Author: OECD
Publisher: OECD Publishing
ISBN: 9264071504
Category :
Languages : en
Pages : 6
Book Description
The mouse heritable translocation test detects structural and numerical chromosome changes in mammalian germ cells as recovered in first generation progeny. The types of chromosome changes detected in this test system are reciprocal translocations ...
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 485: Genetic toxicology, Mouse Heritable Translocation Assay
OECD Guidelines for the Testing of Chemicals
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 484: Genetic Toxicology: Mouse Spot Test
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071482
Category :
Languages : en
Pages : 4
Book Description
The mouse spot test detects presumed somatic mutations in fetal cells following transplacental absorption of the test substance. This is an in vivo test in mice in which developing embryos are exposed to a chemical (solid, liquid, vapour or ...
Publisher: OECD Publishing
ISBN: 9264071482
Category :
Languages : en
Pages : 4
Book Description
The mouse spot test detects presumed somatic mutations in fetal cells following transplacental absorption of the test substance. This is an in vivo test in mice in which developing embryos are exposed to a chemical (solid, liquid, vapour or ...
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 481: Genetic Toxicology: Saacharomyces cerevisiae, Miotic Recombination Assay
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071423
Category :
Languages : en
Pages : 6
Book Description
This assay may be used to measure mitotic recombination (gene conversion or crossingover) in yeast, a eukaryotic micro-organism. Crossing-over is generally assayed by the production of recessive homozygous colonies or sectors produced in a ...
Publisher: OECD Publishing
ISBN: 9264071423
Category :
Languages : en
Pages : 6
Book Description
This assay may be used to measure mitotic recombination (gene conversion or crossingover) in yeast, a eukaryotic micro-organism. Crossing-over is generally assayed by the production of recessive homozygous colonies or sectors produced in a ...
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 477: Genetic Toxicology: Sex-Linked Recessive Lethal Test in Drosophila melanogaster
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071342
Category :
Languages : en
Pages : 6
Book Description
Mutations in the X-chromosome of Drosophila melanogaster are phenotypically expressed in males carrying the mutant gene. When the mutation is lethal in the hemizygous condition, its presence is inferred from the absence of one class of male ...
Publisher: OECD Publishing
ISBN: 9264071342
Category :
Languages : en
Pages : 6
Book Description
Mutations in the X-chromosome of Drosophila melanogaster are phenotypically expressed in males carrying the mutant gene. When the mutation is lethal in the hemizygous condition, its presence is inferred from the absence of one class of male ...
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays
Author: OECD
Publisher: OECD Publishing
ISBN: 9264203907
Category :
Languages : en
Pages : 29
Book Description
This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations in somatic and germ cells. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The transgenes contain reporter genes for the detection of various types of mutations induced by test chemicals.
Publisher: OECD Publishing
ISBN: 9264203907
Category :
Languages : en
Pages : 29
Book Description
This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations in somatic and germ cells. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The transgenes contain reporter genes for the detection of various types of mutations induced by test chemicals.
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 480: Genetic Toxicology: Saccharomyces cerevisiae, Gene Mutation Assay
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071407
Category :
Languages : en
Pages : 5
Book Description
This assay may be used to measure gene mutation in yeast, a eukaryotic micro-organism. Strains of Saccharomyces cerevisiae have been developed which detect forward or reverse mutations. A variety of haploid and diploid strains of the yeast can be ...
Publisher: OECD Publishing
ISBN: 9264071407
Category :
Languages : en
Pages : 5
Book Description
This assay may be used to measure gene mutation in yeast, a eukaryotic micro-organism. Strains of Saccharomyces cerevisiae have been developed which detect forward or reverse mutations. A variety of haploid and diploid strains of the yeast can be ...
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 482: Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells in vitro
Author: OECD
Publisher: OECD Publishing
ISBN: 926407144X
Category :
Languages : en
Pages : 7
Book Description
The Test Guideline for Unscheduled DNA Synthesis (UDS) in mammalian cells in vitro describes procedures utilizing primary cultures, human lymphocytes or established cell lines, to detect DNA repair synthesis after excision and removal of a stretch ...
Publisher: OECD Publishing
ISBN: 926407144X
Category :
Languages : en
Pages : 7
Book Description
The Test Guideline for Unscheduled DNA Synthesis (UDS) in mammalian cells in vitro describes procedures utilizing primary cultures, human lymphocytes or established cell lines, to detect DNA repair synthesis after excision and removal of a stretch ...
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 479: Genetic Toxicology: In vitro Sister Chromatid Exchange Assay in Mammalian Cells
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071385
Category :
Languages : en
Pages : 5
Book Description
The sister chromatid exchange (SCE) assay is a short-term test for the detection of reciprocal exchanges of DNA between two sister chromatids of a duplicating chromosome. Detection of SCEs requires some means of differentially labeling sister ...
Publisher: OECD Publishing
ISBN: 9264071385
Category :
Languages : en
Pages : 5
Book Description
The sister chromatid exchange (SCE) assay is a short-term test for the detection of reciprocal exchanges of DNA between two sister chromatids of a duplicating chromosome. Detection of SCEs requires some means of differentially labeling sister ...
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 470: Mammalian Erythrocyte Pig-a Gene Mutation Assay
Author: OECD
Publisher: OECD Publishing
ISBN: 9264366067
Category :
Languages : en
Pages : 37
Book Description
This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant for assessing mutagenicity because physiological factors, such as absorption of the test chemical from the site of exposure, distribution of the test chemical throughout the test system via systemic circulation, and in vivo metabolism and DNA repair processes, all contribute to the mutagenic responses.
Publisher: OECD Publishing
ISBN: 9264366067
Category :
Languages : en
Pages : 37
Book Description
This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant for assessing mutagenicity because physiological factors, such as absorption of the test chemical from the site of exposure, distribution of the test chemical throughout the test system via systemic circulation, and in vivo metabolism and DNA repair processes, all contribute to the mutagenic responses.