OECD Series on Testing and Assessment Detailed Review Paper on the Use of Metabolising Systems for In Vitro Testing of Endocrine Disruptors PDF Download
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Author: OECD
Publisher: OECD Publishing
ISBN: 9264085491
Category :
Languages : en
Pages : 95
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Book Description
This Detailed Review Paper describes some endocrine pathways that have been shown to be susceptible to environmental endocrine disruption and whose disruption could contribute to increasing incidents of some disorders in humans and wildlife populations.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264085491
Category :
Languages : en
Pages : 95
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Book Description
This Detailed Review Paper describes some endocrine pathways that have been shown to be susceptible to environmental endocrine disruption and whose disruption could contribute to increasing incidents of some disorders in humans and wildlife populations.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264274715
Category :
Languages : en
Pages : 148
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Book Description
This scoping document aims at bringing forward relevant in vitro and ex vivo thyroid assays to the attention of OECD member countries, to provide recommendations for their development/use, and also, to identify aspects/blocks of the thyroid signalling pathways that are not covered and would ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264221352
Category :
Languages : en
Pages : 213
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Book Description
This paper provides methods for both the mechanistic evaluation of the action of Endocrine Disrupter Chemicals (EDCs).
Author: OECD
Publisher: OECD Publishing
ISBN: 9264221468
Category :
Languages : en
Pages : 182
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Book Description
This paper reviews what is known about the responses of molluscs to endocrine disrupting chemicals (EDCs), to consider whether it would be desirable and feasible to standardise mollusc-based partial- and full-lifecycle tests that are sensitive to EDCs and to other chemicals.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264304746
Category :
Languages : en
Pages : 692
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Book Description
This guidance document was originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264304797
Category :
Languages : en
Pages : 206
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Book Description
In the past several decades, there has been a substantial increase in the availability of in vitro test methods for evaluating chemical safety in an international regulatory context. To foster confidence in in vitro alternatives to animal testing, the test methods and conditions under which ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264221417
Category :
Languages : en
Pages : 524
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Book Description
This document is a tool to support regulatory authorities’ decisions on the hazard of specific chemicals when they receive test results from a Test Guideline (TG) or draft TG for the screening/testing of chemicals for endocrine disrupting properties.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264221441
Category :
Languages : en
Pages : 105
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Book Description
This document describes the state of knowledge of the adverse outcome pathway (AOP) for skin sensitisation initiated by covalent binding to proteins, assesses the weight-of-evidence supporting the AOP, identifies the key events, and identifies databases containing test results related to key events.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264221433
Category :
Languages : en
Pages : 174
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Book Description
This document presents a review of fish toxicity testing for the regulatory purpose of chemical safety. The main focus is on fish toxicity, but fish bioaccumulation is also considered where relevant.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264221484
Category :
Languages : en
Pages : 118
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Book Description
This document provides guidance on how to use the OECD (Q)SAR Application Toolbox to build chemical categories according to the OECD Guidance on Grouping of Chemicals. It is part of an overall effort to provide guidance on the use of the (Q)SAR Application Toolbox.
