NMR Characterizations of Sequence-specific, Minor-groove-binding, Polyamide Ligands in Complex with DNA Oligomers PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download NMR Characterizations of Sequence-specific, Minor-groove-binding, Polyamide Ligands in Complex with DNA Oligomers PDF full book. Access full book title NMR Characterizations of Sequence-specific, Minor-groove-binding, Polyamide Ligands in Complex with DNA Oligomers by Cheryl Augusta Hawkins. Download full books in PDF and EPUB format.
Author: Cheryl Augusta Hawkins
Publisher:
ISBN:
Category :
Languages : en
Pages : 318
Get Book Here
Book Description
Author: Cheryl Augusta Hawkins
Publisher:
ISBN:
Category :
Languages : en
Pages : 318
Get Book Here
Book Description
Author: Khalid Aman
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
Chapter 1 introduces the regulation of gene expression using MGB small molecules.Chapter 2 describes the synthesis of hairpin polyamides, starting with the building blocks and then the solid phase synthetic protocol for constructing 8-ring hairpin polyamides.Chapter 3 showcases the thermal UV melt data, and examines the polyamide binding kinetics with DNA duplexes. Further insight into the binding was obtained with switchSENSE® technology, which allowed the generation of kinetic rate maps. The data outlined in this chapter enabled the profiling of the kinetic parameters that govern PA-dsDNA binding.Chapter 4 provides a structural view of a novel iPr-Im-containing polyamide-DNA complex, highlighting the closer proximity of the N-terminal iPr-Im N2 to the exocyclic amine of G5 compared with the N-terminal iPr-Nt analogue. Furthermore, the 3D NMR-restrained molecular dynamics (MD) structure indicated the major groove compression was greater for polyamide with the terminal iPr-Im monomer compared with the Me-Im analogue, highlighting the importance of a seemingly subtle change in steric bulk facing away from the minor groove for augmenting structural distortion of the DNA duplex.Chapter 5 takes the key findings of this thesis and uses them as a lens for looking to the future direction that this research may take. Namely, the potential of this novel iPr-Im monomer unit to replace imidazole as a G-selective residue that can induce greater structural distortion of the DNA duplex by polyamides.
Author: Scott Reynolds Carter
Publisher:
ISBN:
Category : Electronic dissertations
Languages : en
Pages : 396
Get Book Here
Book Description
Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 656
Get Book Here
Book Description
Author:
Publisher:
ISBN:
Category : Dissertation abstracts
Languages : en
Pages : 776
Get Book Here
Book Description
Author:
Publisher:
ISBN:
Category : Chemistry
Languages : en
Pages : 2668
Get Book Here
Book Description
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1498
Get Book Here
Book Description
Author: National Academy of Sciences (U.S.)
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 1404
Get Book Here
Book Description
Author: Victor A. Bloomfield
Publisher: Sterling Publishing Company
ISBN: 9780935702491
Category : Science
Languages : en
Pages : 854
Get Book Here
Book Description
Providing a comprehensive account of the structures and physical chemistry properties of nucleic acids, with special emphasis on biological function, this text has been organized to meet the needs of those who have only a basic understanding of physical chemistry and molecular biology.
Author: Jonathan L Sessler
Publisher: Royal Society of Chemistry
ISBN: 1847552471
Category : Science
Languages : en
Pages : 431
Get Book Here
Book Description
Anion recognition plays a critical role in a range of biological processes, and a variety of receptors and carriers can be found throughout the natural world. Chemists working in the area of supramolecular chemistry have created a range of anion receptors, drawing inspiration from nature as well as their own inventive processes. This book traces the origins of anion recognition chemistry as a unique sub-field in supramolecular chemistry while illustrating the basic approaches currently being used to effect receptor design. The combination of biological overview and summary of current synthetic approaches provides a coverage that is both comprehensive and comprehensible. First, the authors detail the key design motifs that have been used to generate synthetic receptors and which are likely to provide the basis for further developments. They also highlight briefly some of the features that are present in naturally occurring anion recognition and transport systems and summarise the applications of anion recognition chemistry. Providing as it does a detailed review for practitioners in the field and a concise introduction to the topic for newcomers, Anion Receptor Chemistry reflects the current state of the art. Fully referenced and illustrated in colour, it is a welcome addition to the literature.
