Origin and Evolution of Telomeres PDF Download
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Author: Jozef Nosek
Publisher: CRC Press
ISBN: 1498713491
Category : Science
Languages : en
Pages : 194
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Book Description
Linear chromosomes represent an evolutionary innovation associated with the origin of eukaryotic cells. This book describes how linear chromosomes and primordial pathways for maintaining their terminal structures, telomeres, emerged in early eukaryotes.Telomeres, derived from the Greek meaning terminal part, were first described by Hermann Muller i
Author: Jozef Nosek
Publisher: CRC Press
ISBN: 1498713491
Category : Science
Languages : en
Pages : 194
Get Book Here
Book Description
Linear chromosomes represent an evolutionary innovation associated with the origin of eukaryotic cells. This book describes how linear chromosomes and primordial pathways for maintaining their terminal structures, telomeres, emerged in early eukaryotes.Telomeres, derived from the Greek meaning terminal part, were first described by Hermann Muller i
Author: Jozef Nosek
Publisher:
ISBN: 9780387790718
Category :
Languages : en
Pages :
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Book Description
Author: Titia De Lange
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 598
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Book Description
An up-to-date survey of the current exciting state of telomere biology. Telomeres – specialized structures found at the ends of chromosomes – are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
Author: Nancy L. Craig
Publisher: Amer Society for Microbiology
ISBN: 9781555812096
Category : Science
Languages : en
Pages : 1204
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Book Description
An extension of the original volume, reflecting the latest advances in understanding these elements. This title is published by the American Society for Microbiology Press and distributed by Taylor and Francis in rest of world territories.
Author: Keiko Hiyama
Publisher: Springer Science & Business Media
ISBN: 1603278796
Category : Medical
Languages : en
Pages : 375
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Book Description
Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.
Author: J. McGlade
Publisher: John Wiley & Sons
ISBN: 1444311514
Category : Science
Languages : en
Pages : 368
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Book Description
Advanced Ecological Theory is intended for both postgraduate students and professional researchers in ecology. It provides an overview of current advances in the field as well as closely related areas in evolution, ecological economics, and natural-resource management, familiarizing the reader with the mathematical, computational and statistical approaches used in these different areas. The book has an exciting set of diverse contributions written by leading authorities.
Author: Christopher A. Cullis
Publisher: John Wiley & Sons
ISBN: 0471488585
Category : Science
Languages : en
Pages : 230
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Book Description
Plant research has stood at the forefront of the genomics revolution. One of the first genome projects, the sequencing of the commonly used model organism Arabidopsis, has already yielded important results for the study of a broad array of crops such as corn and soybeans. With crop and food bioengineering only in its infancy, the need to understand the fundamental genetic mechanisms of plants will only become more pressing. A comprehensive guide to this fascinating area of genomics, Plant Genomics and Proteomics presents an integrated, broadly accessible treatment of the complex relationship between the genome, transcriptome, and proteome of plants. This clearly written text introduces the reader to the range of molecular techniques applicable to investigating the unique facets of plant growth, development, and response to the environment. Coverage includes: Functional and structural genomics addressed within the context of current techniques and challenges to come How to utilize DNA and protein sequence data Practical considerations for choosing and employing the most commonly available computer applications A review of applications for biotechnology, including genetic modification and defense against pathogens Bioinformatics tools and Web resources Numerous examples from the latest research throughout Assuming no specialized knowledge of plant biology on the part of its reader, Plant Genomics and Proteomics provides an invaluable resource for students and researchers in biotechnology, plant biology, genomics, and bioinformatics.
Author: David W. Deamer
Publisher:
ISBN: 9781936113040
Category : Science
Languages : en
Pages : 0
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Book Description
Life arose on Earth more than three billion years ago. How the first self-replicating systems emerged from prebiotic chemistry and evolved into primitive cell-like entities is an area of intense research, spanning molecular and cellular biology, organic chemistry, cosmology, geology, and atmospheric science. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive account of the environment of the early Earth and the mechanisms by which the organic molecules present may have self-assembled to form replicating material such as RNA and other polymers. The contributors examine the energetic requirements for this process and focus in particular on the essential role of semi-permeable compartments in containment of primitive genetic systems. Also covered in the book are new synthetic approaches for fabricating cellular systems, the potentially extraterrestrial origin of life's building blocks, and the possibility that life once existed on Mars. Comprising five sections Setting the Stage, Components of First Life, Primitive Systems, First Polymers, and Transition to a Microbial World it is a vital reference for all scientists interested in the origin of life on Earth and the likelihood that it has arisen on other planets
Author: David Gómez Blanco
Publisher:
ISBN: 9789180396455
Category :
Languages : en
Pages : 0
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Book Description
Studying life history strategies is crucial for understanding the diversity among organisms. The trade-offs in traits related to survival, self-maintenance and reproduction play an important role in the variation of life histories and can be adjusted in response to environmental and physiological factors. Telomeres, which are repetitive DNA sequences found at the ends of chromosomes, can serve as molecular markers linking these factors and ultimately fitness. Telomeres naturally shorten with age and stress, such as diseases, and when they become too short, they trigger cellular senescence and ageing. However, some telomere restoration mechanisms can counteract this process. In this thesis, first I have adopted a theoretical approach to review the telomere research field and develop hypotheses for future exploration. Then, I also included an empirical section that aimed to evaluate and test some of these hypotheses' general patterns using data from a wild population of the polygynous bird species, the great reed warbler (Acrocephalus arundinaceus). I have taken advantage of the longitudinal study conducted for 40 years at Lake Kvismaren that have collected a comprehensive dataset on life history, behaviours and fitness components, along with a sampling of all the bird born and breeding in the area. I measured telomere length using the quantitative PCR method, and to investigate the ecological and evolutionary implications of parasites, I used the multiplex PCR method to detect the presence of avian malaria parasites in the birds' blood. In the first part of this thesis, I and my collaborators present a summary of telomere hypotheses that apply to the fields of ecology and evolution. We also classify and group these hypotheses based on their research context and hierarchical similarities. Furthermore, we identify gaps in the knowledge, such as the lack of hypotheses that can clarify telomere elongation patterns in the wild. As a result, we propose and expand on a novel hypothesis that highlights the significance of elongation patterns and encourages further exploration in this area of telomere dynamics. The second section of the thesis aimed to test some of the assumptions made in the previous hypotheses. The studies were focused on examining the existence of a lower threshold for telomere length and I revealed that individuals with critically short telomeres disappeared from the population at a greater rate than those with longer telomeres. Furthermore, life stressors such as infections had an impact on these selection patterns. In this thesis, I also found that even in early-life a considerable percentage of individuals can display a net increase in telomere length (telomere elongation), and this prospect was dependent on factors like infection and the current telomere length. Finally, this thesis demonstrates that various factors including age, malaria status, and harem size can predict the dynamics of telomere length in male and female great reed warblers. These sex-specific telomere dynamics could potentially provide indications of the individual's phenotypic quality. In summary, this thesis has contributed to our understanding of telomere dynamics in the wild, particularly concerning the complex interactions between telomere length, infections and life history trade-offs. It has addressed some gaps in our knowledge of telomere biology and provided insights into important yet under-explored areas, like telomere elongation patterns. The thesis highlights the need for further research into telomere elongation events, the impact of short telomeres on individual life histories, and the potential use of telomeres as a biomarker for individual quality or as a measure of environmental stressors faced.
