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Author:
Publisher: Academic Press
ISBN: 0128144149
Category : Science
Languages : en
Pages : 252
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Book Description
Nitric Oxide and Other Small Signalling Molecules, Volume 72, the latest release in the Advances in Microbial Physiology series, continues the long tradition of topical, important, cutting-edge reviews in microbiology. The book contains updates in the field, with comprehensive chapters covering the Biochemistry of cysteine persulfides, NO signaling in yeast, The Inflammasome: Regulation of Nitric Oxide and Antimicrobial Host Defense, Nitric Oxide, aN Old molecule with NOble functions in Pseudomonas aeruginosa biology, the Emerging roles of nitric oxide synthase in bacterial physiology, and Anaerobic bacterial response to nitrosative stress. Contains contributions from leading authorities in microbial physiology Informs and updates on all the latest developments in the field of microbial physiology
Author:
Publisher: Academic Press
ISBN: 0128144149
Category : Science
Languages : en
Pages : 252
Get Book Here
Book Description
Nitric Oxide and Other Small Signalling Molecules, Volume 72, the latest release in the Advances in Microbial Physiology series, continues the long tradition of topical, important, cutting-edge reviews in microbiology. The book contains updates in the field, with comprehensive chapters covering the Biochemistry of cysteine persulfides, NO signaling in yeast, The Inflammasome: Regulation of Nitric Oxide and Antimicrobial Host Defense, Nitric Oxide, aN Old molecule with NOble functions in Pseudomonas aeruginosa biology, the Emerging roles of nitric oxide synthase in bacterial physiology, and Anaerobic bacterial response to nitrosative stress. Contains contributions from leading authorities in microbial physiology Informs and updates on all the latest developments in the field of microbial physiology
Author: Louis J. Ignarro
Publisher: Academic Press
ISBN: 0080525032
Category : Medical
Languages : en
Pages : 1023
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Book Description
Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems. NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells. NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis. This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications. Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide Authored by world experts on nitric oxide Includes an overview of basic principles of biology and chemical biology Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense
Author: Lorenzo Lamattina
Publisher: Springer
ISBN: 9783319821610
Category : Science
Languages : en
Pages : 0
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Book Description
This book describes the three gasotransmitters nitric oxide (NO), hydrogen sulphide (H2S) and carbon monoxide (CO) and their function as intracellular signalling molecules in plants. Common properties are shared by NO, H2S and CO: they are beneficial at low concentrations but hazardous in higher amounts; they are small molecules of gas; they can freely cross cell membranes; their effects do not rely on receptors; they are generated enzymatically and their production is regulated; their functions can be mimicked by exogenous application; and their cellular effects may or may not be mediated by second messengers, but have specific cellular and molecular targets. In plants, many aspects of the biology of gasotransmitters remain completely unknown and generate intriguing questions, which will be discussed in this book.
Author: John T. Hancock
Publisher: MDPI
ISBN: 3036500065
Category : Science
Languages : en
Pages : 170
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Book Description
This Special Issue is a collection of research articles focused on the production and role of nitric oxide in plants. Nitric oxide is a crucial molecule used in the orchestration of cellular events in animals and plants. With a mixture of primary research papers and review articles written by some of the top researchers in the field, this work encompasses many aspects of this important and growing area of biochemistry.
Author: Santiago Lamas
Publisher: CRC Press
ISBN: 9780824729608
Category : Science
Languages : en
Pages : 456
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Book Description
Since the nineteenth century, when engineers were using nitroglycerin to blow up rockbeds, and doctors were prescribing it to relieve angina, scientists have been exploring the incredible and often baffling behavior of nitric oxide. In the 1980s, researchers discovered that nitric oxide had the capacity to regulate vascular tone through cyclic GMP, firmly establishing its role as a physiological mediator. Over the last ten years, still further roles have been discovered that relate to nitric oxide’s unique ability to interact with and modify a wide variety of other molecules and regulators including glutathione, as well as macromolecules such as DNA and proteins. Nitric Oxide, Cell Signaling, and Gene Expression is the first comprehensive work to showcase the highly useful diversity of cellular effects elicited by nitric oxide. A collection of expert contributors provides cutting-edge information on a variety of topics with tremendous implications in the fields of biology and medicine. These include... Nitric oxide-driven cell signaling mediated by cGMP, GTPases, and S-nitrosylation Nitric oxide’s role in hypoxia, gene expression, post-transcriptional control of gene expression, gene regulation in pulmonary pathophysiology, and tumor biology The intriguing concept of mitochondrial nitric oxide synthase as a regulator of mitochondrial bioenergetics and free radical production Modulation of cell metabolism Nitric Oxide, Cell Signaling, and Gene Expression offers cell and molecular biologists, pharmacologists, biochemists, and biomedical researchers, as well as advanced graduate students, the insight and information they need to understand recent developments in this highly fertile area of research.
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
Author: Mohammad Abass Ahanger
Publisher:
ISBN: 9781119800156
Category : Science
Languages : en
Pages : 290
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Book Description
"Nitrogen monoxide, often known as nitric oxide, is a physiologically active chemical that is widely used in animal and plant signaling mechanisms. In plants and animals, it is an intracellular and intercellular signaling molecule with a variety of regulatory roles. Its function in the central nervous, cardiovascular, and immunological systems, platelet inhibition, programmed cell death, and host responses to infection, among other things, has been widely studied in animals. Because of the presence of an unpaired electron, it is a highly reactive gaseous molecule that occurs with oxygen in a variety of reduced states such as nitroxyl ion (NO-), nitric oxide free radical (NOX), and nitrosonium (NOX+). These NOX-derived molecules are referred to as reactive nitrogen species (RNS). NOX influences signaling in biological systems through a variety of mechanisms. The interaction of NOX with O2 results in the formation of several redox compounds (including NO2, N2O3, and N2O4), which may react with cellular amines and thiols or simply change to form the top metabolites radical (NO2-) and nitrate (NO3-) (Wendehenne et al., 2001). NO combines with dioxygen to form NO2 or with reactive oxygen species (ROS) to form peroxynitrite (ONOO-), which triggers cellular damage. NO facilitates electrophilic assault on reactive sulfur, oxygen, nitrogen, and aromatic carbon centers, with thiols being the most reactive of the reactive teams. Nitrosation is the name given to this natural process. Nitrosation of numerous enzymes or proteins results in chemical change, which may affect the function of those entities. These alterations are reversible, and supermolecule nitrosation-denitrosation might be a crucial mechanism for controlling signal transduction (Hayat et al., 2010). In contrast to the mammalian system, the cellular/subcellular localisation of NOX production in plants is exceedingly diverse and contentious. The production of NOX in plants is determined by the plant's physiological condition. These include NOX production during root development, stomatal movement control, blooming, plant component expansion, and leaf senescence (Neill S.J. et al, 2002 and Mishina T.E. et al, 2007). NOX will be produced in plants through non-enzymatic and accelerator systems, depending on the plant species, organ or tissue, as well as the plant's state and ever-changing environmental circumstances. The most effective recognized NOX sources in plants are NOX generation from group as a substrate by cytosolic (cNR) and membrane specific nitrate enzyme (PM-NR), and NOX synthesis by many arginine-dependent gas synthase-like activities (NOS). According to studies, mitochondria are a major source of arginine- and nitrite-dependent NOX synthesis in plants. Tischner et al. acquired the first evidence for mitochondrial NO synthesis in plants when they assessed NO production under anoxic conditions from the unicellular blue green alga Chlorella sorokiniana (Tischner et al., 2004). This green alga does not create NO when exposed to nitrate (NO3), but it does create NO when exposed to nitrite (NO2). NO generation was also inhibited by mitochondrial electron transport inhibitors. Shortly after, mitochondrial NOx synthesis in higher plants was discovered. Gupta et al. discovered mitochondrial NOX production in barley plants grown in anoxic conditions (Gupta et al., 2010). Under anoxic circumstances, a tobacco nia1, 2 (nitrate reductase deficient) cell suspension was able to manufacture NOX from exogenous nitrite, despite the absence of nitrate reductase (which can also manufacture NOX from nitrite) (Gupta et al., 2011). Other putative NOX producers in plants include xanthine oxido reductase, peroxidase, and cytochrome P450. NOX is an ubiquitous chemical that is found in all eukaryotes. The NR system is by far the most effective and well-characterized mechanism for NOX generation in plants. In this case, the cytosolic NR mostly catalyzes the reduction of nitrate to group victimization NADH as the predominant negatron donor (Wilson. et al., 2008). NR's NAD (P) H-dependent NOX production has been demonstrated in vitro and in vivo (Rockel et al., 2002)"--
Author: Francesca Fenzi
Publisher:
ISBN:
Category :
Languages : en
Pages : 250
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Book Description
Author: Lucia Morbidelli
Publisher: Academic Press
ISBN: 0128172797
Category : Medical
Languages : en
Pages : 372
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Book Description
Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a variety of diseases. This book examines various studies related to the application of novel therapeutic NO (donors/inhibitors) compounds in the treatment of various cancers. These studies have been shown to exert significant therapeutic activities against various cancers and various inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, allergies, and asthma, where no current effective therapies exist. Pathologies based on functional and structural vascular alterations are also taken into consideration. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides readers with a clear overview of the recent findings and references as well as summaries, significant molecular pathways, and conclusions Discusses new ideas proposed and makes suggestions for further investigations that will advance the field Presents introductory and summary information on the contributions of the field, all the findings of the studies discussed, and projects future goals for research
Author: Sagarika Bhattacharya
Publisher: CRC Press
ISBN: 1000334775
Category : Medical
Languages : en
Pages : 117
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Book Description
Although nitric oxide (NO) is an important biological signaling molecule, its free-radical electronic configuration makes it a most reactive molecule and the scariest colorless gas causing immense environmental and health hazards. Detection of NO levels in biological samples and in the atmosphere is therefore crucial. In the past few years, extensive efforts have been devoted to developing many active sensors and effective devices for detecting and quantifying atmospheric NO, NO generated in biological samples, and NO exhaled in the human breath. This book provides a concrete summary of recent state-of-the-art small-molecule probes and novel carbon nanomaterials used for chemical, photoluminescent, and electrochemical NO detection. One chapter is especially dedicated to the available devices used for detecting NO in the human breath that indirectly infers to lung inflammation. The authors with expertise in diverse dimensions have attempted to cover almost all areas of NO sensing.
