Perspectives in Receptor Research PDF Download
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Author: Dario Giardina
Publisher: Elsevier
ISBN: 9780080545011
Category :
Languages : en
Pages : 422
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Book Description
Perspectives in Receptor Research
Author: Dario Giardina
Publisher: Elsevier
ISBN: 9780080545011
Category :
Languages : en
Pages : 422
Get Book
Book Description
Perspectives in Receptor Research
Author: Francesco Bresciani
Publisher: Raven Press (ID)
ISBN:
Category : Binding sites (Biochemistry)
Languages : en
Pages : 348
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Book Description
Author: Francesco Bresciani
Publisher:
ISBN:
Category : Steroid hormones
Languages : en
Pages :
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Book Description
Author: Mostafa Z. Badr
Publisher: Springer Nature
ISBN: 3030783154
Category : Medical
Languages : en
Pages : 676
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Book Description
Nuclear receptors are ligand activated transcription factors that control numerous biological functions. Consequently, altering activity of these receptors is proposed, and indeed documented, to affect many physiological and pathological conditions in experimental animals and humans. Thus, nuclear receptors have become a major target in the effort to treat numerous diseases. This book will shed light on and emphasize intricate processes involved in designing as well as discovering physiological and pharmacological modulators of these important proteins. World-renowned scientists will share with the reader their professional expertise and extensive experience acquired through decades working with nuclear receptors. Chapters address the various means and consequences of modulating nuclear receptor activity will be presented and discussed. These modulators cover a wide span of moieties ranging from synthetic chemicals to natural products. In addition, the classification of these chemicals ranges from pan agonists to selective agonists and inverse agonists to antagonists. They also include proteolytic means to obliterate the receptor in the event that modulating its activity through canonical pharmacological agents becomes less effective and/or less desirable due to anticipated or experienced toxicities. Modulation of receptor activity may also take place in the absence of a ligand or through manipulating the structure of the receptor itself by controlling posttranslational events.
Author: Yi Ma
Publisher: Frontiers Media SA
ISBN: 288945973X
Category :
Languages : en
Pages : 192
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Book Description
Author: Kazuwa Nakao
Publisher: Springer
ISBN: 4431556516
Category : Science
Languages : en
Pages : 330
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Book Description
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Author: Kenneth S . Korach
Publisher: CRC Press
ISBN: 9781420002898
Category : Medical
Languages : en
Pages : 748
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Book Description
This timely resource offers extensive discussions on the pharmacological, environmental,endocrinological, and natural factors that alter reproductive or developmental processes-elucidating the effects of toxicants on mechanisms of reproduction. Describing biological actions common to both genders as well as gender-specific processes, Reproducti
Author: Xiaoting Zhang
Publisher: Humana Press
ISBN: 9783030075934
Category :
Languages : en
Pages : 432
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Book Description
The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.
Author:
Publisher: ScholarlyEditions
ISBN: 148160242X
Category : Science
Languages : en
Pages : 125
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Book Description
Orphan Nuclear Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Orphan Nuclear Receptors in a concise format. The editors have built Orphan Nuclear Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Orphan Nuclear Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Orphan Nuclear Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Mark L. Latash
Publisher: Academic Press
ISBN: 0128192852
Category : Medical
Languages : en
Pages : 242
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Book Description
Physics of Biological Action and Perception helps researchers interested in exploring biological motor control from a physics or alternative viewpoint perspective. The book introduces the idea of parametric control as a distinguishing feature of living systems. Sections cover how the CNS creates stable percepts based on fuzzy and continuously changing signals from numerous receptors and the variable processes related to ongoing actions. The author also develops the idea of control with referent coordinates to stability of salient variables in fields typically united under the label of "cognition." Examples of this include communication (how the gist of a message is preserved despite variability of phrases), thought processes (how one can solve a mental problem via different logical routes), and playing chess (how one selects an optimal move given a position on the board). The book is written for researchers, instructors, clinicians and other professionals in all the fields related to biological movement and perception. Presents a unifying theory of motor control based on physics Encompasses action, perception and cognition Discusses referent coordinates, kinesthetic perception and stability of actions Identifies the importance of the CNS over computational brain function
