Novel Pharmacological Inhibitors for Bacterial Protein Toxins PDF Download
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Author: Holger Barth
Publisher:
ISBN: 9783038424314
Category : Electronic book
Languages : en
Pages :
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Book Description
Author: Holger Barth
Publisher:
ISBN: 9783038424314
Category : Electronic book
Languages : en
Pages :
Get Book Here
Book Description
Author: Holger Barth
Publisher: MDPI
ISBN: 3038424307
Category : Science
Languages : en
Pages : 125
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Book Description
This book is a printed edition of the Special Issue "Novel Pharmacological Inhibitors for Bacterial Protein Toxins" that was published in Toxins
Author: Holger Barth
Publisher: Springer
ISBN: 3319588931
Category : Medical
Languages : en
Pages : 261
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Book Description
This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the transport of the A subunits from endosomes into the cytosol and the role of trans-membrane pores formed by the B subunits and host cell chaperones for this process are reviewed. The book’s closing chapters focus on compounds which inhibit the transport of the A subunits from endosomes into the cytosol and therefore might lead to novel therapeutic strategies for toxin-associated diseases. These substances include pharmacological inhibitors of the host cell chaperones involved, as well as multivalent and heterocyclic molecules that specifically block the toxins’ translocation channels. This volume offers an up-to-date resource for scientists.
Author: Klaus Aktories
Publisher: John Wiley & Sons
ISBN: 3527614605
Category : Science
Languages : en
Pages : 334
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Book Description
This is a survey of well characterized and recently discovered bacterial protein toxins. Leading investigators of the respective toxins review the various molecular mechanisms of action, ranging from toxin-induced ADP-ribosylation up to membrane perforation by pore-forming toxins. Thy also describe the consequences on host physiology before focusing on potential applications as cell biological and pharmacological tools for research and medical applications. Detailed descriptions of the methodology include the engineering and use of modified and chimeric toxins for better performance. A solid introduction to toxin structure and functions, as well as a valuable source of methodology for researchers in molecular biology, pharmacology and experimental medicine.
Author: Joseph E. Alouf
Publisher: Academic Press
ISBN: 0128005890
Category : Science
Languages : en
Pages : 1201
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Book Description
The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content. Descriptions of relevant toxins as well as representative toxins of the main bacterial toxin families to allow for a better comparison between them Focused chapters on toxin applications and common properties or general features of toxins
Author: K. Aktories
Publisher: Springer Science & Business Media
ISBN: 3662059711
Category : Medical
Languages : en
Pages : 713
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Book Description
In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.
Author: Roger Finch
Publisher: OUP Oxford
ISBN: 0191628654
Category : Medical
Languages : en
Pages : 409
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Book Description
Antimicrobial agents are essential for the treatment of life-threatening infections and for managing the burden of minor infections in the community. In addition, they play a key role in organ and bone marrow transplantation, cancer chemotherapy, artificial joint and heart valve surgery. Unlike other classes of medicines, they are vulnerable to resistance from mutations in target microorganisms, and their adverse effects may extend to other patients (increased risk of cross-infection). As a consequence, there is a constant requirement for new agents, as well as practices that ensure the continued effective prescribing of licensed agents. Public awareness and concerns about drug resistant organisms has led to widespread publicity and political action in the UK, Europe and worldwide. The control of drug resistance and the implementation of good prescribing practice are now legal requirements in the UK as a result of the UK Health Act (2008). These fundamental changes underscore the need for a thorough understanding of the advantages and risks associated with specific antibiotic choices. This sixth edition of Antimicrobial Chemotherapy continues to be a valuable resource for undergraduates and graduates requiring a thorough grounding in the scientific basis and clinical application of these drugs. This new edition is updated to include the most recently licensed agents, notably in the treatment of viral infections including HIV/AIDS, and contains new guidance on prescribing practice and infection control practices that limit the development and spread of resistant organisms.
Author: Søren K. Rasmussen
Publisher: MDPI
ISBN: 3039288776
Category : Science
Languages : en
Pages : 238
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Book Description
This Special Issue on molecular genetics, genomics, and biotechnology in crop plant breeding seeks to encourage the use of the tools currently available. It features nine research papers that address quality traits, grain yield, and mutations by exploring cytoplasmic male sterility, the delicate control of flowering in rice, the removal of anti-nutritional factors, the use and development of new technologies for non-model species marker technology, site-directed mutagenesis and GMO regulation, genomics selection and genome-wide association studies, how to cope with abiotic stress, and an exploration of fruit trees adapted to harsh environments for breeding purposes. A further four papers review the genetics of pre-harvest spouting, readiness for climate-smart crop development, genomic selection in the breeding of cereal crops, and the large numbers of mutants in straw lignin biosynthesis and deposition.
Author: Andrei I. Ivanov
Publisher: Springer Science & Business Media
ISBN: 1588298655
Category : Medical
Languages : en
Pages : 407
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Book Description
In this book, skilled experts provide the most up-to-date, step-by-step laboratory protocols for examining molecular machinery and biological functions of exocytosis and endocytosis in vitro and in vivo. The book is insightful to both newcomers and seasoned professionals. It offers a unique and highly practical guide to versatile laboratory tools developed to study various aspects of intracellular vesicle trafficking in simple model systems and living organisms.
Author: Richard A. Lehne
Publisher: Elsevier Health Sciences
ISBN: 0323293549
Category : Medical
Languages : en
Pages : 1483
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Book Description
A favorite among nursing students, Pharmacology for Nursing Care, 8th Edition, features a uniquely engaging writing style, clear explanations, and unmatched clinical precision and currency to help you gain a solid understanding of key drugs and their implications -- as opposed to just memorization of certain facts. Compelling features such as a drug prototype approach, use of large and small print to distinguish need-to-know versus nice-to-know content, and a focus on major nursing implications save you study time by directing your attention on the most important, need-to-know information. The new edition also features an abundance of content updates to keep you ahead of the curve in school and in professional practice. UNIQUE! Engaging writing style with clear explanations makes content easy to grasp and even enjoyable to learn. A drug prototype approach uses one drug within each drug family to characterize all members of its group to help you learn about related drugs currently on the market and drugs that will be released once you begin practice. UNIQUE! Special Interest Topic boxes address timely issues in pharmacology and connect pharmacology content with current trends. Large print/small print design distinguishes essential "need-to-know" information from "nice-to-know" information. Limited discussion of adverse effects and drug interactions keeps your limited study time focused on only the most clinically important information. Reliance on up-to-date evidence-based clinical guidelines ensures that therapeutic uses are clinically relevant. Integrated and summarized nursing content demonstrates the vital interplay between drug therapy and nursing care. Coverage of dietary supplements and herbal interactions equips you to alert patients and caregivers to the potential dangers of certain dietary supplements, including interactions with prescribed and over-the-counter drugs and herbal therapies. Additional learning features provide a touchstone for study and review as you complete reading assignments and build a foundation of pharmacologic knowledge.
