Oncolytic Viruses - Genetically Engineering the Future of Cancer Therapy PDF Download
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Author: Benjamin Gesundheit
Publisher: Frontiers Media SA
ISBN: 2889453588
Category :
Languages : en
Pages : 195
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Book Description
The ability to genetically engineer oncolytic viruses in order to minimize side effects and improve the selective targeting of tumor cells has opened up novel opportunities for treating cancer. Understanding the mechanisms involved and the complex interaction between the viruses and the immune system will undoubtedly help guide the development of new strategies. Theranostic biomarkers to monitor these therapies in clinical trials serve an important need in this innovative field and demand further research.
Author: Benjamin Gesundheit
Publisher: Frontiers Media SA
ISBN: 2889453588
Category :
Languages : en
Pages : 195
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Book Description
The ability to genetically engineer oncolytic viruses in order to minimize side effects and improve the selective targeting of tumor cells has opened up novel opportunities for treating cancer. Understanding the mechanisms involved and the complex interaction between the viruses and the immune system will undoubtedly help guide the development of new strategies. Theranostic biomarkers to monitor these therapies in clinical trials serve an important need in this innovative field and demand further research.
Author: David H. Kirn
Publisher: Humana
ISBN: 9781493958122
Category : Medical
Languages : en
Pages : 241
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Book Description
Since the first report of an engineered oncolytic virus, there has been a continuing and steady increase of interest in the field, and while bench research remains vital for the translation of research in this field, its success depends on breakthroughs in clinical studies. Oncolytic Viruses: Methods and Protocols describes the construction and purification of capsid-modified adenoviruses as well as oncolytic adenoviruses, presents protocols for many individual virus species including engineering and preparation of oncolytic HSV, propagation, purification, and in vivo testing of oncolytic VSV, details properties of oncolytic reovirus and NDV, and describes the generation and testing of next generation of oncolytic vaccinia virus. As the host immune system plays a critical role in determining efficacy of oncolytic viruses, two chapters are devoted to the study of immune response. Recent advances in stem cell research have led the field in two distinct directions: the use of stem cells as carrier vehicles for oncolytic viruses and the targeting of cancer stem cells. As such, the volume describes the use of explant tissue samples from patients to potentially provide useful information predicting responses prior to clinical translation. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Oncolytic Viruses: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies in an effort to further our knowledge of this essential and vital field.
Author: Dr. Hakim. K. Saboowala
Publisher: Dr.Hakim Saboowala
ISBN:
Category : Medical
Languages : en
Pages : 40
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Book Description
Understanding the “Oncolytic Virus (OV) Basis & Therapy.” Oncolytic viruses (OVs) are an emerging class of cancer therapeutics that offer the: · Benefits of selective replication in tumour cells, · Delivery of multiple eukaryotic transgene payloads, · Induction of immunogenic cell death and promotion of antitumour immunity, and · Tolerable safety profile that largely does not overlap with that of other cancer therapeutics. To date, four OVs and one non-oncolytic virus have been approved for the treatment of cancer globally although talimogene laherparepvec (T-VEC) remains the only widely approved therapy. Despite increasing research interest, a better understanding of the underlying biology of OVs is needed to enable the full therapeutic potential of these agents in patients with cancer. Thus, it is strived in this Booklet to precisely describe: ü Time-line History of oncolytic virus development, ü Mechanisms of Tumour Tropism, ü Mechanisms of action of virus destroying tumour cells and ü Inherent and engineered oncolytic viruses. Further, it is also attempted to describe on optimization of the use of OVs in clinical practice along with plenty of relevant IMAGES for better understanding. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)
Author: Dr. Hakim Saboowala
Publisher: Dr.Hakim Saboowala
ISBN:
Category : Medical
Languages : en
Pages : 56
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Book Description
In recent years, there has been an explosion in the number of immune-oncology drugs approved or in development for cancer treatment, and some of these therapies have demonstrated objective responses not seen with small molecules Three oncolytic viruses (OVs): 1. an echovirus, 2. an adenovirus, and 3. a herpes simplex-1virus, have passed governmental regulatory approval in Latvia, China, and the USA and EU. Numerous other recombinant viruses from diverse families are in clinical testing in cancer patients and we highlight the design features of selected examples, including: · Adenovirus, · Herpes simplex virus, · Measles virus, · Retrovirus, · Reovirus, · Vaccinia virus, · Vesicular stomatitis virus. An attempt has been made in this Booklet to discuss current clinical advancements in oncolytic viral therapy, with a focus on the viral platforms approved for clinical use and highlights the benefits each platform provides. Further, thoughts have been provided on the path forward for this rapidly expanding field especially in combination with immune modulating drugs …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)
Author: Christine E. Engeland
Publisher: Humana
ISBN: 9781493997961
Category : Medical
Languages : en
Pages : 329
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Book Description
This book aims to provide a guide for virologists, translational researchers, and clinicians in the field of cancer research by providing reference protocols and methodologies from vector development through clinical translation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Oncolytic Viruses: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Author: Fouad Sabry
Publisher: One Billion Knowledgeable
ISBN:
Category : Medical
Languages : en
Pages : 288
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Book Description
What Is Oncolytic Virus A virus is said to be oncolytic if it targets cancer cells for infection and then proceeds to destroy those cells. As a result of the oncolysis, infected cancer cells are being eliminated, which results in the production of additional infectious virus particles called virions, which further contribute to the elimination of the residual tumor. It is believed that oncolytic viruses not only induce the direct killing of tumor cells, but also activate the host's anti-tumor immune system responses. [Citation needed] [Citation needed] In addition to this, oncolytic viruses are able to influence the microenvironment of the tumor in a variety of different ways. How You Will Benefit (I) Insights, and validations about the following topics: Chapter 1: Oncolytic virus Chapter 2: Virotherapy Chapter 3: Virus latency Chapter 4: Herpes simplex virus Chapter 5: Tony Minson Chapter 6: Genetically modified virus Chapter 7: Pelareorep Chapter 8: Pexastimogene devacirepvec Chapter 9: Herpes simplex research Chapter 10: Jennerex Chapter 11: Talimogene laherparepvec Chapter 12: Oncolytic herpes virus Chapter 13: Oncolytic adenovirus Chapter 14: GL-ONC1 Chapter 15: Genelux Corporation Chapter 16: ONCOS-102 Chapter 17: Akseli Hemminki Chapter 18: Infected cell protein 34.5 Chapter 19: Oncolytic AAV Chapter 20: HSV epigenetics Chapter 21: Transgene (company) (II) Answering the public top questions about oncolytic virus. (III) Real world examples for the usage of oncolytic virus in many fields. (IV) 17 appendices to explain, briefly, 266 emerging technologies in each industry to have 360-degree full understanding of oncolytic virus' technologies. Who This Book Is For Professionals, undergraduate and graduate students, enthusiasts, hobbyists, and those who want to go beyond basic knowledge or information for any kind of oncolytic virus.
Author: Philippe Fournier
Publisher: Frontiers Media SA
ISBN: 2889194507
Category : Cancer
Languages : en
Pages : 111
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Book Description
Oncolytic viruses (OVs) have emerged as a promising anticancer treatment. OVs selectively infect, replicate in, and kill tumor cells. Oncolytic viral therapy occurs in two phases: an initial phase where the virus mediates direct oncolysis of tumor cells, and a second phase where an induced post-oncolytic immune response continues to mediate tumor destruction and retards progression of the disease. For a long time, the therapeutic efficacy was thought to depend mainly on the direct viral oncolysis based on their tumor selective replication and killing activities. But the post-oncolytic anti-tumor activity induced by the OV therapy is also a key factor for an efficient therapeutic activity. The topic adresses various strategies how to optimize OVs anti-tumor activity.
Author: Kevin J. Harrington
Publisher: John Wiley & Sons
ISBN: 047098578X
Category : Science
Languages : en
Pages : 432
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Book Description
In the last decade there has been an explosion of interest in viral therapies for cancer. Viral agents have been developed that are harmless to normal tissues but selectively able to kill cancer cells. These agents have been endowed with additional selectivity and potency through genetic manipulation. Increasingly these viruses are undergoing evaluation in clinical trials, both as single agents and in combination with standard chemotherapy and radiotherapy. This book provides a comprehensive yet succinct overview of the current status of viral therapy of cancer. Chapters coherently present the advances made with individual agents and review the biological and clinical background to a range of viral therapies: structured to proceed from basic science at the bench to the patient’s bedside, they give an up-to-date and realistic evaluation of a therapy’s potential utility for the cancer patient. Presents state of the art knowledge on how viruses can be, and have been, used in novel therapeutic approaches for the treatment of cancer Describes the use of viruses as oncolytic agents, killing cells directly Editors are experts in the field, with experience of both laboratory and clinical research Viral Therapy of Cancer is essential reading for both basic scientists and clinicians with an interest in viral therapy and gene therapy.
Author:
Publisher: Elsevier
ISBN: 0443192502
Category : Science
Languages : en
Pages : 276
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Book Description
Viral Vectors in Cancer Immunotherapy, Volume 379 in the International Review of Cell and Molecular Biology presents the latest on cancer immunotherapy and how it has transformed cancer treatment through advances in immune checkpoint inhibitors and adoptive cell therapy. Chapters in this new release include Past, present and future of viral vectors in cancer immunotherapy, Alphaviruses in cancer immunotherapy, Adenoviral-based cancer gene therapy, Armored modified vaccinia Ankara in cancer immunotherapy, Strategies of Semliki Forest virus in immuno-oncology, Maraba virus in cancer immunotherapy, Oncolytic viruses in hematological malignancies, Oncolytic virus for cancer therapies: Overview and future directions, and more. The use of genetically modified viruses allows the expression of pro-inflammatory molecules, while the immune system receives danger signals from the viruses themselves. In some cases, the virus can also induce tumor cell death. This book will review advances in virus-based cancer immunotherapy in both solid tumors and hematologic malignancies. Provides an overview of the landscape of virotherapy for solid tumors and hematologic malignancies Reviews advances in alphaviruses, adenoviruses, vaccinia viruses and Maraba virus Presents lessons on how to improve viruses to enhance immune responses
Author:
Publisher: Academic Press
ISBN: 0128145161
Category : Science
Languages : en
Pages : 4109
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Book Description
Encyclopedia of Virology, Fourth Edition, Five Volume Set builds on the solid foundation laid by the previous editions, expanding its reach with new and timely topics. In five volumes, the work provides comprehensive coverage of the whole virosphere, making this a unique resource. Content explores viruses present in the environment and the pathogenic viruses of humans, animals, plants and microorganisms. Key areas and concepts concerning virus classification, structure, epidemiology, pathogenesis, diagnosis, treatment and prevention are discussed, guiding the reader through chapters that are presented at an accessible level, and include further readings for those needing more specific information. More than ever now, with the Covid19 pandemic, we are seeing the huge impact viruses have on our life and society. This encyclopedia is a must-have resource for scientists and practitioners, and a great source of information for the wider public. Offers students and researchers a one-stop shop for information on virology not easily available elsewhere Fills a critical gap of information in a field that has seen significant progress in recent years Authored and edited by recognized experts in the field, with a range of different expertise, thus ensuring a high-quality standard
