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Author: Hélène Pellissier
Publisher: Royal Society of Chemistry
ISBN: 1839166363
Category : Science
Languages : en
Pages : 171
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Book Description
In a classical kinetic resolution, two enantiomers of a racemate are transformed into chiral products at different rates with a maximum theoretical yield of 50%. However, the need to reduce costs and waste in synthesis have led to efforts to develop novel resolution procedures proceeding beyond this 50% limited yield. This has led to the evolution of classical kinetic resolution into dynamic kinetic resolution (DKR), allowing a quantitative yield of one of the enantiomers. DKR combines the resolution step of kinetic resolution with an in-situ racemization of the chirally-labile substrate. It is only in the last two decades that chiral green organocatalysts have been demonstrated to be capable of promoting DKRs considerably expanding the synthetic scope of the powerful concept of DKR. Collecting all the developments in the field of DKR, this book shows that a wide variety of organocatalysts allow excellent levels of stereocontrol and yields in many types of transformations. It is a great resource for academics and industrialists interested in green enantioselective catalytic reactions.
Author: Hélène Pellissier
Publisher: Royal Society of Chemistry
ISBN: 1839166363
Category : Science
Languages : en
Pages : 171
Get Book Here
Book Description
In a classical kinetic resolution, two enantiomers of a racemate are transformed into chiral products at different rates with a maximum theoretical yield of 50%. However, the need to reduce costs and waste in synthesis have led to efforts to develop novel resolution procedures proceeding beyond this 50% limited yield. This has led to the evolution of classical kinetic resolution into dynamic kinetic resolution (DKR), allowing a quantitative yield of one of the enantiomers. DKR combines the resolution step of kinetic resolution with an in-situ racemization of the chirally-labile substrate. It is only in the last two decades that chiral green organocatalysts have been demonstrated to be capable of promoting DKRs considerably expanding the synthetic scope of the powerful concept of DKR. Collecting all the developments in the field of DKR, this book shows that a wide variety of organocatalysts allow excellent levels of stereocontrol and yields in many types of transformations. It is a great resource for academics and industrialists interested in green enantioselective catalytic reactions.
Author: Hélène Pellissier
Publisher: Royal Society of Chemistry
ISBN: 1839165650
Category : Science
Languages : en
Pages : 171
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Book Description
Collecting for the first time all the developments in the field of DKR, this book shows that a variety of organocatalysts allow excellent levels of stereocontrol and yields in many types of transformations.
Author: Aldo Peschiulli
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Jan-E. Bäckvall
Publisher: Georg Thieme Verlag
ISBN: 3132453781
Category : Science
Languages : en
Pages : 544
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Book Description
Principles and applications of DKR and DYKAT DKR and DYKAT are of ever increasing importance in the synthesis of enantiomerically enriched compounds. The preparation of enantiomerically pure compounds is of great importance in society today, in particular in pharmaceutical chemistry and in the agrochemical sector. Kinetic resolution is a popular method for differentiating two enantiomers in a racemic mixture that react at different rates with a chiral catalyst or reagent. The drawback of kinetic resolution is that the yield of one pure enantiomer is limited to a maximum of 50%. To overcome this limitation, an in situ racemization of the starting material can be combined with a kinetic resolution. This combination leads to a so called “dynamic kinetic resolution” (DKR), where the two enantiomers are in equilibrium with one another. The slow-reacting enantiomer will continuously be converted into the fast-reacting one, when the latter is transformed into the enantiomerically pure product. Thus, a racemic starting material can be transformed in catalytic processes into a single isomer of a chiral compound in up to 100% yield. DKR only applies to the resolution of racemic mixtures and the involvement of enantiomers leads to simple kinetics. When diastereomers, either as starting materials or as diastereomeric intermediates, are involved in the resolution process under dynamic conditions (via equilibria between diastereomers), the kinetics is different from DKR. These reactions are classified as “dynamic kinetic asymmetric transformations” (DYKAT). This volume covers the principles of DKR and DYKAT and presents examples of organocatalytic, chemoenzymatic, and transition-metal catalyzed approaches, including applications in the synthesis of complex, biologically active compounds.
Author: Keiji Maruoka
Publisher: John Wiley & Sons
ISBN: 3527622632
Category : Science
Languages : en
Pages : 228
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Book Description
Edited by the leading expert on the topic, this is the first book to present the latest developments in this exciting field. Alongside the theoretical aspects, the top contributors provide practical protocols to give readers additional important information otherwise unavailable. A must for every synthetic chemist in academia and industry.
Author: Uwe Theo Bornscheuer
Publisher: John Wiley & Sons
ISBN: 3527607129
Category : Science
Languages : en
Pages : 368
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Book Description
From reviews to the first edtion: "Bornscheuer and Kazlauskas have set out, and succeeded, in producing a definitive manual on hydrolytic enzymes (especially lipases, esterases, and proteases) for organic chemists. This is quite simply the best book of its type and can be unreservedly recommended to organic chemists who have an interest in using hydrolytic enzymes in synthesis." (Nicholas J. Turner, University of Edinburgh) "The book is an indispensable source of information on the use of hydrolases in organic synthesis. The subject matter is very well set out, and the chapters are clearly written and presented from a critical viewpoint. Bornscheuer and Kazlauskas have succeeded admirably in describing the capabilities and limitations of the use of hydrolytic enzymes and in critically evaluating them. No library should be without the book." (Fritz Theil, WITEGA Angewandte Werkstoff-Forschung GmbH, Berlin) The second edition of this extremely successful and well-proven book presents recent developments in the use of hydrolases for organic synthesis, reflecting in particular the enormous progress made in enzyme discovery and optimization with a new chapter on "Protein Sources and Optimization of Biocatalyst Performance". The renowned authors survey the stereoselective reactions of hydrolases, especially lipases, esterases and proteases, giving researchers an overview of what has worked in the past so that they can judge how to solve their own synthetic problems. In total, the book contains over one thousand chemical structures, rounded off by some 1,800 invaluable references.
Author: Hans Ulrich Blaser
Publisher: John Wiley & Sons
ISBN: 3527605770
Category : Science
Languages : en
Pages : 483
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Book Description
Edited by two of the experts in the field, the central aim is to show organic chemists working in process development that enantioselective catalysis is suitable for the large-scale production of enantioenriched intermediates. In so doing, it is equally a source of information and inspiration for academic research, and, with its contribution by Noble prizewinner W. S. Knowles, will also heighten the status of industrial catalyst specialists working in the exciting field of enantioselective catalysis. Some 25 contributions from top industrial researchers around the world present case studies on the development of the widest possible range of large-scale enantioselective processes, featuring stereoselective production processes of fine-chemicals, agrochemicals and pharmaceuticals. Clearly structured according to the nature of the task, this handbook adopts a problem-driven approach such that readers can easily find how colleagues have dealt with a similar situation.
Author: Manfred Reetz
Publisher: Springer Science & Business Media
ISBN: 3540734953
Category : Science
Languages : en
Pages : 348
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Book Description
This book provides an excellent overview on state-of-the-art of modern organocatalysis. It presents the contributions from leading experts, with backgrounds in academia and industry, to an Ernst Schering Research Foundation Symposium held in April 2007. It will be of interest to those who want a general overview of the topic, but also to those who want to learn more about the state-of-the-art, current trends and perspectives in this highly dynamic field of research.
Author: Bin Tan
Publisher: John Wiley & Sons
ISBN: 3527347127
Category : Science
Languages : en
Pages : 338
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Book Description
Axially Chiral Compounds Explore this comprehensive and current volume summarizing the characteristics, synthesis, and applications of axial chirality Appearing widely in natural products, biologically active molecules, asymmetric chemistry, and material science, axially chiral motifs constitute the core backbones of the majority of chiral ligands and organocatalysts in asymmetric catalysis. In a new work of particular relevance to synthetic chemists, Axially Chiral Compounds: Asymmetric Synthesis and Applications delivers a clearly structured and authoritative volume covering the classification, characteristics, synthesis, and applications of axial chirality. A must read for every synthetic chemist practicing today, the book follows the development history, research status, and applications of axial chirality. An introductory chapter familiarizes the reader with foundational material before the distinguished authors describe the different classes and the synthesis of axial chiral compounds used in asymmetric synthesis. The book concludes with a focus on the applications of chiral ligands, chiral catalysts, and materials. Readers will also benefit from the inclusion of: A thorough introduction to asymmetric synthesis, including biaryls atropisomers, heterobiaryls atropisomers, and non-biaryls atropisomers Explorations of chiral allene, spiro skeletons, and natural products Practical discussions of asymmetric transformation, chiral ligands, and chiral catalysts An examination of miscellaneous applications of axially chiral compounds Perfect for organic chemists, chemists working with or on organometallics, catalytic chemists, and materials scientists, Axially Chiral Compounds: Asymmetric Synthesis and Applications will also earn a place in the libraries of natural products chemists who seek a one-stop reference for compounds exhibiting axial chirality.
Author: Iyad Karamé
Publisher: BoD – Books on Demand
ISBN: 9535126725
Category : Science
Languages : en
Pages : 194
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Book Description
Organocatalysis has recently attracted enormous attention as green and sustainable catalysis. It was realized as a fundamental field providing wide families of catalysts for important organic transformations. It will certainly develop in the future. Given the diversity of accessible transformations, metal-catalyzed reactions have become major tools in organic synthesis that will undoubtedly continue to have an important impact in the future. Alternatively, over the last years, a metal-free approach such as organocatalysis has reached a level of faithfulness, allowing researchers to discover new catalytic systems based on engagement of new or early-prepared organic molecules as organocatalysts. Organocatalysis meets green chemistry principles, especially the reduction of toxicity and chemical accidents, the biodegradability, and the use of benign and friendlier reaction media and conditions.
