Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome PDF Download
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Author: Helmut Sies
Publisher: CRC Press
ISBN: 142004379X
Category : Medical
Languages : en
Pages : 346
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Book Description
Characterized by obesity, insulin resistance, dyslipidemia, and hypertension, metabolic syndrome is associated with the risks of type 2 diabetes mellitus and cardiovascular disease. Obesity, which increases the incidence of atherosclerotic cardiovascular disease and subsequently leads to increased stress and inflammation, appears to play a central
Author: Helmut Sies
Publisher: CRC Press
ISBN: 142004379X
Category : Medical
Languages : en
Pages : 346
Get Book Here
Book Description
Characterized by obesity, insulin resistance, dyslipidemia, and hypertension, metabolic syndrome is associated with the risks of type 2 diabetes mellitus and cardiovascular disease. Obesity, which increases the incidence of atherosclerotic cardiovascular disease and subsequently leads to increased stress and inflammation, appears to play a central
Author:
Publisher:
ISBN:
Category : Health behavior
Languages : en
Pages :
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Book Description
In the 2001 Surgeon General's Call to Action to Prevent and Decrease Overweight and Obesity, former Surgeon General David Satcher, MD, PhD, warned of the negative effects of the increasing weight of American citizens and outlined a public health response to reverse the trend. The Surgeon General plans to strengthen and expand this blueprint for action created by her predecessor. Although the country has made some strides since 2001, the prevalence of obesity, obesity-related diseases, and premature death remains too high.
Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
ISBN:
Category : Government publications
Languages : en
Pages : 728
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Book Description
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author: H. Böhles
Publisher: CRC Press
ISBN: 9783887631048
Category : Medical
Languages : en
Pages : 188
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Book Description
During the last years the understanding for the aetiology of cardiomyopathies could be greatly improved. A great deal of information has accumulated in the field of inherited metabolic diseases, which provides a new basis for our understanding of many heart muscle problems and their corresponding clinical disease entities. This book is meant to give the reader a comprehensive overview of the cardiological manifestations of inborn errors of metabolism. Latest information, such as cardiomyopathy in Fabry disease or in patients with CDG-syndrome is included. It should be helpful, not only to cardiologists, paediatricians, internists and general practicioners, but also to all those interested in a better understanding of the metabolic basis of clinical disease entities.
Author: Shamim I. Ahmad
Publisher: Springer
ISBN: 3319198211
Category : Medical
Languages : en
Pages : 375
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Book Description
This book brings a comprehensive treatise about obesity, examining the measures that can be taken to stop and even reduce obesity if these right measures are taken in time. Recent studies show that obesity is on the increase at an alarming rate, especially in the industrialized and affluent countries. A number of reasons have been put forward for this increase, including life style choices, over-eating, over-use of commercially processed food, addiction for fast food, high caloric diet specially containing high levels of sugar and fat, lack of exercise and sedentary life style. Also genetic make up has been associated with obesity. Obesity can lead to a variety of lethal diseases, notably coronary heart disease, cancer and diabetes. These diseases account for the highest number of human death amongst all other causes. There are also a number of other side effects associated with obesity including increased stress, loss of intelligentsia, pancreatitis, premature birth and osteoarthritis. In recent years media have been playing important roles in highlighting the lethality and damage caused by obesity, nevertheless no significant effects can be seen in the population and obesity remains on the increase, especially amongst children. The editors believe that it is important that more education, campaign and research are used to stop this increasing disease.
Author: Lawrence H. Lash
Publisher: Elsevier
ISBN: 1483218619
Category : Science
Languages : en
Pages : 527
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Book Description
Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
Author: Bharat B. Aggarwal
Publisher: CRC Press
ISBN: 1439839905
Category : Medical
Languages : en
Pages : 483
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Book Description
Oxidative stress and inflammation are among the most important factors of disease. Chronic infections, obesity, alcohol and tobacco usage, radiation, environmental pollutants, and high-calorie diets have been recognized as major risk factors for a variety of chronic diseases from cancer to metabolic diseases. All these risk factors are linked to ch
Author: Roger D. Cone
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 416
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Book Description
In the decade before the publication of this study, melanocortin biology matured. Three additional receptors were discovered, and animal models were established addressing the function of each receptor. Researchers now know that the diverse physiologic responses to melanocortins - including their role in development, weight and endocrine regulation, cortisol production, secretion from exocrine glands, and pigmentation - can be defined in terms of individual receptors. In this text, contributors from the field of evolutionary biology, peptide chemistry, pigmentation biology, neuroscience, endocrinology and genetics provide the reader with a comprehensive review of melanocortin biology. Six areas of active research are addressed: peptide and small molecule chemistry; receptor structure and function; energy homeostasis; pigmentation; adrenocorticol function; and behaviour. There are 56 papers and 20 posters altogether, taken from the Fifth Melanocortin Meeting, held in 2002.
Author: Bodh I. Jugdutt
Publisher: Springer Science & Business Media
ISBN: 1493902687
Category : Medical
Languages : en
Pages : 482
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Book Description
This book synthesizes the major research advances in molecular, biochemical and translational aspects of aging and heart failure over the last four decades and addresses future directions in management and drug discovery. It presents clinical issues and molecular mechanisms related to heart failure, including the changing demographics in the aging population with heart failure; hypertension and prevention of diastolic heart failure in the aging population; polypharmacy and adverse drug reactions in the aging population with heart failure; changes in the heart that accompany advancing age from humans to molecules; aging-associated alterations in myocardial inflammation and fibrosis and aging-related changes in mitochondrial function and implications for heart failure therapy. The book succinctly summarizes the large volume of data on these key topics and highlights novel pathways that need to be explored. Featuring contributions from leading clinician-scientists, Aging and Heart Failure: Mechanisms and Management is an authoritative resource on the major clinical issues in heart failure therapy in the elderly for cardiologists, gerontologists and internists.
Author: Amelia Marti del Moral
Publisher: Academic Press
ISBN: 0128125055
Category : Medical
Languages : en
Pages : 306
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Book Description
Obesity: Oxidative Stress and Dietary Antioxidants cover the science of oxidative stress in obesity and associated conditions, including metabolic syndrome, bariatric surgery, and the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are not described in isolation, but in concert with other processes, such as apoptosis, cell signaling and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is but a single component. The book is designed for nutritionists, dietitians, food scientists, physicians and clinical workers, health care workers and research scientists. - Covers the basic processes of oxidative stress, from molecular biology, to whole organs - Highlights antioxidants in foods, including plants and other components of diet - Provides the framework for further, in-depth analysis or studies via well-designed clinical trials or via the analysis of pathways, mechanisms and componentsa
