy, chemical engineering, and related fields.
Author: Elka Touitou
Publisher: CRC Press
ISBN: 1420004816
Category : Medical
Languages : en
Pages : 631
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Book Description
Providing a significant cross-fertilization of ideas across several disciplines, Enhancement in Drug Delivery offers a unique comprehensive review of both theoretical and practical aspects of enhancement agents and techniques used for problematic administration routes. It presents an integrated evaluation of absorption enhancers and modes fo
Author: Heather A. E. Benson
Publisher: John Wiley & Sons
ISBN: 1119769604
Category : Medical
Languages : en
Pages : 580
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Book Description
A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristics Describes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug disposition Details the physiology and barriers to drug delivery for each administration route Presents a historical perspective and a look into the possible future of advanced drug delivery systems Explores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issues Includes comprehensive references and links to the primary literature Edited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.
Author: Lionel Trottet
Publisher: Springer
ISBN: 3319595040
Category : Medical
Languages : en
Pages : 154
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Book Description
The authors show how the pharmaceutical industry faces the development of dermal drugs and provide the only book of its kind that describes how the industry develops and selects dermal drugs, complete with the challenges and opportunities of the field. Delivery of drugs through the skin has been an attractive and challenging area for research, and advances in modern technologies have resulted in a larger number of drugs being delivered transdermally, including conventional hydrophobic small molecule drugs, hydrophilic drugs and macromolecules. Offering the perspective from the industrial side of selection and development of drugs, the primary audience is geared towards the pharmaceutical industry but can also offer valuable information to clinicians, compounding pharmacists, and similarly pharmacy students. Dermal Drug Selection and Development covers the scientific gaps that exist in terms of dermal pharmacokinetics and the resulting uncertainty by clinicians when choosing a drug candidate.
Author: Heather A. E. Benson
Publisher: John Wiley & Sons
ISBN: 1118140494
Category : Medical
Languages : en
Pages : 393
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Book Description
Practical drug development approaches presented by leading experts Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and then demonstrates how these principles are put into practice in the design and development of new drug products. Drawing together and reviewing the latest research findings, the book focuses on practical, tested, and proven approaches that are backed by industry case studies and the authors' firsthand experience. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development. Topical and Transdermal Drug Delivery: Principles and Practice is divided into two parts: Part One, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the principles and techniques needed to successfully perform experimental approaches, covering such issues as skin permeation, enhancement, and assessment. Part Two, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field. This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics. Throughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results. With contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the science and the standards of practice.
