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Author: Kursad Turksen
Publisher: Humana
ISBN: 9781493976164
Category : Science
Languages : en
Pages : 363
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Book Description
This detailed volume addresses the challenge of how to instruct stem/early progenitor cells to progress through appropriate steps to generate functional 3-dimensional organs, one of the outstanding issues in regenerative medicine. The field of organoids is geared towards defining and demonstrating the in vitro conditions that achieve this goal. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Organoids: Stem Cells, Structure, and Function serves as an aid to researchers working in this vital area of research.
Author: Kursad Turksen
Publisher: Humana
ISBN: 9781493976164
Category : Science
Languages : en
Pages : 363
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Book Description
This detailed volume addresses the challenge of how to instruct stem/early progenitor cells to progress through appropriate steps to generate functional 3-dimensional organs, one of the outstanding issues in regenerative medicine. The field of organoids is geared towards defining and demonstrating the in vitro conditions that achieve this goal. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Organoids: Stem Cells, Structure, and Function serves as an aid to researchers working in this vital area of research.
Author: Jamie A. Davies
Publisher: Academic Press
ISBN: 012812637X
Category : Science
Languages : en
Pages : 286
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Book Description
Organs and Mini-Organs combines contributions from leading practitioners who work under the editorial control of an acclaimed researcher who also served for eight years as Editor-in-Chief of the journal Organogenesis, the first journal on this topic. The book begins with an introduction, but then delves into chapters that present advice on how to make organoids for many systems. In addition, case studies that illustrate the uses of organioids are presented, along with discussions on future directions and specific problems that need to be solved. - Collects the best protocols of organoid cultures from diverse tissues - Covers a wide range of organs - Includes troubleshooting cases for common, but specific problems for each culture conditions - Provides an entire section on the application of organoids
Author: Kitty Verhoeckx
Publisher: Springer
ISBN: 3319161040
Category : Technology & Engineering
Languages : en
Pages : 341
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Book Description
“Infogest” (Improving Health Properties of Food by Sharing our Knowledge on the Digestive Process) is an EU COST action/network in the domain of Food and Agriculture that will last for 4 years from April 4, 2011. Infogest aims at building an open international network of institutes undertaking multidisciplinary basic research on food digestion gathering scientists from different origins (food scientists, gut physiologists, nutritionists...). The network gathers 70 partners from academia, corresponding to a total of 29 countries. The three main scientific goals are: Identify the beneficial food components released in the gut during digestion; Support the effect of beneficial food components on human health; Promote harmonization of currently used digestion models Infogest meetings highlighted the need for a publication that would provide researchers with an insight into the advantages and disadvantages associated with the use of respective in vitro and ex vivo assays to evaluate the effects of foods and food bioactives on health. Such assays are particularly important in situations where a large number of foods/bioactives need to be screened rapidly and in a cost effective manner in order to ultimately identify lead foods/bioactives that can be the subject of in vivo assays. The book is an asset to researchers wishing to study the health benefits of their foods and food bioactives of interest and highlights which in vitro/ex vivo assays are of greatest relevance to their goals, what sort of outputs/data can be generated and, as noted above, highlight the strengths and weaknesses of the various assays. It is also an important resource for undergraduate students in the ‘food and health’ arena.
Author: National Academies of Sciences Engineering and Medicine
Publisher:
ISBN: 9780309303361
Category : Electronic books
Languages : en
Pages : 144
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Book Description
The United States military is arguably the most intensely technological, complex enterprise in existence. When compared to the gross domestic products of other countries, the Department of Defense (DoD) budget ranks above all but about 20 nations. If viewed as a company, it would be the largest globally with the most employees. Major investments in weapons systems using advanced technologies provide an advantage over competing systems. Each weapon, platform, vehicle, and person in an operating force is a node in one or more advanced networks that provide the ability to rapidly form a coherent force from a large number of broadly distributed elements. DoD's ability to create and operate forces of this nature demands a competent understanding by its workforce of the composition, acquisition, and employment of its technology-enabled forces. Review of Specialized Degree-Granting Graduate Programs of the Department of Defense in STEM and Management focuses on the graduate science, technology, engineering, mathematics and management (STEM+M) education issues of the Air Force, Navy, and Marines. This report assesses the cost, benefits, and organizational placement of DoD institutions that grant degrees in STEM+M and evaluates alternative ways - for example, civilian institutions and distance learning - to ensure adequate numbers and high-quality education outcomes for DoD personnel."--Publisher's description.
Author: Shay Soker
Publisher: Humana Press
ISBN: 3319605119
Category : Medical
Languages : en
Pages : 225
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Book Description
Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.
Author: Eumorphia Remboutsika
Publisher: Frontiers Media SA
ISBN: 2889716600
Category : Science
Languages : en
Pages : 216
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Book Description
Author: Anthony Atala
Publisher: Academic Press
ISBN: 0128010150
Category : Science
Languages : en
Pages : 441
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Book Description
Essentials of 3D Biofabrication and Translation discusses the techniques that are making bioprinting a viable alternative in regenerative medicine. The book runs the gamut of topics related to the subject, including hydrogels and polymers, nanotechnology, toxicity testing, and drug screening platforms, also introducing current applications in the cardiac, skeletal, and nervous systems, and organ construction. Leaders in clinical medicine and translational science provide a global perspective of the transformative nature of this field, including the use of cells, biomaterials, and macromolecules to create basic building blocks of tissues and organs, all of which are driving the field of biofabrication to transform regenerative medicine. - Provides a new and versatile method to fabricating living tissue - Discusses future applications for 3D bioprinting technologies, including use in the cardiac, skeletal, and nervous systems, and organ construction - Describes current approaches and future challenges for translational science - Runs the gamut of topics related to the subject, from hydrogels and polymers to nanotechnology, toxicity testing, and drug screening platforms
Author: Badrul Hisham Yahaya
Publisher: Springer Nature
ISBN: 3030930564
Category : Science
Languages : en
Pages : 209
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Book Description
Organoid Technology for Disease Modelling and Personalised Treatment provides a comprehensive overview of current knowledge of the organoid as a human-organ-in-a-dish, a powerful new technology for studying fundamental aspects of human organ development and disease progression in the search for drugs for personalised treatment. This preclinical tool is extensively being utilised as a model for studying human diseases in a dish, which is critical for accurate predictive modelling in precision medicine. The chapters in this book introduces readers to the numerous applications of organoids in various fields of study, as well as ethical considerations associated with organoids. In stem cell biology and regenerative medicine, where chimaera research, biomaterials for tissue vascularisation, gene-editing technologies, and their use in clinical procedures especially issues related to ethical concern over the use of human organoids have gotten much attention. Organoid Technology for Disease Modelling and Personalised Treatment is an excellent resource for in-depth research on one of the most interesting and significant topics in stem cell and regenerative medicine. This book's chapter collection covers a fresh viewpoint on organoid technology that scholars will require reading.
Author: Jonathan Soboloff
Publisher: CRC Press
ISBN: 149870509X
Category : Medical
Languages : en
Pages : 258
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Book Description
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Author:
Publisher: Academic Press
ISBN: 9780128134818
Category : Science
Languages : en
Pages : 150
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Book Description
Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication
