O-GlcNAcylation: Expanding the Frontiers

O-GlcNAcylation: Expanding the Frontiers PDF Author: Tarik Issad
Publisher: Frontiers Media SA
ISBN: 2889634256
Category :
Languages : en
Pages : 238

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O-GlcNAcylation: Expanding the Frontiers

O-GlcNAcylation: Expanding the Frontiers PDF Author: Tarik Issad
Publisher: Frontiers Media SA
ISBN: 2889634256
Category :
Languages : en
Pages : 238

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Book Description


Insights in Aging, Metabolism and Redox Biology: 2021/2022

Insights in Aging, Metabolism and Redox Biology: 2021/2022 PDF Author: Jianhua Zhang
Publisher: Frontiers Media SA
ISBN: 2832551521
Category : Science
Languages : en
Pages : 117

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Book Description
We are now in the third decade of the 21st Century and, especially in recent years, the achievements made by scientists have been exceptional, leading to major advancements in the fast-growing field of Aging, Metabolism, and Redox Biology. This editorial initiative of particular relevance is focused on new insights, novel developments, current challenges, latest discoveries, recent advances, and future perspectives in the field of Aging, Metabolism, and Redox Biology.

Frontiers in Clinical Drug Research - Anti-Cancer Agents: Volume 9

Frontiers in Clinical Drug Research - Anti-Cancer Agents: Volume 9 PDF Author: Atta-ur-Rahman
Publisher: Bentham Science Publishers
ISBN: 9815223925
Category : Science
Languages : en
Pages : 206

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Book Description
Frontiers in Clinical Drug Research - Anti-Cancer Agents is a book series intended for pharmaceutical scientists, postgraduate students and researchers seeking updated and critical information for developing clinical trials and devising research plans in anti-cancer research. Reviews in each volume are written by experts in medical oncology and clinical trials research and compile the latest information available on special topics of interest to oncology and pharmaceutical chemistry researchers. Volume 9 features reviews on these topics: · Dietary Strategy for Cancer Therapy - Amino Acid Restrictions and Beyond · The Revolutionary Potential of Noble Metal Nanoparticles as Anti-Cancer Agents: State-of-the-Art Applications and Future Perspectives · Algal Polysaccharides as Promising Anticancer Agents · Cardiotoxicity Caused by Doxorubicin and Trastuzumab: Current Understanding for Future Preventive Strategies · Emodin: Anticancer Agent Readership Pharmaceutical Scientists, Medicinal Chemists, Clinical Oncologists, Researchers in Pre-clinical studies and clinical trials.

30 years old: O-GlcNAc reaches age of reason - Regulation of cell signaling and metabolism by O-GlcNAcylation

30 years old: O-GlcNAc reaches age of reason - Regulation of cell signaling and metabolism by O-GlcNAcylation PDF Author: Tony Lefebvre
Publisher: Frontiers Media SA
ISBN: 2889195910
Category : Diseases of the endocrine glands. Clinical endocrinology
Languages : en
Pages : 115

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Book Description
Hundreds post-translational modifications (PTM) were characterized among which a large variety of glycosylations including O-GlcNAcylation. Since its discovery, O-GlcNAcylation has emerged as an unavoidable PTM widespread in the living beings including animal and plant cells, protists, bacteria and viruses. In opposition to N- and O-glycosylations, O-GlcNAcylation only consists in the transfer of a single N-acetylglucosamine moiety through a beta-linkage onto serine and threonine residues of proteins confined within the cytosol, the nucleus and the mitochondria. The O-GlcNAc group is provided by UDP-GlcNAc, the end-product of the hexosamine biosynthetic pathway located at the crossroad of cell metabolisms making O-GlcNAcylation a PTM which level tightly reflects nutritional status; therefore regulation of cell homeostasis should be intimately correlated to lifestyle and environment. Like phosphorylation, with which it can compete, O-GlcNAcylation is reversible. This versatility is managed by OGT (O-GlcNAc transferase) that transfers the GlcNAc group and OGA (O-GlcNAcase) that removes it. Also, like its unsweetened counterpart, O-GlcNAcylation controls fundamental processes, e.g. protein fate, chromatin topology, DNA demethylation and, as recently revealed, circadian clock. Deregulation of O-GlcNAc dynamism may be involved in the emergence of cancers, neuronal and metabolic disorders such as Alzheimer's or diabetes respectively. This Research Topic in Frontiers in Endocrinology is the opportunity to celebrate the thirtieth anniversary of the discovery of "O-GlcNAc" by Gerald W. Hart.

Innovators in Chemical Biology

Innovators in Chemical Biology PDF Author: John D. Wade
Publisher: Frontiers Media SA
ISBN: 2832500692
Category : Science
Languages : en
Pages : 222

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Chemistry and Biology of O-GlcNAcylation

Chemistry and Biology of O-GlcNAcylation PDF Author: Wen Yi
Publisher: Springer Nature
ISBN: 981974864X
Category :
Languages : en
Pages : 178

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Drug-Resistance in Cancer Cells: A New Wine in an old Bottle

Drug-Resistance in Cancer Cells: A New Wine in an old Bottle PDF Author: Leonardo Freire-de-Lima
Publisher: Frontiers Media SA
ISBN: 2832518486
Category : Medical
Languages : en
Pages : 226

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Frontiers in Aging Neuroscience Editor’s Pick 2021

Frontiers in Aging Neuroscience Editor’s Pick 2021 PDF Author: Thomas Wisniewski
Publisher: Frontiers Media SA
ISBN: 2889711374
Category : Science
Languages : en
Pages : 143

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Essentials of Glycobiology

Essentials of Glycobiology PDF Author: Ajit Varki
Publisher: CSHL Press
ISBN: 9780879696818
Category : Medical
Languages : en
Pages : 694

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Book Description
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Marine Environmental Epigenetics

Marine Environmental Epigenetics PDF Author: Jose M. Eirin-Lopez
Publisher: Frontiers Media SA
ISBN: 2889669777
Category : Science
Languages : en
Pages : 218

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Book Description