Patterns of Air Flow and Particle Deposition in the Diseased Human Lung PDF Download
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Author: Rebecca Anne Segal
Publisher:
ISBN:
Category :
Languages : en
Pages : 112
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Book Description
Keywords: COPD, tumors, CFD.
Author: Rebecca Anne Segal
Publisher:
ISBN:
Category :
Languages : en
Pages : 112
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Book Description
Keywords: COPD, tumors, CFD.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
In this work, we investigate particle deposition and air flow in thehuman lung. In particular we are interested in how the motion ofparticulate matter and air is affected by the presence of lungdisease. Patients with compromised lung function are more sensitiveto air pollution; understanding the extent of that sensitivity canlead to more effective air quality standards. Also, understanding ofair flow andparticle trajectories could lead to the development of better aerosoldrugs to treat the lung diseases. We focus our efforts on twodiseases: chronic obstructive pulmonary disease (COPD) and bronchialtumors. Because COPD affects the majority of airways in a patientwith the disease, we are able to take a more global approach toanalyzing the effects of the disease. Using a FORTRAN codewhich computes total deposition in the lung over the course of onebreath, we modified the pre-existing code to account forthe difference between healthy subjects and patients with COPD. Usingthe model, itwas possible to isolate the different disease components of COPD andsimulate their effects separately. It was determined thatthe chronic bronchitis component of COPD was responsible for the increaseddeposition seen in COPD patients. While COPD affects the whole lung, tumors tend to belocalized to one or several airways. This led us to investigate theeffects of bronchial tumors in detail within these individualairways. Using a computational fluid dynamics package, FIDAP, wedefined a Weibel type branching network of airways. In particular, we modeled theairways of a four-year-old child. In the work with the tumors, we ran numerous simulations with variousinitial velocities and tumor locations. It was determined that tumorslocated on the carinal ridge had the dominant effect on the flow. Athigher initial velocities, areas of circulation developed downstream from the tumors. Extensive simulations were run with a 2-D model. Theresults from the 2-D model were then compared with some initial 3-Dsimula.
Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
ISBN:
Category : Government publications
Languages : en
Pages : 728
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Book Description
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author: James D. Crapo
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 400
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Book Description
Extrapolation Modeling, Advancements and Research Issues in Lung Dosimetry; Lung Structure, Function Relationships; Species Differences in Airway Cell Distribution and Morphology; Alternative Methods to Evaluate Species Differences in Upper Airway Structure, Function; Preparation of Rat Nasal Airway Casts and Their Application to Studies of Nasal Airflow; Age Related Morphometric Analysis of Human Lung Casts; Anatomical Modeling of Microdosimetry of Inhaled Particles and Gases in the Lung; Experimental Dosimetry; Particle Deposition at the Alveolar Duct Bifurcations; Effects of Airway Branch Angle, Branch Point Number, and Gravity on Particle Deposition and Retention; Regional Deposition of Inhaled Particulates in Conducting Airways and Lung Segments; The Physical Properties of Mainstream Cigarette Smoke and Their Relationship to Deposition in the Respiratory Tract; Localization of 14C Dotriacontane Labeled Cigarette Smoke Particulate in the Dog Lung; Human Lung Clearance Following Bolus Inhalation of Radioaerosols; Effects of Ventilatory Patterns and Pre-existing Disease on Deposition of Inhaled Particles in Animals; Nasopharyngeal Uptake of Ozone in Humans and Animals; New Methods; Regional Dosimetry of Inhaled Particles Using SPECT; Dual Laser Doppler System for Real Time, Simultaneous Characterization of Aerosols by Size and Concentration; Dosimetry of Inhaled Particles by Means of Light Scattering; Modeling Approaches; Issues That Must Be Addressed When Constructing Anatomical Models of the Developing Lung; Significances of the Variability of Tracheobronchial Airway Paths and Their Air Flow Rates to Dosimetry Model Predictions of the Absorption of Gases; Predicting Respiratory Tract Clearance in Man; The Role of Particle Hygroscopicity in Aerosol Therapy and Inhalation Toxicology; Age-Dependent Lung Dosimetry of Radon Progeny; Deposition and Retention Modeling of Inhaled Cadmium in Rat and Human Lung, An Example for Extrapolation of Effects and Risk Estimation.
Author: Chiu-sen Wang
Publisher: Elsevier
ISBN: 0080455018
Category : Technology & Engineering
Languages : en
Pages : 214
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Book Description
Inhaled Particles integrates all that is known about inhaled particles in a unified treatment. It aims to provide a scientific framework essential to a reasonable understanding of inhaled particles. The emphasis is placed on demonstrating the key roles of lung morphology on airflow and particle transport as well as identifying physical and biological factors that influence deposition. Special attention is paid to maintaining consistency of treatment and a balance between theoretical modeling and experimental measurements. The book covers all important aspects of inhaled particles including inhalability, aerosol dispersion, particle deposition, and clearance. It reviews concisely the basic background of lung morphology, respiratory physiology, aerodynamics, and aerosol science pertinent to the subject. Essential aspects of health effects and applications are also included. An easy-to-read, self contained introduction to the field An excellent source of updated research information Useful for students and professionals in aerosol science, environmental health science, occupational hygiene, health physics and biomedical engineering
Author: Sponsored by The Health Effects Institute
Publisher: National Academies Press
ISBN: 0309037263
Category : Science
Languages : en
Pages : 703
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Book Description
"The combination of scientific and institutional integrity represented by this book is unusual. It should be a model for future endeavors to help quantify environmental risk as a basis for good decisionmaking." â€"William D. Ruckelshaus, from the foreword. This volume, prepared under the auspices of the Health Effects Institute, an independent research organization created and funded jointly by the Environmental Protection Agency and the automobile industry, brings together experts on atmospheric exposure and on the biological effects of toxic substances to examine what is knownâ€"and not knownâ€"about the human health risks of automotive emissions.
Author: Nilay Atul Kulkarni
Publisher:
ISBN:
Category :
Languages : en
Pages : 84
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Book Description
Author: National Research Council (U.S.). Subcommittee on Airborne Particles
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 376
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Book Description
Author: Peter Gehr
Publisher: CRC Press
ISBN: 1420072579
Category : Medical
Languages : en
Pages : 324
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Book Description
Written by an expanded team of leading international scientists, the second edition thoroughly investigates research and therapies for managing adverse physiological effects of air-borne particles on the respiratory tract. The book examines the lung as the gateway for particle damage to organs outside the respiratory system and provide the informat
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
People may inhale 100 millions of particles each day, including toxic particulate matter as well as drug aerosols. Some of those deposited in the respiratory system can be either harmful or therapeutic to humans depending upon the particle material, deposition site, and local concentration. These transport and deposition phenomena as well as the resulting biomedical processes are greatly determined by the airflow field, particle properties, breathing pattern, and geometric airway characteristics. Realistic models of tracheobronchial and nasal⁄oral- tracheobronchial airways were built. Airflow and particle transport and deposition in these airway models were investigated in detail by mainly using the validated, in-house FORTRAN code CFPD (computational fluid-particle dynamics), which is a cell-centered, finite volume multi-block code. Both laminar and transitional-turbulent-laminar flows were considered for different transient and steady inhalation flow rates and inlet velocity profiles. The resulting effects of transients, upstream conditions and geometric characteristics, i.e., spatial angle and/or cartilaginous rings, are fully discussed. A new code based on the lattice-Boltzmann method (LBM) has been developed and validated to investigate airflow patterns and pressure changes in representative alveolar structures of the human respiratory zone. The new idea of targeted drug aerosol delivery technology was numerically tested for a more realistic human airway configuration and thereby addressing the problem of inter-subject variability. Specifically, controlled air-particle streams were studied using the oral and asymmetric tracheobronchial airway models. The results were compared with data obtained for a symmetric Weibel Type A tracheobronchial airway model.
