OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 403: Acute Inhalation Toxicity PDF Download
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Author: OECD
Publisher: OECD Publishing
ISBN: 9264070605
Category :
Languages : en
Pages : 20
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Book Description
This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264070605
Category :
Languages : en
Pages : 20
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Book Description
This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 ...
Author: Organisation for Economic Co-operation and Development
Publisher: Organisation for Economic Co-operation and Development ; [Montréal : Renouf]
ISBN: 9789264122215
Category : Chemical industry
Languages : en
Pages :
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Author: OECD
Publisher: OECD Publishing
ISBN: 926407094X
Category :
Languages : en
Pages : 14
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Book Description
A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a ...
Author: Marc Williams
Publisher: Elsevier
ISBN: 0128004800
Category : Science
Languages : en
Pages : 725
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Book Description
Wildlife Toxicity Assessments for Chemicals of Military Concern is a compendium of chemical-specific toxicity information with discussions on the rationale and development of Wildlife Toxicity Reference Values (TRVs) intended for use on terrestrial wildlife for risk assessment applications. Substances covered include military-related chemicals including explosives, propellants, pesticides and metals. Wildlife Toxicity Assessments for Chemicals of Military Concern is a much-needed resource designed to meet the needs of those seeking toxicological information for ecological risk assessment purposes. Each chapter targets a specific chemical and considers the current knowledge of the toxicological impacts of chemicals to terrestrial wildlife including mammalian, avian, amphibian and reptilian species. - Provides detailed information on how Wildlife Toxicity Values (TRVs) for military chemicals of concern are derived and evaluated. - Covers wildlife toxicity assessments of explosives, metals and environmental chemicals. - Compiles relevant information on the environmental effects of chemicals on wildlife in relation to public and environmental health.
Author:
Publisher:
ISBN:
Category : Freshwater invertebrates
Languages : en
Pages : 150
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Book Description
Sediment contamination is a widespread environmental problem that can potentially pose a threat to a variety of aquatic ecosystems. The sediment test methods in this manual will be used by The United States Environmental Protection Agency (USEPA) to make decisions under a range of statutory authorities concerning such issues as: dredged material disposal, registration of pesticides and toxic substances, superfound site assessment, and assessment and cleanup of hazardous waste treatment, storage, and disposal facilities. The use of uniform sediment testing procedures by USEPA programs is expected to increase data accuracy and precision, facilitate test replication, increase the comparative value of test results, and ultimately, increase the efficiency of regulatory processes requiring sediment tests.
Author:
Publisher:
ISBN:
Category : Toluene
Languages : en
Pages : 366
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Author:
Publisher:
ISBN:
Category : Methyl chloride
Languages : en
Pages : 264
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Book Description
Author: Andrew Teasdale
Publisher: John Wiley & Sons
ISBN: 1119551218
Category : Medical
Languages : en
Pages : 548
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Book Description
Learn to implement effective control measures for mutagenic impurities in pharmaceutical development In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective. The editor has created a primary reference for any professional or student studying or working with mutagenic impurities and offers readers a definitive narrative of applicable guidelines and practical, tested solutions. It demonstrates the development of effective control measures, including chapters on the purge tool for risk assessment. The book incorporates a discussion of N-Nitrosamines which was arguably the largest mutagenic impurity issue ever faced by the pharmaceutical industry, resulting in the recall of Zantac and similar drugs resulting from N-Nitrosamine contamination. Readers will also benefit from the inclusion of: A thorough introduction to the development of regulatory guidelines for mutagenic and genotoxic impurities, including a historical perspective on the development of the EMEA guidelines and the ICH M7 guideline An exploration of in silico assessment of mutagenicity, including use of structure activity relationship evaluation as a tool in the evaluation of the genotoxic potential of impurities A discussion of a toxicological perspective on mutagenic impurities, including the assessment of mutagenicity and examining the mutagenic and carcinogenic potential of common synthetic reagents Perfect for chemists, analysts, and regulatory professionals, Mutagenic Impurities: Strategies for Identification and Control will also earn a place in the libraries of toxicologists and clinical safety scientists seeking a one-stop reference on the subject of mutagenic impurity identification and control.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309164869
Category : Nature
Languages : en
Pages : 270
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Book Description
Toxicity testing in laboratory animals provides much of the information used by the Environmental Protection Agency (EPA) to assess the hazards and risks associated with exposure to environmental agents that might harm public health or the environment. The data are used to establish maximum acceptable concentrations of environmental agents in drinking water, set permissible limits of exposure of workers, define labeling requirements, establish tolerances for pesticides residues on food, and set other kinds of limits on the basis of risk assessment. Because the number of regulations that require toxicity testing is growing, EPA called for a comprehensive review of established and emerging toxicity-testing methods and strategies. This interim report reviews current toxicity-testing methods and strategies and near-term improvements in toxicity-testing approaches proposed by EPA and others. It identifies several recurring themes and questions in the various reports reviewed. The final report will present a long-range vision and strategic plan to advance the practices of toxicity testing and human health assessment of environmental contaminants.
Author:
Publisher:
ISBN:
Category : Cobalt
Languages : en
Pages : 170
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Book Description
