Novel Therapeutic Target and Drug Development in Neurovascular Retinal Diseases PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Novel Therapeutic Target and Drug Development in Neurovascular Retinal Diseases PDF full book. Access full book title Novel Therapeutic Target and Drug Development in Neurovascular Retinal Diseases by Amy Cheuk Yin Lo. Download full books in PDF and EPUB format.
Author: Amy Cheuk Yin Lo
Publisher: Frontiers Media SA
ISBN: 2889668681
Category : Science
Languages : en
Pages : 153
Get Book Here
Book Description
Author: Amy Cheuk Yin Lo
Publisher: Frontiers Media SA
ISBN: 2889668681
Category : Science
Languages : en
Pages : 153
Get Book Here
Book Description
Author: Rhian M. Touyz
Publisher: Springer
ISBN: 3030164810
Category : Medical
Languages : en
Pages : 497
Get Book Here
Book Description
This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.
Author: Derek J. Chadwick
Publisher: John Wiley & Sons
ISBN: 0470319429
Category : Science
Languages : en
Pages : 260
Get Book Here
Book Description
The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.
Author: Francesco Belfiore
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805569076
Category : Medical
Languages : en
Pages : 270
Get Book Here
Book Description
Diabetes mellitus and its complications are conditions of growing importance from both the clinical and epidemiological standpoint. Diabetes has life-threatening complications affecting several organs and systems, with increased risk for ocular, renal, cardiac, cerebral, nervous and peripheral vascular disease. In many developed countries and in special ethnic groups diabetes causes premature disability and mortality. It is, therefore, mandatory for both the specialist and the practitioner to be acquainted with the pathophysiological mechanisms, clinical manifestations and, above all, therapy of diabetes mellitus. Recent data showing that control of hyperglycemia may prevent the onset or slow down the progression of complications point to the importance of appropriate and efficacious treatment. Indeed, the aim of this book is to serve as a tool for physicians, giving the latest diagnostic aspects and pathophysiological mechanisms, to enable a better understanding of the various facets of modern diabetes management. Presented in a clear and easy-to-read form this book will be useful to all physicians interested in the management of diabetic patients by providing them with a simple yet updated source of information on the new concepts in diabetes and its treatment.
Author: A.G. de Boer
Publisher: CRC Press
ISBN: 9789057020322
Category : Medical
Languages : en
Pages : 240
Get Book Here
Book Description
The availability of various in vitro and in vivo techniques has considerably advanced the research on drug transport and metabolism across the blood-brain barrier (BBB). These specialized and sophisticated experimental strategies are of fundamental importance if one is to gain a greater understanding of enhanced and selective drug delivery to the brain. The reader will find in this book methods for in vitro endothelial/astrocyte cell culture models, and for in vivo intracerebral microdialysis to study drug tranport across the BBB. This book, however, is not merely a laboratory manual consisting of recipes for BBB research; it permits the presentation of the different methods in fine detail, revealing tricks and short cuts that frequently do not appear in the literature. The researcher is well aware that differences (subtle or otherwise) in experimental steps used in different laboratories may influence the outcome of any particular procedure. The book also illustrates the accessibility and the application of the different methods in different species. Background information of the protocol is given in every chapter, which also contains a literature list that the reader may wish to refer to for further information. This volume will be invaluable to basic researchers as well as to those involved in the search for agents suitable for pharmaceutic intervention in the central nervous system.
Author: Rajalekshmy Shyam
Publisher: Frontiers Media SA
ISBN: 2832528759
Category : Science
Languages : en
Pages : 221
Get Book Here
Book Description
Author: John Penn
Publisher: Springer Science & Business Media
ISBN: 1402067801
Category : Medical
Languages : en
Pages : 567
Get Book Here
Book Description
This book provides a comprehensive, in-depth review of our current understanding of the growth of blood vessels within the eye. Novel therapeutic strategies for the treatment of ocular angiogenesis are discussed, as are the unique challenges presented by delivery of drugs to the eye. The book emphasizes basic principles rather than specific experimental results, although recently acquired data is frequently cited to illustrate points of broader theoretical significance.
Author: Rishabha Malviya
Publisher: CRC Press
ISBN: 1040052118
Category : Medical
Languages : en
Pages : 235
Get Book Here
Book Description
Neurological illnesses pose one of the biggest hazards to the healthcare system today. This new book brings together the latest methods of gene therapy that can be used to treat both inherited and sporadic neurodegenerative diseases. It presents the most significant advances in gene transfer methods as well as the most recent understandings of the mechanisms behind specific neurodegenerative illnesses, placing these into the context of gene therapy approaches for the central nervous system. The book introduces the basics of neurodegenerative conditions and the physiological basis for their occurrence in humans. It also discusses the various proteins useful in neuro diseases and their viral applications. The book explores how stem cells can be used to learn about the future of gene therapy along with the significance of the sequences that silence genes. It discusses the functions of astrocytes in different brain regions, as well as in-vivo research in gene therapy for neurodegenerative disorders.
Author: Elias I. Traboulsi
Publisher: OUP USA
ISBN: 0195326148
Category : Medical
Languages : en
Pages : 940
Get Book Here
Book Description
This book takes a clinical approach to the patient with a genetic disease that affects the eye. The chapters on particular types of diseases follow the same organizational format, covering history, pathogenesis and etiology, epidemiology, classification, clinical manifestations and diagnosis, and treatment. The recent progress achieved in the molecular genetics of eye disease is fully reflected throughout the book. It is written by leading experts in the field and provides clinical, molecular genetic and management information on common and rare diseases. The chapters are heavily illustrated and provide a good Atlas for the practicing ophthalmologist or geneticist.
Author: Kevin Gillmann
Publisher: Elsevier
ISBN: 0323884431
Category : Science
Languages : en
Pages : 484
Get Book Here
Book Description
The Science of Glaucoma Management: From Translational Research to Next-Generation Clinical Practice bridges the gap between laboratory research and clinicians by bringing the latest promising research directly from researchers to clinicians long before they translate into clinical advances, and often before they are presented at conferences. Organized as a series of clinically relevant topics written by world-leading experts, this book summarizes the current state of laboratory and translational research and draws on the potential implications for day-to-day clinical practice. It offers new insights and mind-opening statements through contributions from some of the most respected glaucoma research groups. The book allows glaucoma specialists to explore novel ways to refine and rethink their practice based on the latest discoveries in basic sciences and breakthrough technologies, and to gain a better understanding on how their specialty is evolving and how research may shape tomorrow's practice. - Presents a detailed report on the latest translational research and breakthroughs that may transform glaucoma practice - Overviews the specialty from a scientific and clinical point-of-view - Written by world-renowned clinicians and researchers in the field of glaucoma - Includes insights, opinions and recommendations from some of the most prominent scientists and ophthalmologists - Covers hot topics and the latest technologies in glaucoma, such as minimally invasive glaucoma surgery, telemedicine, gene therapy, neuroprotection and artificial intelligence
