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Author: Sanaa Ben Djemaa
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Dans l'optique d'améliorer le traitement des cancer du sein triple négatif (CSTN), les objectifs de ces travaux de thèse sont : 1) d'optimiser la formulation d'un nanovecteur de siRNA fonctionnalisé par un peptide membranotrope (CS-MSN) pour augmenter son efficacité de transfection et pour avoir des caractéristiques compatibles avec une administration par voie systémique, ii) étudier ses voies d'internalisation et son trafic et devenir intracellulaire et iii) valider son efficacité sur un modèle cellulaire de CSTN. L'optimisation de la formulation des CS-MSN a abouti à un nanovecteur d'une taille d'environ 170 nm avec une charge de surface légèrement positive. Les CS-MSN ont montré une capacité à protéger les siRNA contre la dégradation en présence du sérum sans toxicité remarquable sur les cellules. L'entrée des CS-MSN dans les cellules est augmentée par la présence du peptide membranotrope gH625 à leur surface et elle implique une voie d'endocytose médiée par les clathrines et par les cavéoles. Les CS-MSN ont montré une capacité à échapper à la dégradation par les vésicules endo-lysosomales, cet échappement étant facilité par la présence du peptide gH625. Cet échappement endosomal résulte en une inhibition de 73 % de l'expression de la protéine GFP et une réduction significative de l'ARNm et de la protéine Bcl-xL.
Author: Sanaa Ben Djemaa
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Dans l'optique d'améliorer le traitement des cancer du sein triple négatif (CSTN), les objectifs de ces travaux de thèse sont : 1) d'optimiser la formulation d'un nanovecteur de siRNA fonctionnalisé par un peptide membranotrope (CS-MSN) pour augmenter son efficacité de transfection et pour avoir des caractéristiques compatibles avec une administration par voie systémique, ii) étudier ses voies d'internalisation et son trafic et devenir intracellulaire et iii) valider son efficacité sur un modèle cellulaire de CSTN. L'optimisation de la formulation des CS-MSN a abouti à un nanovecteur d'une taille d'environ 170 nm avec une charge de surface légèrement positive. Les CS-MSN ont montré une capacité à protéger les siRNA contre la dégradation en présence du sérum sans toxicité remarquable sur les cellules. L'entrée des CS-MSN dans les cellules est augmentée par la présence du peptide membranotrope gH625 à leur surface et elle implique une voie d'endocytose médiée par les clathrines et par les cavéoles. Les CS-MSN ont montré une capacité à échapper à la dégradation par les vésicules endo-lysosomales, cet échappement étant facilité par la présence du peptide gH625. Cet échappement endosomal résulte en une inhibition de 73 % de l'expression de la protéine GFP et une réduction significative de l'ARNm et de la protéine Bcl-xL.
Author: Steven Kronowitz
Publisher: CRC Press
ISBN: 1000762211
Category : Business & Economics
Languages : en
Pages : 499
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Book Description
Oncoplastic and Reconstructive Management of the Breast, Third Edition provides a comprehensive and contemporary account of techniques in oncoplastic and reconstructive breast surgery. Uniquely, this book includes short, concise chapters containing only the most critical information. Many of the chapters are entitled "My Approach" and this enables the reader to gain an insight into the clinical practice of the world's breast disease experts. The true multidisciplinary nature of the book ensures that the perspectives of all members of the breast cancer team are included. This transfer of knowledge between disciplines leads to improved patient care and the integration of multidisciplinary treatment, thus providing an educational and practical multidisciplinary breast cancer book for practicing breast cancer doctors, and trainees worldwide.
Author: Simona Stolnicu
Publisher: Springer
ISBN: 3319932578
Category : Medical
Languages : en
Pages : 510
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Book Description
This book presents the basic concepts for understanding and practicing breast pathology in routine practice. It explains how to tackle the diagnosis, emphasizing diagnostic clues for each entity as well as pitfalls and mimickers. Each chapter has concise, relevant text illustrated by numerous high-quality pictures highlighting the pearls and challenges in the diagnosis of breast lesions. Experts from around the world describe common and rarer conditions affecting the breast. Histology, immunohistochemistry, cytology, radiology and key morphologic criteria are covered. The book includes a chapter dedicated to breast normal histology, which is very important for understanding breast pathology, and a separate chapter for breast radiology, which is essential in understanding and diagnosing the breast lesions especially in a multidisciplinary team. Also, there is a chapter with the latest TNM staging system as well as the recently revised World Health Organization classification of breast tumors. Since in many breast units the cytology is still used to diagnose breast lesions there is a chapter dedicated to this technique. This book is aimed at trainees and practicing pathologists in surgical pathology, particularly those with an interest in breast pathology and those tackling the daily sign-out.
Author: Monica Castiglione
Publisher: Springer Science & Business Media
ISBN: 0387751157
Category : Medical
Languages : en
Pages : 483
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Book Description
Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. Proven success in using medical therapies allowing for breast conserving procedures or reducing risk of occurrence. Although there has been much progress towards a cure, including the introduction of new targeted therapies, metastasizing cancer remains highly incurable.
Author: Fathia Mami-Chouaib
Publisher: Frontiers Media SA
ISBN: 2889459608
Category :
Languages : en
Pages : 183
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Book Description
Tissue-resident memory T (TRM) cells play a major role in control of viral infections. Their involvement in cancer diseases has been more recently demonstrated. This non-circulating T-lymphocyte subset lacks molecules enabling egress from the tissue and migration to lymph nodes, expresses specific markers of residency and displays specific transcription factors. The present special issue elucidates our current knowledge on CD8+ TRM cells and explores less frequently described resident subsets, such as CD4+ TRM and innate-like cells, as well as their specific metabolism and niches for their formation in infectious and cancer diseases.
Author: Oreste Gentilini
Publisher: Springer Nature
ISBN: 3030247627
Category : Medical
Languages : en
Pages : 218
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Book Description
This contributed book covers all aspects concerning the clinical scenario of breast cancer in young women, providing physicians with the latest information on the topic. Young women are a special subset of patients whose care requires dedicated expertise. The book, written and edited by internationally recognized experts who have been directly involved in the international consensus guidelines for breast cancer in young women, pays particular attention to how the disease and its planned treatment can be effectively communicated to young patients. Highly informative and carefully structured, it provides both theoretical and practice-oriented insight for practitioners and professionals involved in the different phases of treatment, from diagnosis to intervention, to follow-up – without neglecting the important role played by prevention.
Author: Alan D. Lopez
Publisher: World Bank Publications
ISBN: 0821362631
Category : Medical
Languages : en
Pages : 511
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Book Description
Strategic health planning, the cornerstone of initiatives designed to achieve health improvement goals around the world, requires an understanding of the comparative burden of diseases and injuries, their corresponding risk factors and the likely effects of invervention options. The Global Burden of Disease framework, originally published in 1990, has been widely adopted as the preferred method for health accounting and has become the standard to guide the setting of health research priorities. This publication sets out an updated assessment of the situation, with an analysis of trends observed since 1990 and a chapter on the sensitivity of GBD estimates to various sources of uncertainty in methods and data.
Author: Richard J. Wassersug, PhD
Publisher: Springer Publishing Company
ISBN: 0826183956
Category : Health & Fitness
Languages : en
Pages : 247
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Book Description
Praise for Androgen Deprivation Therapy: "To my knowledge [this] is the only book written in plain language (no medical jargon) explaining what’s happening during ADT, and detailing how to limit and often solve most associated side effects. It should be read by every man undergoing ADT, as well as family members and also healthcare providers. They will find all the details they need to get the most from this treatment..." Prof. N. Mottet, MD, PhD, Urologist, Medical Oncologist, Head of the Prostate Cancer Guidelines panel of the European Association of Urology Androgen Deprivation Therapy is the only guide written exclusively about the side effects of hormone therapy. The authors have collaborated with the European Association of Urology to produce this specially revised new edition to serve men affected by ADT across the globe. This comprehensive workbook for prostate cancer patients and their loved ones is filled with practical advice from experts in the field. The book covers a wealth of strategies to help men cope with ADT and maintain a good quality of life while on this treatment. It is not only an informational manual, but a guide for both patients and partners about ways to make changes in their lives that can keep them healthy and positive when the patient is on ADT. New to this Edition: Updates on the physical side effects of ADT and management strategies Expanded information on exercise and nutrition for men diagnosed with prostate cancer Updates on the primary drugs used to treat prostate cancer and extensive drug tables with common brand names worldwide Revisions throughout based on critical feedback from international medical experts in the field of prostate cancer and related disciplines Exercises, activities, worksheets, and other tools to promote discussion and inspire behavioural changes that can reduce the burden of ADT Officially endorsed by the European Association of Urology
Author: Sighard Neckel
Publisher: Springer
ISBN: 3319528874
Category : Psychology
Languages : en
Pages : 311
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Book Description
This interdisciplinary book explores both the connections and the tensions between sociological, psychological, and biological theories of exhaustion. It examines how the prevalence of exhaustion – both as an individual experience and as a broader socio-cultural phenomenon – is manifest in the epidemic rise of burnout, depression, and chronic fatigue. It provides innovative analyses of the complex interplay between the processes involved in the production of mental health diagnoses, socio-cultural transformations, and subjective illness experiences. Using many of the existing ideologically charged exhaustion theories as case studies, the authors investigate how individual discomfort and wider social dynamics are interrelated. Covering a broad range of topics, this book will appeal to those working in the fields of psychology, sociology, medicine, psychiatry, literature, and history.
Author: M.W. Büchler
Publisher: Springer Science & Business Media
ISBN: 3540274499
Category : Medical
Languages : en
Pages : 284
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Book Description
Rectal cancer is one of the most prevalent cancers world-wide. It is also a paradigm for multimodal management, as the combination of surgery, chemotherapy and radiotherapy is often necessary to achieve the optimal outcome. Recently, international experts met in Heidelberg, Germany to discuss the latest developments in the management of rectal cancer, including the anatomic and pathologic basis, staging tools, surgical concepts including fast-track surgery and laparoscopic resection, functional outcome after surgery and the role of radio- and chemotherapy. This monograph summarizes this meeting and gives an extensive overview of the current concepts in management of rectal cancer.
