Non-coding RNA in immunotherapies and immune regulation PDF Download
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Author: Bertrand Kaeffer
Publisher: Frontiers Media SA
ISBN: 2832510361
Category : Medical
Languages : en
Pages : 203
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Book Description
Author: Bertrand Kaeffer
Publisher: Frontiers Media SA
ISBN: 2832510361
Category : Medical
Languages : en
Pages : 203
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Book Description
Author: Adam Williams
Publisher: Frontiers Media SA
ISBN: 2889669173
Category : Medical
Languages : en
Pages : 68
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Book Description
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Author: Yanyan Tang
Publisher: Frontiers Media SA
ISBN: 2889769577
Category : Science
Languages : en
Pages : 446
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Book Description
Author: Shuai Jiang
Publisher: Academic Press
ISBN: 9780323855044
Category : Medical
Languages : en
Pages : 316
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Book Description
Advances in Non-coding RNAs in Cancer-Biology and Immunology is a resource for three major types of non-coding RNAs including microRNA, LnRNA and piRNA. It covers machinery of non-coding RNAs, including microRNA, LnRNA and piRNA, and the identification of targets of these non-coding RNAs, and the identification of physiological and pathological roles of miRNAs, LnRNAs and piRNAs in immunology and cancer biology. The aberrant expressions of these non-coding RNAs within the cells cause various abnormalities and diseases including cancer and immune system-associated diseases. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health. Advances in Non-coding RNAs in Cancer-Biology and Immunology introduces basic ideas of miRNAs, LnRNAs and piRNAs, along with their detailed bio-processing steps, critical functions in the development of tumorigenesis and controlling immune cell responses, which benefits for identifying different classes of non-coding RNAs and their targets, identifying new members of these non-coding RNAs and predicting the possible functions of these molecules. It captures the essence of the pioneering work of some of the world's leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs, LnRNAs, piRNAs highlighting their potential towards the diagnosis and therapeutics of various diseases. Provides a unified cutting-edge resource for non-coding RNAs including miRNAs LnRNAs, and piRNAs, their physiological and pathological roles and potential applications Showcases high-throughput technologies and other approaches for discovery of these non-coding RNAs and their downstream targets Unveils the diverse molecular mechanisms by which miRNAs, LnRNAs and piRNAs regulate gene expression in animal cells Showcases recent discoveries on involvement of these non-coding RNAs in different biological processes and diseases as well as their possible use in diagnosis Reports breakthroughs in the use of these non-coding RNAs for diagnosis and personalized therapy
Author: Nicholas Delihas
Publisher: MDPI
ISBN: 3038420050
Category : Non-coding RNA.
Languages : en
Pages : 837
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Book Description
Printed Edition of the Special Issue Published in IJMS
Author: Joanna Sztuba-Solinska
Publisher: Elsevier
ISBN: 0323907008
Category : Science
Languages : en
Pages : 450
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Book Description
Navigating Non-coding RNA: From Biogenesis to Therapeutic Application provides a concise overview of the field of non-coding RNA (ncRNA). Chapters cover the history of discoveries that have occurred in the area of ncRNA, specific types of ncRNA, housekeeping ncRNAs such as ribosomal RNA, transfer RNA, small nuclear RNA and telomerase RNA, regulatory ncRNAs such as microRNA, small interfering RNA, long non-coding RNA and Y RNA. Biogenesis, structure, function, and regulation of each of these are also explored in addition to traditional and cutting-edge methods for the identification, functional characterization and structural characterization of ncRNA. The book also focuses on the different types of epitranscriptomic modifications and their involvement in regulating ncRNA structure, stability and intermolecular interactions in addition to the role of ncRNAs in a range of diseases and potential therapeutic applications. Covers a wide range of non-coding RNAs, including ribosomal RNA, transfer RNA, telomerase RNA, microRNA, small interfering RNA and circular RNA Features both traditional and novel methodologies for investigating ncRNA, from microarray and conventional chemical probing to CAGE-seq and computational methods Includes chapters on ncRNAs in a range of diseases, including cancers, neurological disorders, cardiovascular conditions and infectious illnesses Discusses novel therapeutic strategies for targeting ncRNAs, including CRISP/Ca9 applications and RNAi-based strategies Explores the molecular mechanisms and intermolecular interactions of ncRNA
Author: Jonathan J. Kotzin
Publisher:
ISBN:
Category :
Languages : en
Pages : 262
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Book Description
The immune system is comprised of diverse cell types that work together to protect the host from infection and maintain tissue homeostasis. To achieve this complex balance, extracellular cues determine highly specific epigenetic landscapes and transcriptional profiles of each immune cell subtype. New evidence indicates that long non-coding RNAs (lncRNAs) play critical roles in epigenetic and transcriptional regulation in mammals. Here we identify the lncRNA Morrbid, and examine its role in immune function. In Chapter 2, we assess the function of Morrbid at homeostasis and describe its role in finely tuning the lifespan of short-lived myeloid cells. In Chapter 3, we examine Morrbid under inflammatory conditions and illustrate its role in restraining CD8 T cell responses following viral infection. These data demonstrate that lncRNAs can function as highly cell-type specific effectors of extracellular cues to control immunological processes that require rapid and strict regulation.
Author: Junjie Yang
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Genomic imprinting, a unique epigenetic regulation resulting in a parent-of-origin specificgene expression, is essential for normal mammalian development and growth. H19 is amaternally expressed long non-coding RNA that is a central regulator of the imprinting gene network controlling development and growth. H19 is expressed throughout embryonic development in multiple tissues including all hematopoietic cells. The role of H19 during embryonic development has only been documented for the placenta where it controls growthand the role of H19 in lymphopoiesis has not been investigated. The laboratory has previouslyfound H19 as the major differentially expressed transcript in two microarrays comparing fetalliver (FL) and bone marrow (BM) derived pro-B cells, as well as between early and latethymic settling progenitors. However, a role for imprinting gene H19 in B cell development,or even in immune system remains elusive. Here we sought to analyze mice where a large segment of the H19 locus has been deleted. In our work, we found that loss of H19 have specific impact on the FL B cell development byproducing increased numbers of BP1+ proB cell. Although BP1+ proB cells from H19-/- FLshowed impaired Ig heavy chain V-D-J rearrangement, that increase resulted in a net enlarged B cell compartment in the adult periphery of H19 mutant. In adult mice, although H19 is notexpressed in B lymphocytes after birth, B cells from H19-/- mice exhibited altered B cellsurface phenotype, represented by an upregulated B220 expression on all B cell subsets. After immunization with different T cell dependent antigens, H19-/- exhibits reduced GC B cells, and impaired specific IgM titer in the serum, indicating a defected B cell response in H19-/-mice. Competitive reconstitution analysis showed a B cell autonomous impairment in the Bcell response. Consistently we found a reduced BCR responsiveness of H19-/- naïve B cells that together with less efficient upregulation of MHCII and CD40 expression after immunization might be responsible for the impaired immune response in H19-/- mice. Genome-wide transcription analysis revealed differential expression of genes involved inregulating the intensity of B cell receptor signaling. This work brings new insights on the regulation role of long non-coding RNA H19 in the early B cell development and immune system.
Author: Gordon G. Carmichael
Publisher:
ISBN: 9781493913695
Category : Genetic regulation
Languages : en
Pages : 181
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Book Description
Regulatory Non-Coding RNAs: Methods and Protocols offers a collection of methods for those interested in the discovery, localization, and functional analysis of these non-coding transcripts that have the potential and ability to orchestrate and control gene expression. After a review of the field, this detailed volume continues with methods useful for the study of siRNAs, microRNAs and their targets, techniques concerned with long non-coding RNAs, as well as studies of the critical parameters of functional non-coding RNA protein-RNA interactions and the environment in which they act. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips for troubleshooting and avoiding known pitfalls.Dependable and easy to use, Regulatory Non-Coding RNAs: Methods and Protocols provides a current, state-of-the-art collection of methods and approaches that will be of value to researchers in this expanding and fascinating field.
Author: Alfons Navarro
Publisher: Humana
ISBN: 9781071615836
Category : Medical
Languages : en
Pages : 0
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Book Description
This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery of siRNAs in vivo, lncRNA-protein interactions, viral lncRNAs and circRNAs are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Long Non-Coding RNAs in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field.
