Omega-3 Fatty Acids Attenuate DNA Damage in Experimental Diabetes PDF Download
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Author: Jihan Hussein
Publisher: LAP Lambert Academic Publishing
ISBN: 9783659664762
Category :
Languages : en
Pages : 148
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Book Description
Supplementation of omega-3 fatty acids is very effective in reducing oxidative stress through the improvement of antioxidant enzymes activities . Fish and flaxseed oils are nutritional supplements have a high concentration of omega-3 fatty acids.Flax seed oil is rich in alpha linolenic acid (ALA) while fish oil is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In this study we aimed to compare the effects of flaxseed and fish oils in reducing oxidative stress especially in attenuating DNA damage through the evaluation of urinary 8-hydroxyguanosine (8-OHdG) in experimental diabetes. The main finding in our study was the reduction of urinary isoprostanes and 8-OHdH, in addition to the reduction of insulin resistance during diabetes. In conclusion, flaxseed and fish oils administration has a potential effect on decreasing insulin resistance in diabetic rats through the scavenging of free radicals and increasing superoxide dismutase . This study also concluded that, fish oil was more effective than flaxseed oil.
Author: Jihan Hussein
Publisher: LAP Lambert Academic Publishing
ISBN: 9783659664762
Category :
Languages : en
Pages : 148
Get Book Here
Book Description
Supplementation of omega-3 fatty acids is very effective in reducing oxidative stress through the improvement of antioxidant enzymes activities . Fish and flaxseed oils are nutritional supplements have a high concentration of omega-3 fatty acids.Flax seed oil is rich in alpha linolenic acid (ALA) while fish oil is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In this study we aimed to compare the effects of flaxseed and fish oils in reducing oxidative stress especially in attenuating DNA damage through the evaluation of urinary 8-hydroxyguanosine (8-OHdG) in experimental diabetes. The main finding in our study was the reduction of urinary isoprostanes and 8-OHdH, in addition to the reduction of insulin resistance during diabetes. In conclusion, flaxseed and fish oils administration has a potential effect on decreasing insulin resistance in diabetic rats through the scavenging of free radicals and increasing superoxide dismutase . This study also concluded that, fish oil was more effective than flaxseed oil.
Author: Ronald Ross Watson
Publisher: Academic Press
ISBN: 0128152397
Category : Medical
Languages : en
Pages : 520
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Book Description
Research has clearly established a link between omega fatty acids and general health, particularly cardiovascular health. Omega Fatty Acids in Brain and Neurological Health, Second Edition, illustrates the importance of omega-3 fatty acids in longevity, cognitive impairment and structure and function of the brain's neurons and also the adverse effects of omega-6 fatty acids on neurological function. This book encompasses some of the most recent research on the links between omega fatty acids and the developing brain, aging, dementia, Alzheimer's disease and multiple sclerosis, including the role of omega-3 fatty acid supplements on hippocampal neurogenesis, substantia nigra modulation, migraine headaches, the developing brain in animals, sleep and neurodegenerative diseases. This completely updated second edition focuses on the counterbalancing dietary and tissue omega-6 fatty acids as well as it studies the effects in pregnancy and early infancy, animal model studies and autoimmune neurological diseases. - Provides a comprehensive introduction to omega-3 and omega-6 fatty acids in neurological health and directions for future research - Features novel focus on the adverse effects of omega-6 fatty acids on neurological function and the counterbalancing of dietary and tissue omega-6 - Illustrates the importance of omega-3 fatty acids in longevity and cognitive impairment - Features new chapters on early effects in pregnancy and early infancy, animal model studies and autoimmune neurological diseases - Discusses links between omega fatty acids and the developing brain, aging, dementia, Alzheimer's disease and multiple sclerosis, including the role of omega-3 fatty acid supplements
Author:
Publisher:
ISBN: 9780642345325
Category : Fatty acids
Languages : en
Pages : 54
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Book Description
Author: P.C. Calder
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318027537
Category : Medical
Languages : en
Pages : 188
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Book Description
Lipids have been in clinical use as components of intravenous nutrition for over 50 years. Over the last 15 years, new and improved lipids that include olive oil and/or fish oil have replaced the more traditional ones. These new lipids offer the opportunity to deliver high amounts of fatty acids and possess different functional properties: in particular, they can influence inflammatory processes, immune responses and hepatic metabolism. This book brings together articles written by leading international authorities in the area of intravenous lipids. Contributions discuss the latest findings in the field, ranging from pre-clinical research to the most recent clinical trials. Lipid functionality and utility in pediatric, adult surgical and critically ill patients are covered, as is the use of lipids in long-term home parenteral nutrition. Addressing a broad spectrum of topics, this publication provides a wealth of information for basic scientists, clinical researchers and clinical practitioners alike.
Author: Vincenzo Tufarelli
Publisher: MDPI
ISBN: 3039438530
Category : Science
Languages : en
Pages : 754
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Book Description
The aim of this Special Issue is to publish high quality papers concerning poultry nutrition and the interrelations between nutrition, metabolism, microbiota and the health of poultry. Therefore, I invite submissions of recent findings, as original research or reviews, on poultry nutrition, including, but not limited to, the following areas: the effect of feeding on poultry meat end egg quality; nutrient requirements of poultry; the use of functional feed additives to improve gut health and immune status; microbiota; nutraceuticals; soybean meal replacers as alternative sources of protein for poultry; the effects of feeding poultry on environmental impacts; the use of feed/food by-products in poultry diet; and feed technology.
Author: Cinthia Bau Betim Cazarin
Publisher: Academic Press
ISBN: 0128225904
Category : Technology & Engineering
Languages : en
Pages : 257
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Book Description
Bioactive Food Components Activity in Mechanistic Approach presents the role of functional foods and bioactive compounds in inflammation. This book focuses on bioactive compounds, including phenolics, prebiotics, carotenoids, tocopherols, bioactive peptides, probiotics, polyunsaturated and monounsaturated fatty acids, and describes their actions in several diseases, mainly obesity and co-morbidities, inflammatory bowel disease, cognitive decline and cancer, and aging. Intended for food, nutrition, and nutraceutical researchers, as well as those studying related fields, the book offers a mechanistic approach that is currently lacking in the market. - Explores the mechanistic approach of functional foods in health and disease - Contains definitions, case studies, applications, literature reviews, recent developments and text boxes - Provides coverage of phenolic compounds, prebiotics and probiotics, carotenoids, tocopherols, bioactive peptides, polyunsaturated and monounsaturated fatty acids, and sulfur compounds
Author: Ralf Henkel
Publisher: Academic Press
ISBN: 0128125675
Category : Medical
Languages : en
Pages : 322
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Book Description
Oxidants, Antioxidants and Impact of the Oxidative Status in Male Reproduction is an essential reference for fertility practitioners and research and laboratory professionals interested in learning about the role of reactive oxygen species in sperm physiology and pathology. The book focuses on unravelling the pathophysiology of oxidative stress mediated male infertility, recruiting top researchers and clinicians to contribute chapters. This collection of expertise delves into the physico-chemical aspects of oxidative stress, including a new focus on reductive stress. Furthermore, the inclusion of clinical techniques to determine oxidative stress and the OMICS of reductive oxidative stress are also included. This is a must-have reference in the area of oxidative stress and male reproductive function. Offers comprehensive information on oxidative stress and its role in male reproduction, including new therapeutic approaches Deals with current approaches to oxidative stress using OMICS platform“/li> Designed for fertility practitioners, reproductive researchers, and laboratory professionals interested in learning about the role of reactive oxygen species in sperm physiology and pathology
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309039940
Category : Medical
Languages : en
Pages : 765
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Book Description
Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.
Author: Anne Le
Publisher: Springer
ISBN: 331977736X
Category : Medical
Languages : en
Pages : 186
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Book Description
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
ISBN:
Category : Government publications
Languages : en
Pages : 728
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Book Description
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
