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Author: Erwin B. Montgomery Jr.
Publisher: Elsevier
ISBN: 0443216983
Category : Medical
Languages : en
Pages : 405
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Book Description
Nonlinear Dynamics of Parkinson's Disease and the Basal Ganglia-Thalamic-Cortical System examines current research regarding the operations of the basal ganglia-thalamic-cortical system that causes neurological disorders like Parkinson's disease. While there have been remarkable advances in the understanding of the anatomy, physiology and chemistry of these systems, there remains a significant degree of inconsistency and incompleteness between facts and advancements. This book introduces the novel concepts of nonlinear complex systems and their connection to Parkinsonism as well as hyperkinetic disorders. The actual mechanisms underlying the motor disorders of Parkinson's disease at the level of the lower motor neuron are also discussed. - Outlines phenomenological selectivity of pallidotomy and Deep Brain Stimulation - Reviews the anatomical models of pathophysiology and physiology - Discusses the instrumental and analytical misrepresentations and the inferences that misrepresent the data in Nonmonotonic Nonlinear Dynamics
Author: Erwin B. Montgomery Jr.
Publisher: Elsevier
ISBN: 0443216983
Category : Medical
Languages : en
Pages : 405
Get Book Here
Book Description
Nonlinear Dynamics of Parkinson's Disease and the Basal Ganglia-Thalamic-Cortical System examines current research regarding the operations of the basal ganglia-thalamic-cortical system that causes neurological disorders like Parkinson's disease. While there have been remarkable advances in the understanding of the anatomy, physiology and chemistry of these systems, there remains a significant degree of inconsistency and incompleteness between facts and advancements. This book introduces the novel concepts of nonlinear complex systems and their connection to Parkinsonism as well as hyperkinetic disorders. The actual mechanisms underlying the motor disorders of Parkinson's disease at the level of the lower motor neuron are also discussed. - Outlines phenomenological selectivity of pallidotomy and Deep Brain Stimulation - Reviews the anatomical models of pathophysiology and physiology - Discusses the instrumental and analytical misrepresentations and the inferences that misrepresent the data in Nonmonotonic Nonlinear Dynamics
Author: Rajesh Pahwa
Publisher: CRC Press
ISBN: 1040053629
Category : Medical
Languages : en
Pages : 622
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Book Description
Highly Commended, BMA Medical Book Awards 2014This volume has long prevailed as one of the leading resources on Parkinson's disease (PD). Fully updated with practical and engaging chapters on pathology, neurochemistry, etiology, and breakthrough research, this source spans every essential topic related to the identification, assessment, and treatme
Author: Erwin B. Montgomery Jr.
Publisher: Elsevier
ISBN: 0443138303
Category : Science
Languages : en
Pages : 464
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Book Description
Reproducibility in Biomedical Research: Epistemological and Statistical Problems, 2nd Ed. explores the ideas and conundrums inherent in scientific research. Reproducibility is one of the biggest challenges in biomedical research. It affects not only the ability to replicate results, but the very trust in the findings. Since published in 2019, Reproducibility of Biomedical Research: Epistemological and Statistical Problems established itself as a solid ethical reference in the area, leading to significant reflection on biomedical research. The second edition addresses new challenges to reproducibility in biosciences, namely reproducibility of machine learning Artificial Intelligence (AI), reproducibility of translation from research to medical care, and the fundamental challenges to reproducibility. All current chapters will be expanded to cover advances in the topics previously addressed. Reproducibility in Biomedical Research: Epistemological and Statistical Problems, 2nd Ed. provides biomedical researchers with a framework to better understand the reproducibility challenges in the area. Newly introduced interactive exercises and updated case studies help students understand the fundamental concepts involved in the area. - Includes four new chapters and updates across the book, covering recent developments of issues affecting reproducibility in biomedical research - Covers reproducibility of results from machine learning AI algorithms - Presents new case studies to illustrate challenges in related fields - Includes a companion website with interactive exercises and summary tables
Author: James A. Reggia
Publisher: World Scientific
ISBN: 9810228791
Category : Medical
Languages : en
Pages : 494
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Book Description
During the last few years there has been a rapidly increasing interest in neural modeling of brain and cognitive disorders. This multidisciplinary book presents a variety of such models in neurology, neuropsychology and psychiatry. A review of work in this area is given first. Computational models are then presented of memory impairment in Alzheimer's disease, functional brain reorganization following a stroke, patterns of neural activity in epilepsy, disruption of language processes in aphasia and acquired dyslexia, altered cognitive processes in schizophrenia and depression, and related disorders. This is the first book on this topic, with contributions from many of the leading researchers in this field.
Author: Shamim I. Ahmad
Publisher: Springer Science & Business Media
ISBN: 1461406536
Category : Medical
Languages : en
Pages : 421
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Book Description
The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.
Author: Toru Itakura
Publisher: Springer
ISBN: 3319084763
Category : Medical
Languages : en
Pages : 212
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Book Description
Chronic electrical stimulation of the brain has demonstrated excellent outcomes in patients with Parkinson’s disease and has recently also been applied to various other neurological diseases. This comprehensive, up-to-date textbook will meet the needs of all who wish to learn more about the application of deep brain stimulation and will provide a sound basis for safe and accurate surgery. The book comprises two main parts, the first of which presents relevant anatomical and functional background information on the basal ganglia, thalamus and other brain structures as well as on the mechanism of brain stimulation. The second part describes clinical studies on deep brain stimulation, covering results in a range of movement disorders and psychiatric diseases and also important aspects of instrumentation and technique. The authors are outstanding scientists and experts in the field from across the world.
Author: Vassilis Cutsuridis
Publisher: Springer Nature
ISBN: 3030188302
Category : Medical
Languages : en
Pages : 223
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Book Description
This book focuses on our current understanding of brain dynamics in various brain disorders (e.g. epilepsy, Alzheimer’s and Parkinson’s disease) and how the multi-scale, multi-level tools of computational neuroscience can enhance this understanding. In recent years, there have been significant advances in the study of the dynamics of the disordered brain at both the microscopic and the macroscopic levels. This understanding can be furthered by the application of multi-scale computational models as integrative principles that may link single neuron dynamics and the dynamics of local and distant brain regions observed using human EEG, ERPs, MEG, LFPs and fMRI. Focusing on the computational models that are used to study movement, memory and cognitive disorders as well as epilepsy and consciousness related diseases, the book brings together physiologists and anatomists investigating cortical circuits; cognitive neuroscientists studying brain dynamics and behavior by means of EEG and functional magnetic resonance imaging (fMRI); and computational neuroscientists using neural modeling techniques to explore local and large-scale disordered brain dynamics. Covering topics that have a significant impact on the field of medicine, neuroscience and computer science, the book appeals to a diverse group of investigators.
Author: Dieter Jaeger
Publisher:
ISBN: 9781461473206
Category : Computational neuroscience
Languages : en
Pages :
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Book Description
Author: Paul Cordo
Publisher: Cambridge University Press
ISBN: 9780521456074
Category : Medical
Languages : en
Pages : 296
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Book Description
Movement is arguably the most fundamental and important function of the nervous system. Purposive movement requires the coordination of actions within many areas of the cerebral cortex, cerebellum, basal ganglia, spinal cord, and peripheral nerves and sensory receptors, which together must control a highly complex biomechanical apparatus made up of the skeleton and muscles. Beginning at the level of biomechanics and spinal reflexes and proceeding upward to brain structures in the cerebellum, brainstem and cerebral cortex, the chapters in this book highlight the important issues in movement control. Commentaries provide a balanced treatment of the articles that have been written by experts in a variety of areas concerned with movement, including behaviour, physiology, robotics, and mathematics.
Author: Erwin B. Montgomery (Jr.)
Publisher: Oxford University Press
ISBN: 0190259604
Category : Medical
Languages : en
Pages : 249
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Book Description
Principles of DBS electronics -- Principles of electrophysiology -- Controlling the flow of electrical charges -- DBS safety -- Nervous system responses to DBS -- DBS effects on motor control -- Pathophysiological mechanisms -- Approaches to programming -- Clinical assessments -- Approach to subthalamic nucleus -- Approach to globus pallidus internal -- Approach to thalamic DBS -- Algorithm for selecting electrode configurations and stimulation parameters -- Helpful programming hints -- Oscillator basics -- Discrete neural oscillators
