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Author: Thomas Thum
Publisher: Springer
ISBN: 3319529455
Category : Medical
Languages : en
Pages : 108
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Book Description
This volume describes important functions and roles of micro RNAs in the vasculature in health, disease, therapeutics and diagnostics. It shows how miRNAs can be used to improve stem cell-based regenerative therapies of cardiovascular diseases; further the role of miRNAs as regulators in lipoprotein metabolism in the liver and reverse cholesterol transport is depicted, as well as their pathological function in diabetes and atherosclerosis. The book discusses the use of circulating miRNAs as disease biomarkers and shows interesting correlations with the amount of detectable miRNAs in the blood and future cardiovascular risks. This book is edited and written by leading figures in the field and will be an invaluable resource for academics, researchers and students working on non-coding RNAs in biomedicine, physiology and vascular biology.
Author: Vijay Nambi
Publisher: Elsevier Health Sciences
ISBN: 0323548369
Category : Medical
Languages : en
Pages : 199
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Book Description
Get a quick, expert overview of the ways in which biomarkers can be used to assess and guide the management of cardiovascular disease in the clinical setting. This concise, clinically-focused resource by Dr. Vijay Nambi consolidates today's available information on this rapidly changing topic into one convenient resource, making it an ideal, easy-to-digest reference for cardiology practitioners, fellows, and residents. - Covers lab standards and statistical interpretation of biomarkers with a clinical focus. - Discusses relevant conditions such as hypertension and diabetes as key markers of injury and prognosis. - Includes current information on biomarkers to assess and guide the management of heart failure, acute coronary syndrome, chest pain, shortness of breath, and more. - Concludes the book with a timely chapter on how biomarkers may guide cardiologists in the future.
Author: Takahiro Ochiya
Publisher: Humana Press
ISBN: 9781627034524
Category : Medical
Languages : en
Pages : 0
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Book Description
microRNAs (miRNAs) are small non-coding RNAs that regulate various biological phenomena, such as development and homeostasis. The dysregulation of miRNA leads to disease progression, particularly of cancer. In Circulating MicroRNAs: Methods and Protocols, expert researchers in the field detail recent advances in the isolation, purification and analysis of circulating miRNAs from a variety of sources for research. The book is divided into three main topics. The first section involves the study of secretory miRNAs in cell-cell communication, and the second, the study of circulating miRNAs in body fluids. The last describes the novel techniques used to study circulating miRNAs. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Circulating MicroRNAs: Methods and Protocols seeks to aid scientists in dealing with the recent advances of RNAi technology from the bench to the bedside.
Author: Junjie Xiao
Publisher: Springer
ISBN: 9811043973
Category : Science
Languages : en
Pages : 300
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Book Description
The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects. It firstly describes the general aspects of exosomes including the definition, formation and secretion of exosomes and highlight their roles as biomarkers and pathological and therapeutic effects in cardiovascular diseases as well. Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized. Thirdly, exosomes as biomarkers of cardiovascular diseases are overviewed including their roles in diagnosis, prognosis and reaction to therapy. Fourthly, pathological effects of exosomes and therapeutic effects of exosomes are highlighted. Finally, future prospects of exosomes in cardiovascular research would be provided. This is an essential reference for researchers working in cell biology and regeneration, as well as clinicians such as cardiologist.
Author: Thomas Thum
Publisher: Springer
ISBN: 3319529455
Category : Medical
Languages : en
Pages : 108
Get Book Here
Book Description
This volume describes important functions and roles of micro RNAs in the vasculature in health, disease, therapeutics and diagnostics. It shows how miRNAs can be used to improve stem cell-based regenerative therapies of cardiovascular diseases; further the role of miRNAs as regulators in lipoprotein metabolism in the liver and reverse cholesterol transport is depicted, as well as their pathological function in diabetes and atherosclerosis. The book discusses the use of circulating miRNAs as disease biomarkers and shows interesting correlations with the amount of detectable miRNAs in the blood and future cardiovascular risks. This book is edited and written by leading figures in the field and will be an invaluable resource for academics, researchers and students working on non-coding RNAs in biomedicine, physiology and vascular biology.
Author: Bi-Cheng Liu
Publisher: Springer
ISBN: 9811388717
Category : Science
Languages : en
Pages : 707
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Book Description
This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.
Author: Julia A. Chekanova
Publisher: Humana Press
ISBN: 9781493990443
Category : Science
Languages : en
Pages : 480
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Book Description
This volume focuses on various approaches to studying long non-coding RNAs (lncRNAs), including techniques for finding lncRNAs, localization, and observing their functions. The chapters in this book cover how to catalog lncRNAs in various plant species; determining subcellular localization; protein interactions; structures; and RNA modifications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and innovative, Plant Long Non-Coding RNAs: Methods and Protocols is a valuable resource that aids researchers in understanding the functions of lncRNAs in different plant species, and helps them explore currently uncharted facets of plant biology.
Author: Mustapha Kandouz
Publisher: Springer
ISBN: 9401773807
Category : Medical
Languages : en
Pages : 370
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Book Description
Cells are by nature compelled to live in groups. They develop dependence over signaling cues received from their microenvironment, in particular from other cells, whether of their own “kind” or of a different type. Therefore, communicating with these cells is a critical aspect of their behavior and fate, as they live and die normally or as they undergo disease-related pathological changes, with dramatic repercussions. In this book, we have asked expert researchers in the field of Intercellular Communication in Cancer to provide chapters on different aspects of interaction between neighboring cells, in the context of cancer diseases. We have specifically focused our efforts on membrane-to-membrane contact-based rather than growth factors-mediated modes of intercellular communications. The contributing authors provide an extensive overview of their respective area of specialization, with an in-depth discussion of the molecular mechanisms of cell-cell interactions, the impact on tumor progression and response to therapies, as well as the cancer diagnostic value of this scientific information. This book aims to introduce essential aspects of the normal and pathological cellular fate and homeostasis to both scientists and clinicians, and also to provide established researchers with an update on the novelties and future directions this expanding field is witnessing.
Author: En-Zhi Jia
Publisher: Frontiers Media SA
ISBN: 2832517307
Category : Medical
Languages : en
Pages : 156
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Book Description
Author: Yvan Devaux
Publisher: Academic Press
ISBN: 012822259X
Category : Medical
Languages : en
Pages : 500
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Book Description
Epigenetics in Cardiovascular Disease, a new volume in the Translational Epigenetics series, offers a comprehensive overview of the epigenetics mechanisms governing cardiovascular disease development, as well as instructions in research methods and guidance in pursing new studies. More than thirty international experts provide an (i) overview of the epigenetics mechanisms and their contribution to cardiovascular disease development, (i) high-throughput methods for RNA profiling including single-cell RNA-seq, (iii) the role of nucleic acid methylation in cardiovascular disease development, (iv) epigenetic actors as biomarkers and drug targets, (v) and the potential of epigenetics to advance personalized medicine. Here, readers will discover strategies to combat research challenges, improve quality of their epigenetic research and reproducibility of their findings. Additionally, discussion of assay and drug development for personalized healthcare pave the way for a new era of understanding in cardiovascular disease. - Offers a thorough overview of role of epigenetics mechanisms in cardiovascular disease - Includes guidance to improve research plans, experimental protocols design, quality and reproducibility of results in new epigenetics research - Explores biomarkers and drug targets of therapeutic potential to advance personalized healthcare - Features chapter contributions from a wide range of international researchers in the field
Author: Junjie Xiao
Publisher: Springer Nature
ISBN: 9811516715
Category : Science
Languages : en
Pages : 417
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Book Description
This book presents the latest research on non-coding RNAs in cardiovascular disease, a major cause of death worldwide. Non-coding RNAs play a significant role in development, proliferation, differentiation and apoptosis. Since altered non-coding RNA expression is often associated with various diseases, their potential use in diagnostics, prognostics and therapeutics is an important current area of study. The book consists of six parts: 1) An overview of non-coding RNAs and cardiovascular system, 2) Bioinformatics and interactions, 3) Non-coding RNA regulation in cardiovascular system, 4) Non-coding RNAs and cardiovascular diseases, 5) Potential biomarkers and therapeutic implications, 6) Future prospects. It is particularly useful for researchers and students in the field of non-coding RNA and cardiovascular biology, as well as for cardiologists, pharmacologists and physiologists.
